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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Pharmaciana: Jurnal Kefarmasian JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Insan Farmasi Indonesia Jurnal Kesehatan Tambusai Archives Pharmacia Pharmaceutical Sciences and Research (PSR) Sciences of Pharmacy Jurnal Farmasi Indonesia Jurnal Kefarmasian Indonesia Jurnal Ilmiah Nusantara
Naniek Widyaningrum
Prog. Studi Farmasi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Fakultas Farmasi Universitas Wahid Hasyim (UNWAHAS) Semarang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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RATIONAL USE OF MEDICINES BASED ON SHARIA PRINCIPLES IN SELF-MEDICATION AT SIROTO PHARMACY BANYUMANIK SEMARANG Rahma, Dinda; Rosyid, Abdur; Widyaningrum, Naniek
SAINS INDONESIANA Vol. 3 No. 2 (2025): Vol. 3 No. 2 (2025): Vol. 3, No. 2 Edisi April 2025
Publisher : Gamma Publishing

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Abstract

In Islamic teachings, Muslims are encouraged to make efforts (ikhtiar) in facing various challenges, including when experiencing illness. Self-medication is one form of ikhtiar that is carried out independently to treat mild symptoms using over-the-counter or limited over-the-counter medicines. Rational drug use is key to ensuring the safety and effectiveness of treatment. The World Health Organization (WHO) defines rational drug use as the provision of medicines according to the patient's clinical needs, in the right dose and duration, and at an affordable cost. for Muslims, in addition to rationality, the halal aspect is also an important consideration in the use of medicines. The halal-thayyib principle, as explained in the Qur'an Surah Al-Baqarah verse 168, emphasizes the importance of choosing medicines that are not only safe and effective but also halal. however, the public's level of knowledge about the halal status of medicines is still relatively low. education about halal medicines is highly necessary, especially among Muslims, to increase awareness and understanding. this study aims to determine the level of public knowledge regarding the rational use of medicines based on sharia principles in self-medication practices. the method used is descriptive with a questionnaire instrument distributed directly to respondents. the results show that the majority of respondents understand the concept of rational drug use and prefer to obtain medicines from pharmacies and doctors. in terms of sharia, the understanding of the halal and haram concept in medicines is relatively high, but awareness of ingredients such as gelatin and alcohol remains low. therefore, more intensive education on the halal aspects of medicine use is needed so that Muslims can be more selective in accordance with Islamic law.     Ask ChatGPT  
Pengetahuan Apoteker terkait Covid-19 selama Pandemi Fatiha, Chilmia Nurul; Rahmadani, Azmi; Widyaningrum, Naniek
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.228

Abstract

Pharmacists’ role during Covid-19 pandemic is important in order to prevent and reduce the transmission rate. Pharmacist need to have good level of knowledge to ensure the role. This study aims to determine the level of pharmacists’ knowledge regarding Covid-19 and related factors. This is an observational study with cross-sectional approach. A questionnaire regarding Covid-19 was distributed to webinar participants in December 2021. The questionnaire is consisted of demographic questions and 15 Covid-19 knowledge questions. A total of 333 pharmacists responded, consisting of 32.4% community pharmacists, 33.9% hospital pharmacists, 24.0% clinical pharmacists, and 9.6% public health center pharmacists. Pharmacists have good knowledge of the causative virus (92%), symptoms (95.3%), supporting examinations (90.2%), therapy (95.8%), and prevention of Covid-19 transmission (94.4%) . Pharmacists' knowledge that needs to be improved is regarding vaccine storage (69.4%) and antibiotic use (56.1%). Semarang City pharmacists have good knowledge about Covid-19. Pharmacist knowledge was related to workplace (p<0.001) and length of work (p<0.001).
Optimization of Formula, Stability Testing, and Antioxidant Activity of Clay Masks as Skin Moisturizers Widyaningrum, Naniek; Anggoro Bhakti, Agung Dwi; Evan Maulana, Alghafiqy Harya; Safitri, Amalia; Ramadhani, Adinda Fajrah; Febriani, Anisa; Hanafi, Anggit Naufal; Arief, Thendi Abdul
Pharmaceutical Sciences and Research Vol. 12, No. 1
Publisher : UI Scholars Hub

