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All Journal The Journal of Experimental Life Sciences (JELS) Jurnal Kesehatan Andalas Jurnal Kimia Mulawarman Syntax Literate: Jurnal Ilmiah Indonesia JUARA: JURNAL WAHANA ABDIMAS SEJAHTERA Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Sjarif Ismail
Fakultas Kedokteran, Universitas Mulawarman, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Aktivitas Anti-Inflamasi In Vitro Ekstrak Etanol Daun Vernonia amygdalina DELILE Dengan Pengujian Stabilisasi Membran Muhammad Khairul Nuryanto; Swandari Paramita; Abdillah Iskandar; Sjarif Ismail; Andre Kusuma Ruslim
Jurnal Sains dan Kesehatan Vol. 1 No. 8 (2017): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v1i8.80

Abstract

Inflammation is a normal process in the human body as a response to injury from the healing process. Meanwhile, chronic inflammation will cause new health problems to patients. Anti-inflammatory agents generally used for those conditions, have several side effects to patients. The objective of this research was to find alternative anti-inflammatory agents, especially from natural sources. Vernonia amygdalina Delile knew locally as “Daun Bismillah” belong to family Apiaceae is one of those potential natural sources for alternative anti-inflammatory agents. This plant is known as traditional medicine and used as material in this research. The experimental method of in vitro anti-inflammatory measurement using membrane stabilization activity for ethanol extracts of V. amygdalina leaves. The results showed that significant differences of EC50 (p<0.05) were achieved between indomethacin as the positive control with V. amygdalina leaves extracts for concentration 1% and 10%. EC50 of leaves ethanol extract of V. amygdalina showed the potential anti-inflammatory activities. It could be concluded that V. amygdalina leaves ethanol extracts to have anti-inflammatory activities, which could be further developed as a new natural source of the anti-inflammatory agents.
Pengaruh Manipulasi Tangan secara Mandiri terhadap Nyeri Ulu Hati pada Mahasiswa Fakultas Kedokteran Universitas Mulawarman: Effect of In-Hand Manipulation on Heartburn Among Students at Medicine Faculty, Mulawarman University Azizah Salsa Billa; Sjarif Ismail; Yenny Abdullah
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1196

Abstract

Heartburn is a physical pain that is experienced and felt in the epigastrium area. It can be managed with non-pharmacological therapy. Massage therapy with in-hand manipulation can be used as non-pharmacological therapy to treat heartburn. This study is aimed at finding the effect of in-hand manipulation therapy on heartburn among students at the Medicine Faculty, Mulawarman University. A quasi-experimental method with a nonequivalent pretest-posttest control group design was applied in this study. The primary data were obtained from a questionnaire, pre-test, and post-test at Medicine Faculty, Mulawarman University. Using a purposive sampling technique, 15 research subjects were assigned to the intervention and control groups. Based on Mann-Whitney statistical analysis, it was found that a p-value of 0.01 (p < 0,05) indicated a significant difference in the intensity scale of heartburn between the intervention group with treatment and the control group without treatment. Therefore, it can be concluded that in-hand manipulation helps to reduce the intensity scale of heartburn. Keywords: Heartburn, Non-Pharmacological Therapy, Massage, Hand Manipulation Abstrak Nyeri ulu hati adalah keluhan fisik yang dialami dan dirasakan di daerah epigastrium pada abdomen. Pada penatalaksanaan nyeri ulu hati dapat dilakukan tindakan terapi secara non-farmakologi. Terapi pijat dengan manipulasi tangan dapat digunakan sebagai terapi non-farmakologi pada penderita nyeri ulu hati. Tujuan dari penelitian ini untuk melihat pengaruh terapi dengan manipulasi tangan secara mandiri terhadap nyeri ulu hati pada mahasiswa Fakultas Kedokteran Universitas Mulawarman. Penelitian ini menggunakan desain eksperimen semu dengan metode nonequivalent pretest-posttest control group design. Data yang didapatkan berasal dari data primer berupa kuesioner, pre-test, dan pos-test di Fakultas Kedokteran Universitas Mulawarman. Teknik sampling dengan metode purposive sampling diperoleh sebanyak 15 subjek tiap kelompok terdiri dari kelompok intervensi dan kelompok kontrol. Hasil uji statistik Mann Whitney didapatkan p sebesar 0,01 (p < 0,05) yang berarti adanya perbedaan bermakna antara persentase perubahan skala nyeri ulu hati pada kelompok intervensi yang diberikan perlakuan dan kelompok kontrol yang tidak diberikan perlakuan. Oleh karena itu, dapat disimpulkan bahwa manipulasi (Su Jok) pada tangan berpengaruh dalam menurunkan skala intensitas nyeri ulu hati. Kata Kunci: Nyeri ulu hati, Terapi Non-Famakologi, Pijat, Manipulasi Tangan
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MEKAI (Pycnarrhena cauliflora DIELS.) TERHADAP Staphylococcus aureus Yayuk Bulam Sarifati; Sjarif Ismail; Khemasili Kosala
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.369

