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All Journal Jurnal Sains Materi Indonesia Indonesian Journal of Pharmaceutical Science and Technology Proceeding Seminar LPPM UMP Tahun 2014 INDONESIAN JOURNAL OF PHARMACY IDJP (Indonesian Journal of Pharmaceutics) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Sehat Indonesia (JUSINDO) Lansau: Jurnal Ilmu Kefarmasian Borneo Journal of Pharmacy

Sundani Nurono Soewandhi

Keilmuan Farmasetika, Sekolah Farmasi Institut Teknologi Bandung, Bandung, Indonesi

Author-ID : 384369

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Pengembangan Inovasi Kesehatan dan Teknologi Menuju Masyarakat Madanis Soewandhi, Sundani Nurono
Proceeding Seminar LPPM UMP Tahun 2014 2014: Proceeding Seminar Nasional LPPM 2014, 20 Desember 2014
Publisher : Proceeding Seminar LPPM UMP Tahun 2014

Show Abstract | Download Original | Original Source | Check in Google Scholar

Persoalan aktual yang dihadapi seluruh industri farmasi di dunia disebabkan karena; (1) sifat hidrofobik bahan aktif farmasi (BAF) yang menyebabkan kelarutannya rendah di dalam air dan berakibat pada rendahnya laju disolusi serta bioavailabilitasnya; (2) sifat polimorfisme yang ditunjukkan 70-80% BAF dengan segala konsekuensinya; (3) antaraksi antarmolekular sistem biner yang terdiri dari minimal dua BAF atau kombinasi BAF dan eksipien atau Non BAF; (4) transformasi polimorfik BAF yang berpengaruh pada masa kadaluwarsa sediaan.Â Untuk mengatasi persoalan-persoalan tersebut, akhir-akhir ini di dunia farmasi mulai diterapkan metode kristalografik yang terdiri dari difraksi sinar-X serbuk, difraksi sinar-X kristal tunggal, analisis termal, spektroskopi inframerah, spektroskopi Raman, mikrokop polarisasi dan mikroskop elektron. Melalui penggunaan instrumen-intrumen ini dapat diketahui habit, dimensi, kondisi permukaan partikel, sistem kristal, indeks kristalinitas, enthalpi, suhu lebur, suhu transisi dan perubahan-perubahannya akibat perlakukan tribomekanik, termal, hidrotermal ataupun kompresi. Dengan demikian, peristiwa transformasi polimorfik BAF teridentifikasi, kebenaran informasi dalam Certificate of Analysis BAF, CoA terjamin dan antaraksi antarmolekular kombinasi BAF terdeteksi sejak dini. Jika metode-metode tersebut digunakan untuk tujuan kuantitatif, maka kinetika reaksi transformasi polimorfik dapat ditentukan. Dengan demikian, batas waktu kadaluwarsa sediaan farmasi yang disebabkan perubahan fisika dapat ditetapkan. Prinsip rekayasa kristal atau crystal engineering yang mulai berkembang pesat sejak tahun 2005 diterapkan dengan tujuan mengubah sementara karakter fisika BAF yang semula sukar menjadi mudah larut di dalam air, semula higroskopis menjadi tidak higroskopis, semula sukar dikompresi menjadi mudah dikompresi dan sebagainya. Rekayasa kristal melibatkan BAF dan koformer membentuk ko-kristal atau molekul super melalui adanya ikatan hidrogen atau van der Waals. Pada dasarnya baik BAF maupun koformer harus memiliki gugus-gugus penerima dan penyuplai proton (sinton) yang dapat berikatan melalui homosinton (karboksilat-karboksilat atau amida-amida), atau heterosinton (seperti karboksilat-amida, karboksilat-piridin).Kata kunci: molekul super (ko-kristal), metode kristalografik, rekayasa kristal

PENGARUH PENGGILINGAN TERHADAP KARAKTERISTIK PADATAN DIDANOSIN Fikri Alatas; Sundani Nurono Soewandhi; Lucy D. N. Sasongko
Jurnal Sains Materi Indonesia VOL 13, NO 1: OKTOBER 2011
Publisher : Center for Science & Technology of Advanced Materials - National Nuclear Energy Agency

