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All Journal PROSIDING SEMINAR NASIONAL EKSAKTA: Journal of Sciences and Data Analysis Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian dan Pendidikan IPS Seminar Nasional Informatika (SEMNASIF) MPI (Media Pharmaceutica Indonesiana) Jurnal Rekayasa Mesin Jurnal Informatika Upgris AKSIOMA E-Dimas: Jurnal Pengabdian kepada Masyarakat Biodidaktika : Jurnal Biologi dan Pembelajarannya Jurnal Pendidikan Jasmani Kesehatan dan Rekreasi (Penjaskesrek) Forum Ekonomi : Jurnal Ekonomi, Manajemen dan Akuntansi JURNAL SINEKTIK Jurnal al-Ulum : Jurnal Pemikiran dan penelitian ke-Islaman Jurnal Ilmiah Sekolah Dasar PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal on Education Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Defendonesia (DEFENDONESIA) Journal of Mechanical Engineering and Applied Technology SEMINAR NASIONAL SOSIAL, SAINS, PENDIDIKAN, HUMANIORA
Supandi Supandi
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Religion Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Mekanisme Kerja Peningkat Penetrasi Golongan Asam Lemak Pada Sediaan Transdermal: Review. Vini Almira; Sabrina Dahlizar; Supandi Supandi
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 1 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.102 KB) | DOI: 10.15408/pbsj.v3i1.18448

Abstract

Sediaan transdermal merupakan sediaan yang diaplikasikan pada permukaan kulit dan dirancang untuk dapat mengantarkan obat melalui kulit ke sirkulasi sistemik. Untuk dapat memberikan efek terapeutik, suatu sediaan transdermal harus mampu menembus lapisan kulit. Penetrasi obat sediaan transdermal ke dalam kulit dapat ditingkatkan dengan menambahkan peningkat penetrasi. Asam lemak merupakan peningkat penetrasi kimia yang dapat meningkatkan permeasi obat hidrofilik dan lipofilik. Penelitian ini menggunakan metode systematic literature review (SLR) dan membahas artikel penelitian selama 15 tahun terakhir yang membahas tentang penggunaan peningkat penetrasi golongan asam lemak dalam sediaan transdermal. Diperoleh hasil sebanyak 30 artikel yang memenuhi kriteria. Hasil penelitian ini membuktikan bahwa asam lemak terbukti dapat meningkatkan permeasi obat hidrofilik maupun lipofil pada sediaan transdermal. Faktor yang mempengaruhi kemampuan peningkatan penetrasi asam lemak diantaranya variasi asam lemak, konsentrasi asam lemak yang digunakan dan kombinasi asam lemak dengan peningkat penetrasi lain. Asam lemak tak jenuh lebih efektif meningkatkan permeasi dibandingkan dengan asam lemak jenuh dan asam lemak yang paling banyak digunakan untuk meningkatkan permeasi adalah asam oleat.
The Development of Derivative Method analysis 1,4 Benzodiazepines in Biological Matrix using High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Annisa Larasati Putri; supandi supandi; Umar Mansur
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24629

Abstract

1.4 benzodiazepine derivatives are the benzodiazepine class that is used most frequently in clinical as a sedation agent, anxiolytic, and antiepileptic. The high tense of benzodiazepine consumption can causes addiction and misappropriation. That matter causes benzodiazepine and its metabolites often find in toxicology clinical and forensic. This systematic review aimed to identify an efficient sample preparation procedure and an accurate analysis method to determine benzodiazepine existence in various biological matrices. According to the PRISMA flow diagram’s chart, twenty-four reviewed articles systematically pointed that plasma and urine utilization gave good accuracy results and recovery than other biological matrices. SBSE extraction method development using vinylpyrrolidone ethylene glycol dimethacrylate polymer gave efficient results with the amount of recovery 96%, and HPLC instrument utilization was still selective and sensitive with LOD until 12ng/ml and LOQ 36 ng/ml.
Dampak proyek strategis nasional (PSN) dalam mendongkrak ekonomi lokal Supandi Supandi; Nucke Widowati Kusumo Projo
FORUM EKONOMI Vol 24, No 4 (2022): Oktober
Publisher : Faculty of Economics and Business Mulawarman University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jfor.v24i4.11721

Abstract

Penelitian dampak pembangunan Proyek Strategis Nasional (PSN) terhadap pengeluaran rumah tangga di Indonesia masih belum banyak dijumpai. Di sisi lain, biaya yang digelontorkan dalam setiap PSN tergolong tidak sedikit. Berdasarkan hal tersebut, penelitian ini bertujuan untuk melihat dampak PSN, khususnya pembangunan Pelabuhan Internasional Kijing di Kabupaten Mempawah Kalimantan Barat terhadap pengeluaran makanan, nonmakanan, pengeluaran total, dan pengeluaran per kapita. Data yang digunakan dalam penelitian ini bersumber pada survei sosial ekonomi nasional (susenas) tahun 2016-2021. Penelitian ini bersifat kuantitatif dengan menggunakan alat analisis difference-in-difference (DID). Hasil estimasi menunjukkan bahwa pembangunan proyek Pelabuhan Internasional Kijing secara rata-rata meningkatkan pengeluaran makanan (2021), non-makanan (2019-2021), pengeluaran total (2019-2021), dan pengeluaran per kapita (2020-2021).
Sampul dan Daftar Isi Jurnal Volume 10 Nomer 4 Edisi September 2023 Supandi Supandi
Jurnal Al-Ulum : Jurnal Pemikiran dan Penelitian Ke-Islaman Vol 10 No 4 (2023): al-Ulum: Jurnal Pendidikan, Penelitian dan Pemikiran Keislaman
Publisher : Universitas Islam Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31102/alulum.10.4.2023.i-v

