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All Journal JIK- JURNAL ILMU KESEHATAN Human Care Journal jurnal abdimas saintika NUSANTARA: Jurnal Pengabdian Kepada Masyarakat Safari : Jurnal Pengabdian Masyarakat Indonesia Jurnal Informasi Pengabdian Masyarakat Harmoni Sosial : Jurnal Pengabdian Dan Solidaritas Masyarakat Jurnal Kesehatan Cendikia Jenius Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Roza Erda
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FORMULASI DAN UJI EVALUASI SEDIAAN SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) DARI EKSTRAK METANOL AKAR PANDAN LAUT (PANDANUS ODORIFER) Ghiffari, Habibie Deswilyaz; Suhendra, Arif; Vonikartika, Arie; Roza Erda
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 2 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i2.964

Abstract

Background: Pandanus odorifer is a coastal plant in Southeast Asia with roots rich in bioactive compounds such as phenolics, flavonoids, saponins, and alkaloids. Limited solubility and bioavailability of lipophilic compounds hinder therapeutic effectiveness. Objective: To develop and evaluate Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulation from sea pandanus root methanol extract to enhance solubility and stability. Methods: Root extraction was performed using soxhlet method with methanol solvent. Six SNEDDS formulas were developed with variations of Tween 80/Tween 20 surfactant combinations and PEG 400/propylene glycol cosurfactants. Evaluation included simplicia characterization, organoleptic tests, creaming tests, pH and viscosity measurements, centrifugation, freeze-thaw stability, solubility, and droplet size analysis. Results: Extract yield reached 7.72% with simplicia characterization meeting pharmacopoeial standards. Formula F3 (Tween 80 21.4%, PEG 400 21.4%, VCO 4.75%, extract 5%) demonstrated optimal stability with pH 6.91±0.04, viscosity 253.33±11.55 cPs, HLB value 14.50, and average droplet size 530 nm. This formula maintained homogeneity throughout all stability tests without phase separation. Conclusion: SNEDDS from Pandanus odorifer root methanol extract formula F3 possesses physicochemical characteristics and stability suitable for nanoemulsion-based drug delivery systems.
Co-Authors Afif D Alba Aprilya Roza Werdani Desi Ernita Amru desy desy Didi Yunaspi Ditte Ayu Suntara Ghiffari, Habibie Deswilyaz Haqqelni Nur Rosyidah Hayat, Nahrul Isna Aglusi Badri Justiyulfah Syah Larasuci Arisani Nola Yusra Novita Khairunnisa Alisyah Novizahanis Nurma Zela Gustina Nurul Oktavia Asyriani Rahmadeni, Asfri Sri Rastria Meilanda resi novia Siska Pratiwi Siti Husaidah Suci Fitriani Sammulia Suhendra, Arif Tiara Sonza Vonikartika, Arie Yulia Devi Putri Zela Gustina, Nurma