Perbaikan Sifat Mekanik Deksibuprofen melalui Pembentukan Ko-Kristal Deksibuprofen-Kafein dengan Metode Ultrasound assisted Solution Co- crystallization Fikri Alatas; Titta H. Sutarna; Raisa Fakhrona Salman; Sundani Nurono Soewandhi
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.34713

Kemampuan suatu bahan aktif farmasi untuk dapat dikempa langsung dipengaruhi oleh sifat-sifat mekaniknya, seperti daya alir dan tabletabilitas. Karakterisasi pembentukan ko-kristal meliputi morfologi kristal, difraktogram sinar-X serbuk, dan perilaku termal. Perbandingan sifat-sifat mekanik dilakukan terhadap ko-kristal DXI-CAF hasil USSC dengan DXI murni, meliputi daya alir (indeks kompresibilitas) dan tabletabilitas (tensile strength dan elastic recovery). Pengujian tabletabiltas dilakukan pada kekuatan kompresi 10-60 kg/cm2. Hasil karakterisasi menunjukkan hasil USSC memiliki habit kristal, difraktogram, dan titik lebur yang unik yang berbeda dengan DXI murni, dan hal ini mengindikasikan terbentuknya ko-kristal DXI-CAF. Indeks kompresibilitas ko-kristal DXI- CAF berada pada rentang kategori baik, sementara DXI murni berada pada rentang kategori buruk. Nilai tensile strength maksimum ko-kristal DXI-CAF adalah 1,526 MPa yang dicapai pada kekuatan kompresi 50 kg/cm2, sementara nilai tensile strength maksimum DXI murni hanya 0,853 MPa yang dicapai pada kekuatan kompresi 20 kg/cm2. Kurva elastic recovery menunjukkan persentase elastic recovery ko-kristal DXI-CAF lebih baik daripada DXI murni. Dari hasil-hasil ini dapat disimpulkan bahwa pembentukan ko-kristal DXI-CAF dengan metode USSC mampu memperbaiki sifat-sifat mekanik deksibuprofen.

Freeze drying and calcining hydrotalcite for improving acid neutralizing capacity Deny Puriyani Azhary; Sundani Nurono Soewandhi; Saleh Wikarsa
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Acid neutralizing capacity (ANC) is one of the important factor on effectivity determination of antacid dosage forms. Antacid dosage forms have different values depend on their ANC. The objective of this research was to modified physical and chemical properties of hydrotalcite which can increase its acid neutralization capacity. Hydrotalcite was treated by freeze drying and calcination at different temperature 100, 200, 300, and 500°C. This hydrotalcite was characterized by X-Ray Diffractometer (XRD) and Scanning Electron Microscope (SEM); and was determined acid neutralization capacity. The results showed that acid neutralization capacity of hydrotalcite increased after it was freeze dried and calcined at 200, 300 and 500 °C. The result of XRD for the hydrotalcite calcined at 200 °C have showed the lower intensity of peaks, whereas the calcination at 300 and 500 °C were disappeared and appeared new peaks at different 2θ.Key words: Acid neutralization capacity, hydrotalcite, calcination, XRD, SEM

Solubility Enhancement of Clozapine Through Co-Crystal Formation with Isonicotinamide Fikri Alatas; Hestiary Ratih; Hesti Kurnia; Sundani Nurono Soewandhi
Indonesian Journal of Pharmaceutics Vol 2, Issue 1, Jan - April 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i1.23957

