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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Pharmaciana: Jurnal Kefarmasian Pharmascience Jurnal Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Insan Farmasi Indonesia Jurnal Kesehatan Tambusai Archives Pharmacia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia Jurnal Kefarmasian Indonesia Jurnal Ilmiah Nusantara
Naniek Widyaningrum
Prog. Studi Farmasi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Fakultas Farmasi Universitas Wahid Hasyim (UNWAHAS) Semarang
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Journal : Jurnal Kefarmasian Indonesia

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Optimization, Characterization, and Primary Irritation Test of Serum Based on Simplex Lattice Design Widyaningrum, Naniek; Arief, Thendi Abdul; Ningrum, Yuyun Darma Ayu
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 2, AUGUST 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Using ingredients in cosmetic serum formulation necessitates meticulous consideration to mitigate potential pharmaceutical and clinical issues, and guarantee their safety for application. Xanthan gum functions as a gelling agent, while sodium metabisulfite is an additional antioxidant capable of enhancing formulation viscosity. This research aimed to ascertain the optimal formula's physical characteristics, stability, and irritation potential. The optimal formula was derived through the utilization of the Simple Lattice Design. Physical characterization encompassed parameters such as pH, viscosity, organoleptic properties, adhesion, spreadability, and homogeneity. Stability testing involved a cycling test performed over 24 hours for six cycles under cold and hot temperatures. Subsequently, an analysis was conducted using the paired t-test. In-vitro primary irritation testing was carried out using rabbits and volunteers. The optimal formula was identified to consist of 0.66% xanthan gum and 0.34% sodium metabisulfite, exhibiting favorable physical quality and meeting the requisite standards. The stability testing results revealed that sig. values <0.05 indicated storage temperature's influence on viscosity enhancement while it did not influence pH with sig. values <0.08. The outcomes of the primary irritation test yielded values of 0, signifying the absence of erythema and edema in both rabbits and volunteers. In conclusion, the optimal formula derived from this study exhibits commendable characteristics, stability, and non-irritating attributes, rendering it safe for application.
Co-Authors Abdul Arief, Thendi Abdur Rosyid Adi, Reza Saeful Amalia Safitri Andriani, Ainul Anggoro Bhakti, Agung Dwi Aprilia, Laela Aprilianti, Yunita Arief, Thendi Abdul Atina Hussaana Chilmia Nurul Fatiha Dewi Yuliana Djoko Wahyono Evan Maulana, Alghafiqy Harya FEBRIANI, ANISA Hanafi, Anggit Naufal Hussana, Atina Maula, Ajni Minhatul Mimiek Murrukmihadi Ningrum, Yuyun Darma Ayu Oktasari, Masita Permata, Amaliyah Puspitasari, Nesya Ayu Putri, Chintiana Nindya Rahma, Dinda Rahmadani, Azmi Ramadhani, Adinda Fajrah Sampurno Sampurno Saputri, Novitasari Adi Sekar Tanjung, Ayu Sholeh, Aries Badrus Sofa, Nada Aini Syarifatun Karunia Ekawati Tianingsih, Anis Tiastuti, Memi Utami, Karina Misti Virdaus, Monica Wahyu Timur, Willi Willi Wahyu Timur Yuyun Darma Ayu Ningrum