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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Cancer Chemoprevention Adi Widya : Jurnal Pengabdian Masyarakat Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Media Ilmu Kesehatan JFIOnline Jurnal Mandala Pharmacon Indonesia Indonesian Journal of Global Health research Formosa Journal of Multidisciplinary Research (FJMR) Riset Informasi Kesehatan Journal of Health Management and Pharmacy Exploration (JOHMPE) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Titik Sunarni
Faculty of Pharmacy Setia Budi University Jl. Letjen Sutoyo Mojosongo – Solo, 57127, Phone. 0271-852518, HP:08121520941
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Indonesian Journal of Global Health research

 1 
Test for Inhibition of the Enzyme Α-Glucosidase Fraction of Ethanol Extract of Onco Leaves (Spondias pinnata (L.f.) Kurz.) and the Antidiabetic Activity of the Selected Fraction Pagal, Fajria Rezky Priyanti Amara; Sunarni, Titik; Supriyadi, Supriyadi
Indonesian Journal of Global Health Research Vol 6 No 3 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i3.3166

Abstract

Degenerative diseases are the number one disease in Southeast Asia. Based on WHO data in 2008, the death rate in Southeast Asia was around 14.5 million, around 55% (7.9 million) caused by degenerative diseases. One of the degenerative diseases is diabetes mellitus. Diabetes mellitus is a metabolic disorder characterized by hyperglycemy. Research that has been carried out to look at the antidiabetic activity of onco (Spondias pinnata (L.f.) Kurz) leaves is still limited to the extraction results. Objectives: This study aims to determine the fraction of onco leaf ethanol extract in inhibiting the enzyme alpha glucosidase, having antidiabetic activity and histopathological picture of pancreatic cells in streptozotocin-induced male white rats (Rattus norvegicus). This study used inhibition testing of the enzyme α-glucosidase fraction of onco leaf ethanol extract with concentrations of 12.5, 25, 50,100 and 200 μg/mL using a microplate reader with a wavelength of 405 nm, as well as with experimental laboratory test animal methods as many as 28 mice divided into 7 treatment groups the induced streptozotocin except the normal group. Group I as normal control of rats that were only given regular drinking food, group II as negative control without treatment, group III as positive control using glibenclamide drugs and group IV ethanol extract 500, V n-hexane fraction 132.54, VI ethyl acetate fraction 126.24 and VII water fraction 239 mg/KgBB treatment given for 14 days. The results showed that onco leaf ethanol extract inhibits the enzyme α-glucosidase with very strong strength (IC50 = 39.13 μg / ml) and the n-hexane fraction has the effect of reducing glucose levels as well as the ability to correct the histopathology of the pancreas of male white rats (Rattus norvegicus) induced streptozotocin. Conclusions: Ethanol extract and the fraction of onco leaves (Spondias pinnata (L.f.) Kurz) has antidiabetic activity with a mechanism of action inhibiting the enzyme alpha glucosidase and the activity of decreasing blood glucose levels and has the ability to correct the histopathology of the pancreas of male white rats (Rattus norvegicus) induced streptozotocin.
Antifertility Activity and Chemical Content of Moringa Oleifera Lam Plant Extract on The Reproductive System of Male and Female White Rats Munawir, Munawir; Sunarni, Titik; Saptarini, Opstaria
Indonesian Journal of Global Health Research Vol 6 No S6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS6.4821

Abstract

Research shows that Moringa extract possesses anti-fertility effects on the reproductive systems of male and female rats. This study investigates Moringa's active chemical compounds and their impact on reproductive parameters such as sperm concentration, motility, morphology, and seminiferous tubule diameter, along with hormone levels (progesterone, LH, FSH), estrogenic activity, and the estrous cycle. The research, a literature review, compiles findings from quality international (Scopus) and national (SINTA) journals, Translation and proofreading: there are 8 articles that meet the research inclusion criteria, selected within a range from the year 2010 to 2024. Key active compounds identified in Moringa include alkaloids, tannins, flavonoids (kaempferol and quercetin), and benzyl isothiocyanate, all of which demonstrate anti-fertility effects. These compounds were observed to reduce sperm concentration, motility, and morphology, and to decrease seminiferous tubule diameter in males, while also impacting hormone levels and the estrous cycle in females. The findings support Moringa’s potential as an anti-fertility agent, highlighting its impact across various reproductive parameters in both genders.
Co-Authors Ahmad Suriyadi Muslim Daniel Happy Putra Doso, Tri Efrilia, Erin Fransiska Leviana Ika Purwidyaningrum Ilham Kuncahyo, Ilham Khairunnisa, Rizky Dila Mardiana, Lia Mardiyono Mardiyono, . Munawir Munawir Murukmihadi, Mimiek Opstaria saptarini Pacheco, Mergita Angela Pagal, Fajria Rezky Priyanti Amara Reslely Harjanti Rini Prastiwi Siti Aisiyah Suhartinah, Suhartinah Supriyadi Supriyadi Taena, Adriani Tri Murti Andayani Vivin Nopiyanti Wiwin Herdwiani Yudi Rinanto