Clozapine (CLO) is an effective atypical antipsychotic to control the symptoms of psychosis and schizophrenia. Clozapine has low solubility and high permeability, so it is classified as a class II in the biopharmaceutical classification system. The aim of this study was to improve the solubility and dissolution rate of clozapine by clozapine-isonicotinamide (CLO-INA) co-crystal formation. CLO-INA co-crystal was prepared by solvent-drop grinding (SDG) method using water as a solvent. Characterization of SDG result was conducted by powder X-ray diffraction (PXRD) and Fourier transform infrared (FTIR). Solubility test was performed in water at room temperature. The dissolution test was performed in 900 mL of pH 6.8 phosphate buffer solution, 50 rotation per minute of paddle rotation, and at 37±0.5 °C. The PXRD pattern of SDG result of CLO-INA has many different peaks from its parent components, and this may indicate the co-crystal formation. The solubility of the co-crystal clozapine was fifteen folds higher than pure clozapine. The dissolution rate of CLO-INA co-crystal increased in the first 10 minutes compared to pure clozapine. Percentage of clozapine dissolved after 10 minutes from CLO-INA co-crystal and pure CLO were 10.2 and 2.4%, respectively. CLO and INA can form co-crystal by SDG method that can improve the solubility and dissolution rate of clozapine.Keywords: Clozapine, Isonicotinamide, Co-crystal, Solubility, Dissolution

Karakterisasi Rekristalit Antalgin-Fenilbutason dengan Pelarut Aseton sebagai Suatu Sistem Interaksi Fisika Ilma Nugrahani; Slamet Ibrahim; Sundani Nurono Soewandhi; Sukmadjaja Asyarie
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (911.173 KB)

Recrystallization with acetone of antalgyne, phenylbutazone, and the mixture of binary system has been characterized. The aim of this research was looking for thermodynamic and x-ray diffraction characteristic of re-crystallite to compare with raw material characteristics. The result used to confirm validity of cool contact methods to identify physical interaction of antalgine-phenylbutazone that has been developed in the preliminary research. Recrystallites characterized by DSC and powder-XRD shows the polymorphism cases, but the co-recrystallite of binary system show the peritecticum physical interaction, similar with the physical interaction of the raw material binary system before recrystallization. Principally, the results of this investigation prove that cool contact methods by acetone could be used for identify physical interaction of antalgine-phenylbutazone.

Pembuatan dan Karakterisasi Ko-kristal Flukonazol-Resorsinol Fikri Alatas Alatas; Hestiary Ratih; Titta Hartyana Sutarna; Yoga Windu Wardhana; Dini Tereslina; Sundani Nurono Soewandhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.779

Fluconazole (FLU), an oral antifungal widely used in the treatment of vaginitis andcandidiasis, is known to have low bioavailability due to its low solubility. The purpose of this studywas to prepare and characterize co-crystal fl uconazole-resoscinol (FLU-RES). The preparation ofco-crystal was performed by grinding together the equimolar mixture of FLU-RES which is drippedwith a few ethanol. Powder X-ray diff raction, diff erential scanning calorimetry (DSC), and polarizedmicroscopy methods were performed to characterize the formation of FLU-RES co-crystal. Relevantphysicochemical properties include solubility tests in water and dissolution tests in pH 1.2; 4.5 and6.8 buff er solution. The powder X-ray diff ractogram of FLU-RES milled result showed the presenceof new peaks and loss of the main peaks of FLU and RES. The characterization of grinding result byDSC and polarized microscopy methods also showed the co-crystal formation between FLU and RES.The solubility of FLU-RES co-crystal in water is solubility two folds more than pure FLU, while itsdissolution rate is 1.67-1.72 times faster than pure FLU.

Pengaruh Disintegran dan Cara Pencampuran Terhadap Sifat Fisika Kimia Telmisartan Hestiary Ratih; Fikri Alatas; Jessie Sofia Pamudji; Sundani Nurono Soewandhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1013