Abstract

Mekai leaves (Pycnarrhena cauliflora Diels.) (P. cauliflora). Are known to contain flavonoid compounds, tannins and phenolics that act as antibacterial agents and are used in the treatment of eye pain. Staphylococcus aureus (S. aureus) is one of the examples of bacterial diseases of eye pain and also a major cause of many infections in communities and health facilities with cases of resistance to various antimicrobial agents. The purpose of this study was to prove the antibacterial activity of mekai leaves ethanol extract against S. aureus bacteria. This research is an experimental research. The stages of this research began by extracting mekai leaves using maceration method with 96% ethanol solvent. Antibacterial activity was tested by the disc method (Kirby-Bauer) using ethanol extract concentrations of mekai leaves (EPC) 20%, 30%, 40%, 50%, 60%, 70%, and 80%, positive control using 25 μg amoxicillin and negative control using DMSO 10%. The measurement results of inhibition zones of mekai leaf ethanol extract 20%, 30%, 40%, 50%, 60%, 70% and 80% respectively were 8.32 mm, 8.32 mm, 8.32 mm, 8.67 mm, 9.00 mm, 8.67 mm, and 8.33 mm. While the positive control measurement of 25 μg amoxicillin against S. aureus is 28.67 mm and the measurement of 10% negative DMSO control does not produce inhibitory zones, so it can be concluded that the ethanol extract of mekai leaves has antibacterial activity, but the area of ​​inhibition zone produced is smaller than amoxicillin 25 µg. The results of statistical tests using Mann Whitney between negative controls with all EPC concentrations obtained significant differences with p values ​​<0.05, it can be concluded that there is antibacterial activity produced at all EPC concentrations.
EFEK HEPATOPROTEKTIF SECARA IN VITRO TERHADAP TANAMAN OBAT (STUDI TERHADAP SKRIPSI MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS MULAWARMAN ANGKATAN 2001- 2009) Desy Merindasari; Swandari Paramita; Sjarif Ismail
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 2 No 2 (2014): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hepatitis merupakan salah satu masalah kesehatan utama di Indonesia dan kebanyakan terjadi padatahap akut. Tatalaksana utama pada tahap ini ialah pemberian bahan-bahan yang berkhasiathepatoprotektif yang banyak terkandung dalam tanaman obat. Penelitian ini mengumpulkan sembilantanaman obat yang telah diuji efek hepatoprotektif secara in vitro dengan induksi CCl4 oleh mahasiswaFakultas Kedokteran Universitas Mulawarman angkatan 2001-2009, kemudian dilakukan penelitianmeta-analisis untuk mengetahui tanaman obat yang memiliki efek hepatoprotektif terbaik. Hasilpenelitian efek hepatoprotektif tanaman obat diatas dihitung nilai konsentrasi efektif 50% (EC50)dengan regresi linier dan heterogenitas diuji dengan One Way Anova, selanjutnya diaplikasikan dalammeta-analisis. Hasil penelitian meta-analisis pada nilai EC50 Mallotus paniculatus, Koordersiodendronpinnatum, Elaeocarpus stipalaris, Piper crocatum, Omalanthus populneus, Spatolobus ferrugineus,Aristolochia papilifolia dan Coccinia grandis didapatkan nilai p<0.001 terhadap Dracontomelon dao.Hasil meta-analisis disimpulkan Dracontomelon dao memperlihatkan efek hepatoprotektif yang palingefektif.
Co-Authors Abdillah Iskandar Andre Kusuma Ruslim Andre Kusuma Ruslim Azizah Salsa Billa Desy Merindasari Djoko W. Soeatmadji Eka Marwansyah Oli’I Endang Sawitri Eva Marliana Fikriah, Ika Gerhana Ferina Hary Nugroho Hasdianti Rosma Khemasili Kosala Khemasili Kosala Khoirunnissa Nabila M. Mulyohadi Ali Magdaleni Agustina Rahayu Marihot Pasaribu Masyhudi Amir Masyudhi Masyudhi Meiliati Aminyoto Muhammad Khairul Nuryanto Muhammad Rizki Rahman Pratama Juan Muhammad Tajul Nataniel Tandirogang Ngadiman Ngadiman Rita Hairani Ronny Isnuwardana Silvia Anitasari Sinar Yani Siti Nur Azizah Swandari Paramita Swandari Paramita Viter Pernando Limbong Wenda Safitri Wilman Rante Marampa Yayuk Bulam Sarifati Yenny Abdullah Yuniati Yuniati Yuwinda Cindy Elisabet Panggabean