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All Journal Jurnal Sain Veteriner Pharmaciana: Jurnal Kefarmasian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi Journal of Pharmaceutical and Health Research JUKESHUM: Jurnal Pengabdian Masyarakat Mejuajua Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Jurnal Kedokteran Hewan
Vivi Sofia
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Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pemanfaatan Tumbuhan Herbal Dalam Mencegah Penyakit Hipertensi Untuk Edukasi Masyarakat di Stadion Teladan Medan Rahma Yulia; Kanne Dachi; Salman Salman; Meutia Indriana; Mariany Razali; Dea Anggraini; Vivi Sofia
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 3 No. 2 (2023): Edisi Juli 2023
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v3i2.624

Abstract

Hipertensi merupakan salah satu penyakit yang menyebabkan angka morbiditas tinggi dimana penyakit ini ditandai  dengan peningkatan tekanan darah. Di Indonesia, prevalensi hipertensi pada tahun 2020 sebesar 31,7 persen penduduk berusia 18 tahun ke atas. Sekitar 80% orang dengan tekanan darah tinggi diklasifikasikan sebagai hipertensi esensial. Pengobatan tekanan darah tinggi dapat dilakukan dengan menggunakan  obat (terapi farmakologis) dan terapi komplementer menggunakan obat tradisional dari tanaman berkhasiat obat. Berdasarkan latar belakang tersebut tim dosen Fakultas Farmasi Universitas Tjut Nyak Dhien tertarik memberikan edukasi kepada masyarakat terkait penggunaan tanaman obat yang berasal dari alam yang dapat mencegah penyakit hipertensi. Kegiatan ini merupakan salah satu bentuk pengabdian masyarakat dari dosen untuk memberikan informasi yang berguna bagi masyarakat. Edukasi tentang pemanfaatan tanaman obat untuk mencegah hipertensi dilakukan dengan memberikan penyuluhan dan pembagian brosur serta pemeriksaan tekanan darah pada masyarakat yang sedang melakukan kegiatan di Stadion Teladan Medan. Hasil yang diperoleh dari kegiatan ini meunjukkan sebagian besar peserta yang berkontribusi memilki tekanan darah yang cukup tinggi. 7 dari 10 orang yang diperiksa tekanan darahnya memiliki tekanan darah 140/90 mmHg, 2 orang memiliki tekanan darah normal 120/90 mmHg dan 1 orang memiliki tekanan darah 100/70 mmHg. 60 % peserta memiliki pengetahuan mengenai penggunaan tanaman obat untuk mencegah hipertensi seperti daun seledri dan bawang putih yang diracik sendiri dengan cara direbus kemudian diminum air rebusannya
Aphrodisiaca Activity of Momordica charantia L. and Areca catechu L. Ethanolic Extract Againts Blood Pressure and Body Weight of White Mile Rats Sofia, Vivi; Aji, Abisyahdan Satria
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 14, No 1 (2024): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v14i1.9778

Abstract

Advances in the discovery of herbal medicine and the increasing popularity of traditional  medicines have made accessto traditional medicines in the market increasingly easier. Bitter melon and areca nut are known to have many benefits and potential as natural medicine. Previous studies has shown the aphrodisiac effects of these two natural ingredients. This research aimed to  determine the additional effects, particularly on blood pressure and body weight of rats, when bitter melon and areca nut are administered as aphrodisiacs. Test animal retrieval techniques based on complete randomized design (RAL). Blood pressure was measured using the CODA® instrument on 25 white rats divided into 5 treatment groups, namely the control group (CMC Na 0.5 % 0.5 % w/v), the bitter melon extract group at a dose of 280 mg / kg BW, the areca nut extract group at a dose of 50 mg/kg 50 mg / kg BW, the mixed  bitter melon and areca nut extracts group (1: 1), and the X-Gra® group. Blood pressure profiles measured included systolic and diastolic blood as well as changes in rat body weight before and after treatment. The results of the study of systole and diastole blood pressure parameters and rat body weight in groups I, II, III, IV, V analyzed using the Tukey HSD method obtained results that were not significantly different (sig 0.05) in all groups. Based on this study, it was concluded that the aphrodisiac activity of bitter melon and areca nut seeds did not significantly influence changes  in blood pressure, systole and diastole, and  body weight rats.
Phytochemical Screening and Anti-hyperglycemic Effect Test of Ethanol Extract of Waru Leaf (Hibiscus tiliaceus) on Glucose-loaded Mice Sofia, Vivi; Firdaus, Tya Novita; Saputri, Muharni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.345-355

