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All Journal Journal of Dentistry Indonesia Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Bambang Sutrisna
Faculty of Public Health, Universitas Indonesia
Dentistry Health Professions Medicine & Pharmacology Public Health

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Serum Level of Vascular Endothelial Growth Factor (VEGF) can be used to Assess Response of Radiation Therapy in Cervical Cancer Armanza, Ferry; Andrijono, Andrijono; Sutrisna, Bambang
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.533 KB) | DOI: 10.32771/inajog.v2i1.378

Abstract

Objective: To compare the sensitivity and specificity of Squamous Cell Carcinoma (SCC) and Vascular Endothelial Growth Factor (VEGF) levels to assess the response of radiation therapy. Method: The study was conducted by the method of analytic observational cohort study in 24 patients with cervical cancer stage II-B and III-B in RSCM that met inclusion criteria. Examination of VEGF and SCC in serum samples was performed in the Prodia Laboratory Jakarta. The examination was conducted twice before and after radiation therapy. The subjects were treated by radiation therapy/chemoradiation according to standard procedures. After the completion of radiation was declared, the response of radiation therapy was conducted by clinical assessment. Result: Of the 24 subjects, we obtained a mean level of SCC pre-radiation was 23.43 ± 5.84 ng/ml and post-radiation was 2.19 ± 0.68 ng/ml. The mean VEGF pre-radiation was 790.41 ± 111.06 pg/ml and post-radiation was 497.47 ± 79.26 pg/ml. ROC curves of each tumor marker obtained SCC pre-radiation AUC 40%, p 0.53 (CI 0.18-0.68) and SCC post-radiation AUC 48.1%, p 0.91 (CI 0.21-0,75) can not be used as a diagnostic and prognostic factors of response to radiation therapy. VEGF pre-radiation produced an AUC of 17.5%, p 0.04 (CI 0.00-0.36), thus cannot be used as a prognostic factor for response to radiation therapy. VEGF after radiation produced an AUC of 92.5%, p 0.01 (CI 0.81-1.00), thus can be a diagnostic factor for response to radiation therapy. VEGF post-radiation with cut-off point 614.75 pg/ml had a sensitivity 80%, specificity 75%, NDP 94.12%, NDN 42.86%; RKP 3.2; RKN 0.26 and accuracy 79.16%. There is a significant correlation between the decrease of serum VEGF level post-radiation and a positive response of radiation therapy (p 0.01, CI 1.00-3.23). Conclusion: Examination of VEGF levels can be used to assess the response of radiation therapy with a sensitivity of 80% and specificity of 75%.  Keywords: cervical cancer, SCC, therapeutic response, VEGF
Changes in Cortisol Levels before and after Supportive Psychotherapy in Patients with Comorbid Cervical Cancer Distress with Depression Type Nuranna, Laila; Nuryanto, Kartiwa H; Andriansyah, Andriansyah; Elvira, Sylvia D; Sutrisna, Bambang
Indonesian Journal of Obstetrics and Gynecology Volume 6 No. 3 July 2018
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.702 KB) | DOI: 10.32771/inajog.v6i3.784

Abstract

Objective: To prove the success of supportive psychotherapy thatwas provided as a distress therapy on advanced cervical cancer.Knowing the prevalence of distress type of depression in patientwith epithelial cervical cancer, proving the benefits of psychotherapysupportive for distress can decreasing cortisol level in cervicalcancer patient, can assess distress thermometer score, HAM-D17score and scoring incident predictors of distress with depressiontype.Methods: There were 32 subjects from 71 advanced cervical cancerpatients had mild-moderate depression. Then randomizationblocking was performed to determine a subject who entered thetreatment group (n = 16) who got supportive psychotherapy orcontrol group who got common psychotherapy (n = 16). All ofparticipants assessed the distress level with cortisol value, distressthermometer score, and HAM-D17 score before and after they gotsupportive psychotherapy.Results: After the intervention of psychotherapy in the treatmentgroup decreased HAM-D17 score, the average decline 7.53 (SB 3.34).The mean decreasing in the control group was 3.98 (SB 2.85). Thereis a significant difference in mean reduction in HAM-D17 scores ontreatment and control groups with p = 0.003 (p <0.005). There wasdecreasing blood cortisol level in the treatment group amounted to39.43, while the control group there was a drop of 1.59. The reductionof cortisol level in the treatment group and the control has a pvalue0.302. After got supportive psychotherapy, found a decreasingthe average value of the thermometer distress in the treatmentgroup 3.02 and the control group 2.51, with a p value more than0.492.Conclusion: There were 45% of cervical cancer patients in the clinicexperiencing distress disorder with depressive type. The bloodcortisol level could be decreased by giving supportive psychotherapywith a mean decrease of 39.43 nmol/l. There was a significantreduction in the level of depression (HAM-D17 score) of 7.53 pointsand distress thermometer impairment by 3 points after givensupportive psychotherapy. Obtained scoring predictors for theoccurrence of distress type of depression in patients with advancedcervical cancer with a sensitivity of 46.15% and a specificity of89.47%.[Indones J Obstet Gynecol 2018; 6-3: 179-187]Keywords: cervical cancer, cortisol, distress, distress thermometer,HAM-D17 score
Mouth Breathing, Head Posture, and Prevalence of Adenoid Facies in Patients with Upper Respiratory Tract Obstruction Purwanegara, Miesje Karmiati; Sutrisna, Bambang
Journal of Dentistry Indonesia Vol. 25, No. 1
Publisher : UI Scholars Hub

