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All Journal Saintia Biologi Buletin Penelitian Tanaman Rempah dan Obat Biology, Medicine, & Natural Product Chemistry Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Journal of Science and Applicative Technology Pharmasipha Majalah Farmasetika Jurnal Pengabdiaan Masyarakat Kasih (JPMK) Indonesia Natural Research Pharmaceutical Journal (INRPJ) Buletin Penelitian Tanaman Rempah dan Obat JPK: Jurnal Proteksi Kesehatan Spizaetus: Jurnal Biologi dan Pendidikan Biologi Jurnal Farmasi Etam CELEBES Agricultural Jurnal Farmasi Sains dan Praktis Journal of Biotechnology and Natural Science JUSTE (Journal of Science and Technology) Jurnal Pepadu Jurnal Pengabdian Kesehatan Jurnal Sains dan Kesehatan Jurnal Pengabdian Masyarakat Hutan
Sister Sianturi
STIKES DIRGAHAYU SAMARINDA
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Pharmasipha

 1 
Uji Aktivitas Antibakteri Perasan Jeruk Nipis (Citrus aurantifolia) terhadap Pertumbuhan Bakteri Propionibacterium acnes Jeremia Eden Frihendranus; Sister Sianturi; Wiwi Erwina
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8597

Abstract

The main causes of skin infections is Propionibacterium acnes. The use of antibiotics can be an effective treatment of acne for example: clindamycin. Lime was a plant that is used as a treatment for acne’s inhibition. The lemon part often used to treat acne was the juice. The purpose of this study was to determine the activity of lime juice in inhibiting the growth of Propionibacterium acnes and to determine the minimum inhibitory concentration of lime juice against Propionibacterium acnes. The study used lime juice with various concentrations of 100%, 50%, 25%, and 12.5% on the growth of Propionibacterium acnes bacteria using the disc diffusion method. The data obtained were tested for normality Kolmogorov-Smirnov and homogeneity test. Then the Kruskall Wallis and Mann-Whiteney test were performed. Based on this study, lime juice was proven to be able to inhibit the growth of Propionibacterium acnes bacteria. The inhibition zone with the highest average concentration was at 100% concentration, which was 18.7 mm and the smallest average inhibition zone was found at a concentration of 12.5%, which was 11.5 mm. The results of the statistical test showed a significant difference with p-value= 0.029 between the positive control and the variation of the sample concentration.
Uji Aktivitas Antibakteri Perasan Jeruk Nipis (Citrus aurantifolia) terhadap Pertumbuhan Bakteri Propionibacterium acnes Frihendranus, Jeremia Eden; Sianturi, Sister; Erwina, Wiwi
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 6 No. 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8597

Abstract

The main causes of skin infections is Propionibacterium acnes. The use of antibiotics can be an effective treatment of acne for example: clindamycin. Lime was a plant that is used as a treatment for acne’s inhibition. The lemon part often used to treat acne was the juice. The purpose of this study was to determine the activity of lime juice in inhibiting the growth of Propionibacterium acnes and to determine the minimum inhibitory concentration of lime juice against Propionibacterium acnes. The study used lime juice with various concentrations of 100%, 50%, 25%, and 12.5% on the growth of Propionibacterium acnes bacteria using the disc diffusion method. The data obtained were tested for normality Kolmogorov-Smirnov and homogeneity test. Then the Kruskall Wallis and Mann-Whiteney test were performed. Based on this study, lime juice was proven to be able to inhibit the growth of Propionibacterium acnes bacteria. The inhibition zone with the highest average concentration was at 100% concentration, which was 18.7 mm and the smallest average inhibition zone was found at a concentration of 12.5%, which was 11.5 mm. The results of the statistical test showed a significant difference with p-value= 0.029 between the positive control and the variation of the sample concentration.
Uji aktivitas antibakteri daun lakump (Cayratia trifolia L.) terhadap bakteri Staphylococcus haemolyticus ATCC 29970 secara in-vitro Tiara, Anastasia; Sianturi, Sister; Butar-Butar, Maria Elvina Tresia
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 8 No. 1 (2024): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v8i1.10623

