Bambang Budi Siswanto
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, University Of Indonesia, And National Cardiovascular Center Harapan Kita, Jakarta

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Journal : Heart Science Journal

Periodontitis and venous thromboembolism risk: Investigating the connection through a systematic review and meta-analysis Pratama, Erlan Anugrah; Sadikaningtya, Lirasati; Indarto, Malik Jantra; Adi, Andi Wahjono; Siswanto, Bambang Budi
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.8

Abstract

BACKGROUND: The relationship between periodontitis and venous thromboembolism (VTE) remains controversial. Some studies show an association, while others do not show an association between periodontitis and VTE. OBJECTIVES: This study aims to determine the relationship between periodontitis and the risk of VTE using a meta-analysis approach. METHODS: A meta-analysis study, registered in PROSPERO, was conducted from August to September 2024. The sources for article searches in this study were Scopus, Embase, and PubMed. Data on the proportion of VTE occurrences in the periodontitis and non-periodontitis groups were collected from each article, and pooled point estimates were calculated using the Mantel-Haenszel test. RESULTS: We identified 40,397 VTE cases and 2,215,063 controls from six articles. Among these six articles, three showed an association between periodontitis and an increased risk of VTE. Additionally, we identified one article reporting that periodontitis was associated with a decreased risk of VTE. Furthermore, two articles revealed that periodontitis had no association with VTE occurrence. Our calculations using the Mantel-Haenszel test showed that, overall, an increased risk of VTE was found in individuals with periodontitis compared to those without (RR: 1.61; 95% CI: 1.09 – 2.39; Egger's p: 0.7917; Heterogeneity p: <0.0001; p: 0.0200). CONCLUSION: We have identified that periodontitis is an important factor in the occurrence of VTE.
Periodontitis and venous thromboembolism risk: Investigating the connection through a systematic review and meta-analysis Pratama, Erlan Anugrah; Sadikaningtya, Lirasati; Indarto, Malik Jantra; Adi, Andi Wahjono; Siswanto, Bambang Budi
Heart Science Journal Vol. 6 No. 1 (2025): Challenges in Managing Acute Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.01.8

Abstract

BACKGROUND: The relationship between periodontitis and venous thromboembolism (VTE) remains controversial. Some studies show an association, while others do not show an association between periodontitis and VTE. OBJECTIVES: This study aims to determine the relationship between periodontitis and the risk of VTE using a meta-analysis approach. METHODS: A meta-analysis study, registered in PROSPERO, was conducted from August to September 2024. The sources for article searches in this study were Scopus, Embase, and PubMed. Data on the proportion of VTE occurrences in the periodontitis and non-periodontitis groups were collected from each article, and pooled point estimates were calculated using the Mantel-Haenszel test. RESULTS: We identified 40,397 VTE cases and 2,215,063 controls from six articles. Among these six articles, three showed an association between periodontitis and an increased risk of VTE. Additionally, we identified one article reporting that periodontitis was associated with a decreased risk of VTE. Furthermore, two articles revealed that periodontitis had no association with VTE occurrence. Our calculations using the Mantel-Haenszel test showed that, overall, an increased risk of VTE was found in individuals with periodontitis compared to those without (RR: 1.61; 95% CI: 1.09 – 2.39; Egger's p: 0.7917; Heterogeneity p: <0.0001; p: 0.0200). CONCLUSION: We have identified that periodontitis is an important factor in the occurrence of VTE.
Co-Authors Achir Yani S. Hamid Adi, Andi Wahjono Agung Waluyo Ambari, Ade Meidian Amiliana M Soesanto Amiliana M. Soesanto Andi Mahavira Andy Kristyagita Anna Ulfah Rahajoe Anwar Santoso Aria Kekalih Asrory, Virna Dwi Oktariana Astari Pranindya Sari Basuni Radi BRM Ario S. Kuncoro Budhi Antariksa Budhi S. Purwowiyoto Dedi Afandi Desandri, Dwita Rian Dewi H Suprobo Dewi H Suprobo Dewi Irawati DEWI IRAWATI Dewi Irawati Diana Septiyanti Doni Firman Dwiputra, Bambang Emir Yonas Endang Ratnaningsih Erwin Mulia Fatoni, Mukhamad Ganesja M Harimurti Ganesja M Harimurti Gipta Galih Widodo Hadrian Deka Hananto Andriantoro Harahap, Alida R. Harahap, Alida Rosita Hari Utomo Hariadi Hariawan Harmani Kalim Herliana , Rini Huda , Khoirul I Made Putra Swi Antara Idrus Alwi Ikhda Ulya, Ikhda Indarto, Malik Jantra Indriwanto Sakidjan Januar W Martha Jaya, Irvantri Aji Junaiti Sahar Jusup Endang Juzni Alkatiri Katsukawa, Hajime Kusuma, Nico Listyaningsih, Erlin Lukman H. Makmun Muhammad Munawar Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nani Hersunarti Nico Kusuma Nico Kusuma Nitia A. Asbarinsyah Nur Haryono Nurhay Abdurachman Nusanti, Synthia Oktarina, Virna Dwi Pius Almindu Leki Berek Poppy S Roebiono Pranata, Raymond Pratama, Erlan Anugrah Prima Almazini Purwowiyoto, Budhi S. Rachel Vania Rachel Vania Radityo Prakoso Raja Adil C Siregar Rarsari S. Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Rarsari Soerarso Raymond Pranata Retna Dewayani Rif'ati, Lutfah Rizki Rizki Rony Mario Candrasatria, S Taofan Sadikaningtya, Lirasati Sekarsari, Rita Seskoati Prayitnaningsih Siska Sulistiowati Sri Yona Syntia Nusanti Tambunan, Tresia Fransiska Ulianna Tambunan, Tresia FU. Teuku Heriansyah, Teuku Tony Suharsono, Tony Triangto, Kevin Vania, Rachel Vidya Gilang Rejeki Wahju Aniwidyaningsih Wendy M. Saragih Wienta Diarsvitri William Sanjaya Wisnu Jatmiko Yoga Yuniadi Yonas, Emir