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All Journal Jurnal Farmasi Klinik Indonesia Acta Pharmaciae Indonesia : Acta Pharm Indo JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Academic Hospital Journal
Dewi Latifatul Ilma
Jurusan Farmasi, Fakultas Ilmu-Ilmu Kesehatan, Universitas Jenderal Soedirman
Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Deteksi Dini Hipertensi dengan Pemeriksaan Tekanan Darah pada Masyarakat Desa X, Kabupaten Banyumas: Early Detection of Hypertension by Checking Blood Pressure in The Community Of Village X, Banyumas Regency Parmasari, Damairia Hayu; Suryanto; Beti Pudyastuti; Dewi Latifatul Ilma
Jurnal Pengabdian Kepada Masyarakat: Kesehatan Vol. 4 No. 3 (2024): September
Publisher : Sekolah Tinggi Ilmu Kesehatan Notokusumo Yogyakarta

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Abstract

Abstrak: Kesehatan merupakan faktor penting untuk meningkatkan derajat kualitas hidup masyarakat. Jumlah penderita penyakit tidak menular tertinggi di Banyumas yaitu hipertensi sebanyak 173.434 orang. Faktor risiko hipertensi adalah stres, aktivitas fisik yang kurang, konsumsi makanan tidak sehat, obesitas, serta umur yang ditandai gejala klinis yaitu tekanan darah yang tidak normal (>120/80 mmHg). Deteksi dini melalui pengukuran tekanan darah secara rutin menjadi upaya preventif pengelolaan risiko hipertensi. Masyarakat Desa X, Kabupaten Banyumas memiliki kasus yang sama, dimana tahun 2022 hipertensi merupakan penyakit dengan prevalensi tertinggi. Hal ini berbahaya jika tidak ditangani karena akan banyak yang menderita hipertensi sehingga tidak produktif bekerja. Tujuan: Mencegah hipertensi dan meminimalisasi tingkat keparahan hipertensi pada Masyarakat Desa X, Kabupaten Banyumas. Metode: Deteksi dini hipertensi melalui pemeriksaan tekanan darah dengan spigmomanometer. Hasil: Berdasarkan hasil pengukuran tekanan darah pada Masyarakat Desa X, Kabupaten Banyumas kepada 25 orang diperoleh hasil rata-rata tekanan sistole dan diastole masing-masing adalah 146 mmHg dan 83,2 mmHg.Ini menunjukkan bahwa tekanan darah di Masyarakat Desa X masih di atas normal (hipertensi). Kesimpulan: Deteksi dini hipertensi melalui pengukuran tekanan darah dan edukasi faktor risiko hipertensi pada Masyarakat Desa X merupakan langkah preventif untuk mencegah hipertensi dan meminimalisasi tingkat keparahan hipertensi Masyarakat Desa X, Kabupaten Banyumas.   Abstract: Health is an important factor in improving people's quality of life. The highest number of non-communicable disease sufferers in Banyumas, namely hypertension, was 173,434 people. Risk factors for hypertension are stress, lack of physical activity, consumption of unhealthy food, obesity, and age which is characterized by clinical symptoms, namely abnormal blood pressure (>120/80 mmHg). Early detection through routine blood pressure measurement is a preventive measure for managing the risk of hypertension. The people of Village X, Banyumas Regency have the same case, where in 2022 hypertension will be the disease with the highest prevalence. This is dangerous if not treated because many people will suffer from hypertension and will not be productive at work. Objective: Prevent hypertension and minimize the severity of hypertension in the Village X Community, Banyumas Regency. Method: Early detection of hypertension through checking blood pressure with a sphygmomanometer. Results: Based on the results of measuring blood pressure in Village Community normal (hypertension). Conclusion: Early detection of hypertension through measuring blood pressure and education on hypertension risk factors in Village X Community is a preventive measure to prevent hypertension and minimize the severity of hypertension in Village X Community, Banyumas Regency.
Hubungan Kadar Obat Gentamisin Dalam Darah Terhadap Outcome Clinic Pada Pasien Anak Yang Menderita Pneumonia Di RSUD Ajibarang Masita Wulandari Suryoputri; Dewi Latifatul Ilma; Nialiana Endah Endriastuti
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 3 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i3.61849