Abstract

Sampul dan Daftar Isi Jurnal Volume 10 Nomer 4 Edisi September 2023
Rancang Bangun dan Analisis Shutter Conveyor Reversible Semi–Otomatis Berbasis PLC Guna Mengurangi Waktu Proses Material Handling Pada Line Assembly Steering Tipe D74 di PT. Akashi Wahana Indonesia Supandi Supandi; Wahyu Isti Nugroho; Iswanocta Candra Yudhistira
Journal of Mechanical Engineering and Applied Technology Vol 1, No 1 (2023): Volume 1 Issue 1 Year 2023 (March 2023)
Publisher : Politeknik Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32497/jmeat.v1i1.4771

Abstract

PT Akashi Wahana Indonesia is an automotive manufacturer that specializes in producing steering gear assemblies. The steering gear assembly process involves assembling the components of the steering gear into a single unit. A problem related to cycle time has been identified at a process position on the D74 steering gear assembly line. The cause of this issue is the manual shutter used to transfer assembly results between process positions, which requires manual intervention by operators, resulting in non-value-added time and unnecessary movement. The proposed solution to this problem is to design and development a PLC based semi-automatic reversible shutter conveyor. This shutter conveyor will serve as a material handling tool to change the transfer system between process positions. Operators can initiate the transfer to the next position by simply pressing the start button. The research methodology encompasses problem identification, literature review, design, production, and testing. The analysis includes calculations of stress and strain on the base slider, and percentage comparisons of material handling process time before and after improvement. Testing will be conducted through experiments on material handling process time. The result of this research is the implementation of a PLC-based semi-automatic reversible shutter conveyor in the D74 steering assembly line, which has achieved a 69.1% reduction in material handling process time.
UPAYA MENINGKATKAN HASIL BELAJAR IPAS MELALUI PBL (PROBLEM BASED LEARNING) PADA SISWA KELAS IV SD N JOHO 02 Endang Safitri; Candra Dewi; Supandi Supandi
SEMINAR NASIONAL SOSIAL, SAINS, PENDIDIKAN, HUMANIORA (SENASSDRA) Vol 2, No 1 (2023): Implementasi kurikulum merdeka menuju transformasi pendidikan dalam mempersiapka
Publisher : SEMINAR NASIONAL SOSIAL, SAINS, PENDIDIKAN, HUMANIORA (SENASSDRA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penelitian ini dilakukan untuk meningkatkan hasil belajar mata pelajaran IPAS pada siswa kelas 4 SD N Joho 02 dengan penerapan model pembelajaran Problem Based Learning (PBL). Penelitian ini merupakan penelitian tindakan kelas yang dilakukan dengan dua siklus dan masing-masing siklus terdapat dua kali pertemuan. Subjek dalam penelitian adalah siswa kelas 4 SD N Joho 02 yang berjumlah 3 siswa, terdiri dari 1 siswa laki-laki dan 2 siswa perempuan. Teknik yang digunakan dalam pengumpulan data adalah tes. Teknik analisis data yang digunakan berupa deskripsi presentase dari hasil belajar IPAS saat pra siklus dan setelah siklus. Hasil rata-rata yang diperoleh siswa dalam satu kelas sebelum dilakukan siklus adalah 43 dengan keterangan tidak ada yang nilainya mencapai ketuntasan minimum. Pada siklus I menunjukkan peningkatan hasil belajar dengan nilai rata-rata yaitu 60 dengan 1 siswa atau 33% yang mencapai KKM 75. Adapun pada siklus II semakin mengalami peningkatan dimana 2 siswa atau 67% tuntas belajar pada mata pelajaran IPAS. Penelitian ini dikatakan berhasil karena mencapai indikator kinerja yaitu ≥ 67% dari seluruh siswa di kelas mencapai KKM ≥ 75. Model pembelajaran Problem Based Learning dapat meningkatkan hasil belajar mata pelajaran IPAS pada siswa kelas 4 SD N Joho 02 tahun pelajaran 2022/2023.
The Development of Derivative Method analysis 1,4 Benzodiazepines in Biological Matrix using High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Annisa Larasati Putri; supandi supandi; Umar Mansur
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 4, No 1 (2022)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v4i1.24629