Abstract

Background: The treatment of diabetes mellitus relies on synthetic drugs with various side effects. Therefore, it is necessary to explore alternative treatments with herbal therapies, such as Hibiscus tiliaceus leaves. Objectives: The aim of this study was to determine the anti-hyperglycemic effect of an ethanol extract from Hibiscus tiliaceus leaves in glucose-loaded mice. Methods: The initial stage of dried leaf characterization was to ensure the identity, quality, purity, and safety to be used, and then extracted using the maceration method with 70% ethanol solvent. The next step was phytochemical screening to identify secondary metabolite content. The anti-hyperglycemic effect was evaluated using the oral glucose tolerance test (OGTT) on 25 male mice divided into five treatment groups. The negative control group was given Na CMC 0.5% w/v Na CMC, and the positive control group was administered glibenclamide. The ethanol extract of Hibiscus tiliaceus leaves was administered at doses of 200, 400, and 800 mg/kg. Approximately 200 µL of blood was collected and analyzed for glucose levels. The data were statistically analyzed using one-way analysis of variance (ANOVA) with SPSS ver. 25 program. Results: Hibiscus tiliaceus leaves contain alkaloids, flavonoids, saponins, and tannins. The highest decrease in blood glucose levels was observed in the ethanol extract group at a dose of 400 mg/kg BW, with a decrease of 78.52%, followed by a dose of 200 mg/kg BW of 76.63%, a dose group of 800 mg/kg BW of 73.48%, and a positive control group (glibenclamide) of 34.68%, which was significantly different from the negative control group (Na CMC 0.5%) (p < 0.05). Conclusion: The ethanol extract of H. tiliaceus has anti-hyperglycemic effects.
Uji Aktivitas Analgesik Dari Ekstrak Daun Ara Sungsang (Asystasia gangetica L.) Terhadap Mencit Jantan dengan Metode Hot Plate Fujiko, Muflihah; Saputri, Muharni; Sofia, Vivi; Mauliza, Indah
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6881

Abstract

Pain is a body response that indicates a disorder. The use of conventional drugs to treat pain is quite worrying because of its long-term effects. This causes people to use drugs derived from nature. Breech fig leaves contain flavonoids and alkaloids that are able to reduce pain. This study aims to see the potential of breech fig leaves as an analgesic induced to male mice using the hot plate method. This research began with plant identification, material collection, simplicia and extract, phytochemical screening, and testing on mice. This study was carried out in vivo using male mice. Twenty birds were divided into five groups, namely the negative control group (CMC-Na 0.5%), the positive control group (Ibuprofen 200 mg/kg BB), the breech fig leaf extract group (dosage 50 mg/kg BB, 100 mg/kg BB, 200 mg/kg BB). Then the analgesic activity test was carried out by looking at the responsse of mice who were given pain using the hot plate method with a temperature of 55ºC. Then the percent of analgesic power and percent of the effectiveness of the analgesic were calculated. The results of the study showed that flavonoid compounds, alkaloids, tannins, steroids, and saponins were contained in breech fig leaves (Asystasia gangetica L.). dose 200 mg/kg BB has the highest percent analgesic power and effectiveness percentage, which is 99.12% (p<0,05) and 99.67% (p<0,05). From dose 50 mg/kg BB, the analgesic effect can be seen, and the best analgesic effect is at a dose of 200 mg/kg BB. This shows that breech fig leaf extract has analgesic activity in male mice by hot plate method.
Antihypertensive Activity of Black Garlic Extract in Rats and Its Phytochemical Analysis using GC-MS Estiningsih, Daru; Saiful Bachri, Moch; Hayu Nurani, Laela; Ma’ruf, Muhammad; Yuliani, Sapto; Sofia, Vivi; Prasasti, Dian
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.67-74

