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All Journal VALENSI The Journal of Pure and Applied Chemistry Research Indonesia Chimica Acta Science and Technology Indonesia Indonesian Journal of Chemistry Acta Chimica Asiana Makara Journal of Science Jurnal Pengabdian Inovasi Masyarakat Indonesia Jurnal Ilmiah Multidisiplin
Emmy Yuanita
Natural Products, Synthesis and Transformation Research Groups, Mataram University, Jl. Majapahit 62 Mataram 83125
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Social Sciences Other

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Free-Radical Scavenging Activity and Total Phenolic Compounds of Red and Green Poinsettia Leaves (Euphorbia pulcherrima Willd.) from Lombok Island Muliasari, Handa; Sopiah, Baiq; Yuanita, Emmy; Ningsih, Baiq Nila Sari
Makara Journal of Science Vol. 27, No. 4
Publisher : UI Scholars Hub

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Abstract

To determine the free-radical scavenging activity and total phenolic content of the ethanol extract of Poinsettia leaves (Euphorbia pulcherrima Willd.) from Lombok Island, we used the 1,1-diphenyl-2-picrylhydrazyl method and expressed the total phenolic content as gallic acid equivalent (GAE) per gram of ethanol extract. The results show the strong antioxidant activity (79.77 ppm) of the ethanol extract of red Poinsettia leaves and the moderate antioxidant activity of green Poinsettia leaves (118.350 ppm). The ethanol extracts of red and green Poinsettia leaves possessed an average of 63.276 ± 0.228 and 22.715 ± 0.090 mg GAE/g extract total phenolic contents, respectively. In addition, the ethanol extracts of red and green Poinsettia leaves exhibited moderate and strong free-radical inhibitory activities, respectively. These findings indicate that color affects the antioxidant ability of leaves and their phenolic content.
Profiling of Modified Chitosan-Based Composites as Tetracycline Hydrochloride Drug Release Systems Anjartikasari, Nurul; Yuanita, Emmy; Dharmayani, Ni Komang Tri; Sudirman, Sudirman; Sudewianingsih, Ni Made; Ulfa, Maria
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 17, No 1: June 2024
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v17i1.33590

Abstract

Controlled drug release systems (DRS) are a crucial technology in the medical field, and they continue to be developed today. Chitosan is useful in manufacturing-controlled drug release systems due to its non-toxic, biodegradable, and biocompatible properties. However, it has some limitations when it comes to its physical and mechanical properties. Combining chitosan with other materials, such as bacterial cellulose (BC), graphite (Gr), ZnO, and TiO2, can improve its mechanical properties and antibacterial activity. This study aims to synthesize Chi/BC/Gr/TiO2 and Chi/BC/Gr/ZnO composites as drug release systems. When tested with TCH, an antibiotic model, the drug release kinetics of the composite followed the Hixson-Crowell and Korsmeyer-Peppas kinetics models. Additional tests for physical and mechanical properties, as well as antibacterial activity, have also been conducted. Mechanical properties in terms of tensile strength and Young’s modulus in composites with adding Gr, TiO2, and ZnO have higher values than Chi/BC alone. Compared to positive control, both TCH-loaded composites show higher inhibition against S. aureus bacteria. Based on the results of this study, composite Chi/BC/Gr/TiO2 and Chi/BC/Gr/ZnO have potential applications as DRS such as wound dressing.
Modified Bacterial Cellulose-Based Composite Profile for Drug Release of Tetracycline Hydrochloride Cahyani, Ni Wayan Chyntia Pramesti; Yuanita, Emmy; Dharmayani, Ni Komang Tri; Sudirman, Sudirman; Sudewianingsih, Ni Made; Ulfa, Maria
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.37663

