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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Acta Pharmaciae Indonesia : Acta Pharm Indo SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JFIOnline JCPS (Journal of Current Pharmaceutical Sciences) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Pharmaceutical and Health Research Jurnal Pengabdian kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian OMNICODE Journal (Omnicompetence Community Developement Journal) Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan
Zamzani, Irfan
Universitas Muhammadiyah Banjarmasin
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Antibacterial activity of Sappan (Caesalpinia sappan L.) wood methanol extract against Staphylococcus epidermidis Waro Atunnisa; Irfan Zamzani; Siti Nashihah
Media Farmasi: Jurnal Ilmu Farmasi Vol 20, No 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.21900

Abstract

The entry and proliferation of microorganisms, such as bacteria, cause skin infections. One of the bacteria that causes skin infections is Staphylococcus epidermidis. Sappan (Caesalpinia sappan L.) wood has been known to have various pharmacology activities, one of which is antibacterial, so its activities need to be developed and improved. This study aimed to determine the activity of the methanol extract of Sappan (C. sappan L.) wood as an antibacterial against S. epidermidis. This research was conducted by extracting Sappan wood powder with 96% methanol as solvent using the Ultrasound-Assisted Extraction (UAE) method and testing for antibacterial activity with concentrations of 25%, 50%, 75% and 100% using the disc method. Results showed that the methanol extract of Sappan wood had an antibacterial activity; the highest inhibition zone at a concentration of 75% was 29.25 mm. Sappan wood was expected to be a promising alternative therapy for overcoming acne problems and can increase economic value for the wider community. 
Community Development in Barak’s Slum Area Towards a Healthy and Livable Neighborhood in Kotabaru Hanny Maria Caesarina; Cici Maryani Widayanti; Muhammad Rizqi Fatullah; Irfan Zamzani
OMNICODE Journal (Omnicompetence Community Developement Journal) Vol 2 No 2 (2023)
Publisher : UrbanGreen Central Media

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55756/omnicode.v2i2.145

Abstract

The Kotabaru District Government has a plan to improve the slum area in the Barak area, Dirgahayu village, North Laut Island sub-district. This received pro and con reactions from the local community. This community service activity seeks to empower local communities in the Barak area about the importance of a healthy and livable residential environment. The methods used are observation, interviews and giving exposure to the Barak community to understand the current conditions of the Barak slum area and the responses of the people living in it. At the end of the activity, the percentage of people who rejected the plan to improve the quality of the Barak slum area dropped from 64% to 36%. Meanwhile, the percentage of people who agreed increased from 40% to 60% with the suggestion that improvement plans should pay attention to the social, cultural and economic aspects of the local community. In addition, the development plan for the relocation of the Barak slum area must pay attention to the balance between open space, built-up areas, and regional-scale public infrastructure.
ANTIBACTERIAL POTENTIAL OF EGGPLANT FRUIT (Solanum melongena L) ETHANOL EXTRACT AGAINST Propionibacterium acnes BACTERIAL GROWTH Irfan Zamzani; Islan Nor; Muhammad Raihan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.840

Abstract

Acne is one of the skin problems that, without our realizing it, can reduce self-confidence, despair, and even depression among teenagers and young adults. The incidence of bacterial infections is increasing with the increasing cases of resistance of bacteria, such as Propionibacterium acnes, to the side effects of anti-acne drugs. Indonesia has many plants that are beneficial to humans and have properties for treating and improving health, one of which is the eggplant. The purpose of this study is to test whether eggplant has antibacterial activity against P. acnes. The eggplant was extracted using a maceration extraction method. For antibacterial activity, well diffusion agar was used with extract concentrations of 60%, 70%, 80%, and 90%. The inhibition zones of the ethanol extract of S. melongena at 60%, 70%, and 80% concentrations were 13,76 mm, 18,63 mm, and 20,79 mm, respectively, with the highest inhibition zone at 90% concentration at 20,64 mm. The ethanolic extract of S. melongena has a strong inhibitory effect on P. acnes.  Keywords: antibacterial activity, Solanum melongena L, maceration, Propionibacterium acnes.
Column Chromatography Fractionation and Antioxidant Activity of Passiflora foetida Leaves Nita Triadisti; Irfan Zamzani
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.1830