Abstract

Gentamisin merupakan obat dengan indeks terapi sempit yang perlu dilakukan pemantauan kadar obat dalam darah karena dapat berpengaruh pada luaran klinis pasien. Penelitian ini bertujuan untuk mengetahui hubungan kadar gentamisin dengan outcome clinic pada pasien anak yang menderita pneumonia. Perhitungan kadar gentamisin dalam darah dapat dilakukan secara farmakokinetika berdasarkan dosis dan frekuensi pemberian obat menggunakan rumus matematika. Penelitian ini merupakan penelitian dengan desain observasional dan retrospektif. Pengumpulan data dilakukan selama 3 bulan di Instalasi Rekam Medik RSUD Ajibarang. Pengambilan data secara total sampling yang memenuhi kriteria inklusi dan eksklusi. Analisis data statistik menggunakan uji chi square untuk mengetahui hubungan kadar gentamisin dengan outcome clinic responden. Hasil penelitian ini menunjukkan terdapat 52 responden (96,3%) memiliki kadar Cssave sesuai kisaran terapi (0,5-10mg/L) dan 2 responden (3,7%) memiliki kadar Cssave tidak sesuai kisaran terapi. Dari 52 responden yang memiliki kadar Cssave sesuai kisaran terapi (0,5-10mg/L) terdapat 21 responden memberikan outcome clinic membaik dan 31 responden memberikan outcome clinic belum membaik, sedangkan 2 responden yang memiliki kadar Cssave tidak sesuai kisaran terapi terdapat 1 responden memberikan outcome clinic membaik dan 1 responden memberikan outcome clinic belum membaik. Kesimpulan: berdasarkan perhitungan estimasi kadar obat gentamisin, tidak terdapat hubungan yang signifikan antara kadar Cssave gentamisin dengan outcome clinic pasien anak penderita pneumonia di RSUD Ajibarang (p>0.05).
Prevalence and characteristics of potential drug-drug interactions in hospitalized atrial fibrillation patients receiving anticoagulant therapy Putri, Atika; Ilma, Dewi Latifatul; Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah
Acta Pharmaciae Indonesia Vol 12 No 2 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.2.11882

Abstract

Background: Anticoagulants are essential for stroke prophylaxis in atrial fibrillation but carry significant interaction potential with commonly used medications. Understanding the prevalence and patterns of these interactions is crucial for optimizing therapy. Objective: To assess the incidence and characteristics of potential drug-drug interactions (DDIs) in hospitalized atrial fibrillation patients receiving anticoagulant therapy. Methods: This retrospective, descriptive observational study analyzed medical records of 324 atrial fibrillation patients hospitalized between January 2019 and December 2021 at a regional hospital in Banyumas Regency. Potential DDIs were assessed using Lexicomp, Drugs.com, and Merck Manual databases, and categorized by severity, mechanism, and clinical manifestation. Results: Nearly all patients (98.90%) experienced at least one potential DDI. Of 1,249 identified DDI events, most were moderate in severity (83.27%) and primarily involved warfarin (69.73%). Pharmacodynamic mechanisms predominated (51.24%), and decreased anticoagulant efficacy was the most common potential clinical manifestation (64.21%). Warfarin accounted for most pharmacokinetic (10.49%) and pharmacodynamic (32.42%) interactions. Elderly patients (>65 years) constituted the largest population group (40.74%), and most patients (65.74%) had atrial fibrillation as a secondary diagnosis. Conclusion: The high prevalence of potential DDIs involving anticoagulants in hospitalized atrial fibrillation patients underscores the need for vigilant medication management, particularly for patients receiving warfarin and those with multiple comorbidities.
Pemantauan Penggunaan Antikoagulan terhadap Perubahan Nilai aPTT pada Pasien Kardiovaskuler Suryoputri, Masita Wulandari; Ilma, Dewi Latifatul; Endriastuti, Nialiana Endah
Indonesian Journal of Clinical Pharmacy Vol 14, No 2 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2025.v14i2.49454

Abstract

Antikoagulan merupakan obat pengencer darah untuk mencegah pembentukan dan perkembangan trombus pada aliran darah. Warfarin dan heparin termasuk antikoagulan generasi lama. Rivaroxaban, edoksaban, dabigatran, dan apiksaban termasuk antikoagulan generasi baru. Obat ini memerlukan monitor yang ketat karena berindeks terapi sempit, dan memiliki potensi efek samping obat berupa perdarahan. Tujuan penelitian ini untuk mengetahui pengaruh penggunaan antikoagulan terhadap perubahan nilai aPTT dan mengetahui adanya kejadian adverse drug reaction (ADR) pada pasien kardiovaskuler di RSUD Prof. Dr. Margono Soekarjo Purwokerto. Metode penelitian ini dilakukan dengan rancangan deskriptif observational retrospektif, serta pengumpulan data didapat dari data rekam medis pasien rawat inap penyakit kardiovaskuler. Hasil penelitian ini menunjukkan bahwa responden paling banyak terdiagnosis miokard infark sebesar 39,9%, berusia 20–60 tahun (44%) dan paling banyak berjenis kelamin laki-laki (69,8%). Penggunaan antikoagulan yang digunakan pada responden penelitian ini, antara lain: heparin i.v. (64,70%), warfarin oral (14,11%), fondaparinux i.v. (18,86%), rivaroxaban oral (1,17%), dan enoxaparin oral (1,17%). Kejadian ADR yang timbul pada pasien yang menggunakan antikoagulan UFH mengalami hematuria (56,52%), epistaksis (13,04%), melena (13,04%), batuk berdarah (8,7%), hematemesis (4,35%), dan gusi berdarah (4,35%). Sedangkan pasien yang menggunakan antikoagulan fondaparinux mengalami hematuria (66,67%), epistaksis (11,11%), hematemesis (11,11%), dan gusi berdarah (11,11%). Hasil paired t-test menunjukkan terdapat pengaruh perubahan nilai aPTT setelah penggunaan antikoagulan heparin (p<0,05), dan kejadian ADR antikoagulan yang paling banyak timbul adalah hematuria. Penggunaan antikoagulan heparin dapat mengubah nilai aPTT sehingga perlu adanya monitoring tanda gejala perdarahan lebih lanjut.
Correlation Between Warfarin Levels in the Blood and the Value of Normal INR in Fibrillation Atrium Inpatients Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah; Ilma, Dewi Latifatul; Azzahra, Alfita
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.89898

