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All Journal International Journal of Public Health Science (IJPHS) Indonesian Journal of Rheumatology Essential: Essence of Scientific Medical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rudy Hidayat
Department Of Internal Medicine, Rheumatology Division, Faculty Of Medicine Universitas Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Risiko Kardiovaskuler pada Pasien Artritis Reumatoid Hidayat, Rudy
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 2
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Indonesian Rheumatology Association (IRA) Recommendations for Diagnosis and Management of Osteoarthritis (Knee, Hand, Hip) Rakhma Yanti Helmi; Najirman; Ida Ayu Ratih Wulansari Manuaba; Andri Reza Rahmadi; Pande Ketut Kurniari; Malikul Chair; Ika Vemilia Warlisti; Eka Kurniawan; Harry Isbagio; Handono Kalim; Rudy Hidayat; Laniyati Hamijoyo; Cesarius Singgih Wahono; Sumariyono
Indonesian Journal of Rheumatology Vol. 15 No. 1 (2023): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v15i1.225

Abstract

Background: Osteoarthritis (OA) is the most common form arthritis in the world, and its prevalence is predicted to rise higher in the future due to increasing life expectancy and growing number of elderly population. With the emergence of new treatment options in the last several years, a better understanding of OA diagnosis and management is required by every physician in Indonesia. Methods: A panel of eight selected rheumatologists from the Indonesian Rheumatologist Association (IRA) developed recommendations based on key questions formulated by a steering committee from IRA. These recommendation materials were taken from several online databases such as PubMed, Science Direct, and Google Scholar. Level of evidence and grades of recommendation were then assigned, and each member of the panelist team will assign a score to express their level of agreement. Results: A total of 25 recommendations discussing the diagnosis, pharmacological and non-pharmacological therapies, as well as monitoring for OA were formulated. Conclusion: These recommendations can be used to help clinicians in accurately diagnosing OA and choosing the most suitable therapy for their patients. All recommendation statements were tailored to the clinical setting, facility, and drug availability in Indonesia.
Pengaruh Terapi Metotreksat pada Pasien Artritis Reumatoid terhadap Penurunan Fungsi Kognitif: Meta-Analisis Berdasarkan Telaah Sistematik Fauzia, Fara; Prihartono, Nurhayati Adnan; Hidayat, Rudy; Araminta, Abirianti P.
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 2
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Introduction. Rheumatoid arthritis (RA) is a systemic and chronic autoimmune disease involving the joints disorder as the main manifestations. Methotrexate (MTX) is currently still the drug of choice for RA treatment due to the good clinical response. However, there was a case reported by the American Geriatric Society in 2015 regarding the presence of reversible dementia after treatment with low-dose oral methotrexate. This study aimed to identify the effect of MTX treatment on cognitive disorder in RA patients. Methods. The study protocol was registered with PROSPERO (CRD42023414937). A systematic literature search was conducted in Medline Embase database, Scopus, CENTRAL to identify cohort observational studies, case controls, and randomized control trial (RCT) studies, evaluating the effect of methotrexate therapy on cognitive function disorder in RA patients. The Newcastle-Ottawa Scale (NOS Scale) was used to analyze the quality of existing observational studies and The COCHRANE was used to analyze the RCT studies which included in the journals reviewed. Results. There were 4 observational studies that met the criteria, including 2 case control studies and 2 cohort studies. Pooling was carried out in two different types of studies. The OR was 0.81 (95%CI 0.4 – 1.68) in the case control studies group, whereas the RR was 0.88 (95% CI 0 .6 – 1.3) in the cohort studies group. The heterogeneity of each type of case-control studies and cohort studies were I2 92% (p-value277% (p-value Conclusion. Methotrexate therapy has not been proven to have an effect on cognitive disorder in RA patients either as a protective factor or as a risk factor.
