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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Obstetri dan Ginekologi Jurnal Kesehatan Reproduksi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Pengabdian Masyarakat Multidisiplin Cendana Medical Journal Malahayati International Journal of Nursing and Health Science
Jojor Sihotang
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Riau
Aerospace Engineering Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The role of curcumin in enhancing endometrial receptivity in a rat model of adenomyosis: A preclinical basis for herbal therapeutics development Jojor Sihotang; Imelda EB Hutagaol; Adriansyah; Muhammad Yusuf
Majalah Obstetri & Ginekologi Vol. 34 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V34I12026.9-15

Abstract

HIGHLIGHTS Nano-curcumin increases expression of endometrial receptivity markers HOXA10, LIF, and integrin ß3 in adenomyosis rat models. Nano-curcumin shows potential as a non-surgical therapy to improve implantation in adenomyosis without affecting lesion severity.   ABSTRACT Objective: This study aimed to evaluate the effects of nano-curcumin on markers of endometrial receptivity in a rat model of adenomyosis, focusing on lesion characteristics and gene expression related to embryo implantation. Materials and Methods: An experimental study was conducted using 30 female Wistar rats (Rattus norvegicus) at the Biomedical Laboratory, Faculty of Medicine, Universitas Riau, from March to October 2024. The rats were randomly assigned into five groups: control, adenomyosis model, and adenomyosis treated with nano-curcumin at doses of 25, 50, and 75 mg/kg body weight. Adenomyosis was induced via oral administration of tamoxifen (2.7 µmol/kg) from postnatal day 2 to 5. Nano-curcumin was administered orally for 15 consecutive days starting 75 days after induction. Adhesion scores, lesion number, and lesion volume were evaluated, while expression levels of HOXA10, Leukemia Inhibitory Factor (LIF), and integrin β3 were quantified using polymerase chain reaction assays during days 4–6 of pregnancy. Results: Nano-curcumin reduced lesion count, lesion volume, and adhesion scores in a dose-dependent manner. However, these changes were not statistically significant (all p > 0.05). In contrast, nano-curcumin demonstrated a clear dose-dependent enhancement of endometrial receptivity. Expression of HOXA10, LIF, and integrin  β3, markers suppressed in the adenomyosis group, was progressively restored toward control levels with increasing doses, indicating improved endometrial readiness for implantation despite minimal changes in lesion morphology. Conclusion: Nano-curcumin enhances the expression of key endometrial receptivity markers without significantly affecting lesion characteristics in rats with adenomyosis, suggesting its potential as a therapeutic agent to improve fertility outcomes.
The Relationship Between Primary Dysmenorrhea And Sleep Quality In Students Of The Faculty Of Medicine, University Of Nusa Cendana Imelda Martha Somi Kelore; Jojor Sihotang; Conrad Liab H. Folamauk; Derri Tallo Manafe
Cendana Medical Journal Vol 13 No 2 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i2.17400

Abstract

When experiencing menstruation, it is often accompanied by pain which is commonly called dysmenorrhea. Primary dysmenorrhea experienced can cause discomfort both during activities and at rest so that it can affect sleep quality. The sleep quality of medical students is bad, apart from the lecture burden, it is suspected that it can also be influenced by the intensity of pain, such as when experiencing primary dysmenorrhea. To determine the relationship between primary dysmenorrhea and sleep quality in students of the Faculty of Medicine, University of Nusa Cendana. This research is an observational analytic study with a cross sectional design in students of the Faculty of Medicine, University of Nusa Cendana. Data was conducted by filling out the primary dysmenorrhea questionnaire and Pittsburgh Sleep Quality Index (PSQI) questionnaire by 106 respondents who met the inclusion criteria. Sampling was done by using stratified random sampling technique. The result was analyzed univariate and bivariate using Phi Correlation test. Data from 106 respondents showed that 63.2% of respondents experienced primary dysmenorrhea and as many as 36.8 respondents did not experience primary dysmenorrhea. For sleep quality, 80.2% of respondents had poor sleep quality and 19.8% of respondents had good sleep quality. In this study, it was found that more respondents had primary dysmenorrhea with poor sleep quality than good sleep quality. The results of the bivariate analysis with the Phi Correlation test showed the results of p value=0.520 (p> 0.05). There is no significant relationship between primary dysmenorrhea and sleep quality in students of the Faculty of Medicine, University of Nusa Cendana.
Analisis Faktor Risiko Prolaps Organ Panggul pada Pasien Ginekologi di RSUD Arifin Achmad: Studi Retrospektif 2022–2025 Jojor Sihotang; Edy Fakhrizal; Sri Wahyu Maryuni; Imelda E.B Hutagaol; Agnes Regina Bagariang; Clarentia Sitangang; Artia Martha Vania Butarbutar
JURNAL KESEHATAN REPRODUKSI Vol 12, No 3 (2025)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jkr.114434

