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All Journal VALENSI The Journal of Pure and Applied Chemistry Research Jurnal Riset Kimia Indonesia Chimica Acta Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry Indonesian Journal of Pure and Applied Chemistry Acta Chimica Asiana Makara Journal of Science Jurnal Pengabdian Inovasi Masyarakat Indonesia
Emmy Yuanita
Natural Products, Synthesis and Transformation Research Groups, Mataram University, Jl. Majapahit 62 Mataram 83125
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Social Sciences Other

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IN SILICO INVESTIGATION OF MOLECULAR INTERACTIONS BETWEEN INULOSUCRASE DERIVED FROM Aspergillus awamori AND EPE COMPOUNDS Aini, Diah Miftahul; Fajriati, Elza Kamila; Yuanita, Emmy; Antari, Gladeva Yugi; Ratnasari, Baiq Desy; Damayanti, Eva Hikmatul
Indonesian Journal of Pure and Applied Chemistry Vol 8, No 2 (2025)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v8i2.96978

Abstract

Fructooligosaccharides (FOS) are important prebiotics synthesized by the enzymatic activity of inulosucrase, and understanding their molecular interactions is essential for exploring potential modulators. This study examined the interaction between inulosucrase from Aspergillus awamori (PDB ID: 1Y4W) and the compound EPE (4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid) using an in silico molecular docking approach. Since the 1Y4W structure lacks a co-crystallized ligand, EPE was selected as a surrogate ligand derived from PDB ID: 3SC7 and prepared for docking simulations. Docking with AutoDock Vina produced a best binding affinity of "“5.6 kcal/mol, with the strongest hydrogen bond observed with TRP305 (1.92 Ã…) and additional interactions with TYR279 (3.75 Ã…). These results indicate a moderate but stable interaction, weaker than the native substrate fructose reported in crystallographic studies. Overall, EPE shows potential as a modulatory compound of inulosucrase activity and provides a basis for further enzymological and biotechnological research.
Profile of a Composite Based on Bacterial Cellulose and Polyvinyl Alcohol as a Drug Release Matrix for Tetracycline Hydrochloride Sukmaningrum, Afif Dwi; Yuanita, Emmy; Dharmayani, Ni Komang Tri; Sudirman, Sudirman; Sudewianingsih, Ni Made; Ulfa, Maria
Jurnal Riset Kimia Vol. 15 No. 2 (2024): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v15i2.692

Abstract

Bacterial cellulose (BC) is a natural polymer with good mechanical properties and hydrophilicity. Polyvinyl alcohol (PVA) is a synthetic polymer widely used in medicine. Both have been researched for their potential in drug release and acceptance. This study aims to determine the role of BC and PVA as drug release matrices for tetracycline hydrochloride (TCH), with additional fillers such as graphite (G) and TiO2. The results showed that the composites with BC matrix had lower mechanical properties than those with PVA matrix, with tensile strength values of 6.4075 and 17.446 MPa, respectively. However, the BC matrix was superior in porosity and swelling ability. The drug release testing of TCH from the composites showed that the appropriate model to describe drug release in BC matrix composites was in zero order, while the PVA matrix was in first order. The antibacterial activity of the composites on both matrices was tested against Staphylococcus aureus. The results indicate that both composites have potential applications in promising biomedical fields.
MENGOPTIMALKAN PEMANFAATAN SUMBER DAYA KENTANG: KETERLIBATAN MASYARAKAT DAN PENINGKATAN KETERAMPILAN DALAM MENGGALI POTENSI TINGGI TEPUNG KENTANG DI DESA WISATA SEMBALUN BUMBUNG Dharmayani, Ni Komang Tri; Yuanita, Emmy; Ulfa, Maria; Ningsih, Baiq Nila Sari; Sudirman, Sudirman; Septiyana, Maulida; Wardhana, I Gede Adhitya Wisnu
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 3 No. 1 (2024): Edisi Februari
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v3i1.3344