Abstract

Background: Hypertension is defined as a medical condition where blood pressure rises above 140/90 mmHg. Black garlic is recognized as a natural remedy that may help lower high blood pressure, primarily due to its abundant antioxidant properties, which are believed to inhibit the function of the angiotensin-converting enzyme (ACE) that is essential for regulating blood pressure. Objective: This study aimed to identify the chemical composition of black garlic using GC-MS and assess its antihypertensive effects in rat models. Methods: This study characterized the chemical composition of black garlic using GC-MS (Agilent 7890A) and evaluated its antihypertensive effects in rats. Hypertension was induced by oral administration of NaCl at a dose of 3.75 g/20 g body weight (BW) from day 0 to day 14. Blood pressure measurements were taken on days 0, 14, and 21. Black garlic extract was administered at three dose levels 4.2 mg/20 g BW, 8.4 mg/20 g BW, and 12.4 mg/20 g BW to evaluate dose dependent antihypertensive responses. Statistical analysis included the Kolmogorov-Smirnov test for normality, homogeneity testing, One-Way ANOVA Results: The GC-MS analysis identified 9-octadecenoic acid as the dominant compound in black garlic, accounting for 34.53% of its total composition. The antihypertensive activity test showed that administering black garlic at a dose of 12.4 mg/20 g BW significantly lowered systolic, diastolic, and mean arterial blood pressure while enhancing nitric oxide levels in hypertensive rats. Conclusion: Black garlic has the potential as an effective herbal treatment to lower blood pressure.
Pengaruh Campuran Ekstrak Etanol Buah Pare dan Biji Pinang Terhadap Kadar Testosteron Tikus dengan Menggunakan Metoda ELISA Sofia, Vivi; Rahmawanti, Salsabila
Journal of Pharmaceutical and Health Research Vol 6 No 2 (2025): June 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i2.6580

Abstract

Testosterone is a hormone that plays an important role in sexual development and reproductive function. Infertility problems, decreased libido and erectile dysfunction are closely related to decreased testosterone levels in the blood. This study aims to see the effect of a mixture of ethanol extracts of bitter melon (Momordica charantia L.) and areca nut (Areca catechu L) on testosterone levels in male white rats. This study used the Sexual Behavior method. 30 Wistar rats were divided into 5 groups consisting of distilled water control, positive control (X-Gra®) 45 mg/kg BW, ethanol extract of bitter melon (EEBP) dose of 100 mg/kg BW, ethanol extract of areca nut (EEP) dose of 50 mg/kg BW and mixed group of EEBP:EEP (1:1), after 15 days, blood samples were taken and testosterone levels were analyzed. The data obtained were statistically analyzed with one-way ANOVA test and continued with Tukey's HSD test with 95% confidence level (p<0.05) using SPSS ver.20 software. The results showed that testosterone levels in the EEBP group at a dose of 100 mg / kg BW and a mixture of EEBP: EEP (1: 1) of 2.31 ± 0.84 ng/ml and 1.65 ± 0.54 ng/ml were not significantly different when compared to the distilled water control group (p < 0.05). Testosterone levels in the EEP group at a dose of 50 mg/kg BW of 3.43 ± 0.98 ng/ml showed a significant difference with the aquades control group (p<0.05). The mixture of bitter melon ethanol extract at a dose of 100 mg/kg BW and areca nut seeds at a dose of 50 mg/kg BW was not able to increase testosterone levels, while the ethanol extract of areca nut seeds given singly at a dose of 50 mg/kg BW could increase testosterone hormone levels in male white rats. Based on the results obtained in this study, it can be concluded that a mixture of bitter melon ethanol extract at a dose of 100 mg / kg BW and areca nut seeds at a dose of 50 mg / kg BW is not able to increase testosterone levels, while areca nut ethanol extract given singly at a dose of 50 mg / kg BW can increase testosterone levels in male white rats.
Sosialisasi Pemanfaatan Tanaman Obat Keluarga (TOGA) Sebagai Alternatif Pengobatan Mandiri Pada Masyarakat Desa Marindal-1 Nadia, Syarifah; Karima, Nurul; Rahmi Ningrum, Siti; Sofia, Vivi; Antri Andra Lubis, Dello; Aulia Putri, Melati; Natasya E.Purba, Nazwa
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 5 No. 1 (2025): Agustus 2025
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v5i1.258

