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All Journal Tropical Medicine Journal Majalah Kedokteran Bandung The Indonesian Biomedical Journal Jurnal Respirologi Indonesia Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Green Medical Journal Jurnal Keperawatan Klinis dan Komunitas (Clinical and Community Nursing Journal) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Widya Wasityastuti
Department Of Physiology, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effects of Yacon Leaf Extract on MCP-1 and IL-10 Expressions and Macrophage Phenotypes in CKD Mouse Model Sofyana, Meida; Wasityastuti, Widya; Ihsana, Nuni; Purwono, Setyo; Arfian, Nur
Majalah Kedokteran Bandung Vol 56, No 2 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3605

Abstract

Macrophages are essential in tissue homeostasis and immunity, but also contribute to disease development and progression. Chronic kidney disease (CKD) is characterized by interstitial infiltration of macrophages, the density of which correlates inversely with kidney survival. Studies have shown that yacon (Smallanthus sonchifolius) has beneficial effects on CKD. Therefore, this study aimed to investigate the effects of yacon leaf extract on mice with subtotal nephrectomy by evaluating the M1 and M2 macrophage counts and mRNA expressions of monocyte chemoattractant protein-1 (MCP-1 and IL-10. The mice were randomly divided into five groups: SO (negative control: underwent sham operation), SN (positive control: underwent subtotal nephrectomy), and yacon-treated groups: YK1, YK2, and YK3 (underwent subtotal nephrectomy, given peroral yacon leaf extract for 14 days with doses of 24,5 mg/kgBW/day, 49 mg/kgBW/day, and 98 mg/kgBW/day, respectively). The macrophage subtypes were assessed using immunohistochemistry anti-CD68 for M1 and anti-Arginase I for M2. MCP-1 and IL-10 mRNA expressions were analyzed using semi-quantitative PCR. Results showed that yacon leaf extract could significantly lower the M2 macrophage count (p<0.001) and the mRNA expressions of MCP-1 and IL-10 in all yacon-treated groups when compared to the SN group. However, the M1 macrophage count was only lower in the YK2 group (p=0.009). In conclusion, the administration of yacon leaf extract could attenuate kidney injury by lowering the macrophage count and the expression of MCP-1 and IL-10.
Stage 3 HIV Patient with Severe Dysfunctional APGAR Score: A Palliative Approach Prastiwi, Silvia Hari; Wasityastuti, Widya
Review of Primary Care Practice and Education Vol 8, No 1 (2025): January
Publisher : Faculty of Medicine, Public Health, and Nursing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/rpcpe.91275

Abstract

Mr. D, a 45 years old patient was visited at home for his HIV stage 3.  The patient admitted that he had shortness of breath that was not affected by activity and there was no swelling in both legs. He also has a cough that produces sticky phlegm. He experiences diarrhea, even though it doesn’t happen every day. He was diagnosed with HIV since 2012 and admitted that did not comply with taking ARTs. He underwent the test two years after his wife was diagnosed with HIV; during this time, he also had persistent shortness of breath and lost weight due to a co-infection with tuberculosis. He acknowledged not taking ARTs on a regular basis for about ten years after receiving his diagnosis because he believed he had accepted his predicament. Since four years ago, his wife has been gone, leaving him with their children.He has two sons: the oldest, a 20-year-old who provides the family's foundation, and the younger, a 17-year-old who is still in school. The patient and their kids currently don't get along well because there isn't much communication between them and because the kids spend much of their time alone at home and don't say hello to each other. Because of the low economic status and the family's lack of concern for the patient's diet, the patient consumes the same foods every day, such as instant noodles or fried eggs.The patient's shortness of breath prevents him from working and interferes with his daily routines. He stated that because he was alone at home and was experiencing discomfort with his shortness of breath, he could only rest and lie down there. The patient was urged to be referred to Sardjito Hospital by the doctor at the Community Health Center (Puskesmas), but he was rejected on the grounds that he could not have a companion with him. 
Co-Authors Achmad Djunaidi Achmad Djunaidi Andika Dhamarjati Demianus Tafor Demianus Tafor Dwi Aris Agung Nugrahaningsih Eko Purnomo Eti Nurwening Sholikhah Etika Ratnasari Gandes Endah Pakarti I Gusti Bagus Budi Dharma Ihsana, Nuni Kurnia Putri Utami Marsetyawan HNE Soesatyo Marsetyawan HNE Soesatyo Mujur Mujur Naibey, Rosdiana Nisrina Nafi’atul Huda Nungki Anggorowati Nur Arfian Nur Arfian, Nur Prastiwi, Silvia Hari Ronny Martien Setyo Purwono Siswanto Siswanto Sofyana, Meida Sri Hartini Tety Hartatik Yanri W Subronto Yayi Suryo Prabandari