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Frequent upper respiratory tract infections and allergic reactions may cause upper respiratory tract obstruction (OURT). Mouth breathing (MB) occurs in individuals with nasal breathing problems. A person with MB will raise his head higher; thus, MB is a risk factor for head posture (HP) deviation. Children with MB during growth and development may exhibit dentocraniofacial (DCF) deviation. Objective: To evaluate the prevalence of MB, HP, and DCF deviation in OURT patients to know risk factors of HP deviation, morphological aberrations of DCF and DCF deviation growth and development. Methods: This cross-sectional study included 285 OURT subjects aged 9–15 years. Data obtained from cephalometric analysis, physical examination, and questionnaires were analyzed. Results: Of 285 OURT subjects, 80.4% showed MB, 44.2% HP deviation, and 66.7% DCF deviation. As risk factors for DCF deviation, MB and HP showed odds ratios of 20.45 and 8.11 and population attributable risks of 87.5% and 59.7%, respectively. Conclusion: The prevalence of MB and DCF deviation in OURT patients is high, but that of HP deviation is generally comparable. MB and deviated HP are risk factors for DCF deviation growth and development.
Survival Kidney Transplantation from Related and Emotionally Related Living Donors in Cipto Mangunkusumo Hospital 2010-2015 Susilowati, Utami; Sutrisna, Bambang; Marbun, Maruhum Bonar H; Susalit, Endang
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

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Kadar Kolesterol Total dan Tekanan Darah Orang Dewasa Indonesia Margarita, Yohana; Princen, Princen; Andi, Andi; Rumawas, Marcella Erwina; Kidarsa, Valentinus Budi; Sutrisna, Bambang
Kesmas Vol. 8, No. 2
Publisher : UI Scholars Hub

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Penelitian dengan desain potong lintang ini bertujuan untuk menguji hubungan antara kadar kolesterol total dengan tekanan darah. Data dikumpulkan pada 14 -21 Juni 2011, terhadap 51 subjek penelitian berusia > 30 tahun yang tidak mengonsumsi obat antihipertensi ataupun antikolesterol, dipilih secara consecutive antara pengunjung Puskesmas Kelurahan Joglo-II, Jakarta. Tekanan darah diukur dengan sfigmomanometer sesuai pedoman baku. Kadar kolesterol total darah sewaktu diukur dari sampel darah tepi dengan alat tes kolesterol. Analisis data menggunakan regresi linier, korelasi Pearson dan General Linear Model dengan koreksi Bonferroni. Pada 51 responden (nilai tengah usia 50 tahun, 70,6% perempuan), rerata kadar kolesterol total adalah 200 mg/dL dan rerata tekanan darah adalah 135/84 mmHg. Pada faktor perancu yang disetarakan, kadar kolesterol total yang tinggi berhubungan dengan tingginya tekanan darah sistolik (r = 0,39; nilai p = 0,005) ataupun diastolik (r = 0,43; nilai p = 0,002). Responden pada kelompok kuartil ketiga total kolesterol memiliki tekanan darah 26/11 mmHg lebih tinggi secara bermakna dibandingkan mereka pada kelompok kuartil kedua (nilai p = 0,001 dan nilai p = 0,002 berturut-turut untuk tekanan darah sistolik dan diastolik). Menjaga kadar kolesterol total dalam batas normal merupakan salah satu upaya untuk mencegah hipertensi. This cross-sectional study was aimed to examine the association between total cholesterol levels and blood pressures. Data was collected on June 14-21, 2011, among 51 subjects, aged > 30 years, who were taking neither antihypertensive nor anticholesterol drug, consecutively selected among peoples attending Joglo-II Sub-district Primary Health Center, Jakarta. Blood pressures were measured using a manual sphygmomanometer according to the standard protocols. Peripheral blood samples were collected and non-fasting total cholesterol were assessed using a cholesterol-test kit. Analyses were perfomed using linear regression, Pearson correlation, and General Linear Model (with Bonferroni correction). In 51 respondents (median age 50 years, 70.6% female), mean total cholesterol level was 200 mg/dL and blood pressure were 135/84 mmHg. After adjustment for confounding factors, higher total cholesterol levels were associated with higher systolic (r = 0.39; p value = 0.005) or diastolic (r = 0.43; p value = 0.002) blood pressures. Participant in the third quartile category had blood pressures 26/11 mmHg significantly higher than that of those in the second quartile category (p value = 0,001 and p value = 0,002 for sistolic and diastolic blood pressures, respectively). Maintaining total cholesterol levels within the normal limits may be one way to prevent hypertension.
Hipertensi dan Risiko Mild Cognitive Impairment pada Pasien Usia Lanjut Abadi, Kasmianto; Wijayanti, Dian; Gunawan, Ellen A.; Rumawas, Marcella Erwina; Sutrisna, Bambang
Kesmas Vol. 8, No. 3
Publisher : UI Scholars Hub