Abstract

Staphylococcus haemolyticus merupakan salah satu bakteri yang memiliki tingkat resistensi yang cukup tinggi terhadap beberapa jenis antibiotik. Hal ini menjadi alasan untuk mencari senyawa antimikroba baru dari sumber alami. Tumbuhan yang berpotensi sebagai senyawa antibakteri adalah tumbuhan lakump (Cayratia trifolia L.). Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol daun lakump terhadap bakteri S. haemolyticus menggunakan metode difusi sumuran. Metode ekstraksi yang digunakan pada penelitian ini adalah maserasi. Pengamatan dilakukan terhadap diameter zona hambat yang terbentuk disekitar sumuran. Rata-rata diameter zona hambat yang terbentuk adalah, untuk konsentrasi 20% sebesar 7,37 mm, konsentrasi 30% sebesar 10,29 mm, dan konsentrasi 40% sebesar 11,23 mm, serta untuk kontrol positif antibiotik kloramfenikol sebesar 28,58 mm, sedangkan kontrol negatif DMSO 1% tidak terbentuk zona hambat. Hasil uji analisis data One Way-Anova menggunakan program SPSS 26 diperoleh hasil p-value (p<0.05), artinya terdapat aktivitas antibakteri dan perbedaan rata-rata diameter zona hambat antara ekstrak etanol daun lakump konsentrasi ekstrak 20%, 30%, dan 40% dengan kontrol positif dan negatif dalam menghambat pertumbuhan bakteri S. haemolyticus.
Uji aktivitas antibakteri ekstrak etanol daun sirih cina (Peperomia pellucida L.) terhadap Staphylococcus saprophyticus ATCC 49907 penyebab infeksi saluran kemih Citraningsih, Ni Putu Dewi; Sianturi, Sister; Taufiqurrahman, Muh.
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 8 No. 2 (2024): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v8i2.10654

Abstract

Tingginya tingkat resistensi antibiotik menjadi ancaman serius bagi kesehatan masyarakat secara global. Hal ini menjadi alasan untuk mencari senyawa antimikroba baru dari sumber alami. Tanaman yang berkhasiat untuk membunuh bakteri adalah tanaman yang mengandung metabolit sekunder. Salah satu tanaman yang mengandung metabolit sekunder adalah tanaman sirih cina (Peperomia pellucida L). Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol daun sirih cina terhadap pertumbuhan Staphylococcus saprophyticus penyebab infeksi saluran kemih dengan metode disc diffusion test. Metode ekstraksi yang digunakan adalah maserasi dangan pelarut etanol 96% yang dibuat menjadi tiga variasi konsentrasi 10%, 50% dan 90%. Kontrol positif menggunakan amoxicillin dan kontrol negatif menggunakan DMSO 1%. Rata-rata diameter zona hambat dengan konsentrasi 10%, 50% dan 90% berturut-turut, yaitu 4,06 mm, 6,46 mm dan 10,64 mm yang termasuk kategori lemah hingga kuat. Sedangkan pada kontrol positif rata-rata zona hambat adalah sebesar 26,49 mm dengan kategori sangat kuat. Hasil uji analisis data One Way Anova menggunakan program SPSS IBM versi 26 diperoleh hasil (p<0.05) yang bermakna H0 ditolak dan H1 diterima atau terdapat perbedaan rata-rata diameter zona hambat ekstrak daun sirih cina yang signifikan antara kelompok perlakuan dengan kontrol positif dalam menghambat bakteri S. saprophyticus.                                                                            Kata Kunci: Peperomia pellucida L, Staphyloccoccus saprophyticus, antibakteri, difusi cakram
Co-Authors Andrian Fernandes, Andrian Annisa Farida Muti Aprilia Ulfa Citraningsih, Ni Putu Dewi Clara Ritawany Sinaga Desy Satrana Elianto, Nopriani Elzius Fransiscus Lumban Gaol Emita Sabri Erwina, Wiwi Fahrudin Gozali Fajar Febriani, Amelia Febry Rahmadhani Hasibuan Frihendranus, Jeremia Eden Gaol, Elzius Fransiscus Lumban Gesha Desy Alisha Hanindita, Shafira Jeremia Eden Frihendranus Manalu, Mia Aty Dolok Rosa Maria Elvina Tresia Butar-Butar Masitta Tanjung Meriska Susi Ayuni Moh. Benny Perdana Nugraha, Rieffal Rendra Nurillahi Febria Leswana Prehatin, Chrisbaningrum Rahmi Syariifatul Riska Yulianti, Riska Saharuddin, Tria Saputra Simanjuntak, Servis Simanullang, Raymon Sinaga, Clara Ritwany Tampubolon, Pebri Sara Taufiqurrahman, Muh Teodhora, Teodhora Tiah Rachmatiah Tiara, Anastasia Wiwi Erwina Wiwi Erwina Yanti Ariyanti