Abstract

Available synthetic antioxidants have been reported to have mutagenic and toxic effects. On the other hand, natural antioxidants show their superiority as they are not or less toxic. Passiflora foetida has the potential as an antioxidant, but the investigation of the antioxidant activity of the P. foetida chromatography column fraction has not been reported. This studied aims to investigate the antioxidant activity of the column chromatographic fractions of P. foetida leaves. An antioxidant assay using the DPPH and FRAP methods. The extraction was carried out by graded maceration, then fractionation using column chromatography. The antioxidant activity test was carried out using the DPPH and FRAP methods. Thin Layer Chromatography analysis was performed to determine the chromatogram pattern. The EC50 using DPPH method from n-hexane extract: 129.035 µg/mL, ethyl acetate extract: 206.398 µg/mL, methanol extract: 97.453 µg/mL, while the EC50 using FRAP method from n-hexane extract: 67.851 µg/mL, ethyl acetate extract : 68.981 µg/mL, and methanol extract: 58.787 µg/mL. Column chromatography fractions have antioxidant activity, with FMetPF6 as the fraction with the best activity, with percent inhibition 41.85±1.96 at concentration 25 µg/mL (DPPH), and with percent antioxidant activity 26.03±0.84 at concentration 9 µg/mL (FRAP). Passiflora foetida leaves have great potential as an antioxidant; both the extract and its fractions have antioxidant activity. The FMetPF6 has the best activity compare to other extracts and fractions. Further analysis to determine the various compounds in FMetPF6 using LC-MS/MS will facilitate the active compound's isolation.
EVALUASI AKTIVITAS ANTIOKSIDAN DAN PENGHAMBATAN ENZIM ?-GLUCOSIDASE DARI EKSTRAK KERING DAN FRAKSI DAUN JAMBU BOL (Syzygium malaccense): EVALUATION OF ANTIOXIDANT ACTIVITY AND INHIBITION OF ?-GLUCOSIDASE ENZYME FROM DRIED EXTRACT AND FRACTIONS OF JAMBU BOL (Syzygium malaccense) Islan Nor; Irfan Zamzani; Joko Priyanto Wibowo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.630

Abstract

Jambu bol (Syzygium malaccense) diberbagai belahan dunia digunakan sebagai pengobatan tradisional untuk mengobati berbagai penyakit dan gejala, termasuk sakit kepala, batuk, peradangan, dan hipertensi. Penyakit degeneratif menimbulkan beberapa penyakit seperti diabetes melitus. Pada tahun 2014 terdapat 422 juta orang dewasa menderita Diabetes Melitus di dunia. Prevalensi meningkat dari 4,7% pada tahun 1980 menjadi 8,5% pada tahun 2014 pada orang dewasa. Angka tertinggi diabetes melitus di Indonesia ditempati oleh DKI Jakarta (3,4%), Kalimantan Timur (3,3%), Yogyakarta (3,2%), dan Sulawesi Utara (3,0%). Antioksidan berperan mencegah penyakit degeneratif yang dikarenakan oleh radikal bebas. Agen penghambat ?-glucosidase dapat menjadi solusi dalam menangani diabetes melitus tipe 2. Tanaman dengan aktivitas antioksidan dan penghambat enzim ?-glucosidase dapat menangani pasien dengan penyakit degeneratif terutama diabetes melitus dengan stres oksidatif, dan menjadi alternatif yang kurang berbahaya dibandingkan obat sintetis. Penelitian ini dilakukan dengan mengekstraksi daun jambu bol dan dikeringkan dengan metode freeze drying, ekstrak difraksinasi dan didapatkan lima fraksi. Ekstrak dan fraksi dilakukan evaluasi terhadap antioksidan dengan metode DPPH dan antihiperglikemik dengan metode penghambatan enzim ?-glucosidase. Hasil dari penelitian ini didapatkan hasil IC50 ekstrak daun jambu bol (Syzygium malaccense) sebesar 57,14 ± 0,42 µg/mL yang termasuk dalam kategori kuat, begitu pula dengan fraksinya yaitu Fr4 dan Fr6 dengan nilai IC50 sebesar 35,52 ± 0,81 µg/mL dan 39,56 ± 1,17 µg/mL, berturut-turut yang tergolong kategori kuat. Begitu pula aktivitas ekstrak dalam menghambat enzim ?-glucosidase dengan persen penghambatan sebesar 83,72 ± 2,06 %. Maka perlu dikembangkan lagi jambu bol (Syzygium malaccense) sebagai agen antioksidan dan agen antihiperglikemia.
ANTIBACTERIAL POTENTIAL OF EGGPLANT FRUIT (Solanum melongena L) ETHANOL EXTRACT AGAINST Propionibacterium acnes BACTERIAL GROWTH Irfan Zamzani; Islan Nor; Muhammad Raihan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.840

