Article Per Year (5 Year)
p-Index From 2021 - 2026
1.556
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer Chemoprevention Mutiara Medika: Jurnal Kedokteran dan Kesehatan INDONESIAN JOURNAL OF PHARMACY Berkala Kedokteran Jurnal Abdimas Mahakam Bubungan Tinggi: Jurnal Pengabdian Masyarakat Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Prosiding Seminar Nasional Program Pengabdian Masyarakat Journal of Agri-Food Science and Technology (JAFoST) Jurnal Farmasi Sains dan Praktis
Sri Tasminatun
Bagian Farmakologi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Muhammadiyah Yogyakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

Published : 27 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Chemopreventive effect of ethanolic extract of Gynura procumbens (Lour), Merr on the carcinogenesis of Rat breast cancer development Meiyanto, Edy; Susilowati, Sri; Tasminatun, Sri; Murwanti, Retno; ., Sugiyanto
INDONESIAN JOURNAL OF PHARMACY Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.982 KB) | DOI: 10.14499/indonesianjpharm0iss0pp154-161

Abstract

Gynura procumbens (Lour) Merr., empirically, used to prevent cancer development and has been proven to be able to suppress lung cancer development. The aim of this research is to examine the potential of ethanolic extract of G. procumbens to suppress DMBA-induced breast cancer development. Sprague Dawly Rats were used in this research and were grouped as indicated treatment. Ethanolic extract of G. procumbens was administered into 3 levels of doses, namely 250, 500, and 750 mg/kgBW. Tumor development was examined by palpation every week and terminated at week 16th after the end of DMBA treatment. The result showed that extract treatment at the dose of 250, 500, and 750 mg/kgBW reduced tumor incidence by 60%, 30 %, and 20 % respectively. The doses of 500 and 750 mg/kgBW exhibited strong suppression of tumor multiplicity, where as the dose of 250 performed less potential suppression. In conclusion, ethanolic extract of G. procumbens performs chemopreventive effect to suppress breast cancer development at the dose of 250 mg/kgBW.Key words : chemopreventive, Gynura procumbens (Lour) Merr, breast cancer.
Suppression of DMBA-induced carcinogenesis of breast cancer in post initition stage by ethanolic extract of Gynura procumbens (Lour), Merr leaves Edy Meiyanto; Sri Tasminatun; Sri Susilowati; Retno Murwanti; Sugiyanto .
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.092 KB) | DOI: 10.14499/indonesianjpharm0iss0pp169-175

Abstract

Gynura procumbens (Lour) Merr., has been shown to suppress lung cancer development in mice and breast cancer development in rat when the extract was given at initiation stage. The aim of this research is to examine the potential of ethanolic extract of G. procumbens to suppress DMBAinduced breast cancer development at early development (post initiation I) and late development (post initiation II). Sprague Dawley Rats were used in this research and were grouped as indicated treatment. Ethanolic extract of G. procumbens was administered into 2 levels of doses, namely 250, 750 mg/kgBW. Tumor development was examined by palpation every week and terminated at week 16th after the end of DMBA treatment. The result showed that extract treatment at the dose of 250, and 750 mg/kgBW at the post initiation I could not reduce tumor incidence but suppressed of tumor multiplicity. However, the treatment at the post initiation II, the extract could not reduce neither incidence nor multiplicity. In conclusion, ethanolic extract of G. procumbens performs potential effect to suppress breast cancer development at the dose of 250 mg/kgBW when administered at the early stage of carcinogenesis.Key words : Carcinogenesis inhibition, G. procumbens, breast cancer, post initiation
Co-Authors Arum Indrasari, Arum Asifa, Nadia Nur Barii Hafidh Pramono, Barii Hafidh Edy Meiyanto Edy Meiyanto Eni Istiyanti Erika Loniza Fitri Rizkia Putri Fitri Rizkia Putri, Fitri Rizkia Githa Fungie Galistiani Juniananda, Melisa Kita, Masaki Krisridwany, Annisa Kurnia Chairunnisa Kusumaningtyas, Triana Arum Muhammad Thesa Ghozali Nadia Nur Asifa Nanang Kurniawan Ningrum, Dhecella Winy Cintya Noerma Shovie Rizqiea Nugraheni, Peni Nur Shani Meida Nur Wahyuningsih NUR WAHYUNINGSIH Pramitha Esha Nirmala Dewi, Pramitha Esha Nirmala Pravitasari, Ria Putri, Hikma Yulia Rahmadhia, Safinta Nurinda Retno Murwanti Ria Pravitasari Ricky Andy Setyawan Rifki Febriansah Rizqi Afrian Jamaludin Husein, Rizqi Afrian Jamaludin Sarjiyah Sarjiyah, Sarjiyah Setyawan, Ricky Andy Setyawati, Ika Sherly Usman Siti Aminah Tri Susila Estri SN Nurul Makiyah SN. Nurul Makiyah Sri Nabawiyati Nurul Makiyah Sri Susilowati Sugiyanto . Sugiyanto . Syaifabila, Imania Afidatus Wardono, Aditiya Pramudya Wiwik Kusumawati, Wiwik Yudha, Raditya Purna Yuli Kuswandari