Obesity and methotrexate treatment failure in rheumatoid arthritis patients in Cipto Mangunkusumo Hospital, Indonesia Fauzia, Fara; Adnan Prihartono, Nurhayati; C. Adisasmita, Asri; Umi Partan, Radiyati; Djuwita Hatma, Ratna; Hidayat, Rudy
International Journal of Public Health Science (IJPHS) Vol 13, No 3: September 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i3.24046

Abstract

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease which mainly manifests in the joints. Methotrexate (MTX) is a widely used pharmacological treatment for RA. To date, no prior research has investigated the effect of obesity on MTX treatment outcomes among RA patients in Indonesia. This research aimed to investigate the effect of obesity on MTX monotherapy failure in RA patients. We conducted a retrospective cohort study using medical records from the Rheumatology Clinic at Cipto Mangunkusumo Hospital from March 2017 to December 2021. Descriptive and estimation analyses were performed to assess the sample characteristics based on each variable and a logistic regression analysis was conducted to evaluate the association between obesity and MTX treatment failure. Out of 72 subjects, the proportion of MTX treatment failure was 57.1% (20/35) among obese patients and 37.8% (14/37) among non-obese patients. Obese subjects exhibited a 2.11-fold increased risk of MTX treatment failure compared to non-obese patients (OR 2.11; 95% CI 0.81-5.45). The number of joints involved was found to emerge as a confounding factor in this study. Our findings suggest that RA patients with obesity potentially have an increased risk of MTX treatment failure compared to non-obese RA patients.
Sarkopenia sebagai Faktor Risiko Varises Esofagus Risiko Tinggi berdasarkan Stratifikasi Child-Pugh Pasien Sirosis Hati Sepmeitutu, Iwandheny; Kurniawan, Juferdy; Maulahela, Hasan; Rinaldi, Ikhwan; Shatri, Hamzah; Pramana, Triyanta Yuli; Makmun, Dadang; Lesmana, Cosmas Rinaldi A; Hidayat, Rudy; Laksmi, Purwita Wijaya; Sunardi, Diana
Jurnal Penyakit Dalam Indonesia Vol. 11, No. 3
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Background The high prevalence of sarcopenia in chronic liver disease negatively impacts the quality of life and increases the risk of various complications of cirrhosis, one of which is the development of esophageal varices. The aim of this study was to determine the prevalence of sarcopenia in cirrhosis patients based on the severity of liver cirrhosis and to explore the association of sarcopenia with high-risk esophageal varices stratified by Child-Pugh. Methods This observational cross-sectional study involved patients with liver cirrhosis at Cipto Mangunkusumo Hospital between January and September 2023. Sarcopenia was defined as a reduction in muscle mass accompanied by decreased grip strength or walking speed, according to the AWGS 2019 criteria (Asian Working Group for Sarcopenia). Multivariate logistic regression analysis was conducted to evaluate the association between sarcopenia and high-risk esophageal varices. Results A total of 155 patients with liver cirrhosis were included in this study. The majority of liver cirrhosis patients were males, with hepatitis B being the most commonly found etiology. The prevalence of sarcopenia was found in 40.0% of Child-Pugh A patients, 53.8% of Child-Pugh B patients, and 50.0% of Child-Pugh C patients with a p-value of 0.411. The high-risk of esophageal varices was found more frequently in Child-Pugh B (53.8%) and Child-Pugh C (50.0%) compared to Child-Pugh A (25.6%) with a p-value of 0.013. Bivariate analysis showed that the presence of sarcopenia in liver cirrhosis patients has a statistically significant association with an increased risk of high-risk esophageal varices, especially in the Child-Pugh B and C subgroups of liver cirrhosis patients (OR = 7.50 (95% CI: 1.48 – 37.91, p<0.030)). However, no association was found between sarcopenia and high-risk esophageal varices in the Child-Pugh A subgroup (OR = 1.46 (95% CI: 0.65 – 3.29, p<0.477)). Conclusion Sarcopenia significantly increases the risk of high-risk esophageal varices in liver cirrhosis, especially in those with Child-Pugh B and C classification.
