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All Journal Biogenesis: Jurnal Ilmiah Biologi Prosiding Semnastek Indonesian Journal of Chemical Science Alotrop Jurnal Pendidikan dan Ilmu Kimia Jurnal Dharma Bhakti Ekuitas Bandung Conference Series: Pharmacy Jurnal Kesehatan Mahardika Indonesian Journal of Chemical Science
Rizkita, Aden Dhana
STIKes Bogor Husada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Isolasi dan Uji Antibakteri Minyak Daun Sirih Hijau dan Merah Terhadap Streptococcus mutans. Rizkita, Aden Dhana; Cahyono, Edy; Mursiti, Sri
Indonesian Journal of Chemical Science Vol 6 No 3 (2017)
Publisher : Indonesian Journal of Chemical Science

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Abstract

The purpose of this research is to identify the chemical content and compare the antibacterial effect of Piper betle L and Piper crocatum R oil against Streptococcus mutan. Betel oil is made at 100%, 75%, 50%, 25% concentration and amoxicillin 0.2% as positive control and propylene glycol as negative control. The research method started with oil isolation using distillation of steam and water then identified the content using GC-MS. Antibacterial activity was tested against Streptococcus mutans by disc diffusion method. The results of this research indicate that Piper betle L and Piper crocatum R oil contains terpenoid group compounds. After being characterized using GC-MS, betel oil contains 5 major active compounds that have antibacterial activity that is Sabinene, Myrsene, Camphene, Germacrene and β - Chariophillene. Piper betle oil has better antibacterial properties than Piper crocatum oil with clear zone reaches 10.5 mm while Piper crocatum oil is 7.1 mm.
EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN SEREH WANGI, SIRIH HIJAU, DAN JAHE MERAH TERHADAP PERTUMBUHAN STREPTOCOCCUS MUTANS Aden Dhana Rizkita
Prosiding Semnastek PROSIDING SEMNASTEK 2017
Publisher : Universitas Muhammadiyah Jakarta

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Abstract

Indonesia sebagai negara tropis memiliki keanekaragaman sumber daya alam hayati diantaranya adalah daun sereh wangi, sirih hijau dan jahe merah. Ketiga tanaman ini dapat digunakan untuk menghambat atau membunuh bakteri patogen di dalam mulut yaitu bakteri Streptococcus mutans. Review penelitian ini bertujuan untuk mengetahui efektivitas daya hambat ketiga tanaman herbal tersebut. Metode penelitian ini mengacu pada berbagai literatur. Berdasarkan penelitian menyatakan bahwa diameter zona hambat ekstrak etanol sereh wangi dengan konsentrasi 5%, 7%, 10%, 15%, dan 20% berturut-turut sebesar 0.00mm, 5.92mm, 6.50mm, 7.88mm, dan 7.92mm. Sedangkan untuk ekstrak daun sirih hijau memiliki efek antibakteri terhadap pertumbuhan Streptococcus mutans sebesar 4.90mm, 7.20mm, 10.20mm, dan 12.00mm. Konsentrasi yang efektif terhadap pertumbuhan Streptococcus mutans dalam penelitian ini adalah konsentrasi 20% dan kadar hambat minimum adalah pada konsentrasi 1%. Sedangkan  pada ekstrak jahe merah menunjukan adanya efektifitas antibakteri terhadap Streptococcus mutans pada konsentrasi masing-masing 10%, 20%, 40%, 60%, dan 80% sebesar 4.80mm, 4.85mm, 4.98mm, 5.23mm, dan 5.93mm. Kesimpulan dari paparan ini adalah masing-masing tanaman herbal tersebut mampu menghambat bakteri Streptococcus mutans. Aktifitas paling efektif untuk menghambat Streptococcus mutans adalah ekstrak daun sereh wangi karena memiliki daya hambat paling besar diantara ketiga tanaman herbal tersebut  pada konsentrasi 20 %. Kata kunci: daya hambat, ekstrak, Streptococcus mutans
Uji Efektivitas Sediaan Obat Kumur Dari Ekstrak Etanol Daun Prasman (Eupatorium Triplinerve Vahl) Terhadap Streptococcus Mutans Ilham Maulana; Anna Uswatun Hasanah; Rahmadhani Tyas; Aden Dhana Rizkita
Jurnal Kesehatan Mahardika Vol. 9 No. 1 (2022): Jurnal Kesehatan Mahardika
Publisher : LPPM ITEKES Mahardika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54867/jkm.v9i1.96

