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All Journal JIK- JURNAL ILMU KESEHATAN Human Care Journal jurnal abdimas saintika NUSANTARA: Jurnal Pengabdian Kepada Masyarakat Safari : Jurnal Pengabdian Masyarakat Indonesia Jurnal Informasi Pengabdian Masyarakat Detector: Jurnal Inovasi Riset Ilmu Kesehatan Harmoni Sosial : Jurnal Pengabdian Dan Solidaritas Masyarakat Jurnal Kesehatan Cendikia Jenius Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Roza Erda
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Agriculture, Biological Sciences & Forestry Arts Humanities Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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FORMULASI DAN UJI EVALUASI SEDIAAN SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) DARI EKSTRAK METANOL AKAR PANDAN LAUT (PANDANUS ODORIFER) Ghiffari, Habibie Deswilyaz; Suhendra, Arif; Vonikartika, Arie; Roza Erda
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.964

Abstract

Background: Pandanus odorifer is a coastal plant in Southeast Asia with roots rich in bioactive compounds such as phenolics, flavonoids, saponins, and alkaloids. Limited solubility and bioavailability of lipophilic compounds hinder therapeutic effectiveness. Objective: To develop and evaluate Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulation from sea pandanus root methanol extract to enhance solubility and stability. Methods: Root extraction was performed using soxhlet method with methanol solvent. Six SNEDDS formulas were developed with variations of Tween 80/Tween 20 surfactant combinations and PEG 400/propylene glycol cosurfactants. Evaluation included simplicia characterization, organoleptic tests, creaming tests, pH and viscosity measurements, centrifugation, freeze-thaw stability, solubility, and droplet size analysis. Results: Extract yield reached 7.72% with simplicia characterization meeting pharmacopoeial standards. Formula F3 (Tween 80 21.4%, PEG 400 21.4%, VCO 4.75%, extract 5%) demonstrated optimal stability with pH 6.91±0.04, viscosity 253.33±11.55 cPs, HLB value 14.50, and average droplet size 530 nm. This formula maintained homogeneity throughout all stability tests without phase separation. Conclusion: SNEDDS from Pandanus odorifer root methanol extract formula F3 possesses physicochemical characteristics and stability suitable for nanoemulsion-based drug delivery systems.
Uji Efektifitas Fraksi Daun Setebal (Glochidion superbum) terhadap Penyembuhan Luka Sayat pada Mencit Putih Jantan (Mus musculus L.) Rivelino William Putra Nazara; Habibie Deswilyaz Ghiffari; Ghalib Syukrillah Syahputra; Desy Gusmali Maniarti; Roza Erda
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 4 No. 1 (2026): Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v4i1.5895

Abstract

Wounds can be defined as the loss and damage of anatomical cells or skin function. Wound healing consists of coagulation, inflammation, proliferation, and remodeling stages. This study aims to determine the effectiveness of the leaf fraction of the thick (Glochidion superbum) on wound healing in male white mice (Mus musculus). This study is experimental. This study used 24 male mice that were given a 10 mm long cut wound. Fractionation was carried out using the liquid-liquid extraction method. Fractionation used 3 different types of solvents, namely methanol, ethyl acetate, and n-hexane. The results showed that the ethyl acetate fraction had a faster wound healing effectiveness than the other groups. The ethyl acetate fraction contains a phenolic compound, namely methyl gallate. Methyl gallate has an important role in wound healing. Methyl gallate has the potential to be an antibacterial, antioxidant, and anti-inflammatory. The results of the Bonferroni post-hoc statistical analysis confirmed the effectiveness of the ethyl acetate fraction in faster wound healing. The thick leaf fraction was effective in healing incisions in male white mice. The ethyl acetate fraction was more effective in accelerating incision healing.
Co-Authors Afif D Alba Aprilya Roza Werdani Desi Ernita Amru desy desy Desy Gusmali Maniarti Didi Yunaspi Ditte Ayu Suntara Ghalib Syukrillah Syahputra Ghiffari, Habibie Deswilyaz Haqqelni Nur Rosyidah Hayat, Nahrul Isna Aglusi Badri Justiyulfah Syah Larasuci Arisani Nola Yusra Novita Khairunnisa Alisyah Novizahanis Nurma Zela Gustina Nurul Oktavia Asyriani Rahmadeni, Asfri Sri Rastria Meilanda resi novia Rivelino William Putra Nazara Siska Pratiwi Siti Husaidah Suci Fitriani Sammulia Suhendra, Arif Tiara Sonza Vonikartika, Arie Yulia Devi Putri Zela Gustina, Nurma