Abstract

Bacterial cellulose (BC) is a biodegradable natural polymer with high mechanical strength and non-toxicity. This biopolymer is widely used as a candidate in biomedical fields, such as drug delivery, wound healing, and filtration systems. However, BC lacks antibacterial activity which limits its use in biomedical applications. So, modification of BC-based composite is required. This study aims to examine the effects of modifying BC-based composites with fillers such as graphite (G) and polyvinyl alcohol (PVA) on the release of tetracycline hydrochloride (TCH) drugs. Adding fillers to BC can alter its physical and mechanical properties, reducing its porosity and swelling rate in acidic and alkaline mediums. The drug release of TCH from modified BC-based composites follows the Korsmeyer-Peppas and Hixson-Crowell kinetics models. Adding filler and TCH antibiotic to the composite enhances its antibacterial activity against Staphylococcus aureus with a significant inhibition zone. The results of the inhibition zone show that composites have the potential to be applied in biomedical fields, especially in transdermal patches.
Effect of Different Treatments During Synthesis on Physical and Chemical Properties of Bacterial Cellulose/Chitosan Composite Film Izzaty, Annisa Nabila; Yuanita, Emmy; Sudirman, Sudirman; Sarkono, Sarkono; Al Faris, Muhammad; Ulfa, Maria
The Journal of Pure and Applied Chemistry Research Vol. 13 No. 2 (2024): Edition May-August 2024
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2024.013.02.3349

Abstract

Bacterial cellulose (BC) and chitosan (Chi) are biopolymers that play a vital role in various industrial applications due to their unique properties, such as biodegradability, biocompatibility, flexibility, and excellent physical properties. Combined, these two materials can create composites with exceptional characteristics, which can be tailored for specific applications. This study aimed to evaluate the effect of different ultrasonication and stirring treatments on the synthesis of BC/Chi composites, focusing on their chemical, physical, and mechanical properties. Based on the results of microscopy, SEM-EDS, and FTIR analysis, it was found that ultrasonication treatment provides a more effective dispersion process, resulting in higher physical and mechanical properties than BC/Chi stirring.
C-prenylation of 1,3 dihydroxyxanthone: synthesis, characterization and antibacterial activity Yuanita, Emmy; Jannah, Baiq Khaeratul; Ulfa, Maria; Sudirman; Ningsih, Baiq Nila Sari; Dharmayani , Ni Komang Tri
Acta Chimica Asiana Vol. 6 No. 1 (2023)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v6i1.149

Abstract

Prenylated 1,3-dihydroxyxanthone has been successfully synthesized using Prenyl bromide and KOH. Characterization of the synthesized compound using Infra Red (IR) and Nuclear Magnetic Resonance (1H-NMR) showed that monosubstituted c-prenylation was occurred at carbon number 2 to form 1,3-dihydroxy-2-prenylxanthone. The synthesis result was a yellow-brown paste with a yield of 43.09%. This prenylated 1,3-dihydroxyxanthone had moderate antibacterial activity against Escherichia coli with an inhibition zone > 5 mm at a concentration of 15%.
Sintesis dan Karakterisasi Komposit Selulosa Bakteri dengan Grafit dan TiO2-ZnO: Structural and Functional Analysis Fariz Nafiir, Muhammad; Sudirman; Yuanita, Emmy; Arshad, Sazmal E.; Lusiana, Retno Ariadi; Ulfa, Maria
Acta Chimica Asiana Vol. 7 No. 2 (2024)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v7i2.204

Abstract

This research aims to synthesize and characterize a bacterial cellulose (BC)-based composite with graphite and TiO2-ZnO as reinforcement materials using ex-situ synthesis with CTAB as a surfactant. FTIR and SEM-EDS analysis revealed interactions between the matrix and the reinforcement materials, as well as irregular particle distribution in the BC/G-TiO2-ZnO composite. The addition of graphite to BC significantly increased the conductivity of the composite, while the addition of TiO2-ZnO had the opposite effect. The mechanical properties of the composite exhibited an inverse relationship with the conductivity parameter. Swelling tests indicated that pH and the addition of CTAB influenced the swelling behavior of the BC-based composite. The results of this study provide a strong foundation for the development of potential applications in the fields of electronics and pollutant filtration. The synthesis of this composite aims to harness the unique properties of BC, graphite, and TiO2-ZnO, creating a multifunctional material with potential uses in flexible electronics, sensors, biocompatible conductive materials, and advanced filtration systems.
Sosialisasi Pengemasan Produk dengan Plastik Biodegradable Berbahan Selulosa dan Strategi Pemasarannya di Kelompok Wanita Tani Alummahat, Lendang Nangka, Lombok Timur, NTB Ningsih, Baiq Nila Sari; Ulfa, Maria; Yuanita, Emmy; Dharmayani, Ni Komang Tri; Septiyana, Maulida; Haviz, Nur Vinna; Hayani, Hafiyatul; Tamara, Cynthia Claudia; Septiari, Wayan Uni
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 3 No. 2 (2024): Edisi Agustus
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v3i2.6002