Faktor Prediktif Post Dialysis Fatigue Sedang pada Pasien yang Menjalani Hemodialisis Reguler Amu, Ivan Virnanda; Marbun, Maruhum Bonar H; Nugroho, Pringgodigdo; Rinaldi, Ikhwan; Shatri, Hamzah; Mardiana, Nunuk; Hidayat, Rudy; Susalit, Endang; Yunihastuti, Evy; Purnamasari, Dyah; Wardoyo, Elizabeth Y
Jurnal Penyakit Dalam Indonesia Vol. 12, No. 4
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Introduction. Fatigue is often found in patients with CKD-HD. Fatigue serves as an indicator of mortality and may be a viable target in a treatment strategy. Current research has not established the determinants of moderate PDF in individuals with CKD who are undergoing HD. Therefore, this study was conducted to prove the predictor factors of moderate PDF. Methods. A retrospective cohort study in CKD-HD patients at Fatmawati Central General Hospital during the period of November-December 2024. The independent variables of this study are comorbidities, MIS, depression, intradialytic SBPV, dialysis vintage, UFG, IDWG, and anemia status. Primary data from the PDF Scale, MIS, and BDI II questionnaire were collected through patient interviews during the eighth hemodialysis session. Demographic and clinical information of the patients was obtained from medical records. Intradialytic SBPV was determined by the ARV. All variables were examined using the chi-square test, except for the depression variable, which failed to fulfil the requirements and was assessed using the Fisher exact test. A logistic regression analysis was performed to identify the most significant association among the predictor variables of moderate PDF. Results. A total of 135 research subjects were included in the study. Based on the results of the bivariate analysis, MIS, depression, and the type of dialysis were significantly linked to moderate post dialysis fatigue (p < 0.05). From the results of the multivariate analysis, inflammatory malnutrition (RR 1.580; 95% CI 1.017–2.455; p = 0.042), dialysis vintage (RR 1.850; 95% CI 1.208–2.834; p = 0.005), and depression (RR 2.165; 95% CI 1.542–3.039; p < 0.001) were obtained. The logistic regression model shows a significant relationship between moderate PDF and severe malnutrition inflammation score, mild to moderate depression, and dialysis vintage exceeding 12 months. Conclusion. Our findings underscore a significant association between depression, dialysis vintage, and malnutrition inflammation score (MIS) with moderate PDF in CKD-HD patients.
Achieving and Sustaining Treatment Targets in Rheumatoid Arthritis: A Retrospective Cohort Analysis in Indonesia Fauzia, Fara; Hidayat, Rudy; Kusumo Wibowo, Suryo Anggoro; Sumariyono, Sumariyono; Parlindungan, Faisal; Ariane, Anna; Damanik, Johanda; Araminta, Abirianty Priandani; Damaratri, Suci
Kesmas Vol. 21, No. 1
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Achieving and sustaining low disease activity (LDA) and remission in rheumatoid arthritis (RA) remains challenging. This study examined the rates and predictors of LDA/remission and sustained LDA/remission in an Indonesian RA cohort. A retrospective study of newly diagnosed adult patients attending a rheumatology clinic in 2020-2021 was conducted. Patients were followed for 12 months to evaluate achievement of LDA/remission, defined as DAS28-ESR ≤3.2, and those meeting the target were observed for an additional 12 months to evaluate sustained LDA/remission. Cox regression was used to identify predictors of time to LDA/remission and loss of LDA/remission. Of 166 participants, 91 (54.8%) achieved LDA/remission, with a median time of 10 months. Among these, 39 (41.8%) maintained LDA/remission for 12 months. The median time to loss of LDA/remission was also 10 months. In multivariate analysis, no baseline variables (age, sex, rheumatoid factor (RF) positivity, disease activity, obesity, or disease duration) predicted achieving or sustaining LDA/remission. In this Indonesian cohort, over half of patients reached LDA/remission within 12 months. However, fewer than half sustained it over the following year, highlighting the need for ongoing monitoring and timely treatment adjustments, even after remission is achieved.
