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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Universa Medicina Jurnal Kedokteran Hewan
M. Aris Widodo
Bagian Farmakologi, Fakultas Kedokteran Universitas Brawijaya Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Journal : Jurnal Kedokteran Brawijaya

 1 
ENZIM LIPOPROTEIN LIPASE SUATU ALTERNATIF PEMERIKSAAN GANGGUAN METABOLISME LEMAK PADA PENDERITA DM TIPE 2 IN VITRO Handayani, Dian; Am, Aulani’; Soeadmadji, Djoko W.; Widodo, M. Aris
Jurnal Kedokteran Brawijaya Vol 19, No 2 (2003)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.256 KB) | DOI: 10.21776/ub.jkb.2003.019.02.3

Abstract

ABSTRACT The biggest population of Diabetes Mellitus is type 2 diabetes. Dyslipidemia is frequently found in type 2 diabetic patients, which is characterized by increased TG plasma levels and decreased HDL. Increased TG levels may be due to LPL activity disturbance, which then  lead to impaired lipoprotein metabolism, such as decreased hydrolyzing TGs in VLDL and Chylomicron. LPL is an enzyme which activities are influenced by several factors such as temperature, pH, incubation period, and substrate concentration. LPL attached to vascular endothelium, and can be removed from it by giving heparin intravenous. Heparin acts as lipotropic agent which promote plasma lipid transfer to lipid deposit by secreting lipolitic enzyme such as LPL. After giving information  about the objective of this study on the possible site effect of the blood obtaining technique, the patient was asked  to give her voluntary consent. Heparin IV 60 IU/Kg BB was given 15 minute before blood sample was drawn. Obtain from aid type 2 diabetes individual and aid from non diabetic control subject. To determine optimal LPL action pH variations (6, 6.4, 6.8 and 7), temperature  (30, 32, 35 and 37)oC,
Co-Authors a, Aulanni'am A, Aulanniam Agus Yuwono Alinda, Resha Amiruddin Amiruddin Arman Sayuti Aulani’ Am Bambang Setiawan Basuki B. Purnomo Dewi, Titik Cinthia Dian Handayani Djoko W. Soeadmadji Dorothy, Maria Juliana Dwinna Aliza Erdiansyah Rahmi HMS Chandra Kusuma Izaak Zoelkarnain Akbar, Izaak Zoelkarnain Muhamad Agus Wibowo Muhammad Hambal Mulyadi Adam, Mulyadi Muslim Akmal Nurdiana Nurdiana Permaasari, Nur Prihardina, Bunga Pudji Rahaju, Pudji Sofiana, Kristianingrum Dian Sutiman B. Sumitro Syafruddin s T. Armansyah Tongku Nizwan Siregar Untario, Natanael Wulan, Provisia Marthalita Yuning Yundari, Yundari