Abstract

Desa Lendang Nangka di Lombok Timur, NTB, yang termasuk dalam World Geopark UNESCO di lereng Gunung Rinjani, memiliki potensi besar dalam sektor pertanian. Namun, tantangan muncul dalam pengemasan produk pertanian yang belum ramah lingkungan. Kegiatan ini bertujuan meningkatkan nilai produk pertanian bagi kelompok Wanita Tani Alummahat melalui penggunaan kemasan ramah lingkungan berbahan selulosa dengan metode gelatinisasi dan pemasaran melalui e-commerce. Pelaksanaan kegiatan melibatkan transfer pengetahuan, teknologi, serta pembinaan dan pendampingan untuk memastikan peningkatan nilai ekonomi lokal secara berkelanjutan. Kegiatan meliputi penyuluhan, pelatihan praktis, dan pembentukan Kelompok Usaha Bersama (KUB) sebagai wadah pengembangan ide inovatif. Evaluasi menunjukkan peningkatan signifikan dalam pengetahuan dan keterampilan partisipan terkait pengemasan ramah lingkungan, serta antusiasme yang tinggi. Program ini berkontribusi pada pengembangan strategi pemasaran dan pengemasan yang berkelanjutan di tingkat desa, dengan harapan dapat memberikan dampak positif pada ekonomi masyarakat lokal.
Isolasi dan Uji Aktivitas Antibakteri Metabolit Sekunder Pada Ekstrak N-Heksan Rimpang Temu Kunci (Boesenbergia pandurata) Risma, Melania; Darmayani, Ni Komang Tri; Ulfa, Maria; Yuanita, Emmy; Sudirman, Sudirman; Hadi, Surya; Hermawati, Elvira
Jurnal Ilmiah Multidisipin Vol. 2 No. 6 (2024): Jurnal Ilmiah Multidisiplin, Juni 2024
Publisher : Lumbung Pare Cendekia

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Abstract

Temu kunci (Zingiberceae) merupakan salah satu tanaman obat yang ada di Indonesia. Penelitian terdahulu tentang kajian fitokimia dan bioaktivitas tanaman ini menunjukkan beberapa metabolit sekunder yaitu pinostrobin, pinoscembrin, panduratin A dengan bioaktivitas yang beragam salah satunya sebagai antibakteri. Berdasarkan laporan tersebut diketahui pula bahwa temu kunci yang berasal dari Dompu belum pernah dikaji fitokimia maupun bioaktivitasnya. Oleh karena itu penelitian ini dilakukan dengan tujuan untuk menganalisis kandungan metabolit sekunder pada rimpang temu kunci dan aktivitasnya sebagai antibakteri. Tahapan isolasi pada penelitian ini dimulai dengan ekstraksi dan dilanjutkan dengan pemisahan dan pemurnian. Metode ekstraksi yang digunakan yaitu maserasi dengan pelarut metanol. Ekstrak yang diperoleh kemudian dilakukan pemisahan dan pemurnian dengan berbagai metode kromatografi dan diidentifikasi menggunakan spektroskopi UV-Vis, FTIR, NMR (1D). Berdasarkan hasil analisis spektroskopinya senyawa hasil isolasi yang diperoleh yaitu 5-hidroksi-7-metoksiflavanon (pinostrobin). Hasil pengujian aktivitas antibakteri dengan variasi konsentrasi 50, 100, dan 150 ppm dari senyawa pinostrobin menunjukkan zona hambat terhadap bakteri Gram positif (+) Staphylococcus aureus berturut-turut sebesar 11,3, 12, 12,6 mm sedangkan terhadap bakteri Gram negatif (-) Escherichia coli berturut-turut sebesar 10,6, 11,6, 12,3 mm. Hasil pengujian antibakteri dengan konsentrasi 600 ppm dari ekstrak n-heksan menunjukkan zona hambat berturut-turut sebesar 13 dan 12,3 mm. Hal tersebut membuktikan bahwa senyawa pinostrobin dan ekstrak n-heksan temu kunci berpotensi sebagai antibakteri.
Uji Toksisitas Ekstrak Metanol Daun Gaharu Gyrinops versteegii (Gilg.) Domke Menggunakan Metode Brine Shrimp Lethality Test (BSLT) Nurpratama, Jeksi Mahari; Yuanita, Emmy; Hadi, Surya
Jurnal Ilmiah Multidisipin Vol. 2 No. 6 (2024): Jurnal Ilmiah Multidisiplin, Juni 2024
Publisher : Lumbung Pare Cendekia

