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All Journal JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Berkala Kedokteran MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Majalah Kedokteran Andalas Majalah Patologi Indonesia Bearing : Jurnal Penelitian dan Kajian Teknik Sipil Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Ida Yuliana
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Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Transportation

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HUBUNGAN DURASI KOLESISTEKTOMI LAPAROSKOPI DENGAN PERUBAHAN KADAR BILIRUBIN TOTAL PASIEN KOLELITIASIS Manik, Sarmono Lotma Saipon; Wibowo, Agung Ary; Yuliana, Ida; Winata, Winardi Budi; Rosida, Azma
Homeostasis Vol 7, No 3 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i3.14597

Abstract

Abstract: Laparoscopic cholecystectomy is the gold standard treatment for treating symptomatic cholelithiasis. Recent studies have shown an increase in total bilirubin levels in patients undergoing laparoscopic cholecystectomy due to liver ischemia caused by CO2 pneumoperitoneum during the procedure. The duration of cholecystectomy is thought to be related to changes in total bilirubin levels that occur, where the longer the duration, the longer the ischemia that occurs so that total bilirubin levels will increase. This study aims to analyze the correlation between the duration of laparoscopic cholecystectomy and changes in total bilirubin levels in cholelithiasis patients at RSUD Ulin Banjarmasin. This study uses an analytical observational method with a cohort study approach. There is a positive significant correlation between the duration of laparoscopic cholecystectomy and changes in total bilirubin levels in cholelithiasis patients at RSUD Ulin Banjarmasin with moderate strength (p = 0.000; r = 0.511). Keywords: cholelithiasis, laparoscopic cholecystectomy, total bilirubin. Abstrak: Kolesistektomi laparoskopi adalah tatalaksana baku emas untuk mengobati kolelitiasis bergejala. Studi terkini menunjukkan terjadinya peningkatan kadar bilirubin total pada pasien yang menjalani kolesistektomi laparoskopi karena iskemia hati yang disebabkan pneumoperitoneum CO2 selama prosedur. Durasi kolesistektomi diduga berhubungan dengan perubahan kadar bilirubin total yang terjadi dimana semakin lama durasinya maka semakin lama iskemia yang terjadi sehingga kadar bilirubin total akan semakin meningkat. Penelitian ini bertujuan untuk menganalisis hubungan durasi kolesistektomi laparoskopi dengan perubahan kadar bilirubin total pasien kolelitiasis di RSUD Ulin Banjarmasin. Penelitian ini menggunakan metode observasional analitik dengan pendekatan studi kohort. Terdapat hubungan bermakna positif antara durasi kolesistektomi laparoskopi dengan perubahan kadar bilirubin total pasien kolelitiasis di RSUD Ulin Banjarmasin dengan kekuatan sedang (p = 0,000; r = 0,511). Kata-kata kunci: kolelitiasis, kolesistektomi laparoskopi, bilirubin total.
The Relationship between Drinking Water Sources and Nutritional Status of Elementary School Children on the Martapura Riverbank Khatimah, Husnul; Mutttaqien, Fauzan; Fakhrurrazy, Fakhrurrazy; Arganita, Fidya Rahmadhany; Maulana, Irfan; Yuliana, Ida
Berkala Kedokteran Vol 21, No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i1.22154

Abstract

Environment cleanliness has an indirect impact on nutritional status, particularly in the growth and development stages of children. In this study, school-age children living along the Martapura River's banks were asked to assess their nutritional health and the relationship between their drinking water sources. Study methodology employing a cross-sectional study design and analytical observational techniques. Research participants comprised 53 primary school students in grade 4 from SDN Keliling Benteng Ulu 2, SDN Keliling Benteng Tengah, and SDN Sungai Rangas Hambuku. Groups A (Martapura River water source group) and B (non-river water source group) comprised the seven groups of subjects: group 1 (very poor nutrition); group 2 (undernutrition); group 3 (normal nutrition); group 4 (obesity). Based on the data, it was discovered that 37 individuals (69.8%) had very poor nutritional status, and 39 individuals (73%), had the most commonly used gallons. The nutritional quality of primary school-aged children living along the Martapura Riverbanks did not significantly correlate with the sources of their drinking water, as indicated by the Fisher Exact test results, which revealed p = 0.146 (p > 0.05).
Effect of Mercury Administration as an Oxidative Stress Trigger in Hepato-Renal Injuries Yuliana, Ida; Triawanti; Prenggono, Muhammad Darwin; Oktaviyanti, Ika Kustiyah; Irfan Maulana; Fahrina Ulfah
JURNAL KESEHATAN LINGKUNGAN Vol. 17 No. 2 (2025): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v17i2.2025.159-167