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Abstract

Clay masks are cosmetic formulations designed to adhere closely to the skin, effectively lifting contaminants, cleansing the face, and absorbing impurities. We made a clay mask containing active ingredients such as niacinamide, alpha arbutin, ceramide, and hyaluronic acid. A careful selection of ingredients is essential for ensuring safety and mitigating potential dermatological issues. This study aimed to evaluate the physical characteristics, stability, primary irritation potential, and moisturizing efficacy of this clay mask formulation. Kaolin and bentonite are the primary base materials. The research included formulation optimization and physical stability testing using a cycling test, where each cycle was conducted over a 24-hour period for a total of six cycles. Evaluations were performed on organoleptic properties, homogeneity, pH, spreadability, viscosity, and drying time. Subsequently, data were analyzed using paired sample T-tests. Antioxidant activity was assessed using the ABTS method to determine IC50 values. Both preclinical and clinical irritation tests were performed, and the clinical efficacy of the moisturizer was evaluated in 30 participants. The optimal formula consisted of 0.8% kaolin and 0.2% bentonite, and all the evaluation parameters met the required standards. Stability testing and percentage inhibition measurements revealed no significant differences during storage (p>0.05). The formulation demonstrated strong antioxidant activity (IC50<50) and showed no irritation in preclinical or clinical irritation tests. The efficacy results indicated that the developed clay mask formulation has significant potential as a safe and effective skin moisturizer.
Penguatan ASI Eksklusif Melalui Metode Pendampingan Oksitosin, Breast Care Dan Nutrasetika Daun Katuk Widyaningrum, Naniek; Wahyu Timur, Willi; Abdul Arief, Thendi; Oktasari, Masita
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 5 No. 1 (2024): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN)
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v5i1.2011

Abstract

Promosi kesehatan melalui pendampingan merupakan upaya untuk meningkatkan kemampuan masyarakat agar mereka dapat menolong dirinya sendiri, serta mengembangkan sumber daya masyarakat yang berwawasan kesehatan, khususnya pada ibu melahirkan yang akan memberikan ASI kepada bayinya dimana masih banyak ibu-ibu yang belum mengetahui cara meningkatkan ASI eksklusif. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan masyarakat terkait pemberian ASI ekslusif dan kualitasnya melalui pendampingan materi berupa cara terapi pijat oksitosin, breast care dan manfaat nutrasetika daun katuk. Pengabdian ini dilakukan di Apotek Siroto karena termasuk wilayah padat penduduk sehingga banyak pasien berkunjung serta adanya kerja sama dengan dokter kandungan. Metode yang digunakan dalam kegiatan ini berupa pendampingan secara langsung menggunakan leaflet dan melakukan praktik pijat oksitosin secara langsung yang dipaparkan oleh Apoteker. Melalui kegiatan pendampingan ini ibu-ibu akan diberikan pengetahuan dan keterampilan dalam penggunaan dan menghasilkan ASI eksklusif yang baik. Kegiatan ini dihadiri oleh 10 orang yang telah melakukan pemeriksaan langsung oleh dokter kandungan di Apotek Siroto. Hasil dari kegiatan ini berupa ibu-ibu mempunyai peningkatan pemahaman terkait ASI ekslusif, melakukan terapi pijat oksitosin sebagai peningkat ASI serta manfaat kandungan daun katuk terhadap kualitas ASI ekslusif.
UJI ACCEPTANCE LULUR BERAS PUTIH DAN PENDAMPINGAN PENGUSAHA PETANI DI DESA KALIWUNGU KENDAL Widyaningrum, Naniek; Abdul Arief, Thendi
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.26054