Abstract

Background: Warfarin is an anticoagulant inhibitor of vitamin K that is effective in preventing systemic embolization in atrial fibrillation patients. Warfarin has a narrow therapeutic index, so it requires monitoring of rates to prevent the occurrence of toxic effects and to ensure the passage of INR values.Objectives: The study aims to find out the correlation between warfarin levels and normal INR values.Methods: Observational research method with the collection of retrospective data on the medical records of patients treated with atrial fibrillation at Prof. Dr. Margono Soekarjo Hospital, Purwokerto, in January 2019–December 2021. Warfarin levels were calculated pharmacokinetically using the steady-state concentration (Css) and plasma concentration (Cp) formulas. Data analysis is carried out using the Spearman test to determine the correlation between warfarin levels and normal INR values.Results: The number of patients with normal INR values was less than the number of patients with abnormal INR values, namely 21 patients and 48 patients. The Spearman test results show a p-value of 0.31 (p>0.05), showing that the correlation between warfarin levels in the blood and the corresponding INR value is not significant (p> 0.05), and the R value in the Spearman test is 0.122, showing that the direction of the correlation is positive with very weak correlation strength.Conclusion: The correlation between warfarin levels in the blood and the appropriate INR value is not significant (p>0.05), where the R value in the Spearman test shows R=0.122, meaning the direction of the correlation is positive with a very weak correlation strength.
Comparison of unfractionated heparin and fondaparinux in relation to the incidence of recurrent myocardial infarction Suryoputri, Masita Wulandari; Astuti, Dwi Aprilia; Endriastuti, Nialiana Endah; Ilma, Dewi Latifatul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1680

Abstract

Acute Myocardial Infarction (AMI) is a cardiovascular condition that involves necrosis of the heart muscle because of a decrease in blood supply to the heart caused by an obstruction of the coronary arteries. The prevalence of cardiac disease is 1.5% including AMI, and ranked 4th above all provinces in Indonesia. Anticoagulants are administered for the management of AMI treatment. Anticoagulants are treatments utilized to prevent thrombosis and reduce ischemic injury, preventing hemorrhage from developing in the heart's arteries and veins. Unfractionated heparin (UFH) and fondaparinux are both anticoagulants, that are utilized frequently in the treatment of AMI-EST patients. In decreasing the production of thrombin and preventing coagulation, unfractionated heparin, and fondaparinux can avoid death and recurrent myocardial infarction. The research was conducted as an observational study with retrospective data collection from medical records of inpatients diagnosed with acute transmural myocardial infarction of the anterior wall at Prof. Dr. Margono Soekarjo Purwokerto from January 2019 to December 2021. The chi-square test was used to examine the association between the type of anticoagulant therapy (unfractionated heparin or fondaparinux) and the incidence of recurrent myocardial infarction. The statistical analysis showed a significant association between the type of anticoagulant therapy and the incidence of recurrent myocardial infarction (p < 0.05). A higher proportion of patients treated with fondaparinux did not experience recurrent myocardial infarction compared to those treated with unfractionated heparin, suggesting that fondaparinux may be more effective in preventing recurrence.
Co-Authors Anindya Widyasari Ekasuci Anisa Dwi Sasanti Astuti, Dwi Aprilia Azzahra, Alfita Beti Pudyastuti Damairia Hayu Parmasari Djoko Wahyono Djoko Wahyono Endriastuti, Nialiana Endah Ika Mustikaningtias Ika Puspita Sari Ika Puspita Sari Irhamna Yulia Nikma Salsabila Laksmi Maharani Laksmi Maharani Laksmi Maharani Masita Wulandari Suryoputri Masita Wulandari Suryoputri Masita Wulandari Suryoputri Mustikaningtia, Ika MUSTIKANINGTIAS, IKA Nia Kurnia Sholihat Nia Kurnia Sholihat Nia Kurnia Sholihat, Nia Kurnia Nialiana Endah Endriastuti Nialiana Endah Endriastuti Nialiana Endah Endriastuti Nialiana Endah Endriastuti Parmasari, Damairia Hayu Prasetyaningrum, Dina Ayu Putri, Atika Suryanto Suryoputri, Masita Wulandari Tunggul Adi Purwonugroho