Abstract

Acne is one of the skin problems that, without our realizing it, can reduce self-confidence, despair, and even depression among teenagers and young adults. The incidence of bacterial infections is increasing with the increasing cases of resistance of bacteria, such as Propionibacterium acnes, to the side effects of anti-acne drugs. Indonesia has many plants that are beneficial to humans and have properties for treating and improving health, one of which is the eggplant. The purpose of this study is to test whether eggplant has antibacterial activity against P. acnes. The eggplant was extracted using a maceration extraction method. For antibacterial activity, well diffusion agar was used with extract concentrations of 60%, 70%, 80%, and 90%. The inhibition zones of the ethanol extract of S. melongena at 60%, 70%, and 80% concentrations were 13,76 mm, 18,63 mm, and 20,79 mm, respectively, with the highest inhibition zone at 90% concentration at 20,64 mm. The ethanolic extract of S. melongena has a strong inhibitory effect on P. acnes.  Keywords: antibacterial activity, Solanum melongena L, maceration, Propionibacterium acnes.
Identifikasi Daun Sangkareho (Callicarpa longifolia Lam) secara Makroskopis dan Mikroskopis : Macroscopic and Microscopic Identification of Sangkareho (Callicarpa longifolia Lam.) Leaves Helma Novitasari; Siti Nashihah; Irfan Zamzani
Jurnal Sains dan Kesehatan Vol. 3 No. 5 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i5.570

Abstract

The utilization and development of traditional plants is a big investment for the sustainability of Indonesia society. Traditional medicine has its own requirements in order to guarantee the authenticity or correctness of the raw materials used. Sangkareho (Callicarpa longifolia Lam.) Is a family of Lamiaceae and a species of the genus Callicarpa. This study aims to provide scientific information data about the macroscopic and microscopic leaves of Sangkareho. The examination was carried out by observing the fresh leaves and the simplicia powder on the leaves of Sangkareho. The organoleptic results of the fresh Sangkareho leaves are hijua color, the distinctive smell of Sangkareho leaves is weak, and the taste is bitter, while the simplicia powder is slightly brownish in color, the distinctive smell of Sangkareho leaves is strong, and the taste is bitter. Macroscopic obtained by Sangkareho leaves are dark green on the upper surface and light green on the underside of the leaves, bitter taste, distinctive smell of Sangkareho leaves, oval elongated leaf shape, slightly hairy leaf surface, 11-17 cm long, 3 5-6 cm, the leaves are rather thin, the edges of the leaves are serrated, and the tips of the leaves are tapered, while for the simplicia powder it has a dense, smooth, non-stringy and dry texture, slightly brownish green, bitter taste, and has a distinctive smell of sangkareho leaves.
Co-Authors Afiatun Rahma Afrida Noor Hani Agung Endro Nugroho Ahmad Mahdi Mar'ie Akhmad Parhan Naja Annisa Nurislami Ari Suprianto Aulia ul Jannah Basnah Camelia Ulfah Cici Maryani Widayanti Denny Tamara Dewi Nurhanifah Erlina Fatmawati Gunawan Pamudji Gunawan Pamudji Widodo Hanny Maria Caesarina Harsono, Samuel Budi Hayatus Sa adah Hayatus Sa’adah Helma Novitasari Islan Nor Joko Priyanto Wibowo Liana Djeli Maesaroh Muhammad Farid Al Kadri Muhammad Raihan Muhammad Rizqi Fatullah Nashihah, Siti Nor Latifah Siti Norhaliza Titik Sunarni Triadisti, Nita Waro Atunnisa