Abstract

Telah dilakukan penelitian tentang Uji efektivitas sediaan obat kumur dari ekstrak etanol Daun Prasman (Eupatorium triplinerve Vahl.) terhadap Streptococcus mutans. Penelitian ini bertujuan untuk menentukan efektivitas dari ekstrak etanol Daun Prasman terhadap pertumbuhan bakteri Streptococcus mutans. Metode yang digunakan dalam pengambilan ekstrak dengan menggunakan metode maserasi. Ekstrak yang dihasilkan kemudian diformulasikan dengan variasi konsentrasi 1%, 2% dan 4% dan kontrol tanpa zat aktif. Pengujian obat kumur yang dilakukan antara lain pengujian organoleptis,pH dan uji aktivitas antimikroba yang dilakukan dengan menggunakan metode difusi agar untuk menentukan diameter hambatan terhadap Streptococcus mutans dengan menggunakan piperdisk pada Medium Muller Hinton Agar (MNA). Setelah inkubasi 24 jam didapatkan zona hambatan Pada konsentrasi Ekstrak Daun Prasman 4%, 2%dan 1% yaitu sebesar 11,66 mm, 10,5 mm, dan 9,01 mm sedangkan formula kontrol negatif sebesar 7 mm. Hal ini menunjukkan bahwa konsentrasi yang lebih tinggi yaitu 4% memberikan daya hambat yang lebih efektif
Effect Of The Extraction Methods On The Identification Of Caffeine In The Extract Of Dragon Fruit Peel Reza pratama saputra; Nurlita Julianti; Azhari Firmansyah; Rhamal Amir; Aden Dhana Rizkita; Sintia Ayu Dewi
Indonesian Journal of Chemical Science Vol 12 No 3 (2023)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v12i3.75304

Abstract

Dragon fruit is a fruit that is abundantly available in Indonesia. Dragon fruit peel of Hylocereus sp. has become an increasingly popular natural ingredient in the food and beverage industry as it contains rich nutrients that can improve heart health, maintain healthy skin, support weight loss, boost our immune system, and make the body refreshed, including bioactive compounds such as alkaloids. The aim of this study was to identify the most effective extraction method in isolating caffeine compounds from dragon fruit peels. The methods used were maceration, percolation, reflux and fractionation extraction methods. Then for analysis using chromatography method KLT plate Silica Gel GF 254 and compound analysis using HPLC with flow rate of 2 ml/min, pump pressure 75 kgf/cm2, oven temperature 45o C, maximum temperature 85o C, wavelength 275 nm and isocratic eluent flow mode. Based on the research that has been done, it can be concluded that to determine the content of compounds in dragon fruit peel can be done by maceration, percolation and reflux methods. There is caffein at a retention time of 0.7 minutes
A REVIEW ARTICLE: ANTIOXIDANT ACTIVITY IN KALAKAI (Stenochlaena palustris): ARTIKEL REVIEW: AKTIVITAS ANTIOKSIDAN PADA KALAKAI (Stenochlaena palustris) Oksal, Efriyana; Ayuchecaria, Noverda; Agnestisia, Retno; Ariska, Risya; Tampubolon, Mulani Jeni Lestari; Dewi, Sintia Ayu; Maulana, Ilham; Rizkita, Aden Dhana
ALOTROP Vol. 7 No. 2 (2023): Alotrop 2023
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/alo.v7i2.29209

Abstract

Kalakai (scientific name Stenochlaena palustris) is a type of fern that is often used by the people of Kalimantan as a vegetable. The Kalakai plant which grows a lot in the lowland swamp areas of Central Kalimantan is a type of fern plant. Kalakai contains high levels of minerals, vitamin C, folic acid, and protein when compared to other local vegetables in Palangka Raya, Central Kalimantan. The active compounds that act as antioxidants in kalakai are flavonoids and phenols. Flavonoids and phenols act as free radical scavengers to prevent diseases that attack the body thereby strengthening the body's immunity. Traditionally, kalakai is consumed by the Dayak people. This article is a review article that uses the descriptive literature study method to find scientific information or research that proves coherently the benefits or applications of the kalakai. Kalakai which activity as an antioxidant has health benefits such as being able to increase hemoglobin levels so that it can prevent anemia has cytotoxicity in MCF-7 breast cancer cells and prevents antihyperlipidemic by reducing Low-density lipoprotein (LDL).
Understanding the structural foundation of mucroporin peptide as a potential anti-COVID-19 candidate: Computational methods Fakih, Taufik Muhammad; Ramadhan, Dwi Syah Fitra; Rizkita, Aden Dhana
Biogenesis: Jurnal Ilmiah Biologi Vol 11 No 2 (2023)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v11i2.41302

Abstract

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Sosialisasi Cara Mendeteksi Kandungan Boraks pada Makanan Menggunakan Bahan Dapur Rizkita, Aden Dhana; Julianti, Nurlita; Ayu, Putri Diah; Fathimah Azzahra, Erica Ardhana
Jurnal Dharma Bhakti Ekuitas Vol. 7 No. 2 (2023): Jurnal Dharma Bhakti Ekuitas
Publisher : Universitas Ekuitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52250/p3m.v7i2.619

