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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Simetris Indonesian Journal of Cancer Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JURNAL ILMIAH MAKSITEK Abdi Masya Jurnal Abdikarya : Jurnal Karya Pengabdian Dosen dan Mahasiswa JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer IJRETINA - International Journal of Retina

Teguh Triyono

Department Of Clinical Pathology, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada-Dr. Sardjito General Hospital, Yogyakarta, Indonesia

Author-ID : 406246

Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Articles

Title

Correlation of interleukin-6 and monocyte count to troponin I in acute coronary syndrome Usi Sukorini, Teguh Triyono Joni Parinding
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 04 (2008)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Acute coronary syndrome (ACS) becomes an important disease, because of its increased prevalence and mortality rates. Makers of systemic inflammation, including interleukin-6 and monocyte count, have been shown to predict future cardiovascular events. However, the association between these inflammatory markers with cardiac injury is still a controversy.Objective: To evaluate the relationship between IL-6 and monocyte count as inflammation markers and troponin I as cardiac injury.Methods: This was a cross-sectional study. Subjects were patients suspected of ACS admitted to the emergency department of Sardjito Hospital Yogyakarta. Diagnoses were performed based on WHO criteria. Troponin I and interleukin-6 levels were measured from sera using sandwich ELISA method (Roche). Monocyte counts were determined by automatic hematology analyzer (Sysmex). Kruskal-Wallis test and Spearmans correlation test were used to assess the difference and correlation between parameters.Results: Sixty one (61) subjects were included in the study. Age of the subjects were 51-60 years, and diagnosed as ST elevation myocardial infarct (STEMI). Significant differences of IL-6 and troponin I levels were determined among unstable angina pectoris (UAP), non-ST elevation myocardial infarct (NSTEMI), and ST elevation myocardial infarct (STEMI) subjects. There was a moderate correlation (r = 0.54; p = 0.001) between troponin I and Interleukin-6, but not with monocyte count.Conclusion: Interleukin-6, but not monocyte count, was correlated with troponin I in acute coronary syndromes.Key words: acute coronary syndrome - interleukin-6 - monocyte count - troponin I

Correlation of interleukin-6 and monocyte count to troponin I in acute coronary syndrome Teguh Triyono Joni Parinding Usi Sukorini
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 04 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Acute coronary syndrome (ACS) becomes an important disease, because of its increased prevalence and mortality rates. Makers of systemic inflammation, including interleukin-6 and monocyte count, have been shown to predict future cardiovascular events. However, the association between these inflammatory markers with cardiac injury is still a controversy.Objective: To evaluate the relationship between IL-6 and monocyte count as inflammation markers and troponin I as cardiac injury.Methods: This was a cross-sectional study. Subjects were patients suspected of ACS admitted to the emergency department of Sardjito Hospital Yogyakarta. Diagnoses were performed based on WHO criteria. Troponin I and interleukin-6 levels were measured from sera using sandwich ELISA method (Roche). Monocyte counts were determined by automatic hematology analyzer (Sysmex). Kruskal-Wallis test and Spearman's correlation test were used to assess the difference and correlation between parameters.Results: Sixty one (61) subjects were included in the study. Age of the subjects were 51-60 years, and diagnosed as ST elevation myocardial infarct (STEMI). Significant differences of IL-6 and troponin I levels were determined among unstable angina pectoris (UAP), non-ST elevation myocardial infarct (NSTEMI), and ST elevation myocardial infarct (STEMI) subjects. There was a moderate correlation (r = 0.54; p = 0.001) between troponin I and Interleukin-6, but not with monocyte count.Conclusion: Interleukin-6, but not monocyte count, was correlated with troponin I in acute coronary syndromes.Key words: acute coronary syndrome - interleukin-6 - monocyte count - troponin I

