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Aris Soewondo
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Brawijaya University, Malang, 65145, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Veterinary Other

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Journal : Molecular and Cellular Biomedical Sciences (MCBS)

 1 
Green Tea Yoghurt with Encapsulated Lacticaseibacillus paracasei E1 Improves Hepatocyte Damage in High-Fat High-Fructose Diet Mice by Reducing MDA and Increasing SOD Fadlilah, Dawama Nur; Izati, Rahmi; Al Faizah, Belinda Nabiila; Kavitarna, Septhyanti Aprilia; Ardiansyah, Esha; Sa'adah, Nur Alfi Maghfirotus; Atho'illah, Mochammad Fitri; Arifah, Siti Nur; Soewondo, Aris; Jatmiko, Yoga Dwi; Wardhani, Shinta Oktya; Barlianto, Wisnu; Rifa'i, Muhaimin
Molecular and Cellular Biomedical Sciences Vol 8, No 3 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i3.501

Abstract

Background: Obesity is a global epidemic caused by excessive body fat, which is increasing free fatty acids in the liver, causing oxidative stress and liver cell damage. Green tea yogurt (GTY) with encapsulated Lacticaseibacillus paracasei E1 (GTY-LpE1) might have a beneficial effect in reducing liver cell damage. This study was conducted determine GTY-LpE1 effect on superoxide dismutase (SOD) expression, malondialdehyde (MDA) expression and liver histopathology in high-fat high-fructose diet (HFFD) mice. Material and Methods: A completely randomized design (CRD) with 7 groups, including normal diet (ND) group, HFFD group, 1.3 mg/kg BW simvastatin (SIM)-administered HFFD group, 5 g/kg BW probiotic yoghurt (PY)-administered HFFD (PY), 2.5 g/kg BW GTY-administered HFFD (2.5 GTY), 5 g/kg BW GTY-administered HFFD (5 GTY), and 10 g/kg BW GTY-administered HFFD (10 GTY). The diet was given for 16 weeks, followed by oral administration of sim/yoghurt during the last 4 weeks. Mice were sacrificed and the liver was collected. SOD and MDA expression were analyzed by flow cytometry. Histopathology analysis was done by evaluating hematoxylin-eosin (HE) staining of the liver.Result: The percentage of necrotic cells were 34.55, 34.31, and 21.95%, when treated with 2.5, 5, and 10 g/kg BW with GTY-administered HFFD, respectively, these were lower than the ones in the HFFD group (69.49%). The percentage of MDA expression were 15.55, 18.69, and 22.42%, respectively, these were lower than the ones in the HFFD group as well. The percentage of SOD expression were 9.49, 7.85, and 11.11%, respectively, these were higher than the ones in the HFFD group (3.44%). Conclusion: GTY-LpE1 could decrease the number of necrotic cells in the HFFD mice livers and improve the hepatocyte damage by reducing MDA expression and enhancing SOD expression. GTY-LpE1 can be used as an alternative food to control obesity.Keywords: alginate, chitosan, encapsulation, green tea, probiotic
Co-Authors Agung Pramana W. M. Agung Pramana W.M Agung Pramana W.M Agung Pramana W.M Agung Pramana Warih Marhendra Agung Pramana Warih Marhendra Ahmad Shobrun Jamil Al Faizah, Belinda Nabiila Anaqoh Roudhotul Jannah Winarso Anzila, Ivakhul Ardiansyah, Esha Asyhari, Firda Nuri Atho'illah, Mochammad Fitri Dian Siswanto Dliyauddin, Moh Fadlilah, Dawama Nur Farida Rachmawati, Farida fatchiyah . Fatchiyah Fatchiyah Fatchiyah Fatchiyah Fikriya Novita Sari Fikriya Novita Sari Firstiantono, Andista Fitria Eka Aprilia Iskandar, Rossdannisa Isna Hapsari, Ajeng Hanum Ivakhul Anzila Izati, Rahmi Kavitarna, Septhyanti Aprilia Khairatul Insani Febrianti Khairatul Insani Febrianti Laili Nur Zaidah Mansur Ibrahim Moch Sasmito Djati Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa'i Muhaimin Rifa’i Muhaimin Rifa’i Muhammad Halim Natsir Muhammad Halim Natsir Nashi Widodo Nurul Shafa Paramita Putri, Nenis Try Melani Rifa'i, Muhaimin Rifa’i, Muhaimin Rike Wahyuningroom Rike Wahyuningroom Ririn Dwi Prasetiani Ririn Dwi Prasetiani, Ririn Dwi Rivqi Rifa Bia Rizky Senna Samoedra Rizky Senna Samoedra Robitoh Desi Kurniasari Sa'adah, Nur Alfi Maghfirotus Sakti, Muhammad Wisam Wira Sakti, Sefihara Paramitha Sari, Fikriya Novita Serafinah Indriyani Setyaki Kevin Pratama Setyaki Kevin Pratama Shinta Dwi Riestanti Shinta Dwi Riestanti, Shinta Dwi Shinta Oktya Wardhani, Shinta Oktya Siti Nur Arifah, Siti Nur Sofy Permana Sri Rahayu Sri Rahayu Sri Rahayu SRI RAHAYU Sri Widyarti Triandari, Ade W. M., Agung Pramana Warih Marhendra, Agung Pramana Wira Eka Putra Wisnu Barlianto YOGA DWI JATMIKO Yuyun Indriani Kartiko Santi Zulfatim, Heni Sukma