Article Per Year (5 Year)
p-Index From 2021 - 2026
3.43
P-Index
This Author published in this journals
All Journal CHEMISTRY PROGRESS Majalah Farmaseutik JOPS (Journal Of Pharmacy and Science) PREPOTIF : Jurnal Kesehatan Masyarakat Community Development Journal: Jurnal Pengabdian Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Pengabdian Masyarakat Nusantara Jurnal Sains dan Kesehatan FAJR: Jurnal Riset Kefarmasian Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan International Journal Of Public Health International Journal of Health Science
Ahlan Sangkal
Universitas Muhammadiyah Manado
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 22 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 22 Documents
Search

 1   2   3 
Identification of Bioactive Compounds from Cocoa Fruit Skin ( Theobroma Cacao L.) with Variations in Solvent Polarity Properties Ahlan Sangkal; Julia Megawati Djamal; Rifani Hutami Supardi
International Journal Of Health Science Vol. 5 No. 2 (2025): International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v5i2.5676

Abstract

Bioactive compounds are chemical compounds formed through metabolic processes in plants, contributing to their beneficial properties. Cocoa fruit, derived from 22 cultivated Theobroma species, contains a variety of bioactive compounds that offer several health benefits. Identifying these bioactive compounds in plants can be achieved through extraction using various solvents, depending on their polarity properties. This study aims to explore the content of bioactive compounds in dried cocoa fruit peel (Theobroma cacao L.) extract, focusing on variations in solvent polarity. The results of the study showed that the 96% ethanol extract (polar solvent) of cocoa fruit peel contained a range of bioactive compounds, including flavonoids, tannins, alkaloids, and saponins. Ethanol, being a polar solvent, effectively extracted a variety of bioactive compounds due to its ability to dissolve polar substances. This extract is significant due to its wide range of potential health benefits attributed to the presence of flavonoids, tannins, alkaloids, and saponins, all known for their antioxidant, antimicrobial, and anti-inflammatory properties. Additionally, the acetone extract (semi-polar solvent) of cocoa fruit peel also contained alkaloids, flavonoids, tannins, and saponins. Acetone, as a semi-polar solvent, was able to extract a variety of compounds with moderate polarity, making it a versatile solvent for bioactive compound extraction. The presence of alkaloids and saponins in this extract indicates its potential use for various medicinal purposes. On the other hand, the n-Hexane extract (non-polar solvent) of cocoa fruit peel produced primarily alkaloids and terpenoids. Hexane, being non-polar, tends to extract non-polar compounds, which include alkaloids and terpenoids known for their various biological activities. In conclusion, the study demonstrates the varying effectiveness of solvents with different polarities in extracting bioactive compounds from cocoa fruit peel, which can be utilized for health-promoting purposes.
Antihyperglycemic Effectiveness of Ethanolic Extract of Takokak Fruit (Solanum Torvum Swartz) on Male White Rats (Rattus Norvegicus) Induced by Glucose Rahmat Ismail; Ahlan Sangkal
International Journal Of Health Science Vol. 5 No. 2 (2025): International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v5i2.5679

Abstract

Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels resulting from impaired insulin secretion, insulin resistance, or a combination of both. This condition requires long-term treatment and has the potential to lead to serious complications if not properly managed. The search for alternative herbal-based treatments has become a major focus of various pharmacological studies. One such plant with potential is the takokak fruit (Solanum torvum Swartz), which has traditionally been used to treat various health conditions such as hypertension, microbial infections, and reproductive system disorders, as well as possessing antipyretic and antidiabetic properties. This study aimed to evaluate the antihyperglycemic efficacy of the takokak fruit ethanol extract in glucose-induced male white rats (Rattus norvegicus). The extract was obtained through a maceration method using 96% ethanol as a solvent. Five test groups were prepared, each consisting of three rats: a negative control group (Na-CMC), a positive control group (metformin), and three treatment groups with takokak extract concentrations of 5%, 10%, and 20%. Glucose induction was administered orally, and after 30 minutes, the extract was administered to the treatment group, and blood glucose levels were measured for two hours. The results showed that the takokak fruit extract was able to reduce blood sugar levels by 27% in the 5% group, 25% in the 10% group, and 33% in the 20% group, respectively. However, the ANOVA statistical test yielded a significance value of 0.48, indicating that the difference in blood glucose reduction between the groups was not statistically significant. Although not yet significant, these results indicate that the ethanol extract of takokak fruit has potential as an antihyperglycemic agent, which requires further research on a larger scale and duration to obtain more conclusive results.
Co-Authors Abas, Siti Nurul Hikma Hi. Abulkhair Abdullah Adelin Liputo Agust Arthur Laya Ayu S. Jamal Biya, Larassti Daada, Selvina Febrianika Ayu Kusumaningtyas Hamidah Sri Supriati Julia Megawati Djamal Khofifah, Faradilla Nur Lahiya, Firlyawati Lumempow, Dea Putri Imaya Madihutu, Faraumaina Molamahu, Magfira Mutmainnah, Mutmainnah Nini M. Hanafi Nurfatima S. Marasabessy Rahmat Ismail Rahmat Ismail Rahmat Ismail Rahmat Ismail Rahmat Ismail Randi R. Toboleu Rifani Hutami Supardi Rifani Hutami Supardi Rifani Hutami Supardi Rosadalima Mere Tuku Sandra Lewa Supardi, Rifani Hutami Utiarahman, Nur Ain