Abstract

Potatoes are one of the staple crops widely cultivated worldwide, with significant production, especially in Europe and North America. However, the economic potential of potatoes has not been fully harnessed, particularly in villages like Sembalun Bumbung, West Nusa Tenggara Province, Indonesia. This article outlines a community engagement approach aimed at enhancing the understanding and skills of the community in utilizing potato flour as a valuable local resource. The implementation methodology involves three main approaches: knowledge transfer, technology transfer, and mentoring. The activities encompass education, hands-on training, as well as testing and evaluating processed potato flour products, particularly noodles. The results of the program demonstrate high enthusiasm among participants, who have successfully produced high-quality potato flour and noodles. This program provides new opportunities for the community to utilize potatoes as an additional source of income and has the potential to significantly boost the village's economy.
Sosialisasi Pengemasan Produk SMART (Sehat, Menarik, Aman, Ramah Lingkungan, dan Tepat Sasaran) Bagi Masyarakat Desa Sembalun Bumbung Sebagai Upaya Meningkatkan Nilai Jual Produk Lokal Di NTB Ningsih, Baiq Nila Sari; Sudirman, Sudirman; Dharmayani, Ni Komang Tri; Yuanita, Emmy; Ulfa, Maria
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 3 No. 1 (2024): Edisi Februari
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v3i1.3346

Abstract

Desa Sembalun Bumbung, yang terletak di lereng Gunung Rinjani, memiliki potensi alam besar dan diakui sebagai World Geopark oleh UNESCO. Meskipun desa ini menghasilkan berbagai produk pertanian dan perkebunan, kebanyakan produk hanya dijual dalam bentuk bahan mentah, terutama untuk wisatawan yang berkunjung langsung. Pengabdian ini berfokus pada upaya meningkatkan pengetahuan dan keterampilan warga Desa Sembalun Bumbung dalam pengemasan produk pertanian dengan metode SMART (Sehat, Menarik, Aman, Ramah Lingkungan, dan Tepat Sasaran). Kegiatan ini melibatkan pendekatan transfer pengetahuan, transfer teknologi, serta pembinaan dan pendampingan. Produk yang menjadi fokus adalah kopi bubuk dan black onion, dengan pengemasan yang lebih inovatif dan estetis. Selain itu, pelatihan juga mencakup pembukaan toko online di e-commerce dan teknik copywriting. Hasil kegiatan menunjukkan bahwa pelatihan berhasil meningkatkan pengetahuan dan keterampilan peserta dalam pengemasan produk. Beberapa dari mereka bahkan tertarik untuk menjalankan bisnis online. Dengan pengemasan yang baik dan pemasaran yang tepat, produk hasil olahan dari Desa Sembalun Bumbung memiliki peluang untuk meningkatkan pendapatan dan berkontribusi pada pertumbuhan ekonomi lokal.
Sosialisasi Pengemasan Produk dengan Plastik Biodegradable Berbahan Selulosa dan Strategi Pemasarannya di Kelompok Wanita Tani Alummahat, Lendang Nangka, Lombok Timur, NTB Ningsih, Baiq Nila Sari; Ulfa, Maria; Yuanita, Emmy; Dharmayani, Ni Komang Tri; Septiyana, Maulida; Haviz, Nur Vinna; Hayani, Hafiyatul; Tamara, Cynthia Claudia; Septiari, Wayan Uni
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 3 No. 2 (2024): Edisi Agustus
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v3i2.6002

Abstract

Desa Lendang Nangka di Lombok Timur, NTB, yang termasuk dalam World Geopark UNESCO di lereng Gunung Rinjani, memiliki potensi besar dalam sektor pertanian. Namun, tantangan muncul dalam pengemasan produk pertanian yang belum ramah lingkungan. Kegiatan ini bertujuan meningkatkan nilai produk pertanian bagi kelompok Wanita Tani Alummahat melalui penggunaan kemasan ramah lingkungan berbahan selulosa dengan metode gelatinisasi dan pemasaran melalui e-commerce. Pelaksanaan kegiatan melibatkan transfer pengetahuan, teknologi, serta pembinaan dan pendampingan untuk memastikan peningkatan nilai ekonomi lokal secara berkelanjutan. Kegiatan meliputi penyuluhan, pelatihan praktis, dan pembentukan Kelompok Usaha Bersama (KUB) sebagai wadah pengembangan ide inovatif. Evaluasi menunjukkan peningkatan signifikan dalam pengetahuan dan keterampilan partisipan terkait pengemasan ramah lingkungan, serta antusiasme yang tinggi. Program ini berkontribusi pada pengembangan strategi pemasaran dan pengemasan yang berkelanjutan di tingkat desa, dengan harapan dapat memberikan dampak positif pada ekonomi masyarakat lokal.
Synthesis and Characterization of Composites-Based Bacterial Cellulose by Ex-Situ Method as Separator Battery Ulfa, Maria; Noviani, Inda; Yuanita, Emmy; Dharmayani, Ni Komang Tri; Sudirman; Sarkono
Jurnal Penelitian Pendidikan IPA Vol 9 No 6 (2023): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i6.3819