Risk factors in childrenwith platelet refractoriness Jonliberti Purba; Sri Mulatsih; Neti Nurani; Teguh Triyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 01 (2013)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Platelet transfusions are often performed in pediatric patients. Nevertheless, platelet transfusion has its own risk and it alsoincrease the cost of care. Therefore,its effectiveness needs to be evaluated. This study aimed to assess the clinical risk factors namely sepsis, splenomegaly, DIC, severe bleeding and the history of platelet transfusion in the incidence of refractory platelets. This was a case-control study conducted during the period of August 2010 to September 2011.From a total of 1403 cases of transfusion, there were 86 incidences of refractory and 86 of nonrefractory. From the bivariate analysis, it was obtained that sepsis [OR 5.91 (2.90-12.05)], p = 0.000], splenomegaly [OR 2.82 (1.32-6.04.12), p = 0006] heavy bleeding [OR 8:41 (4.19-16.871), p = 0.000 ], DIC [OR 22.96 (6.73-78.35), p = 0.000] and the history of platelet transfusions [OR 5:33 (2.78-10.23), p = 0.000] increase the risk of refractory platelets. On multivariate analysis, sepsis (OR 2.96 [95% CI: 1:19 to 7:32], p = 0019), splenomegaly (OR 3.94 [95% CI: 2:21 to 16:00], p = 0.000), severe bleeding (OR 3:53 [95% CI : 1.40-8.89], p = 0.008), DIC (5:54 OR [95% CI: 1.29-22.75], p = 0021) and platelet transfusion the history (OR 2.84 [95% CI: 2.74-9.77], p = 0.001) were the independent risk factors for the occurrence of children refractory. In conclusion, sepsis, splenomegaly, severe bleeding, DIC, andthe history of platelet transfusion are the risk factors in pediatric patients refractory platelets. ABSTRAKTransfusitrombositseringdilakukanpadapasienanak.Transfusitrombositsendirimemilikirisikoterhadappasiendanmenambahbiayaperawatan, sehinggaperludievaluasiefektifitasnya.Menilaifaktorrisikoklinisyakni sepsis, splenomegali, DIC, pendarahanberatdanriwayattransfusitrombositterhadapkejadianrefraktertrombosit.Penelitianinimerupakanpenelitiankasuskontroluntukmenilaifaktorrisikoterjadinyarefraktertrombositseperti sepsis, DIC, splenomegali, pendarahanberat, riwayattransfusitrombosit.SelamaperiodeAgustus 2010 sampai September 2011 terdapat 1403 kasustransfusi, darikeseluruhankasustersebutdiambil 86 kejadianrefrakterdan 86 non refrakter. bivariatdidapatkan sepsis [OR 5.91 (2.90-12.05)], p = 0.000], splenomegali [OR 2.82 (1.32- 6.04.12), p = 0.006] pendarahanberat [OR 8.41(4.19-16.871), p = 0.000], DIC [OR 22.96 (6.73- 78.35), p = 0.000] riwayattransfusitrombosit [OR 5.33(2.78-10.23), p = 0.000] meningkatkanrisikorefraktertrombosit. Padaanalisismultivariat sepsis (OR 2.96 [95%IK; 1.19-7.32], p = 0.019), splenomegali (OR 3.94 [IK 95%;2.21-16.00], p = 0.000), pendarahanberat (OR 3.53 [95% IK; 1.40-8.89], p = 0.008), DIC (OR 5.54 [95% IK; 1.29-22.75], p =0.021) danriwayattransfusitrombosit(OR 2.84 [95% IK; 2.74-9.77], p =0.001) merupakanfaktorrisikoindependenterjadinyarefrakterpadaanak. Sepsis, splenomegali, pendarahanberat, DIC danriwayattransfusitrombositmerupakanfaktorrisikoterjadinyarefraktertrombositpadapasienanak.

Comparing P-Selectin (CD62P) expression in patients receiving non-leukodepleted vs leukodepleted thrombocyte concentrates Teguh Triyono; Budi Mulyono; . Sutaryo; Abdul Salam Sofro
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 3 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Thrombocyte concentrate (TC) transfusion is an important supportive therapy in patients with thrombocytopenia. The risks in platelet transfusions may be related to the content of TC including the contaminant leukocytes. The aim of this study was to assess the risk of increased level of P-Selectin (CD62P) expression of non-leukodepleted TC transfusions.This was a quasi-experimental study. Subjects were children patients aged 1-18 years who received a non-leukodepleted or a leukodepleted TC transfusions. Comparison of the proportion of increased expression of CD62P in both groups expressed as relative risk. The subjects consisted of 51 patients who received non-leukodepleted and 52 patients who received leukodepleted TC transfusions. The risk of increased expression of CD62P in patients receiving non-leukodepleted TC transfusions were 2.38 (95%CI:1.60-3.53) times higher than those who received leukodepleted TC. Non-leukodepleted have significant higher risks of increased CD62P expression than leukodepleted TC transfusions.

Factors influencing plateletpheresis donations in Yogyakarta, Indonesia Aditya Wicaksana; Teguh Triyono; Umi Intansari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Despite its life saving potential, regrettably, blood transfusion has yet to be optimally applied in Indonesia. Funding difficulties and both public and professional lack of knowledge hinders its progress. More lives can be saved by using a safer, more proper, and specialized blood transfusion procedure. Plateletpheresis, one method to obtain platelet products, requires a different donation procedure than that of whole blood-derived platelet. High quality plateletpheresis product donation will positively impact the transfusion efficacy and platelet recovery of the recipient, improving patient’s clinical state. This study analyzes factors from both the donor and donation procedure that influence the quality of plateletpheresis product. The study analyzes data of plateletpheresis donations from blood transfusion service and plateletpheresis transfusions from medical records at Dr. Sardjito General Hospital, Yogyakarta, Indonesia, within the period of August 2012 to January 2013 using cross sectional design. Forty-four plateletpheresis donations were obtained during the study. All donors were male with the following mean values; age 31.9 ± 9.9 years, weight 70.2 ± 10.2 kg, body mass index (BMI) 24.7 ± 3.2 kg/m2, hematocrit 44 ± 3.2 %, and procedure time 84.2 ± 19.2 min. The median value of platelet yield was 3.2x1011 (2.1x1011 – 4x1011). The median value of pre-donation platelet count was 248.5x103/μL (204x103/μL – 391x103/μL) and the mean value of product volume was 275 ± 22.9 mL. The results showed that pre-donation platelet count (r = 0.329; p < 0.05) and product volume (r = 0.661; p < 0.05) positively correlated to the yield of platetetpheresis products. However, the yield of plateletpheresis products was not correlated to the post-transfusion platelet count (r = 0.327; p > 0.05). In conclusion, pre-donation platelet count and product volume of plateletpheresis influence the yield of plateletpheresis. However, the yield is not correlated to the post-donation platelet count. Thus, other clinical factors should be considered

