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Mega Novita
Universias PGRI Semarang
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Social Sciences Other

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Formulation and Evaluation of Spirulina-Based Gel with Varying Carbopol Concentrations for Anti-Acne Activity against Staphylococcus epidermidis Emmellia Yunitha; Anita Nilawati; Mega Novita; Dian Marlina
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.699-705

Abstract

Spirulina platensis is a blue-green microalga known for its antibacterial properties, offering potential as a natural alternative in acne treatment. Acne vulgaris, often caused by Staphylococcus epidermidis, requires effective topical solutions. Gels are favored for their non-greasy texture, ease of application, and good skin absorption. This study aimed to formulate and evaluate anti-acne gels containing 25% Spirulina extract with varying Carbopol concentrations (0.5%, 1%, 1.5%). Each formulation was assessed for physical properties, stability over 21 days, and antibacterial activity against S. epidermidis. All gel formulations met quality standards for pH, homogeneity, viscosity, spreadability, and adhesiveness. The gel with 0.5% Carbopol (FI) showed the best spreadability, ideal viscosity, and good adhesiveness, along with the highest antibacterial activity, exhibiting an inhibition zone of 16.5 mm—comparable to tetracycline. In conclusion, Spirulina-based gel with 0.5% Carbopol offers an effective, stable, and natural anti-acne option. These findings highlight the potential of Spirulina as a bioactive agent in topical formulations and encourage further research for clinical applications in acne management.
Co-Authors Abdillah Fathan Generus Annajah Achmad Buchori Aris Tri Jaka Harjanta, Aris Tri Bambang Agus Herlambang, Bambang Desi Purwaningsih Dian Ayu Azhari Diva Julia Paramita Dola Mareta Anggarini Emmellia Yunitha Fafa Nurdyansyah Febrian Murti Dewanto Fenny Roshayanti Haryo Kusumo Haryo Kusumo Hayat, Muhammad Syaipul Hery Widijanto I Nyoman Adi Putra Iffah Muflihati Iffah Muflihati, Iffah Joko Setyawan Katarina Herwanti Khoirya Latifah Laelia Puti Aditasar Marlina, Dian Mujiono Mujiono Nila Kusumaningtyas Nilawati, Anita Nugroho Dwi Saputro Nur Khoiri Nurdiyati Nurfiana Rachmawati Retno Setianingsih Rifki Hermana Rifki Hermana Rina Widyawati Rizky Muliani Dwi Ujianti Rizky Muliani Dwi Ujianti Saptono Nugrohadi Saptono Nugrohadi Senowarsito Senowarsito Senowarsito, Senowarsito Shindi Nofitasari Siti Aisiyah Siti Nurlaela Setianingsih Sri Wahyuni Stanislaus Christo Petra Nugraha Sudargo Sudargo Sukma Nur Ardini Sutomo Sutomo Sutomo Sutomo Sutomo Sutomo Sutomo Sutomo Waliyansyah, Rahmat Robi Yuris Setyoadi