Abstract

Introduction: Mercury as the source of free radicals can trigger the activation of oxidative stress pathways. With its high toxicity, it can cause hepato-renal injuries. There have been many studies on mercury toxicity in various organs, but there are still few scientific studies that examine the hepato-renal injuries caused by mercury through the oxidative stress pathway. This study was conducted to investigate the triggering of the oxidative stress pathway due to mercury exposure in hepato-renal injuries. Methods: Research using randomized true laboratory experiment method with post-test control group design. The number of samples used was 28 Wistar rats. The research group consisted of 2 groups, control group was given aquadest ad libitum, and intervention group was given water contaminated with mercury per oral once a day (15 kg/WB). The treatment period was 14 consecutive days and on the 15th day, blood samples were taken. Oxidative stress marker was assessed by examining MDA and GPx levels and hepato-renal injuries were assessed by examining liver function (ALT and AST) and kidney function (ureum and creatinine). The collected data were analyzed by independent t-test with 95% confidence level; significant if p>0.05. Results and Discussion: The study found that mercury can trigger the activation of oxidative stress pathways and have an impact on hepato-renal function. Conclusion: Research still needs to be continued to prove that impaired hepato-renal injuries also occur at the cellular histomorphologic and discover other biomolecular mechanisms such as activation of inflammatory pathways that can also cause organ damage.
The Effects of Heavy Metal Contamination on Liver Function in a Rat Model Yuliana, Ida; Triawanti, Triawanti; Prenggono, Muhammad Darwin; Oktaviyanti, Ika Kustiyah; Asnawati, Asnawati; Ulfah, Fahrina; Maulana, Irfan
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.145-153

Abstract

Background:  Mining activities in South Kalimantan have been widely associated with the emergence of various health issues through heavy metal contamination in the water. Previous studies have demonstrated that the presence of heavy metals has an impact on physiological alterations inside many organs, notably the liver.Objective: The study aimed to determined the impact of liver damaged from heavy metal of lead (Pb), cadmium (Cd), and mercury (Hg), and the combination of the three in rat model.Methods: Our research used the true experiment laboratory method with a post-test group design. Male white rats (Rattus norvegicus), aged 2–6 months and weighing 250–300 grams, were assigned to the control group and the treatment group. Treatment groups were administered orally with water contaminated with heavy metals of Pb, Cd, and Hg orally for 28 days. The serum markers of liver damaged were then measured.Results: The levels of transaminase enzymes (AST and ALT) in the heavy metal-exposed group were increased compared to the control group. However, the increase was not statistically significant (p = 0.247; p = 0.349, respectively). The group exposed to Hg exhibited the highest levels of AST and ALT in comparison to the other groups.Conclusion: Heavy metal exposure tend to raise transaminase enzyme levels, indicating liver damage. Hg exhibited the greatest transaminase value increase of all heavy metals, indicating its highest potential for liver toxicity.
Helicobacter pylori Increasing Spread of An Inflammation Cells and Gastric Mucosal Atrophy in Gastritis Patients Oktaviyanti, Ika Kustiyah; Widodo, Firman Aprilianto; Hafidza, Fadhil; Rosida, Lena; Wibowo, Agung Ary; Yuliana, Ida
Majalah Patologi Indonesia Vol. 33 No. 1 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i1.654

Abstract

Background Helicobacter pylori (H. pylori) is a bacterium which could reason chronic gastritis and then has the capability to purpose gastric mucosal atrophy. The modifications within the degree of gastric mucosal atrophy have been appreciably correlated with the degree of risk of gastric cancer. The purpose of the observe turned into to research the relationship among H. pylori and the spread of inflammatory cellular infiltration and gastric mucosal atrophy in gastritis patients in Banjarmasin. Method The study was carried out in September-November 2021 using a cross-sectional method with purposive sampling, that is as many as 87 samples of histopathological slides of gastritis patients in the anatomical pathology laboratory of Sari Mulia Hospital, Banjarmasin for the period 2019. Research analysis used Kolmogorov-Smirnov. Slide preparations were stained with immunohistochemistry (IHC) and hematoxylin-eosin (HE). Inflammatory cellular clearance was measured the use of a scale from revised Sydney system and gastric mucosal atrophy become measured the use of the OLGA staging system. Results The results showed as many as 40 (45.98%) H.pylori-positive patients with the most chronic inflammatory cell infiltration in 24 (60%) patients at grade 3 (p<0.001) and for gastric mucosal atrophy as many as 29 (72, 50%) of patients at various stages (p<0.001). Conclusion H. pylori has a significant relationship with inflammatory cell infiltration and gastric mucosal atrophy. H. pylori-positive causes a growth within the severity of inflammatory cellular irritation and mucosal atrophy in gastritis patients.
Co-Authors AA Sudharmawan, AA Agung Ary Wibowo Agung Ary Wibowo, Agung Ary Arganita, Fidya Rahmadhany Arifin Syamsul Asnawati Asnawati Azma Rosida, Azma Desy Puspita Sari Desy Puspita Sari, Desy Puspita Dewi Indah Noviana Pratiwi Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Edi Hartoyo Fahrina Ulfah Fakhrurrazy Fakhrurrazy Farida Heriyani Gusti Adistya Naila Juwita Hafidza, Fadhil Husnawati, Herwinda I Gusti Bagus Wiksuana Ika Kustiyah Oktaviyanti Irfan Maulana Irfan Maulana, Irfan Juwita, Gusti Adistya Naila Khatimah, Husnul Laksono Trisnantoro Lena Rosida Lena Rosida Manik, Sarmono Lotma Saipon Maulidya, Nindy Muthmainnah, Noor Mutiara Shifa Mutttaqien, Fauzan Nazwa Salsabila Hadni Nindy Maulidya Poerwosusanta, Hery Prenggono, Muhamad Darwin Rahmiati Rahmiati Ridhana, Achmad Sheni Chang Shifa, Mutiara Soenanto Roewijoko Sorayya, Laina Triawanti Triawanti Triawanti Ulfah, Fahrina Widodo, Firman Aprilianto Widya Shoffa Rosyida Winata, Winardi Budi