Abstract

Latar Belakang: Prolaps organ panggul (POP) merupakan kondisi ginekologis yang signifikan menurunkan kualitas hidup perempuan, terutama pada populasi lanjut usia dan multipara. Prevalensi globalnya diperkirakan mencapai 30,9% (95% CI 24,4–38,2%). Di Indonesia, khususnya di rumah sakit rujukan regional seperti RSUD Arifin Achmad Provinsi Riau, data epidemiologis komprehensif mengenai POP dan faktor risikonya masih sangat terbatas, sehingga menghambat pengembangan strategi pencegahan dan tata laksana klinis yang tepat sasaran.Tujuan: Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis faktor risiko demografis dan klinis utama yang berhubungan dengan POP serta menganalisis hubungan faktor risiko dengan pola diagnosis prolaps organ panggul (sistokel, rektokel, dan prolaps uteri) pada pasien ginekologi yang ditangani di RSUD Arifin Achmad periode 2022–2025.Metode: Studi analitik potong lintang retrospektif dilakukan dengan menggunakan rekam medis pasien ginekologi yang didiagnosis POP. Variabel yang diekstraksi meliputi usia, paritas, jenis persalinan, status menopause, indeks massa tubuh (IMT), dan riwayat penyakit kronis. Data dianalisis menggunakan statistik deskriptif, analisis bivariat dengan uji chi-square, dan regresi logistik multivariat untuk menentukan faktor risiko independen.Hasil: Analisis terhadap 515 rekam medis pasien ginekologi menunjukkan bahwa diagnosis prolaps organ panggul yang paling banyak ditemukan adalah rektokel. Mayoritas pasien berada pada kelompok usia ≥50 tahun, telah memasuki masa menopause, dan memiliki status multiparitas. Temuan ini menunjukkan bahwa prolaps organ panggul bersifat multifaktorial dan lebih dipengaruhi oleh faktor obstetri.Kesimpulan: POP merupakan kondisi multifaktorial yang sangat berkaitan dengan usia, paritas, persalinan pervaginam, menopause, dan obesitas pada populasi kami. Temuan ini menggarisbawahi pentingnya langkah pencegahan terstruktur seperti pelatihan otot dasar panggul, program pengelolaan berat badan, dan edukasi pasien yang ditargetkan untuk kelompok berisiko tinggi. Studi ini menyediakan dasar bukti penting bagi pengembangan pedoman klinis dan intervensi kesehatan masyarakat di bidang uroginekologi di tingkat lokal.
Hubungan Nuliparitas Terhadap Kejadian Preeklampsia dengan Penyulit di Rumah Sakit Rujukan Tersier Jojor Sihotang; Darma Lutfi Ananda; Renardy Reza Razali; Sri Wahyuni
Jurnal Ilmu Kedokteran Vol 20, No 1 (2026): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v20i1.2026.65-70

Abstract

Maternal Mortality Rate (MMR) remains high globally, particularly in developing countries. In Indonesia, hypertensive disorders of pregnancy, including preeclampsia, are major contributors to maternal mortality. The prevalence of preeclampsia at Arifin Achmad Regional General Hospital was 28.12%. Nulliparity is a known risk factor for preeclampsia; however, no studies have examined its association with complicated preeclampsia in Riau Province. This study aimed to analyze the relationship between nulliparity and the occurrence of complicated preeclampsia. This observational analytic study employed a retrospective cross-sectional design using secondary data from medical records of preeclampsia patients at Arifin Achmad Regional General Hospital, Riau Province, from 2019 to 2022. Consecutive sampling was applied to include all patients meeting the inclusion and exclusion criteria. Data were analyzed using Fisher’s exact test. Out of 1,861 pregnant women, 361 (19.4%) developed preeclampsia. A total of 344 patients met the inclusion criteria, of whom 292 (84.9%) had complicated preeclampsia. Based on parity, 95 (32.5%) were nulliparous and 197 (67.5%) were multiparous. Fisher’s exact test showed no significant association between nulliparity and the occurrence of complicated preeclampsia (p = 1.000; OR = 1.007; 95% CI: 0.537–1.889). There was no significant association between nulliparity and the occurrence of complicated preeclampsia at Arifin Achmad Regional General Hospital during the 2019–2022 period.
Pengaruh Injeksi Platelet Rich Plasma Terhadap Proses Penyembuhan Luka Fase Remodeling Berdasarkan Early Wound Healing Score (EHS) pada Kasus Sistokel Betrisya Hanifah; Jojor Sihotang
Jurnal Ilmu Kedokteran Vol 20, No 1 (2026): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v20i1.2026.71-78

