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All Journal The Indonesian Biomedical Journal Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara JUKEJ: Jurnal Kesehatan Jompa Plexus Medical Journal
Asri Ragil Kemuning
Residency Program, Department Of Clinical Pathology, Faculty Of Medicine, Universitas Diponegoro, Jl. Prof. Sudarto, Semarang 50275
Humanities Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Transthyretin, Immature Platelet Fraction, and Mean Platelet Volume in Normotensive and Preeclampsia Pregnancy Asri Ragil Kemuning; Herniah Asti Wulanjani; I Edward Kurnia Setiawan Limijadi; Indranila Kustarini Samsuria; Banundari Rachmawati
The Indonesian Biomedical Journal Vol 14, No 2 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i2.1862

Abstract

BACKGROUND: Transthyretin protein experiences misfolding and aggregation in preeclampsia due to placental ischemia and inflammation. Placental endothelial damage occurring in preeclampsia stimulates the production of larger young platelets in the bone marrow and can be reflected by an increase in the immature platelet fraction (IPF) and mean platelet volume (MPV). Since the change in these markers in preeclampsia remains controversial, this study was conducted to analyze the differences in levels of transthyretin, IPF, and MPV as easily accessible markers in normotensive and preeclampsia pregnancies.METHODS: Total subjects included in this study were 32 normotensive and 26 preeclampsia pregnant woman. The measurement of serum transthyretin level was using enzyme-linked immunosorbent assay (ELISA) method. Meanwhile, IPF and MPV levels were measured by using a hematology analyzer with flowcytometry method. Data was statistically analyzed using unpaired T-test and Mann-Whitney, with significancy of p<0.05.RESULTS: Median value of transthyretin in normotensive and preeclampsia pregnancy were 11 (6-30) mg/dL and 9 (5-18) mg/dL. The mean value of IPF in normotensive and preeclampsia pregnancy were 4.56±2.19% and 6.33±2.99%. Mean value of MPV in normotensive and preeclampsia pregnancy were 10.41±0.76 fL and 11.32±1.2 fL. There were significant differences in levels of transthyretin, IPF, and MPV between normotensive and preeclampsia pregnancies (p=0.008, p=0.017, and p=0.002, respectively).CONCLUSION: There are significant differences in transthyretin levels, IPF, and MPV values in normotensive and preeclampsia pregnancies. Therefore, serum transthyretin, IPF, and MPV can be developed as affordable parameters for the diagnosis of preeclampsia.KEYWORDS: preeclampsia, transthyretin, IPF, MPV 
Efek Asam Klorogenat pada Ekspresi Mrna IL-6 dan CD86 Lobus Frontal Tikus Model Diabetes Mellitus Munawaroh, Fauziyatul; Hanif , Aisyah Amanda; Ragil Kemuning, Asri; Mutmainah, Iffa; Rachmawati, Yenny; Muharam Nurdin, Naufal
Plexus Medical Journal Vol. 3 No. 4 (2024): Agustus
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v3i4.1815

Abstract

Pendahuluan: Diabetes Mellitus (DM) merupakan penyakit kronik dengan berbagai komplikasi, salah satunya yaitu Encephalopati Diabetikum (ED). Hiperglikemia pada DM akan mengakibatkan neuroinflamasi melalui jalur M1 proinflamatorik. Beberapa agen proinflamatori akan meningkat dengan aktifnya jalur ini, seperti IL-6. Neuroglia kemudian teraktivasi dan mengekspresikan CD86 pada membran sel. Asam klorogenat (CGA) merupakan senyawa polyphenol pada kopi  yang  memiliki  efek antiinflamasi.  Tujuan penelitian ini adalah untuk memperjelas efek CGA pada aktivasi mikroglia jalur M1 dengan melihat ekspresi mRNA IL-6 dan CD86 pada lobus frontal tikus dengan model DM. Metode: 24 ekor tikus jantan secara acak dibagi menjadi enam kelompok yaitu :  kontrol,   DM 1,5 bulan dan DM 2 bulan,  dan kelompok dengan pemberian  CGA dengan  tiga  dosis  berbeda  (CGA1,  CGA2,  CGA3).  Jaringan lobus frontal diambil untuk analisa ekspresi mRNA IL-6 dan CD86 menggunakan RT-PCR. Hasil: Ekspresi mRNA IL-6 lobus frontal berbeda signifikan antara kelompok kontrol dengan DM1,5 (p=0.010); kontrol dengan DM2 (p=0.001); kelompok DM2 dengan CGA2 (p=0.028). Ekspresi mRNA CD86 lobus frontal trdapat perbedaan signifikan antara kelompok kontrol dengan semua kelompok DM, baik dengan CGA atau tanpa CGA (p<0.05). Kelompok DM2 berbeda signifikan dengan kelompok CGA2 (p=0.000) dan kelompok CGA3 (p=0,000). Kesimpulan: Ekspresi mRNA penanda jaras proinflamatorik M1 (IL-6 dan CD86) pada neuroinflamasi lobus frontal akibat DM lebih rendah setelah pemberian CGA dengan dosis 25 mg/KgBB.
PREVALENCE AND CLINICAL CHARACTERISTICS OF ALLERGIC RHINITIS AMONG ASTHMATIC PATIENTS IN THE EMERGENCY DEPARTMENT OF A BHAYANGKARA BRIMOB HOSPITAL IN INDONESIA: PREVALENSI DAN KARAKTERISTIK KLINIS RINITIS ALERGI PADA PASIEN ASMA DI INSTALASI GAWAT DARURAT RUMAH SAKIT BHAYANGKARA BRIMOB DI INDONESIA Winugroho, Mohammad Lukmanul Hakim; Kemuning, Asri Ragil; Rusmajati, Jetty; Desdiani
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 24 No. 2 (2025): Juli 2025
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v24i2.930

