Article Per Year (5 Year)
p-Index From 2020 - 2025
1.784
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Indonesian Journal of Cancer Chemoprevention Adi Widya : Jurnal Pengabdian Masyarakat Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Media Ilmu Kesehatan JFIOnline Jurnal Mandala Pharmacon Indonesia Indonesian Journal of Global Health research Formosa Journal of Multidisciplinary Research (FJMR) Riset Informasi Kesehatan Journal of Health Management and Pharmacy Exploration (JOHMPE) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Titik Sunarni
Faculty of Pharmacy Setia Budi University Jl. Letjen Sutoyo Mojosongo – Solo, 57127, Phone. 0271-852518, HP:08121520941
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 15 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Formosa Journal of Multidisciplinary Research (FJMR)

 1 
Optimization and Characterization of Self Nano Emulsifying Drug Delivery System (SNEDDS) Naringenin Components with D-Optimal Mixture Design Method and Anti-Aging Test In Vivo Taena, Adriani; Kuncahyo, Ilham; Sunarni, Titik
Formosa Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v3i9.11236

Abstract

Naringenin (5,7-dihydroxy-2-(4-hydroxyphenyl) chroman-4-one) is one of the flavanone aglycone compounds that has the main activity as an antioxidant. The purpose of this study was to determine the optimum formula and characterization of naringenin SNEDDS and to see the anti-aging activity of the optimum formula of naringenin SNEDDS. The optimum formula of naringenin SNEDDS was obtained by a combination of oil components, surfactants and cosurfactants (miglyol, tween 80 and transcutol) using the D-optimal mixture design method. The characteristics of naringenin SNEDDS are seen based on parameters such as drug loading, emulsification time, % transmittance, particle size analyzer (PSA) and zeta potential. The results of the optimum formula characterization test of naringenin SNEDDS obtained drug loading of 2.004507 mg/5 ml, emulsification time of 13.07 seconds, percent transmittance of 85.1%, particle size of 78.76 nm and zeta potential of -8.14 mV. Based on the results of the characteristics obtained from the optimum formula, the naringenin SNEDDS preparation meets the characteristics of good SNEDDS and has the potential to be developed into a drug preparation.
Antibacterial and Antibiofilm Activity of Katuk Leaf Fraction (Sauropus androgynus (L.) Merr.) against Bacteria Staphylococcus Aureus ATCC 25923 Khairunnisa, Rizky Dila; Sunarni, Titik; Saptarini, Opstaria
Formosa Journal of Multidisciplinary Research Vol. 3 No. 9 (2024): September 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v3i9.11237

Abstract

This study aims to determine the antibacterial and antibiofilm activity of extracts and fractions from katuk leaves against Staphylococcus aureus. Katuk leaves were extracted using the maceration process and fractionated using the liquid-liquid method with solvents such as n-hexane, ethyl acetate, and water. Diffusion and dilution methods were used to measure the antibacterial activity, and crystal violet staining at a wavelength of 595 nm was used to measure the inhibition and biofilm destruction activities. The antibacterial and antibiofilm test results obtained were analyzed using ANOVA statistical test. The results of the diameter of the inhibition zone with a concentration of 75 mg/ml showed that the extract was 11.3 ± 1.02 mm, the ethyl acetate fraction was 18.1 ± 2.46 while the water and n-hexane fractions were 0.0 ± 0.0 mm. The antibiofilm test results showed inhibitory activity against Staphylococcus aureus bacteria with the average IC50 values obtained from extracts, n-hexane, ethyl acetate, and water fractions were 10.248±0.405; 11.799±0.355; 8.332±0.585; and 11.372±0.557. While the average EC50 values obtained from the extract, n-hexane, ethyl acetate, and water fractions were 9.343±0.586; 10.530±0.483; 7.695±0.491; and 8.490±0.954.
Co-Authors Ahmad Suriyadi Muslim Daniel Happy Putra Doso, Tri Efrilia, Erin Fransiska Leviana Ika Purwidyaningrum Ilham Kuncahyo, Ilham Khairunnisa, Rizky Dila Mardiana, Lia Mardiyono Mardiyono, . Munawir Munawir Murukmihadi, Mimiek Opstaria saptarini Pacheco, Mergita Angela Pagal, Fajria Rezky Priyanti Amara Reslely Harjanti Rini Prastiwi Siti Aisiyah Suhartinah, Suhartinah Supriyadi Supriyadi Taena, Adriani Tri Murti Andayani Vivin Nopiyanti Wiwin Herdwiani Yudi Rinanto