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All Journal Medikora: Jurnal Ilmiah Kesehatan Olahraga e-Journal Pustaka Kesehatan Jurnal Ilmu Kesehatan Masyarakat Indonesian Journal of Cancer Chemoprevention Journal of Agromedicine and Medical Sciences INDONESIAN JOURNAL OF PHARMACY UNEJ e-Proceeding Jurnal Ilmiah Kedokteran Wijaya Kusuma Medical Laboratory Technology Journal NurseLine Journal Warta Pengabdian Jurnal Kesehatan Prima JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Kreativitas PKM Manuju : Malahayati Nursing Journal Majalah Kedokteran Andalas J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Journal of Health Sciences Jurnal Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Pengabdian Pada Masyarakat Indonesia (JPPMI) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Alamtana
Ika Rahmawati Sutejo
Departemen Biokimia, Fakultas Kedokteran Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Immunostimulant Effect of Garlic Chives Leaf Ethanolic Extract (Allium tuberosum) by Increasing Level of Antioxidant at Rats Doxorubicin-Induced Rats Ika Rahmawati Sutejo; Kiky Martha Ariesaka; Fuad Adi Prasetyo; Mudzakkir Taufiqurrqhman; Ain Yuanita Insani; Brilliant Givya Ariansari
Indonesian Journal of Cancer Chemoprevention Vol 7, No 3 (2016)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev7iss3pp93-98

Abstract

Cancer is one of the leading causes of death in the world, approximately 14 million new cases and 8.2 million deaths each year. Doxorubicin is a well-known chemotherapy drug which frequently used in treating various types of cancer. However,  doxorubicin posesses several side effects including cardiotoxic, hepatotoxic, nephrotoxic, and immunosuppression. One of the natural product that can be used as an adjuvant of doxorubicin to reduce the toxic effects is garlic chives (Allium tuberosum). The purpose of this study was to determine the effect of Allium tuberosum based on hematological profile, levels of CD4+, CD8+, and MDA serum of male Wistar rats which induced by doxorubicin. The hematological profile was analyzes by blood smear, levels of CD4+ and CD8+ were conducted by flowcytometry and levels of MDA serum were determined by spectrofotometry. The results showed that the etanolic extract of Allium tuberosum (EAT) increased neutrophil and lymphocyte, percentage of CD4+ cells (p<0.01) and CD8+ cells. It also decreased the levels of serum MDA (p<0.01). These results indicated that EAT work as immunostimulant possibly through an antioxidant mechanism (MDA). It can be concluded that EAT can be developed as adjuvant for doxorubicin.Keywords: doxorubicin, Allium tuberosum, immunostimulant, antioxidant, CD4+, CD8+ 
Methanolic Extract of Red Betel Leaves (Piper crocatum Ruiz & Pav) Perform Cytotoxic Effect and Antimigration Activity toward Metastatic Breast Cancer Meirizky Zulharini; Ika Rahmawati Sutejo; Hilyatul Fadliyah; Riris Istighfari Jenie
Indonesian Journal of Cancer Chemoprevention Vol 8, No 3 (2017)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev8iss3pp94-100

Abstract

Breast cancer is one type of cancer with a high mortality rate due to its metastatic property. Red betel leaves (Piper crocatum Ruiz and Pav) has been known as herbal medicine containing biophenolic, such as apigenin and luteolin derivatives which has cytotoxic activity toward cancer cells. This study is intended to explore the inhibitory effect of Piper crocatum leaves methanolic extract (PCM) on cell proliferation and migration by using 4T1 cells as model of metastatic breast cancer. By using MTT assay, PCM performed cytotoxic activity in a dose dependent manner with IC50 value of 120 μg/mL. Wound healing assay revealed that migration inhibitory activity of PCM on 4T1 cells at the concentration of 30 µg/mL. In conclusion, PCM perform cytotoxic effect and antimigration activity toward metastatic breast cancer cells.Keywords : breast cancer cells, Piper crocatum Ruiz & Pav, cytotoxic, cell mgration
Comparison of the Effectiveness of 10% Sulfur Soap and 2-4 Ointment as Single Treatment Alief Ilman Zaelany; Ida Srisurani Wiji Astuti; Ika Rahmawati Sutejo
Journal of Agromedicine and Medical Sciences Vol 3 No 3 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i3.6145