Abstract

Desa Kaliwungu Kendal merupakan daerah dengan hasil padi unggul. Beras memiliki berbagai manfaat dalam kehidupan, selain sebagai bahan makanan, beras juga dapat dimanfaatkan sebagai produk kosmetik. Beras putih mampu menjaga kulit agar tetap terhidrasi, kulit tampak putih dan bersih, mampu mencegah radikal bebas, menahan sinar ultraviolet serta memperbaharui sel kulit yang rusak.  Salah satu produk kosmetik yang dapat dibuat dari beras adalah lulur kosmetik. Penelitian ini bertujuan untuk melakukan pelatihan dan pendampingan pembuatan lulur beras putih kepaada ibu-ibu petani Desa Kaliwungu Kendal. Penelitian acceptance merupakan non-probability sampling dengan pendekatan purposive sampling, pengumpulan data berupa kuesioner kepuasan responden terhadap sifat fisik lulur beras. Sedangkan metode penelitian pendampingan ibu-ibu petani dalam produksi lulur beras menggunakan metode pre post only group design. Formula lulur beras putih diuji penerimaannya pada 30 responden. Hasil uji acceptance didapatkan secara keseluruhan hasil acceptance 86% sehingga dapat diterima oleh masyarakat pada produk lulur beras putih terkait warna lulur yang menarik, aroma harum, mudah diambil, mudah dioleskan, mudah dibilas, mudah melekat, tekstur baik, tidak mengiritasi kulit, membersihkan kulit dalam sekali pemakaian dan memberikan kepuasan yang tinggi. Berdasarkan hasil pendampingan yang telah dilaksanakan terdapat peningkatan pengetahuan petani di Desa Kaliwungu Kendal terkait potensi dari beras selain sebagai makanan pokok dapat dimanfaatkan menjadi produk kecantikan berupa lulur yang memiliki daya saing tinggi dalam upaya meningkatkan perekonomian masyarakat Desa Kaliwungu Kendal.
Optimization, Characterization, and Primary Irritation Test of Serum Based on Simplex Lattice Design Widyaningrum, Naniek; Arief, Thendi Abdul; Ningrum, Yuyun Darma Ayu
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Using ingredients in cosmetic serum formulation necessitates meticulous consideration to mitigate potential pharmaceutical and clinical issues, and guarantee their safety for application. Xanthan gum functions as a gelling agent, while sodium metabisulfite is an additional antioxidant capable of enhancing formulation viscosity. This research aimed to ascertain the optimal formula's physical characteristics, stability, and irritation potential. The optimal formula was derived through the utilization of the Simple Lattice Design. Physical characterization encompassed parameters such as pH, viscosity, organoleptic properties, adhesion, spreadability, and homogeneity. Stability testing involved a cycling test performed over 24 hours for six cycles under cold and hot temperatures. Subsequently, an analysis was conducted using the paired t-test. In-vitro primary irritation testing was carried out using rabbits and volunteers. The optimal formula was identified to consist of 0.66% xanthan gum and 0.34% sodium metabisulfite, exhibiting favorable physical quality and meeting the requisite standards. The stability testing results revealed that sig. values <0.05 indicated storage temperature's influence on viscosity enhancement while it did not influence pH with sig. values <0.08. The outcomes of the primary irritation test yielded values of 0, signifying the absence of erythema and edema in both rabbits and volunteers. In conclusion, the optimal formula derived from this study exhibits commendable characteristics, stability, and non-irritating attributes, rendering it safe for application.
Effectiveness Test of Epigallocatechin Gallate Cream Formula in Acne Vulgaris Therapy Widyaningrum, Naniek; Dhea, Alda Rasni; Rofi, Alina Nur; Arief, Thendi Abdul; Timur, Willi Wahyu
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502542