Abstract

One of the dangerous food factors is the discovery of borax in food. Borax is a preservative that is not intended for food preservatives. Turmeric contains a curcumin compound which is capable of being an indicator for borax detection with color change parameters. The purpose of this research is to provide knowledge to the community around the campus to understand the method of early detection of borax on August 1, 2022 in the form of community service for the Bachelor of Pharmacy Study Program in the pharmaceutical chemistry scientific cluster. The method used is a lecture by giving a presentation of material related to borax followed by a demonstration of how to detect borax. The results of the service will have an impact on the knowledge of the community around the Stikes Bogor Husada campus about identifying food ingredients that contain borax in order to reduce the risk of exposure to borax by using turmeric which contains curcumin as a natural indicator of borax detection by providing an indicator of color change in food samples if it contains borax. The conclusion from this activity is that there is an increase in knowledge from the ignorance of the community around the Bogor Husada Stikes campus by using an assessment matrix in the form of a questionnaire conducted before and after the activity takes place whereby 43.3% increase in knowledge about borax, 83.3% increase in knowledge about how to identification of borax, and 85% increase in knowledge about the use of turmeric as a means of detecting borax. Keywords: Turmeric, curcumin, borax, food preservative, natural indicator. Abstrak Salah satu faktor makanan yang membahayakan adalah dengan ditemukannya boraks pada makanan. Boraks adalah bahan pengawet yang tidak diperuntukan untuk pengawet makanan. Kunyit mengandung senyawa kurkumin yang mampu menjadi indikator untuk mendeteksi boraks dengan parameter perubahan warna. Tujuan penelitian ini adalah untuk memberi pengetahuan kepada masyarakat sekitar kampus untuk memahami metode dini deteksi boraks pada Tanggal 1 Agustus 2022 dalam bentuk pengabdian kepada masyarakat Prodi S1 Farmasi rumpun keilmuan kimia farmasi. Metode yang digunakan yaitu ceramah dengan memberikan pemaparan materi terkait boraks dilanjutkan dengan demonstrasi cara mendeteksi boraks. Hasil pengabdian akan berdampak bagi pengetahuan masyarakat sekitar kampus Stikes Bogor Husada tentang identifikasi bahan makanan yang mengandung boraks agar mengurangi resiko paparan boraks dengan cara penggunaan kunyit yang mengandung kurkumin sebagai indikator alami deteksi boraks dengan memberikan indikator perubahan warna pada sampel makanan jika mengandung boraks. Kesimpulan dari kegiatan ini adalah ada peningkatan pengetahuan dari ketidak tahuan masyarakat sekitar kampus Stikes Bogor Husada dengan menggunakan matriks penilaian berupa kuisioner yang dilakukan sebelum dan sesudah kegiatan berlangsung dimana sebesar 43,3% peningkatan pengetahuan tentang boraks, sebesar 83,3% peningkatan pengetahuan tentang cara identifikasi boraks, dan sebesar 85% peningkatan pengetahuan tentang penggunaan kunyit sebagai cara mendeteksi boraks. Kata kunci: Kunyit, Kurkumin, Borak, Pengawet Makanan, Indikator Alami
In Silico Interaction Study of the Hydrazine Compound as an Antibody Drug Conjugate Linker Against Pertuzumab Ananda, Lintang Tri; Rizkita, Aden Dhana; Gibran , Syahrul Syah; Shapira, Shari Bella; Nour baety, Shelly Siti; Wafa, Shahibatul; Oksal, Efriyana
Indonesian Journal of Chemical Science Vol. 14 No. 1 (2025): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