Abstract

Scabies disease caused by Sarcoptes scabiei var. hominis mites has become a problem in a whole world especially in developing countries like Indonesia. Scabies has a very contagious nature especially in places with dense population levels like Islamic boarding school. Permethrin which is a drug of choice for scabies has a fairly expensive price so it is less effective when used in mass treatment. In Indonesia, sulfur preparations, especially 10% sulfur soap and 2-4 ointment are easy to obtain because the price is affordable and available at the community health clinic. The purpose of this study is to know the difference in effectiveness of 10% sulfur soap and 2-4 ointment as a single treatment and combination on scabies disease. In this clinical trial study, treatment was performed on 3 groups, 10% sulfur soap group (n=36), 2-4 ointment group (n=36) and combination group (n=36). The examination was done on days 8, 15 and 22. Data analysis using SPSS version 23 with chi-square test. The results showed that the highest recovery rate was in combination group (week-1 (22,22%), week-2 (63,89%) and week-3 (94,44%)) followed by 2-4 ointment group (week-1 (11,11%), week-2 (72,22%) and week-3 (88,89%)) and 10% sulfur soap group (week-1 (2,78%), week-2 (52,78%) and week-3 (75,0%). The results of the analysis comparing the 10% sulfur soap group with the combination group showed p value on all consecutive examinations p=0,013, p=0,339 and p=0,022. In the comparison 2-4 ointment group to the combination group obtained p value on all examinations respectively p=0,206, p=0,448 and p=0,394. The conclusion is combination therapy had the highest cure rate and statistically significant (p=<0,05) was obtained in comparison of 10% sulfur soap to combination at week-1 and week-3 examination. Keywords: scabies, comparison of the effectiveness, 10% sulfur soap, 2-4 ointment, combination, Islamic boarding school
An Analysis of Feeding Pattern Factors in Infants at Kencong Public Health Center Laila Auliya Noviyanti; Dwita Aryadina Rachmawati; Ika Rahmawati Sutejo
Journal of Agromedicine and Medical Sciences Vol 6 No 1 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i1.9597

Abstract

The feeding pattern in toddler is an effort and a way for mothers to provide food to toddler with the aim that the toddler eating needs are sufficient, both in quantity and nutritional value. There are factors that influence the feeding pattern in toddler, namely the level of maternal knowledge about toddler nutrition, maternal education level, household income, mother's occupation, and the number of family members. The purpose of this study is to analyze the factors that influence the feeding pattern in toddler at ​​Kencong Public Health Center. The type of research that will be conducted is analytical survey research with a cross sectional approach. The sample of this study is mothers who have children aged 12 months to 59 months in the working area of ​​Kencong Public Health Center. The sample size in this study is 70 samples using stratified random sampling. The majority of the sex of the toddler in this study were male and aged 12-36 months. The majority of mothers in this study are aged 26-35 years, graduated from high school, did not work, have sufficient knowledge of toddler nutrition, and included to have sufficient toddler feeding patterns. The majority has small family and the household income of the respondents was mostly below the regional minimum wage. The results of this study there are factors that influence the feeding pattern in toddler in the work area of ​​Kencong Public Health Center; there are the mother's education level (p= 0,000 dan r= 0,824), the level of maternal knowledge about toddler nutrition (p= 0,000 dan r= 0,895) and household income (p= 0,000) which means the degree of correlation in the category is very strong. Keywords: The feeding pattern in toddler, the factors that influence the feeding pattern in toddler
The Selectivity of Ethanolic Extract of Buah Makassar (Brucea javanica) on Metastatic Breast Cancer Cells Ika Rahmawati Sutejo; Herwandhani Putri; Edy Meiyanto
Journal of Agromedicine and Medical Sciences Vol 2 No 1 (2016)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Treatment of cancer such as surgery, radiotherapy and chemotherapy has many side effects. Chemopreventive agent is needed to reduce the side effect and increase the effectivity of therapy. The discovery of  cochemopreventive agent should consider on its selectivity to reduce side effects. The selective cochemopreventive agents work effectively in cancer cells and safe for normal cells. Buah Makassar (Brucea javanica) is a natural product that is empirically used for anti-inflammatory and antitumor. The purpose of this study is to determine the cytotoxic effect of ethanolic extract of buah Makassar against 4T1, MCF7, HeLa, and Vero cell lines. The cytotoxic test is performed by MTT assay. The parameter obtained from the cytotoxic test was IC50. Selectivity index is determined from IC50 ratio of cancer cells to normal cells. The results showed that ethanolic extract of buah Makassar has a cytotoxic activity on 4T1, MCF7, HeLa, and Vero cells with IC50 were 49,9±0,83 μg/mL; 107,6±8,14 μg/mL; 228,9±4,16 μg/mL and 395,5± 4,21 μg/mL respectively. It also has high selectivity on 4T1 metastatic breast cancer cell with selectivity index of 7,93. It can be concluded that the ethanolic extract of buah Makassar has potential to be delevoped as cochemopreventive agent especially on metastatic breast cancer. Keywords: Brucea javanica, MTT assay, selectivity index, 4T1, MCF7, HeLa, Vero
The Activity of Cainito Leaves Ethanol Extract (Chrysophyllum cainito L.) on Wistar’s Total Erythrocites Induced Cyclophosphamide Heri Puguh Widodo; Ika Rahmawati Sutejo; Rini Riyanti
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i2.7588