Abstract

Many studies have been conducted and developed on cellulose-based battery separator materials, including bacterial cellulose, which has characteristics like plant cellulose. This research aims to synthesize BC/Al2O3 composite and analyze its potential as a battery separator. The synthesis of the composite with the ex-situ method is to immerse BC from tofu liquid waste (fermentation time variation of 6, 7, and 8 days) into Al2O3 suspension. The characterization results showed that the immersion of Al2O3 in BC can increase porosity, electrolyte absorption, and conductivity, indicating that the composite has the potential to be used as a battery separator.
Antibacterial Activity of Marine Sponge (Stylotella sp.) Dharmayani, Ni Komang Tri; Isnaini; Ulfa, Maria; Sudirman; Yuanita, Emmy; Sariningsih, Baiq Nila
Jurnal Penelitian Pendidikan IPA Vol 9 No 6 (2023): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i6.3839

Abstract

Sponges are marine biota that makes up coral reefs that live on the bottom of the waters and have an important role in marine ecosystems. Sponges have bioactive components that have not been widely used by the community. This study aimed to analyze the content of secondary metabolites and the antibacterial activity of the sponge Stylotella sp. antibacterial activity test against Gram-negative (-) Escherichia coli and Gram-positive (+) Staphylococcus aureus was carried out using the good diffusion method. The results of antibacterial testing with various concentrations of 50, 100, and 150 ppm of the isolates showed that the zone of inhibition against E. coli was 11.3; 12; and 13 mm while for S. aureus was 12.3; 13; and 14 mm. The results of antibacterial testing with a concentration of 600 ppm of sponge extract showed an inhibition zone on E. coli and S. aureus in the amount of 13.3 and 14 mm, respectively. The test results showed that the sponge extract and isolate were in the intermediate category and were resistant to E. Coli bacteria. and S. Aureus
Black Cumin Seed Extract as Copper Corrosion Inhibitor in H2SO4 1M: An Experimental and Theoretical Study Elsa, Putri; Hamdiani, Saprini; Yuanita, Emmy; Hadisaputra, Saprizal
Jurnal Penelitian Pendidikan IPA Vol 10 No 10 (2024): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i10.8739

Abstract

Experimental corrosion tests and theoretical calculation were conduct to investigate the corrosion inhibition mechanism of black cumin seed extract for copper in 1 M H2SO4 solution. Electrochemical testing using electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP) method showed that BCS adsorbed to form a protective layer on the copper surface with high inhibition efficiency at 500 ppm concentration (73,35%). Increasing the BCS concentration up to 500 ppm causes the charge transfer resistance increase in the EIS measurement, while the corrosion current density measured by PDP decreases. The values of charge transfer resistance and corrosion current density at 500 ppm BCS are respectively 3687 .cm2 and 2.86 μA.cm-2. The BCS is a mixed inhibitor (anodic and cathodic) that adsorbs physically on the copper surface and obey the Langmuir isothermal adsorption model. Quantum chemical calculation and molecular dynamic simulation show that the studied BCS molecules adsorb strongly on the copper surface with parallel orientation mode. The methyl linoleate (MLIN) molecules from BCS produce the most stable adsorption energy of the other studied compound molecules as a result of molecular dynamic simulation.
Modified Bacterial Cellulose-Based Composite Profile for Drug Release of Tetracycline Hydrochloride Cahyani, Ni Wayan Chyntia Pramesti; Yuanita, Emmy; Dharmayani, Ni Komang Tri; Sudirman, Sudirman; Sudewianingsih, Ni Made; Ulfa, Maria
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 1, May 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i1.37663