Co-Authors A P Utari Achmad Fauzi ACHMAD FAUZI Adiningsih Srilestari Adnan Prihartono, Nurhayati Andri Reza Rahmadi Anindito, Bagus Anna Ariane Anna Ariane Anna Ariane Anna Ariane Anna Ariane Anna Ariane, Anna Araminta, Abirianti P. Araminta, Abirianty Priandani Arief Nurudhin Awalia Awalia Ayu Paramaiswari Ayu Paramaiswari Bagus Anindito Bambang Setiyohadi Bambang Setiyohadi Bambang Setyohadi C Rinaldi A Lesmana C. Adisasmita, Asri Christina Simadibrata Dadang Makmun Damanik, Johanda Damaratri, Suci David Santosa Diana Sunardi Dicky L. Tahapary Dicky Levenus Tahapary Djuwita Hatma, Ratna Dwi Budi Darmawati Dwi R Helianthi, Dwi R Dyah Purnamasari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edy R Wahyudi, Edy R Eka Kurniawan Endang Susalit Endy Adnan Esthika Dewiasty Esthika Dewiasty, Esthika Evy Yunihastuti Faisal Parlindungan Faisal Parlindungan Faisal Parlindungan Farida Isroani Fauzia, Fara Gadang R. Dewantoro Gede Kambayana Ginting, Andi Raga Hamzah Shatri Handono Halim Handono Kalim Harry Isbagio Harry Isbagio Harry Isbagjo Hasan Maulahela Herlina Yani I Nyoman Suarjana Ika Prasetya Wijaya Ika Vemilia Ika Vemilia Warlisti Ikhwan Rinaldi Jerry Eddya Putra Boer Juferdy Kurniawan Kasjmir, Yoga I Kusumo Wibowo, Suryo Anggoro Laniyati Hamijoyo, Laniyati Linda Kurniaty Wijaya Lisa Kurnia Sari Malikul Chair Marcel Prasetyo Marcellus Simadibrata Marcellus Simadibrata Maruhum B.H. Marbun Muhadi Muhadi Muhadi Muhadi, Muhadi Najirman Najirman Nunuk Mardiana, Nunuk Pande Ketut Kurniari Pande Ketut Kurniari Parlindungan, Faisal Perdana Aditya Pratama, Mirza Zaka Prihartono, Nurhayati Adnan Pringgodigdo Nugroho Pringgodigdo Nugroho, Pringgodigdo Purwita Wijaya Laksmi R.M. Suryo Anggoro Kusumo Wibowo Radiyati Umi Partan Rakhma Yanti Hellmi Rakhma Yanti Hellmi Rakhma Yanti Helmi Ratih Manuaba Reza Yogaswara Ricky Ridho Adriansyah RM Suryo Anggoro RM. Suryo Anggoro RM. Suryo Anggoro KW Safri, Ahmad Yanuar Santosa, David Sepmeitutu, Iwandheny Siti Setiati Sosialita, Tiara Diah Sukamto Koesnoe Sukamto Koesnoe Sukamto Koesnoe Sumariyono Sumariyono Sumariyono Sumariyono Sumariyono Sumariyono Sarmidi Sumariyono Sumariyono Sumartini Dewi Sumartini Dewi Surya Darma Surya Darma Suryana, Bagus Putu Putra Triyanta Yuli Pramana Umi Partan, Radiyati Utari, A P Virnanda Amu, Ivan Wahono, Cesarius Singgih Wardoyo, Elizabeth Y Wulansari Manuaba, Ida Ayu Ratih Yoga I Kasjmir Yogaswara, Reza Yulyani Werdiningsih Yulyani Werdiningsih