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All Journal Tropical Medicine Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Farmasi Klinik Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Molucca Medica Indonesian Journal of Pharmacology and Therapy
Jarir At Thobari
Department Of Pharmacology And Therapy, Faculty Of Medicine, Public Health And Nursing, Gadjah Mada University, Yogyakarta, 55281, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Tropical Medicine Journal

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Laboratory Testing of Transovarial Transmission in Aedes Aegypti Mosquito Guntur Benedict Hutadjulu; Sitti Rahmah Umniyati; Jarir At Thobari
Tropical Medicine Journal Vol 2, No 1 (2012): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3188.67 KB) | DOI: 10.22146/tmj.4291

Abstract

Introduction: Ae. aegypti is one of the vectors causing Dengue Hemorrhagic Fever (DHF) that feeds on human blood suffering from DHF and transmit it to another healthy human. The ability of Dengue Virus (DENV) to survive in nature is due to 2 mechanisms i.e. horizontal transmission among viremic vertebratae infected by Aedes mosquitos and vertical (transovarial) transmission from infected female mosquito to another generation.Objectives: To know the differences between next generation’s viral carriage, percentage ofmosquito descendants carrying DENV, and the distribution of DENV in its infected mosquitos.Methods: Study design was a quasi experimental posttest-only design with control group. The study was conducted on 53 second-generation female Ae. aegypti mosquitos which are grouped into treatment and control groups. Dengue Viral antigen in both groups were detected by immunohistochemistry method using Streptavidin Biotin Peroxidase Complex (SBPC) in paraffin embedding preparation of mosquitos aged 1-7 days. Fisher exact test was used to compare proportion of virus detected in moaquitos between 2 groups.Results: The virus detected in second generation of DEN-infected and uninfected mosquitos were 100% and 85.7%, respectively. The virus was distributed from day 1 to 7 in all organs such as brains, thorax, salivary gland, gastric epithelial cells, and ovarium of the infected mosquitos. Similar distribution was not detected in control mosquitoes.Conclusion: There was no difference in next mosquito generation’s transovarial infection among DENV-infected and uninfected Ae. aegypti mosquitos.Keywords: Ae. aegypti mosquito; Dengue virus (DENV); transovarial transmission; immunohistochemistry method, Streptavidin Biotin Peroxidase Complex (SBPC).
Association of hydrazine and SGPT level two hours after drug administration at the end of intensive phase treatment of pulmonary tuberculosis patients Ave Olivia Rahman; Jarir At Thobari; Mustofa Mustofa
Tropical Medicine Journal Vol 2, No 2 (2012): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (385.192 KB) | DOI: 10.22146/tmj.17124

Abstract

ABSTRACTIntroduction: Isoniazid in the regiment treatment of pulmonary tuberculosis patients causes side effects. Hepatotoxicity is one of the isoniazid’s side effects that need medical attention. Isoniazid-induced hepatotoxicity has no correlation with high level of isoniazid in plasma. However, several animal studies show it has an association with hydrazine, a metabolite of isoniazid. The role of hydrazine in isoniazid-induced hepatotoxicity among tuberculosis patients is unclear.Objective: The aim of this study was to analyze the correlation of hydrazine and serum glutamic-pyruvic transaminase (SGPT) levels at two hours after drug administration in the end of intensive phase treatment of pulmonary tuberculosis patients.Methods: This was an observational study with cross-sectional design. Fifty eight newly diagnosed pulmonary tuberculosis patients were enrolled in this study. Venous blood sampling was collected at two hours after drug administration in the end of intensive phase treatment. SGPT level was measured by an automatic chemical analyzer. Hydrazine level was measured by using high-performance liquid chromatography (HPLC). Statistical significance was analyzed using correlation test.Results and Discussion: The incidence of hepatotoxicity was 3.4% and about 8.6% patients had elevated SGPT at two hours after drug administration in the end of intensive phase treatment. There was no correlation between hydrazine level and SGPT levels in this study. These results indicated that hepatotoxicity or minimal liver damage in some patients might occur in the administration of standard dose isoniazid. It might be caused by isoniazid’s metabolites itself, or various other factors.Conclusions: There was no correlation between hydrazine level and SGPT levels at 2 hours after drug administration in the end of intensive phase treatment in this study.
Co-Authors A.A. Ketut Agung Cahyawan W Ady Bagus Indrianto Agung Endro Nugroho Al Razi Sena Alfi Yasmina Alfi Yasmina Anggit Dewi Rahayu Anggoro Budi Hartopo Annisa Setiyaningrum Anwar Santoso Asal Wahyuni Erlin Mulyadi Ave Olivia Rahman Bambang Irawan Chandra, Lukman Ade Christi Mambo David Dwi Putera Deva Bachtiar Dimas Pramita Nugraha Dwi Indria Anggraini Dyah Aryani Perwitasari Endang Mahati Erna Kristin Faridatun Khasanah Fatma Othman Gdara Guntur Benedict Hutadjulu Hari Agus Sanjoto Hendrik Hendrik Indwiani Astuti Iwan Dwiprahasto Iwan Dwiprahasto Iwan Dwiprahasto Johan Kurnianda Jonathan Hasian Haposan Lucia Kris Dinarti Luhur Pribadi Lukman Ade Chandra Maemonah, Maemonah Mardiah Suci Hardianti Mustofa Mustofa Nailatul Arifah Ngatidjan Ngatidjan Pompini Agustina Sitompul Pratiwi, Woro Rukmi Pratiwi, Woro Rukmi Rafika Mutia Sari Rita Suhadi Rizaldy Pinzon Rizki Amalia Gumilang Sari, Rafika Mutia Shofya Indraguna Siahaya, Presli Glovrig Sitti Rahmah Umniyati Sutarman S Syahru Agung Setiawan Teguh Triyono Togi Junice Hutadjulu Tri Asti Isnariani Tri Murti Andayani Tri Murti Andayani Trijayanti, Christiana Ully Adhie Mulyani Umi Sa'adatun Nikmah Wahyu Damayanti Yanri Wijayanti Subronto Yati Soenaro Yati Soenaro Yati Soenarto Yolanda Dyah Kartika Zulpadly, M Fiqri