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Abstract

Penelitian ini bertujuan untuk mengetahui sifat toksisitas ekstrak metanol daun gaharu Gyrinops versteegii (Gilg.) Domke serta mengetahui golongan senyawa aktif toksik terhadap Artemia salina L. Serbuk daun gaharu diekstraksi dengan cara maserasi menggunakan pelarut metanol. Ekstrak metanol yang diperoleh kemudian di uji toksisitasnya menggunakan metode BSLT (Brine Shrimp Lethality Test). Hasil uji toksisitas menunjukkan bahwa ekstrak metanol memiliki aktivitas toksik dengan nilai LC50 sebesar 55,43 ppm. Hal ini menunjukkan ekstrak metanol berpotensi sebagai agen antikanker. Berdasarkan uji fitokimia ekstrak metanol positif terhadap golongan senyawa metabolit sekunder terpenoid, steroid, dan polifenol.
Sintesis dan Karakterisasi Komposit Beads Kitosan/Grafena Melalui Pengikatan Silang oleh Na3PO4 Mukhlisatun, Mukhlisatun; Yuanita, Emmy; Sudirman, Sudirman; Ulfa, Maria; Handayani, Sri Seno
Jurnal Ilmiah Multidisipin Vol. 2 No. 11 (2024): Jurnal Ilmiah Multidisiplin, November 2024
Publisher : Lumbung Pare Cendekia

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Abstract

Komposit merupakan gabungan dua atau lebih material yang terdiri atas material pengikat (matriks) dan material pengisi (filler). Penelitian ini bertujuan untuk mengetahui cara mensintesis komposit kitosan/grafena/Na3PO4 (Chi/G/P) dengan metode gelasi ionik dan mengetahui karakteristik morfologi komposit Chi/G/P. Tahapan sintesis pada penelitian ini dimulai dengan melarutkan kitosan dengan asam asetat kemudian dicampurkan dengan grafena dan dilanjutkan dengan meneteskan komposit Chi/G kedalam larutam Na3PO4 membentuk komposit beads Chi/G/P. Komposit beads Chi/G/P kemudian dikarakterisasi menggunakan Scanning Electron Microscopy (SEM), uji swelling, dan uji stabilitas dalam larutan variasi pH. Berdasarkan hasil karakterisasi menggunakan SEM diketahui bahwa karakteristik komposit beads yang dihasilkan bergantung pada persen grafena dalam komposit.
Co-Authors Al Faris, Muhammad Anjartikasari, Nurul Arshad, Sazmal E. Cahyani, Ni Wayan Chyntia Pramesti Darmayani, Ni Komang Tri Dharmayani , Ni Komang Tri Eryani, Farica Fariz Nafiir, Muhammad Haviz, Nur Vinna Hayani, Hafiyatul Hermawati, Elvira Ima Arum Lestarini Izzaty, Annisa Nabila Jannah, Baiq Khaeratul Maharani Maharani, Maharani Maria Ulfa Maulida Septiyana Mukhlisatun, Mukhlisatun Muliasari, Handa Ningsih, Baiq Nila Sari Nurpratama, Jeksi Mahari Ratnasari, Baiq Desy Retno Ariadi Lusiana Risma, Melania Rohmana, Ainni Septiari, Wayan Uni Sirojuttolibin, Sirojuttolibin Sopiah, Baiq Sri Seno Handayani Sudewianingsih, Ni Made Sudirman Sudirman Sudirman Surya Hadi Tamara, Cynthia Claudia Taufan Hari Sugara Tri Dharmayani, Ni Komang Wahidatun, Wahidatun