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All Journal HAYATI Journal of Biosciences E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kesehatan Andalas Majalah Kesehatan FKUB Oryza : Jurnal Pendidikan Biologi Hang Tuah Medical Journal Jurnal Kefarmasian Indonesia
Ida Ayu Ika Wahyuniari
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Health Professions Medicine & Pharmacology Nursing Public Health Other

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Peran Probiotik dalam Regulasi Kolagen dan Melanin: Systematic Review Badri, Amelia A.; Dewi, Ni Nyoman Ayu; Wahyuniari, Ida Ayu Ika
Jurnal Kesehatan Andalas Vol. 13 No. 3 (2024): November 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v13i3.2524

Abstract

Collagen and melanin production are two biological processes that are significant in determining the health and appearance of the skin. Collagen affects the elasticity, hydration, and overall appearance of the skin. Melanin protects the skin from damage caused by ultraviolet rays, but excessive production can lead to hyperpigmentation. Hyperpigmentation, dry skin, and wrinkles are signs of premature aging and can be caused by oxidative stress due to exposure to UV rays (photoaging). Probiotics are living microorganisms that provide health benefits when consumed in sufficient amounts and are currently gaining more and more attention as potential agents for skin health. This article reviews the role of probiotics in inhibiting melanogenesis through inhibition of tyrosinase cell activity and microphthalmia-associated transcription factor (MITF) expression. Probiotics can slow down collagen degradation due to sunlight by inhibiting the Metalloproteinase Matrix (MMP) activity and improve the skin's barrier function, reduce inflammation, and support a healthy skin microbiota. Recent studies show that the use of probiotics, both oral and topical, offers a natural and multifunctional approach to skin care. In conclusion, probiotics have promising potential as an ingredient for skincare, but more research is needed to understand the underlying mechanisms and ensure their safety and effectiveness in clinical applications. Keywords: hyperpigmentation, melanogenesis, photoaging, probiotics
Analisis Bibliometrik : Mekanisme Aksi dan Efektifitas Flavonoid Terhadap Gagal Ginjal Mathar, Muhammad Ashhabul Kahfi; Linawati, Ni Made; Wahyuniari, Ida Ayu Ika; Widianti, I Gusti Ayu
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.19-28

Abstract

Flavonoids have strong antioxidant properties, which can reduce cell damage that can worsen kidney function. By reducing cellular oxidation, flavonoids help protect the kidneys from damage and inflammation that can lead to kidney failure. In addition, flavonoids also have anti-inflammatory properties to reduce chronic inflammation in the kidneys. Inflammation plays a key role in diseases such as kidney injury, diabetes, asthma, cardiovascular disease and cancer. Diet can affect various stages of inflammation and can have a significant impact on several inflammatory diseases. Increasing scientific evidence suggests that polyphenolic compounds, such as flavonoids, found in fruits, vegetables, nuts, or chocolate, can have anti-inflammatory properties. This reason clearly proves the importance of flavonoid antioxidant activity in inflammation therapy. The method used in this literature review is a bibliometric analysis by searching data through the PubMed database, and Google Scholar and Scopus. The search results of 10 appropriate journals, found that flavonoid compounds can inhibit regulatory enzymes or transcription factors that are important for controlling mediators involved in inflammation. 
The Effect of Stevia (Stevia rebaudiana Bertoni) Leaf Extract Cream on Transforming Growth Factor-β1 Levels and Collagen Amount in the Skin of Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B Febrina, Jessica; Muliarta, I Made; Wahyuniari, Ida Ayu Ika; Sumadi, I Wayan Juli; Linawati, Ni Made; Artini, I Gusti Ayu
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.435-444

Abstract

Ultraviolet B (UVB) exposure is a major cause of skin aging, leading to collagen degradation and wrinkles due to free radical damage. Stevia (Stevia rebaudiana Bertoni) has antioxidant properties that may counteract this by preserving Transforming Growth Factor-β1 (TGF-β1), essential for collagen synthesis. This study evaluated the effects of stevia leaf extract cream on TGF-β1 and collagen levels in male Wistar rats. Thirty rats were divided into five groups: K0 (no UVB, no cream), K1 (base cream), P1 (2.5% stevia cream), P2 (5% stevia cream), and P3 (10% stevia cream). Groups K1, P1, P2, and P3 were exposed to a cumulative UVB exposure of 840 mJ/cm2 over four weeks. However, TGF-β1 levels measured by ELISA did not differ significantly among groups (p>0.05). However, collagen levels, assessed using Picro Sirius Red staining, varied significantly (p<0.05). The K1 exhibited significantly lower collagen compared to K0 (p=0.003), whereas the P2 group effectively prevented collagen degradation compared to K1 (K1: 65.87% vs. P2: 77.92%; p = 0.005). While stevia leaf extract cream did not prevent TGF-β1 reduction, it demonstrated a clear protective effect against UVB-induced collagen loss. Among the tested concentrations, 5% stevia leaf extract cream was the most effective in preserving dermal Collagen, highlighting its potential as a topical agent for preventing photoaging and maintaining skin structural integrity.
Co-Authors ADNYANA PUTRA, I GEDE AGUS DIVA Adnyana, I Made Diatmika Agus Eka Darwinata Arijana, I G Kamasan Nyoman Arijana, I Gusti Nyoman Kamasan Arijana, I.G Kamasan Nyoman Badri, Amelia A. Febrina, Jessica I Gde Haryo Ganesha I Gusti Ayu Artini I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I MADE MULIARTA . I Wayan Juli Sumadi I Wayan Sugiritama Muhammad Ashhabul Kahfi Mathar Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Made Linawati Ni Nyoman Ayu Dewi Radjibu, Gabriela Anastasya Viorezky Rahcmanita, Dhila Cahya Ratnayanthi, I Gusti Ayu Dewi Ratnayanti, Gusti Ayu Dewi Sidauruk, Dona Uli Susilo, Yunike Tohjiwa, G. Raditya Widianti, I Gusti Ayu Wong, Ferdinand