Abstract

Bacterial cellulose (BC) is a biodegradable natural polymer with high mechanical strength and non-toxicity. This biopolymer is widely used as a candidate in biomedical fields, such as drug delivery, wound healing, and filtration systems. However, BC lacks antibacterial activity which limits its use in biomedical applications. So, modification of BC-based composite is required. This study aims to examine the effects of modifying BC-based composites with fillers such as graphite (G) and polyvinyl alcohol (PVA) on the release of tetracycline hydrochloride (TCH) drugs. Adding fillers to BC can alter its physical and mechanical properties, reducing its porosity and swelling rate in acidic and alkaline mediums. The drug release of TCH from modified BC-based composites follows the Korsmeyer-Peppas and Hixson-Crowell kinetics models. Adding filler and TCH antibiotic to the composite enhances its antibacterial activity against Staphylococcus aureus with a significant inhibition zone. The results of the inhibition zone show that composites have the potential to be applied in biomedical fields, especially in transdermal patches.
Molecular docking study of mutant levansucrase (E342A) from Bacillus subtilis as a receptor for D-glucopyranose and β-D-fructofuranose ligands: Molecular docking study of mutant levansucrase Aini, Diah Miftahul; Irmayanti, Firda Ade; Yuanita, Emmy; Septiyana, Maulida; Ratnasari, Baiq Desy
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.262

Abstract

Molecular docking is a widely applied computational approach for predicting the binding modes of small-molecule ligands within the active site of a target protein. This research investigated the interactions of mutant levansucrase E342A from Bacillus subtilis (PDB ID: 1PT2) for β-D-fructofuranose and D-glucopyranose ligands. Using AutoDock Vina, the docking results indicated that β-D-fructofuranose exhibited a higher binding energy of –5.6 kcal/mol, compared to D-glucopyranose with a value of –5.4 kcal/mol, suggesting a more stable interaction. It was supported by the binding interaction analysis of β-D-fructofuranose, which established five hydrogen bonds, including direct interactions with the key catalytic residues Asp86 (2.76 Å) and Asp247 (2.64 Å) that are essential for the enzymatic reaction. In contrast, D-glucopyranose formed four hydrogen bonds, involving Arg360 (3.07 Å) and Glu340 (2.64 Å), with most residues contributing to structural stabilization rather than direct catalysis. These results confirm that β-D-fructofuranose plays a crucial role as a determinant of levansucrase activity in the biosynthesis of levan-type FOS, which are known to exhibit strong prebiotic activity.
Co-Authors Al Faris, Muhammad Anjartikasari, Nurul Antari, Gladeva Yugi Arshad, Sazmal E. Budiana, Irwan Cahyani, Ni Wayan Chyntia Pramesti Damayanti, Eva Hikmatul Darmayani, Ni Komang Tri Dharmayani , Ni Komang Tri Diah Miftahul Aini Elsa, Putri Eryani, Farica Fajriati, Elza Kamila Fariz Nafiir, Muhammad Haviz, Nur Vinna Hayani, Hafiyatul Hermawati, Elvira I Gede Adhitya Wisnu Wardhana Ima Arum Lestarini Irmayanti, Firda Ade Isnaini Izzaty, Annisa Nabila Jannah, Baiq Khaeratul Maharani Maharani, Maharani Maria Ulfa Maulida Septiyana Mukhlisatun, Mukhlisatun Muliasari, Handa Ningsih, Apriliya Ningsih, Baiq Nila Sari Noviani, Inda Nurpratama, Jeksi Mahari Nursofia, Baiq Ike Putri, Baiq Yusmiar Aulia Ramdhani, Restu Agung Ratnasari, Baiq Desy Retno Ariadi Lusiana Risma, Melania Rohmana, Ainni Saprini Hamdiani Saprizal Hadisaputra Sariningsih, Baiq Nila Septiari, Wayan Uni Sirojuttolibin, Sirojuttolibin Sopiah, Baiq Sri Seno Handayani Sudewianingsih, Ni Made Sudirman Sudirman Sudirman Sukmaningrum, Afif Dwi Surya Hadi Tamara, Cynthia Claudia Taufan Hari Sugara Tri Dharmayani, Ni Komang Tsani, M. Khairul Wahidatun, Wahidatun