Abstract

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles that affects more than 80% of adolescents and young adults. Conventional therapies such as antibiotics and topical retinoids have limitations in the form of resistance and irritation. Epigallocatechin gallate (EGCG) from green tea leaves (Camellia sinensis L.) has antibacterial, anti-inflammatory, and antioxidant activities that make it a safe natural anti-acne candidate. The aim of this study was to assess the clinical efficacy and safety of topical EGCG cream on the improvement of inflammatory and non-inflammatory acne lesions. A pre-post clinical trial was conducted on ten participants aged 17–50 years with active acne. Respondents applied 6% EGCG cream twice daily for six months. The number of lesions (papules, pustules, and blackheads) was evaluated monthly and analyzed using a paired t-test (p<0.05). There was a significant decrease in the number of papules (9.4 ± 5.97 to 3.0 ± 3.13), pustules (1.7 ± 1.57 to 0), and comedones (21.5 ± 10.76 to 4.2 ± 3.05) in five months (p<0.05), with the onset of improvement since the first month without side effects. Topical EGCG cream is effective and safe in reducing acne lesions quickly and sustainably. With its multi-target mechanism, EGCG has the potential to be developed as a phytocosmetic active ingredient for acne vulgaris therapy.
Formulasi dan Uji Antibakteri Formula Optimum Gel Kitosan Kulit Udang Vannamei (Litopenaeus vannaemei) sebagai Antiakne Widyaningrum, Naniek; Septiana, Fita Nadia; Wijayanti, Rina; Arief, Thendi Abdul
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.78870

Abstract

Acne vulgaris atau jerawat merupakan infeksi pori-pori kulit yang tersumbat dengan lemak yang berlebih. Faktor lainnya disebabkan oleh aktivitas mikroorganisme Propionibacterium acnes. Kitosan kulit udang vannamei diketahui berfungsi sebagai antibakteri. Kitosan kulit udang vannamei dapat diformulasikan dalam bentuk sediaan gel untuk mendapatkan kenyamaan dan kemudahan dalam penggunaan. Tujuan penelitian ini untuk mengetahui formula optimum sediaan gel kitosan kulit udang vannamei sebagai antiakne. Optimasi formula menggunakan Simplex Latice Design dengan variasi konsentrasi gelling agent berupa karbopol dan HPMC. Uji evaluasi fisik sediaan gel dan uji antibateri terhadap Propionibacterium acnes dilakukan. Hasil penelitian formula optimal karbopol dan HPMC diperoleh perbandingan 0.5 : 0.5 dengan persentase (1,25%)  dan HPMC (0,725%). Uji evaluasi fisik sediaan gel menunjukkan bahwa sediaan gel memiliki sifat fisik yang baik dengan viskositas 4.616 cps, pH 7.25, dan daya sebar 6.43. Hasil uji antibakteri Propionibacterium acnes didapatkan hasil daya hambat dari sampel gel kitosan (20.73 mm ± 1.33) kuat dan kontrol positif (28.56 mm ± 0.91) sangat kuat. Formula optimum dengan perbandingan karbopol dan HPMC (0.5:0.5) gel kitosan kulit udang vannamei memiliki aktivitas antibakteri terhadap Propionibacterium acne dan memenuhi persyaratan uji sifat fisik.  
Co-Authors Abdul Arief, Thendi Abdur Rosyid Adi, Reza Saeful Amalia Safitri Andriani, Ainul Anggoro Bhakti, Agung Dwi Aprilia, Laela Aprilianti, Yunita Arief, Thendi Abdul Atina Hussaana Chilmia Nurul Fatiha Dewi Yuliana Dhea, Alda Rasni Djoko Wahyono Evan Maulana, Alghafiqy Harya FEBRIANI, ANISA Hanafi, Anggit Naufal Hussana, Atina Maula, Ajni Minhatul Mimiek Murrukmihadi Ningrum, Yuyun Darma Ayu Oktasari, Masita Permata, Amaliyah Puspitasari, Nesya Ayu Putri, Chintiana Nindya Rahma, Dinda Rahmadani, Azmi Ramadhani, Adinda Fajrah Rina Wijayanti Rofi, Alina Nur Sampurno Sampurno Saputri, Novitasari Adi Sekar Tanjung, Ayu Septiana, Fita Nadia Sholeh, Aries Badrus Sofa, Nada Aini Syarifatun Karunia Ekawati Tianingsih, Anis Tiastuti, Memi Utami, Karina Misti Virdaus, Monica Wahyu Timur, Willi Willi Wahyu Timur Yuyun Darma Ayu Ningrum