Convalescent plasma for COVID-19: A reasonable option for the pandemic based on both scientific and practical point of views Mardiah Suci Hardianti; Syahru Agung Setiawan; David Dwi Putera; Teguh Triyono; Jarir At Thobari; Johan Kurnianda
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 3 (2020): Special Issue: COVID-19
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Convalescent plasma treatment has become a promising adjunctive option to treat COVID-19. Several case reports consistently supported the feasibility of this approach by showing the safety and improvements of clinical and laboratory aspects from the treated patients. However, more clinical trials are still required to establish the definitive statement about its potential effectiveness. We review the scientific basis for the application of convalescent plasma in COVID-19 to understand its potentials better. We also cover the potential risks and benefits for this treatment in order to be more selective and careful when preparing and deciding to apply this approach. Lastly, we summarize any important points to monitor after the administration of this treatment to prioritize safety and measure the effectiveness of the treatment.

Turnaround time for the provision of packed red cells (PRC) and factors affecting their achievements in the Blood Transfusion Unit of Dr. Sardjito General Hospital, Yogyakarta Kaslam, Surawijaya Bakhtiar; Sukorini, Usi; Triyono, Teguh
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202304

Turnaround time (TAT) is defined as the time it takes since request/sample is received at the blood bank until blood is cross-matched/reserved and available for transfusion. Turnround time prolongation affects patient care and satisfaction. This study aimed to evaluate TAT for the provision of packed red cells (PRC) at the Blood Transfusion Unit of Dr. Sardjito General Hospital, Yogyakarta, analyze factors affected in TAT prolongation, and provide solution the prolongation. It was an analytical descriptive study with a qualitative design, by calculating the time since receipt of the PRC request at the Blood Transfusion Unit or since blood collection from donors until data input of the crossmatch results in Dr. Sardjito General Hospital management information system (SIMETRIS) completed. Moreover, the delay in the provision of PRC at the Blood Transfusion Unit was also analyzed. There were 3 (1.5%) of 200 ER samples that met TAT for the provision of the PRC, which was 30 min after receipt of the request at the Blood Transfusion Unit in cito conditions. There were 20 (10%) of 200 samples from the wards that met TAT for the provision of the PRC, which was 2 h after receipt of the request at the Blood Transfusion Unit if the blood stock was available. There were 55 (27.5%) of 200 samples from the wards that met TAT for the provision of the PRC, which was 4 h after the blood was collected from the donor. TAT for the provision of the PRC at the Blood Transfusion for the available blood stock group was 179.08 (67.2 – 396.27) min, replacement blood donor group was 485.38 (126.43 – 910.68) min, and cito group was 121.29 (27.68 – 421.38) min. In conclusion, there is TAT prolongation of PRC provision at the Blood Transfusion Unit of Dr. Sardjito General Hospital.

Co-Authors Abdul Salam Sofro Aditya Wicaksana Agni, Angela Nurini Akbar, Hammar Ilham Akhmad Fathoni, Akhmad Anak Agung Wiradewi Lestari Andri Christianalusi Bambang Margono Budi Mulyono Budi Mulyono Caesar Haryo Bimoseno Chamim, Moch. David Dwi Putera DIAN A.P PURWANTO Eko Surojo Endang Yuniastuti Fridawati, Veronica Fuad Anshori Hanifah, Shabrina Hans Vrielink Harsito, Catur Indra Tri Mahayana Jarir At Thobari Johan Kurnianda Jonliberti Purba Kaslam, Surawijaya Bakhtiar Mardiah Suci Hardianti Neti Nurani Ni Kadek Mulyantari Nurul Muhayat Pramudi, Ganjar PRITA MURANI NUGRAHETI PURWANTO, DIAN A.P Raehanul Bahraen Singgih Dwi Prasetyo Sri Mulatsih Sri Mulatsih Sri Mulatsih Suhardjo Suhardjo Sukmaji Indro Cahyono, Sukmaji Indro Surawijaya Bakhtiar Kaslam Sutaryo Sutaryo Syahru Agung Setiawan Tri Ratnaningsih Triyono Triyono Triyono Ubaidillah Ubaidillah Umi Solekhah Intansari Usi Sukorini Veronica Fridawati Wijang Wisnu Raharjo Zainal Arifin

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