Abstract

Indonesia merupakan negara yang memiliki keanekaragaman tanaman obat dan dapat dimanfaatkan sebagai Tanaman Obat Keluarga (TOGA). TOGA juga digunakan sebagai tanaman berestetika yang ditanam pada pekarangan rumah dan bermanfaat sebagai pengobatan tradisional yang dapat dikelola bersama keluarga. Penanaman TOGA mengandung senyawa aktif yang secara ilmiah sudah terbukti manfaatnya bagi Kesehatan. Saat ini obat tradisional sering digunakan masyarakat karena memiliki efek samping yang lebih rendah dari obat konvensional. Kegiatan sosialisasi Pemanfaatan tanaman Obat Keluarga (TOGA) pada masyarakat Desa Marindal-1 bertujuan untuk memberikan wawasan terkait manfaat dan pelaksanaannya yang dapat dilakukan secara mandiri, sehingga dapat digunakan sebagai alternatif pengobatan. Kegiatan sosialisasi dilakukan oleh 4 dosen dan  4 mahasiswa dari Universitas Tjut Nyak Dhien. Kegiatan dihadiri perangkat desa dan 25 orang masyarakat  dari Desa marindal, Kecamatan Patumbak, Kabupaten Deli Serdang, Sumatera Utara. Kegiatan sosialisasi memberikan pengetahuan terkait manfaat, jenis-jenis dari Tanaman Obat Keluarga (TOGA). Hasil dari kegiatan yang telah dilakukan didapatkan bahwa pengetahuan masyarakat Desa marindal-1 masih kurang, dengan adanya sosialisasi yang diberikan masyarakat tersebut sangat antusias dalam membudidayakan tanaman obat tradisional sebagai Tanaman Obat Keluarga (TOGA). Antusias tersebut didukung dengan memberikan bibit tanaman obat tradisional oleh perangkat desa pada masyarakat Desa Marindal tersebut untuk langsung dibudidayakan sehingga nanti dapat dimanfaatkan sebagai tanaman obat bagi keluarga.
Edukasi Pemanfaatan Tanaman Alami Dalam Pembuatan Sediaan Balsem Kelurahan Empus Langkat Julianty, Siti Muliani; Siahaan, Desy Natalia; Fujiko, Muflihah; Sofia, Vivi
ABDIMASKU : Jurnal Pengabdian Masyarakat UTND Vol 4 No 1 (2025): Edisi Januari 2025 - Juni 2025
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/jpmtnd.v4i1.1575

Abstract

Masyarakat Indonesia tidak asing lagi dengan sediaan balsam dikarenakan balsam memiliki aromatherapy serta memiliki rasa yang hangat saat digunakan. Balsem merupakan sediaan yang penggunaannya dioleskan ke kulit dengan tangan sehingga dapat mengotori dan memberikan rasa panas yang sulit hilang. Pengabdian kepada masyarakat ini bertujuan untuk mewujudkan membagi pengetahuan kepada warga dalam edukasi pemanfaatan tanaman bahan alami dalam pembuatan sediaan balsam. Kegiatan ini dilakukan di Kelurahan Empus, Kab. Langkat, Sumatera Utara. Kegiatan yang dilakukan berupa pemeriksaan kesehatan, pemaparan edukasi dan tanya jawab. Adapun pemeriksaan kesehatan berupa pengecekan tekanan darah dan gula darah, pemaparan materi yang disampaikan terkait edukasi pemanfaatan tanaman bahan alami dalam pembuatan sediaan balsam kepada masyarakat. Hasil kegiatan ini untuk menambah pengetahuan masyarakat dalam memanfaatkan bahan alam sebagai sediaan balsam. Berdasarkan hasil tanya jawab semua peserta yang hadir menyatakan kegiatan ini memberikan manfaat positif serta tertarik dan ingin untuk mencoba memulai memanfaatkan bahan alami yang ada. secara mandiri. Kata kunci : Balsam, Edukasi, Masyarakat, Pengabdian LSEM
POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki, Frengki; Putra, Deddi Prima; Wahyuni, Fatma Sri; Khambri, Daan; Vanda, Henni; Sofia, Vivi
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v14i3.16652