Telmisartan (TMS) has a compact structure and is interlocked between crystal units. As a result, the substance has a high electrostatic force, which causes TMS to sintering when compressed into tablets. One method of overcoming sintering on TMS tablets is to add a disintegrant to the compressed tablet. The disintegrants used are derived from starch groups: Starch 1500® (S1500) and sodium starch glycolate (SSG), as well as microcrystalline cellulose (MCC) and croscarmellose sodium (CCS) groups. The purpose of this study was to examine the effects of several disintegrants on the dissolution and physicochemical properties of TMS with various treatments. TMS was varied with each disintegrant at a ratio of 1:9 % b/b. The treatment of TMS binary mixtures with various disintegrants includes physical mixtures, milled mixtures, compressed mixtures, and crushed compressed mixtures. Characterization and evaluation include PXRD and SEM testing as well as dissolution test. The characterization of PXRD and SEM in various treatments showed the effect of physicochemical properties on the TMS binary mixture with various disintegrants. The combination of TMS:CCS with a ratio of (1:9) resulted in the highest dissolution rate in all treatments.The treatment of the milled mixture produced the highest dissolution with DP60 minutes, which was around 55.86±2.47%. The addition of disintegrants to TMS with various treatments may reduce sintering but is not sufficient to meet the requirements for TMS dissolution, which dissolves within 30 minutes in phosphate buffer medium pH 7.5 with Q>75%.

Pengaruh Milling Terhadap Laju Disolusi Campuran Metampiron-Fenilbutason (7:3) Soewandhi, Sundani Nurono; Haryana, Aris
Majalah Ilmu Kefarmasian Vol. 4, No. 2
Publisher : UI Scholars Hub

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In pharmaceutical process, milling is a common process to produce particle in certain expectation size. Impact of milling process could lead to physical interaction. Dissolution rate will change as an impact of physical interaction. To observe physical interaction between methampyrone and phenylbutazone during milling process, is needed to analyze its X-ray diffractogram, DSC thermogram and dissolution rate. Data of X-ray diffractogram, differential scanning calorimetry and dissolution test, showed that physical interaction occurred after 5,5 hours and 18 hours of milling and cause enhancement of dissolution rate of phenylbutazone. Dissolution rate of methampyrone was constant after 5,5 hours of milling. Decreasing dissolution rate of methampyrone occured after 18 hours of milling.

Pengamatan Visual Tahap-Tahap Pembentukan Kristal Sistem Eutektikum Asetaminofen-Pseudoefedrin Hidroklorida Nugrahani, Ilma; Asyarie, Sukmadjaja; Soewandhi, Sundani Nurono; Ibrahim, Slamet
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

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The aim of this research was to observe the recrystallization process of two component, acetaminophen-pseudoephedrine hydrochloride in ethanol and the thermal profiles. The visual data resulted from polarization microscope observation confirmed with thermograph DSC showed that the crystal habit was represented to the intrinsic character representative by thermodynamic properties of the binary system.The visualization process proved that in different molar ratios, the binary system formed crystals habit with different and step by step showed inhibit, to form polycrystalline until at molar ratio 6:4 formed the fines single crystals mixture which was smaller than before co-recrystallization. Acetaminophen was observed as monoclinic hexagonal crystals while pseudoephedrine hydrochloride was observed monoclinic/orthorombic forms.

Co-Authors Abdul Azizsidiq, Fahmi Aris Haryana Aris Haryana, Aris Citra Permata Sari Deny Puriyani Azhary Dini Tereslina Erina Sifa Mutmainah Fahrauk Faramayuda, Fahrauk Fikri Alatas Hambali, Luthfi Fathiinah Handoyo Sahumena, Muhamad Hartyana Sutarna, Titta Hesti Kurnia Hestiary Ratih Ilma Nugrahani Ilma Nugrahani Ilma Nugrahani Irfan Imam Taufik Jessie Sofia Pamudji Lucy D. N. Sasongko Nugraha, Yuda Prasetya Prawira, William Ratna Rachmat Mauludin Raisa Fakhrona Salman Ratih, Hestyari Saleh Wikarsa Satrialdi, Satrialdi Simorangkir, Timbul Partogi Haposan Sitti Raodah Nurul Jannah Slamet Ibrahim - Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Susi Sunarty Sigalingging Taufik, Irfan Imam Titta H. Sutarna Yoga Windu Wardhana Yuda Prasetya Nugraha

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