Abstract

One of the commonly used chemotherapy drugs is cyclophosphamide. However, the use of cyclophosphamide can provide various toxic effects. The most common toxic effect of cyclophosphamide is bone marrow suppression with anemia as one of its markers. The antioxidant content of cainito leaf potentially increase the production of blood cells, especially erythrocytes. The aims of this study is determining the effectiveness of the cainito leaf ethanol extract against cyclophosphamide induced mouse erythrocyte count in vivo. A sample of 20 male wistar rats was divided into five groups; normal group, negative control group, and three groups of ethanol extract of cainito leaf with dose 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW were administered for one week followed by intraperitoneal cyclophosphamide with dose 50 mg/kgBW as much as one time. One Way Anova Test result showed a significance of 0.015 (p<0.05). However, the LSD test results showed no significant different results between the negative control group and the treatment group. The conclusion was that there was no difference in the amount of erythrocytes in mice given only cyclophosphamide with previous rats given cainito extract.
Severe Deficit in Energy and Protein Intake Correlates wih Stunting among Children Aged 12-24 Months in Plerean Sumberjambe Jember Nunung Nurhasanah; Dwita Aryadina Rachmawati; Ika Rahmawati Sutejo
Journal of Agromedicine and Medical Sciences Vol 7 No 2 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i2.24828

Abstract

The current nutritional problems are still the world's attention, especially in developing countries, including Indonesia. The Global Nutrition Report shows that Indonesia is a country with three main nutritional problems: wasting, overweight, and stunting (under five) in infants. Stunting has short-term and long-term effects associated with growth and developmental disorders. This study wants to determine the correlation between energy and protein intake of children aged 12-24 months in Plerean, Sumberjambe, Jember. This is an observational research with cross sectional study design. The population of this study were all children aged 12-24 months in Plerean Village, Sumberjambe, Jember. A total of 48 parents/respondents were interviewed about the consumption history of the on the previous day. This is done to determine the energy and protein intake consumed by the research subjects. Measurement of energy and protein intake using 24-hours food recall method and stunting was obtained from secondary data obtained from Puskesmas Sumberjambe. This research used purposive sampling method. The data obtained is then converted into calorie units and processed using a statistical program. The results showed showed 28 subjects were male. Most parents of research subjects earn less than the Minimum Wage District (UMK). A total of 68.75% of subjects had severe deficit in energy intake. A total of 52.08% of subjects had a severe deficit protein. Using Spearman correlation test the correlation of energy intake with the incidence of stunting obtained p value = 0.000 with correlation coefficient -0.589. Then, the relationship of protein intake with the incidence of stunting obtained p = 0.001 with a correlation coefficient of -0.446. So it can be concluded that severe deficit in energy and protein intake correlates with stunting in the study subjects. Keywords: 24-hours food recall, Energy, Protein, Stunting
Antihiperlipidemi and Atheroprotective activity of Kepuh (Sterculia foetida) Leaves Ethanolic Extract on High-Fat-Diet Rat Models Ika Rahmawati Sutejo; Imama Rasyada; Annafira Yuniar
Journal of Agromedicine and Medical Sciences Vol 3 No 1 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i1.4097