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Mild Cognitive Impairment (MCI) meningkatkan risiko penyakit Alzheimer. Tekanan darah tinggi sering didapatkan pada beberapa pasien usia lanjut yang menderita MCI. Penelitian potong lintang ini bertujuan untuk mengetahui hubungan antara hipertensi dan MCI pada lanjut usia (usia ≥ 60 tahun) yang dipilih secara konsekutif dari pengunjung Puskesmas Joglo-I pada 12-18 November 2012. Kuesioner Mini Mental State Examination (MMSE) digunakan untuk skrining gangguan fungsi kognitif dan tekanan darah diukur dengan manual sfigmomanometer menurut prosedur standar. Analisis statistik menggunakan Generalized Linear Model. Dari 32 responden, rata-rata usia adalah 61 tahun dan sebanyak 53,1% responden adalah perempuan. Hipertensi ditemukan pada 21 orang (65,6%) dan MCI pada 21 orang (65,6%). MCI didapatkan pada 17 orang (81%) di antara 21 responden hipertensi, dan 4 orang (36%) di antara 11 responden nor- motensi. Terdapat hubungan statistik yang bermakna antara hipertensi dan MCI. Risiko mild cognitive impairment pada usia lanjut hipertensi adalah 2,2 kali lebih besar daripada mereka yang normotensi (PR = 2,2; nilai p = 0,01). Hubungan ini tetap bermakna setelah faktor usia, diabetes, dan stroke disetarakan (nilai p = 0,04). Menurunkan kasus hipertensi dapat menjadi suatu upaya mengurangi risiko MCI pada usia lanjut. Mild cognitive impairment (MCI) may increase the risk of Alzheimer’s disease. Some geriatric patients with MCI were often identified to have high blood pressures. This cross-sectional study aimed to know association between hypertension and MCI in geriatric patients (age ≥ 60 years), con- secutively selected among people attending Joglo-I Primary Health Center between November 12-18, 2012. The Mini Mental State Examination (MMSE) questionnaires were administered to screen for cognitive impairment, blood pressures were measured using a manual sphygmomanometer according to the standard protocols. Analyzes were done using the Generalized Linear Model procedure of 32 participants (median age: 61 years; 53.1% women), 21 respondents (65.6%) had hypertension, and 21 others (65.6%) had MCI. MCI were identified in 17 persons (81%) out of 21 respondents with hypertension, and in 4 persons (36%) out of 11 respondents with normal blood pressure. Hypertension was significantly associated with MCI. The risk that older individuals diagnosed with hyper- tension had MCI was 2.2 over that of their counterpart with normal blood pressure (PR = 2.2; p value = 0.01). This association remained significant after adjustment for age, diabetes, and stroke (p value = 0.04). Reduced hypertension may be one strategy to lower the risk of cognitive impairment among older adults.
Co-Authors A.A. Ketut Agung Cahyawan W Abdul B. Saifuddin Achmad Tjarta Alida Harahap Alida R Harahap, Alida R Andi Andi Andriansyah Andriansyah Andrijono Andrijono Bethy Suryawati Budiningsih Siregar Dewi Wulandari Dharmeizar Dharmeizar Dian Wijayanti Ediwibowo Ambari Ellen A. Gunawan Endang Susalit Ferry Armanza, Ferry Harahap, Alida Roswita Hariyono Winarto Herdiman T Pohan Idrus Alwi Imam Rasjidi Junita Indarti Kasmianto Abadi Khonsa, Oni Laila Nuranna Lukman H Makmun M. F. Aziz Marcella Erwina Rumawas Markus, Unedo H Markus, Unedo H Maruhum B.H. Marbun Miesje Karmiati Purwanegara, Miesje Karmiati Mohammad F. Aziz Mpu Kanoko Nana Supriana Nuryanto, Kartiwa H Nuryati C. Siregar Pelupessy, Nugraha Utama Pradana Soewondo Princen Princen Rahma Prastasari Rinaldy, Dino Rizal Sanif Rochani Rochani Rukmini T. Mangunkusumo Santoso Cornain Sarwono Waspadji Sigit Purbadi Siti B. Kresno Siti Setiati Slamet Suyono Suhendro Suwarto, Suhendro Susilowati, Utami Suwignyo . Sylvia D Elvira Valentinus Budi Kidarsa Vitantri, Fara Wiguno Prodjosudjadi Yohana Margarita