Abstract

1.4 benzodiazepine derivatives are the benzodiazepine class that is used most frequently in clinical as a sedation agent, anxiolytic, and antiepileptic. The high tense of benzodiazepine consumption can causes addiction and misappropriation. That matter causes benzodiazepine and its metabolites often find in toxicology clinical and forensic. This systematic review aimed to identify an efficient sample preparation procedure and an accurate analysis method to determine benzodiazepine existence in various biological matrices. According to the PRISMA flow diagram’s chart, twenty-four reviewed articles systematically pointed that plasma and urine utilization gave good accuracy results and recovery than other biological matrices. SBSE extraction method development using vinylpyrrolidone ethylene glycol dimethacrylate polymer gave efficient results with the amount of recovery 96%, and HPLC instrument utilization was still selective and sensitive with LOD until 12ng/ml and LOQ 36 ng/ml.
Keefektifan Model PBL terhadap Kemampuan Literasi Numerasi Peserta Didik Kelas X Materi Trigonometri Emi Rahmawati; Supandi Supandi; Loesy Poerhandajani; Nizaruddin Nizaruddin
Journal on Education Vol 7 No 1 (2024): Journal on Education: Volume 7 Nomor 1 Tahun 2024
Publisher : Departement of Mathematics Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joe.v7i1.6671

Abstract

Numeracy literacy is important to improve the ability to think critically and make rational decisions. The employment prospects, mental, physical and economic health of individuals and countries are negatively affected by low numeracy skills. Therefore, teachers must focus on increasing students' numeracy literacy with effective strategies and activities. Therefore, the aim of this research is to test the effectiveness of the PBL model on the numeracy literacy abilities of class X students in trigonometry material. This research uses a quantitative approach, quasi-experimental method, with a sampling technique, namely total sampling, as well as a population and sample of class Based on the results of the research that has been carried out, it can be concluded that the Problem Based Learning (PBL) model is effective on the numeracy literacy abilities of class score ≥ 75 (KKM). 2) The average numeracy literacy ability of students in the PBL model is higher than the average numeracy literacy ability of students in the conventional model. 3) The proportion of completeness of students' numeracy literacy test results in the PBL model is more than the proportion of completeness of students' numeracy literacy test results in the conventional model. Keywords: Problem Based Learning, Numeracy Literacy, Effectiveness.
Exploring the Potential of Hemigraphis alternata Leaves: Docking and Molecular Dynamics Analysis Targeting Cyclooxygenase-2 (COX-2) Yeni, Yeni; Mochamad Dicky Yanuar Mamba'ul Rohman; Supandi Supandi
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 6, ISSUE 1, April 2025
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol6.iss1.art1

Abstract

Cyclooxygenase-2 (COX-2) mediates various physiological responses, including inflammation. In traditional medicine, the leaves of Hemigraphis alternata are commonly used to treat inflammation. The leaves have yielded 22 secondary metabolites that have been isolated. The computational analysis was conducted to identify the compounds with the greatest affinity for COX-2. The molecular docking procedure using DOCK 6.9 and molecular dynamics simulations using GROMACS 5.1.2 were used to screen test compounds. DOCK 6.9 assessed grid scores and ligand-receptor interactions, whereas GROMACS 5.1.2 examined the interactions, Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), Molecular Mechanics-Poisson Boltzmann Surface Area (MM-PBSA), hydrogen bonds, and radius of gyration. The validation of the docking method resulted in an RMSD value of less than 2 Å, indicating that the docking protocols are suitable for screening potential ligands. Phytol exhibited the most attraction compared to the test and reference substances (diclofenac sodium), with a grid score of -32.85 kcal/mol. The MM-PBSA analysis revealed that phytol exhibited a greater affinity than the reference, as evidenced by binding free energy of -36.259 kcal/mol. These data suggest that phytol has the potential to be investigated as a possible source for the generation of COX-2 inhibitors.
Co-Authors Agung Handayanto Alamsah Ade Pradana Almawati Situmorang Annisa Ananda Ulya Annisa Larasati Putri Azrifitria, Azrifitria Bagus Ardi Saputro Bambang Cahyono Candra Dewi Eko Rudiansyah Emi Rahmawati Endang Safitri Eureka Qurrotul Ainiyah Fajar Merdekawati Farika Tono Putri Fitriyatun Nasihah Iin Purnamasari Ikhsan Yoga Utama Indria Susilawati Iswanocta Candra Yudhistira Ita Yuliana Suparjo Lilik Ariyanto Linda Mazroatul Loesy Poerhandajani Mochamad Dicky Yanuar Mamba'ul Rohman Muhammad Haikal Kautsar Muhammad Prayito Muhardi Ritonga Nizaruddin Nizaruddin Nucke Widowati Kusumo Projo Nurina Munasyaroh Poedji Haryanto Putri Alyani Fadhilah Ragil Tri Indrawati Rasiman Rasiman Sabrina Dahlizar Safriana, Eni Syamsul Arifin Tashdiq Anwarulloh Taufiq Nugroho Umar Mansur Vini Almira Vivi Anggia, Vivi Wahyu Isti Nugroho Widya Kusumaningsih Yeni Yeni Yeni Yeni Zaenal Abidin