Abstract

Pelvic organ prolapse (POP) is a common condition in postpartum women, with cystocele being the most common type. Anterior colporrhaphy is a commonly used treatment, but it has a relatively high recurrence rate. Platelet-rich plasma (PRP) is known to have the potential to enhance wound healing through tissue regeneration. This study aims to analyze the effect of PRP injection on remodeling phase wound healing based on the Early Wound Healing Score (EHS) assessment in cystocele cases. The study design used was a retrospective cohort, with data taken from medical records using a consecutive sampling method on 40 women who underwent anterior colporrhaphy. A total of 20 patients who received PRP injection were included in the case group, while 20 other patients who did not receive PRP injection were the control group. The EHS score was assessed on the 14th and 28th days postoperatively. Data analysis was performed using the independent t-test on day 14 and the Mann-Whitney test on day 28. The results showed a significant increase in the mean EHS score in the case group compared to the control group, both on day 14 and day 28. In conclusion, PRP injection during cystocele surgery has been proven effective in accelerating wound healing in the remodeling phase and has the potential to be an additional therapy to reduce the risk of recurrence.
Recognizing Poland syndrome at birth: Chest wall and hand manifestations Laysa Kasminata; Jojor Sihotang
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 12 (2026): Volume 8 Number 12
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i12.1943

Abstract

Background: Poland syndrome is a rare congenital anomaly defined by unilateral agenesis or hypoplasia of the sternocostal head of the pectoralis major, with possible involvement of the pectoralis minor and variable ipsilateral chest wall and upper-limb abnormalities, including syndactyly. The presentation is typically unilateral, more often affecting the right hemithorax, while bilateral involvement is uncommon. Purpose: To report a neonatal case of Poland syndrome and describe the clinical manifestations and early management to support timely intervention and appropriate care planning. Method: A case study was conducted at Dumai Hospital involving a preterm neonate delivered to a 27-year-old woman (G2P1A0) at 27 weeks of gestation who presented with uterine contractions and stable vital signs. Prenatal ultrasonography was performed prior to delivery. After birth, the neonate underwent a structured physical examination focusing on the chest wall and upper extremities to identify congenital anomalies, followed by initial stabilization and referral based on clinical findings. Results: The patient was a female preterm neonate with findings consistent with Poland syndrome, including unilateral absence of the pectoralis major and pectoralis minor on the affected side and ipsilateral hand syndactyly. The infant was referred to the perinatology unit for ongoing monitoring and multidisciplinary management, while the mother received routine postpartum care according to hospital protocol. Conclusion: Poland syndrome may be recognizable at birth through unilateral thoracic muscle absence with ipsilateral limb anomalies, requiring careful newborn examination and early coordinated care.
Co-Authors Adriansyah Agnes Regina Bagariang Artawan, I Made Artia Martha Vania Butarbutar Bagariang, Agnes Regina Betrisya Hanifah Butarbutar, Artia Martha Vania Clarentia Sitangang Damanik, Efrisca M. Br. Dariyanti, Putu Desy Widia Darma Lutfi Ananda Deri Riskiyanti Tallo Manafe Djari, Tesalonica Oryza Sativa Edy Fakhrizal Eighty Mardiyan K, Eighty Fakhrizal, Edy Fania Pancar Fadilla Febriani Febriani Folamauk, Conrad Liab Hendricson Hidayatullah, Amiruddin Hutagaol, Imelda E.B Imelda E.B Hutagaol Imelda EB Hutagaol Imelda Martha Somi Kelore Koamesah, S.M.J Kotta, Merizaputri Wihelmina Laysa Kasminata Lidia, Kartini Maryuni, Sri Wahyu Mawikere, Stevanikov Jetna Marlis Muhammad Yusuf Nababan, Ezra Harun Florentino Ninda Frymonalitza Ratu, Kristian Renardy Reza Razali Riwu, Magdarita Sagita, Sidarta Sasputra, I Nyoman Sinaga, Libertina Rambu D.P.B Sitangang, Clarentia Sofi Sumarlin Sri Wahyu Maryuni Sri Wahyuni Widjiati Widjiati, Widjiati Woda, Rahel Rara Wungouw, Herman Pieter L.