Abstract

Introduction: Asthma and allergic rhinitis frequently coexist. Objective: This study aims to characterize adult asthma patients who visited the emergency department (ED) and had allergic rhinitis between June 2023 and December 2024 at Bhayangkara Hospital, Depok City, West Java. Methods: This retrospective study analyzed 144 asthma patients who visited the ED during the specified period. The cohort included 89 females and 55 males. Diagnoses of bronchial Asthma and allergic rhinitis were confirmed through clinical history and physical examination by the attending physician, and all data is obtained from the patient's medical records. Results: Among the study population, 66.66% had coexisting asthma and allergic rhinitis. The majority were female and aged between 18 and 44 years. Chest X-rays revealed no significant abnormalities. Asthma prevalence was higher in females (61.8%) than males (38.19%), with a mean age of 32.53 years. A history of atopy, encompassing conditions like eczema, food allergies, and eye inflammation, was prevalent among 46.52% of patients. Smoking habits varied, with 74.3% being ex-smokers or non-smokers, while 25.69% were current smokers. Passive smoke exposure was noted in 37.5%, and 7.63% had exposure to biomass fuel. About 88.19% of emergency patients visits were classified as moderate asthma attacks, with 66.93% of these patients also having allergic rhinitis. Severe asthma attacks occurred in 11.8% of cases, with 58.82% of these patients also suffering from allergic rhinitis. Conclusions: The high prevalence of allergic rhinitis among asthma patients emphasizes the necessity of early diagnosis and good management to optimize patient outcomes.
Abses Paru Pada Pasien Tuberkulosis Dengan Diabetes Melitus Yang Tidak Terkontrol Efiyanti, Christy; Prawiro, Asysyukriati; Syahbunan, Khansa Kiasati Chandra; Rusmajati, Jetty; Rukmi, Kartika Widya; Kemuning, Asri Ragil; Desdiani, Desdiani
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 1 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss1.1471

Abstract

The coexistence of tuberculosis (TB) and diabetes mellitus (DM) increases the risk of severe lung complications such as pulmonary abscess. Aim: This study evaluates the outcomes of such cases, emphasizing the effectiveness of combined therapeutic approaches. Methods: This retrospective study reviewed 121 patients diagnosed with TB and DM treated at a hospital in Depok City between January 2023 and April 2024. The study included four patients with confirmed lung abscesses. Diagnosis was established using clinical and supporting examination analyses. We monitored the patients for up to nine months after initiating treatment. All patients received standard TB and DM therapy along with intravenous antibiotics for two weeks and continued with oral antibiotics for six weeks. Results: Radiological findings consistently showed lung cavities with fluid levels and thick walls. Clinical outcomes demonstrated substantial improvement in all cases, with resolution of abscesses and symptom alleviation. Patients with lung abscesses who received early, combination treatment with antibiotics and medication for TB and DM had positive results. Conclusion: In our study, the administration of antibiotics for eight weeks, alongside simultaneous treatment for TB and DM, led to significant clinical improvement. Further research is warranted to management of lung abscesses in patients with TB and DM and intravenous antibiotics as the first-line approach.
Co-Authors Aisyah Amanda Hanif Banundari Rachmawati Christy Efiyanti Desdiani Desdiani, Desdiani Edward Kurnia Setiawan Limijadi Herniah Asti Wulanjani Iffa Mutmainah Indranila Kustarini Samsuria Munawaroh, Fauziyatul Naufal Muharam Nurdin Prawiro, Asysyukriati Rachmawati, Yenny Rukmi, Kartika Widya Rusmajati, Jetty Syahbunan, Khansa Kiasati Chandra Winugroho, Mohammad Lukmanul Hakim