Abstract

Cardiovascular disease causes the highest mortality rate in the world. Atherosclerotic plaque is the most common etiology of cardiovascular disease. High levels of cholesterol in circulation is the pathophysiology of atherosclerosis formation. Atherosclerosis risk can be lowered to 20-40% with statins. Statins are effective in lowering total and LDL cholesterol, but these drugs have been reported to cause side effects. Therefore, it needed an alternative medicine to prevent the process of atherosclerosis using kepuh leaves (Sterculia foetida). Flavonoids contained in Kepuh leaves improve lipid profiles. The aims of this study is to prove the effectiveness of Sterculia foetida in lowering cholesterol, triglyceride and reduce the amount of foam cells on high-fat-diet induced rats. The research design is quasi-experimental with post test only design. Animals are grouped into normal group, negative control group and three treatment groups that were given kepuh leaves extract  at the dose of 200 mg/kgBB, 400 mg/kgBB, and 800 mg/ kgBB. Rats were given high-fat diet of initial intravenous adrenaline injection 0.006 mg/200 gBB and duck egg yolks 5 g/kgBB for 21 days. Cholesterol and triglycerides were measured by enzymatic methods and aortic tissue stained with HE. ESf reduce cholesterol significantly and reduce the amount of foam cells on aorta.Keywords: cholesterol, triglyceride, kepuh leaves, foam cell, high-fat-diet
The Effectiveness of Edamame Seed (Glycine max L. Merril) Ethanolic Extract to Fibroblast Count on Second Degree Burn Wound Healing Arifah Nur Hasanah; Ika Rahmawati Sutejo; Enny Suswati
Journal of Agromedicine and Medical Sciences Vol 5 No 3 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i3.6831

Abstract

Burn wound healing process consists of three phases of inflammation, proliferation and remodelling. The number of fibroblasts has increased during the proliferation phase. Oxidative stress in burn may disrupt proliferation through TGF-β inhibition, result in decreased number of fibroblasts and poor burn wound healing. Genistein in edamame seeds has anti-inflammatory, antibacterial and antioxidant properties. Edamame contains vitamins A, C, and E which is also have antioxidant properties. Edamame has been suggested to protect burn wound healing from oxidative stress. This study aimed to understand the effectiveness of edamame seed (Glycine max L. Merril) ethanolic extract (ED) to fibroblast count in second degree burn wound healing. This is true experimental research with post test only control group design. The study was conducted at University of Jember during November until December 2017. The sample of this research was 24 rat models of second degree burn which was made by attaching hot metal (60 ° C) for 5 seconds on the shaved back of the rats. The sample was divided into 6 groups with topical treatment, among others: positive control group (silver sulfadiazine), negative control group (Na CMC 0.5%), group with ED 20%, ED 40%, ED 60%, and ED 80%. Treatment was given for 15 days and skin sample was taken on the 16th day. Observation of the number of fibroblasts was done by taking pictures of histhologic preparations in Hematoxylin and Eosin staining under 400x magnification of light microscope. The number of fibroblast of each picture was processed using Image-J software. In one way ANOVA test, significance value of 0.011 (p≤0,05) indicated that there was at least a significant difference between 2 groups. LSD’s post hoc analysis showed that there was a significant difference in the group ED 20, 40, and 60% compared with negative control. Keyword: burn wound healing, vegetable soybean, genistein, fibroblast count, silver sulfadiazine
Correlation of Cholinesterase Levels to Lung Function in Farmer Exposed by Organophosphate Pesticides in Sukorambi Village, Jember Regency Puput Sagita Mey Sandra; Kristianingrum Dian Sofiana; Ika Rahmawati Sutejo
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.9651