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method pharmacokinetics screening and molecular docking. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.
Pengaruh Pemberian Ekstrak Etanol Kulit Buah Jeruk Baby (Citrus sinensis L. Osbeck) Selama 28 hari terhadap Kadar SGOT dan SGPT Sofia, Vivi; Widyaningsih, Wahyu; Yuliani, Sapto; Bachri, Moch Saiful
Jurnal Sain Veteriner Vol 42, No 2 (2024): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.71513

Abstract

One of the plants used as natural medicine is baby orange (Citrus sinensis L. Osbeck). Baby oranges contain hesperidin, hesperetin, narirutin and nobiletin compounds. The purpose of this study was to determine the effect of giving ethanol extract of baby orange peel for 28 days on liver function as seen from the increase in SGOT and SGPT levels. This research is a pure experimental study with a completely randomized design (CRD) with a unidirectional pattern, namely the method used to observe the relationship of independent variables (including: normal control, negative control, ethanol extract of baby orange peel (EEKBJB) doses of 50, 100, 200 and 400 mg/kg BW) with the dependent variable (SGOT and SGPT levels). The test animals used in this study were 30 male Wistar rats which were divided into 6 treatment groups which were treated for 28 consecutive days. On day 29, blood samples were taken from the orbital sinus of the eye and the levels of SGOT and SGPT were measured. There was a significant difference in the levels of SGOT and SGPT as indicated by the results of the One Way ANOVA test (p<0.05). The results of the Post Hoc-Tukey test for SGOT levels showed a significant difference between the control group and the 50 mg/kg BW dose group, while the 100, 200 and 400 mg/kg BW doses did not show a significant difference. The results of the Post Hoc-Tukey, s-HSD test for SGPT levels did not show a significant difference between the control group and the 50, 100, 200 and 400 mg/kg BW dose groups. Significant differences were shown by doses of 50 and 400 mg/kg BW. Giving EEKBJB for 28 days did not cause toxic effects on liver function, seen from the absence of an increase in SGOT and SGPT levels.
Co-Authors Aji, Abisyahdan Satria Akrom, Akrom Antri Andra Lubis, Dello Aulia Putri, Melati Cipta Khairunnisa Daan Khambri Dandy Annas Muttaqien Daru Estiningsih Dea Anggraini Deddi Prima Putra Desi Iswahyuni Dian Prasasti Dwi Ari Nugrahani Fatma Sri Wahyuni Firdaus, Tya Novita Frengki Frengki, Frengki Fujiko, Muflihah Galuh Rista Putri Henni Vanda Intan Dwi Rahmita Julianty, Siti Muliani Kanne Dachi Karima, Nurul Khozanatul Ulwy Laela Hayu Nurani M Sandila Okta Mariany Razali Mauliza, Indah Meutia Indriana Moch Saiful Bachri Moch. Saiful Bachri Muhammad Ma'ruf Nadia Selvia Nadia, Syarifah Natasya E.Purba, Nazwa Nugrahani, Dwi Ari Okta, M Sandila Rahma Yulia Rahmawanti, Salsabila Rahmi Ningrum, Siti Reka Rukmiati Salman Salman Sapto Yuliani Sapto Yuliani Saputri, Muharni Shabrina Arwi Laily Siahaan, Desy Natalia Sofina Rahmadita Suci Kurniati Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wiki Yuli Anita