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All Journal Journal of Natural Product and Pharmaceutical Chemistry Journal of Natural Sciences and Mathematics Research Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Applied Research (IJAR)
Siti Morin Sinaga
Department Of Pharmaceutical Chemistry, Faculty Of Pharmacy, Universitas Sumatera Utara, Jl. Tri Dharma No. 5, Kampus USU, Medan. Sumatera Utara, Indonesia 20155.
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Composition of Fatty Acid and Identification of Lauric Acid Position in Coconut and Palm Kernel Oils Silalahi, Jansen; Lida Karo Karo; Sinaga, Siti Morin; Yosy Cinthya Eriwaty Silalahi
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 2 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (713.097 KB) | DOI: 10.32734/idjpcr.v1i2.605

Abstract

The nutritional value and biochemical properties of oil are measured by the fatty acids composition in oil and the position of fatty acids (sn-1,2,3) in the triacylglycerol (TAG) molecule. The purpose of this study was to measure the nutritional value based on the fatty acids composition of virgin coconut oil (VCO) and palm kernel oil (PKO), and the position of lauric acid in sn-2. The VCO used was VCO obtained from one of the Pharmacies store in Medan, and PKO from the Oil Processing Plant. The total fatty acid composition was measured by Gas Chromatography. The nutritional value of fat was evaluated by the percentage deviation from 33.33% (ratio: 1: 1: 1) of each group of fatty acid (saturated fatty acids; SFA: monounsaturated fatty acids; MUFA:polyunsaturated fatty acid (PUFA). The distribution of lauric acid in TAG was conducted through hydrolysis by using specific lipase enzymes active at sn-1,3 positions, so that free fatty acids and 2-monoacylglycerol were produced from one TAG molecule. Then free fatty acids were determined by Gas Chromatography. The distribution of lauric acid at sn-2 position was the difference between total lauric acid on TAG before hydrolysis and free lauric acid from sn-1.3 position after hydrolysis. The results showed that PKO nutritional value was better because of the smaller deviation (95.29%) compared with nutritional value of VCO with a greater deviation (118.55%). Lauric acid in sn-2 from VCO and PKO showed that the distribution of lauric acid in sn-2 position was not different,48.33and 48.59%. Keywords: virgin coconut oil, palm kernel oil, composition of fatty acids, sn-2 position, lauric acids
In Vitro Test of Anticalculi Effect from Ethyl Acetate Fraction of Chives Leaf (Allium schoenoprasum L.) Iksen; Sinaga, Siti Morin; Kevin, Kevin; Hutabalian, Marshinta Romarta Uly
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (720.469 KB) | DOI: 10.32734/idjpcr.v2i2.3030

Abstract

Abstract. The purpose of this study was to analyze the ability of chives leaves of ethyl acetate fraction to dissolve calcium in human kidney stones. This research starts from making the ethyl acetate fraction, calibration curve for calcium and measuring dissolved calcium levels in kidney stones by using atomic absorption spectrophotometry. The results showed that the ethyl acetate fraction with a concentration of 2.5% had the greatest anti-calculi capability of 92.02%. The conclusion of this study is that the ethyl acetate fraction of chives leaf has the potential to be anticalculi in the treatment of kidney stones. Abstrak. Tujuan dari penelitian ini adalah untuk menganalisis kemampuan fraksi etil asetat daun kucai untuk melarutkan kalsium pada batu ginjal manusia. Penelitian ini dimulai dari pembuatan fraksi etil asetat, pembuatan kurva kalibrasi kalsium serta pengukuran kadar kalsium terlarut pada batu ginjal dengan menggunakan spektrofotometri serapan atom. Hasil penelitian menunjukkan bahwa fraksi etil asetat dengan konsentrasi 2,5 % memiliki kemampuan antikalkuli yang terbesar yakni 92,02%. Kesimpulan penelitian ini adalah bahwa fraksi etil asetat daun kucai berpotensi sebagai antikalkuli pada pengobatan batu ginjal.
Simultaneous quantification of B-complex vitamins in tablet dosage form by ultraviolet spectrophotometry using the absorption factor method Effendy De Lux Putra; Siti Morin Sinaga; Harfiansyah, M. Deddy
Journal of Natural Sciences and Mathematics Research Vol. 11 No. 1 (2025): June
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/jnsmr.v11i1.26111

Abstract

A novel ultraviolet (UV) spectrophotometric method using the absorption factor approach was developed for the simultaneous quantification of B-complex vitamins (cobalamin, pyridoxine, riboflavin, nicotinamide, and thiamine) in tablet dosage forms. The analysis was carried out using methanol as the solvent, with distinct wavelengths selected for each vitamin: 361 nm for cobalamin, 291 nm for pyridoxine, 269 nm for riboflavin, 262 nm for nicotinamide, and 239 nm for thiamine. The method exhibited excellent accuracy, with recovery rates of 100.0851%, 100.3548%, 100.3322%, 100.7838%, and 100.4271% for cobalamin, pyridoxine, riboflavin, nicotinamide, and thiamine, respectively. This technique provides a simple, precise, and effective means for simultaneous quantification of B-complex vitamins in tablet formulations. The method satisfies all validation criteria and shows minimal interference from excipients, making it a reliable tool for quality control in pharmaceutical analysis.
Co-Authors Aminah Dalimunthe Cintya, Henni Dea Anggreini Denny Satria, Denny Effendy De Lux Putra Effendy De Lux Putra, Effendy De Lux Effendy De Putra Fathur Rahman Furi, Mustika Ginting, Nahitma Ginting, Nahitma Harfiansyah, M. Deddy Hutabalian, Marshinta Romarta Uly Iksen, Iksen Jansen Silalahi Kevin kevin Lida Karo Karo Mursalina Mursalina Nasri Nasri, Nasri Siregar, Nina Ashariani Siti Khairiyah Suci Wulandari Urip Harahap Wardono, Sri Waruwu, Syukur Berkat Yosy Cinthya Eriwaty Silalahi Yuandani