Abstract

Abstract Most of the Indonesia population work as a farmer. Pesticides are used in agriculture sector for pest and plant diseases. Pesticides can cause intoxication. The World Health Organization (WHO) estimates that 1-5 million cases of pesticides poisoning among agricultural workers occur in developing countries. Indonesia pesticide poisoning cases reach 771 cases. Organophosphate enter the body through inhalation. Organophosphate pesticides work systemic to inhibit the cholinesterase enzyme causing lung function disorders. The purpose of this study was to analyze the correlation of cholinesterase levels to lung function in farmers exposed to organophosphate pesticides in Sukorambi Village, Jember Regency. This is an observational analytic study using a cross sectional design. Cholinesterase levels test using the DGKC method to determine the presence of poisoning, while for lung function test using spirometry with FVC, FEV1 and FEV1 / FVC ratios as parameters. The results of the test in 30 samples showed 14.33% (4/30) abnormal cholinesterase levels or decreased. Lung function test showed 20% (6/30) had obstructive disorders, 43.33% (13/30) restrictive disorders and 36.67% (11/30) were normal. Data analysis using chi square showed a significant relationship (p = 0.049) between cholinesterase levels and lung function. Conclusion: There is a significant relationship between the level of cholinesterase to decrease in pulmonary physiology of farmers exposed to organophosphate pesticides in Sukorambi Village, Jember Regency. Keyword :Organophosphate, cholinesterase level, lung function
Co-Authors Adistha Eka Noveyani Adji, Novan Krisno Ain Yuanita Insani Al Munawir Alief Ilman Zaelany Alief Ilman Zaelany Anaditya Wahyu Kumudhaningsih Anang Dwi Atmoko Ancah Marchianti Angga Mardro Raharjo Annafira Yuniar Annafira Yuniar Arif, Dina Rizky Amalia Arifah Nur Hasanah Avita Lukmawati Baskoro Adi Prayitno Brilliant Givya Ariansari Cholis Abrori, Cholis Diana Chusna Mufida Dimas Zabirrurohman Putra Dini Agustina Dwita Aryadina Rachmawati Edy Meiyanto Edy Meiyanto EDY MEIYANTO Edy Meiyanto ENNY SUSWATI Erfan Efendi Erma Sulistyaningsih Fauqi Amalia Fuad Adi Prasetyo Hairrudin Hairrudin Handayani, Sri Hazmi Dwinanda Nurqistan Hazmi Dwinanda Nurqistan Heni Fatmawati Heri Puguh Widodo Herwandhani Putri Herwandhani Putri Herwandhani Putri Herwandhani Putri Hilyatul Fadliyah I Nyoman Insan Parisudha Ida Srisurani Wiji Astuti Imama Rasyada Imama Rasyada Jenie, Riris Istighfari Jenie, Riris Istighfari Kiky Martha Ariesaka Kiky Martha Arieska Kristianingrum Dian Sofiana Laila Auliya Noviyanti Lailatul Maghfiroh M. Ali Shodikin Meirizky Zulharini Mudzakkir Taufiqurrqhman Ni Nyoman Yuniasih Nunung Nurhasanah Nur Hasyimiyyah Nurfahimi, Yudriani Nurul Indah Saffanah Pratikno, Dela Putri Puput Sagita Mey Sandra Putra Uta, Diego Rafi Putri, Herwandhani Rakhmat Ramadhani Rayyan, Muhammad Isra Rafidin Rini Riyanti septa surya wahyudi, septa surya Septyawati, Ratna Siti Marissa Aisyah Sugiyanta Sugiyanta Tristira Urvina Viddi Agustian Rosyidi Viddi Rosyidi Viddy Agustian Rosyidi Wiwien Sugih Utami Yasmin Auralia Putri Zahrah Febianti