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Abstract

Breast cancer can be initiated, one way or another, by overexpression of the HER-2 protein which can induce dimerization, resulting in metastasis in breast cancer cells. Pertuzumab is one of the methods used to treat metastatic breast cancer that is breast cancer cells that the cancer has spread to other parts of the body. Hydrazine is something hydro nitrogen compounds that has the formula N2H4 molecule. The hydrazine compound has chemical characteristics as a strong reducing agent because hydrazine plays a role as donor group hydrogen can reduce double bonds into single bonds through reaction hydrogenation. Research purposes This is o see the bond between Hydrazine as a linker with pertuzumab as an antibody for development of Antibody Drug Conjugate in silico with molecular docking. The docking method is used to know the conformation and free energy ties involved in the interaction between molecule (pertuzumab) and its ligand (hydrazine). In silico molecular docking was carried out with a number of stages such as ligand preparation, preparation of macromolecules, validation molecular docking method, docking hydrazine with pertuzumab protein and intermediate data analysis optimized hydrazine compound with which pertuzumab protein the lower mark energy bond so the stronger and stable the bond that occurs between hydrazine compound and pertuzumab protein . Obtained the result of docking is in the form of binding affinity from the results of addition of pertuzumab protein with the hydrazine ligand which is -6.8 which shows conformation formed stable or does not require great energy To do binding. Visualization results from complex molecule hydrazine compound against pertuzumab protein own identical confirmation on the part side active binding from pertuzumab protein macromolecules . The hydrazine compound can be bonded with pertuzumab and has potential as a new drug development in the targeting antibody drug conjugate breast cancer.
Analisis Profil ADMET Senyawa Tanaman Ceremai (Phyllanthus acidus) secara In-Silico Hamdan Ramdani; Taufik Muhammad Fakih; Aden Dhana Rizkita
Bandung Conference Series: Pharmacy Vol. 6 No. 1 (2026): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i1.23456

Abstract

Abstract. Ceremai or Phyllanthus acidus is a plant that is widely distributed in various regions of Indonesia. In several studies, compounds found in ceremai have been shown to have pharmacological activity. Before a compound can be used as a medicine, pharmacokinetic and toxicity studies are also required to ensure that the compound is acceptable to the body. Research using an in-silico approach can be conducted to analyze the pharmacokinetic profile and toxicity of compounds found in ceremai. The results of pharmacokinetic predictions for the compounds Hirsutrin; Quercetin 3-O-alpha-L-rhamnoside; Quercetin 3-rutinoside; Myricitrin; Phyllanthusol A; and Phyllanthusol B show poor absorption in the gastrointestinal tract, do not cross the blood-brain barrier, do not inhibit cytochrome P450 enzymes, and do not meet Lipinski's rules. All six compounds also have the potential to cause nephrotoxicity and respiratory toxicity if administered at doses exceeding the predicted LD50. Abstrak. Ceremai atau Phyllanthus acidus merupakan tanaman yang tersebar diberbagai daerah di Indonesia. Dalam beberapa penelitian senyawa yang terdapat di dalam ceremai mempunyai aktivitas farmakologi. Sebelum suatu senyawa dapat dijadikan obat diperlukan juga studi farmakokinetika dan juga toksisitas untuk memastikan senyawa tersebut dapat diterima oleh tubuh. Penelitian menggunakan pendekatan in-silico dapat dilakukan dalam menganalisis profil farmakokinetika dan juga toksisitas dari senyawa yang terdapat di dalam ceremai. Hasil prediksi farmakokinetika dari senyawa Hirsutrin; Quercetin 3-O-alpha-L-rhamnoside; Quercetin 3-rutinoside; Myricitrin; Phyllanthusol A; dan Phyllanthusol B menunjukkan penyerapan dalam saluran cerna yang kurang baik, tidak menembus BBB, dan tidaka ada enzim sitokrom P450 yang dihambat, dan juga keenam senyawa tidak memenuhi aturan lipinski. Keenam senyawa juga berpotensi menyebabkan nefrotoksik dan respiratotoksik jika diberikan melebihi prediksi dosis LD50.
Co-Authors Alwia, Nisa Amir, Rhamal Ananda, Lintang Tri Anis Herliyanti Ariska, Risya Arzanto, Adi Wahyu Ayu, Putri Diah Ayuchecaria, Noverda Azhari Firmansyah Baety, Shelly Siti Nour Chaidir Chaidir Dewi, Sintia Ayu Dwi Syah Fitra Ramadhan Dyan Septyaningsih Hardjono HP, Dyan Septyaningsih Edy Cahyono Emas Agus Prastyo Wibowo, Emas Agus Prastyo Fathimah Azzahra, Erica Ardhana Gibran , Syahrul Syah Gibran, Syahrul Syah Hafidz, Muhammad Rafi Hamdan Ramdani Ika Sri Hardyanti, Ika Sri Ilham Maulana Ilham Maulana ismiati, Silfia Isni Nurani, Isni Julianti, Nurlita Maulana, Iham Maulana, Khoironni Devi Maulidian, Yuda Nour baety, Shelly Siti Nurlita Julianti Oksal, Efriyana Rahmadhani Tyas Retno Agnestisia Reza Pratama Saputra Rhamal Amir Rochjana, Anna Uswatun Hasanah Rohman, Ayu Andini Rizki Lestari S Mursiti Saldaw, Antan Selay, Risma Eka Putri Shapira, Shari Bella Sintia Ayu Dewi Tampubolon, Mulani Jeni Lestari Taufik Muhammad Fakih Wafa, Shahibatul Wahyuni, Nisa Sri Yohanes, Kon