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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Penelitian dan Pengembangan Kesehatan Jurnal Tumbuhan Obat Indonesia Edu Masda Journal Jurnal Sylva Lestari Jurnal Farmasi Kryonaut Pharmaceutical Science Journal Jurnal Kefarmasian Indonesia Jurnal Farmasi Ikifa JIFTK (Jurnal Ilmu Farmasi Terapan dan Kesehatan)
Nanang Yunarto
STIKES Widya Dharma Husada, South Tangerang, Banten
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Indonesian Cinnamon (Cinnamomum burmanni (Nees & T. Nees) Blume) as Promising Medicinal Resources: A Review Handayani, Aisyah; Lailaty, Intani Quarta; Rosyidah, A'liyatur; Sari, Dewi Ratih Tirto; Yunarto, Nanang; Suherman, Dadang
Jurnal Sylva Lestari Vol. 12 No. 3 (2024): September
Publisher : Department of Forestry, Faculty of Agriculture, University of Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jsl.v12i3.929

Abstract

Cinnamomum burmanni (Lauraceae) is one of the Cinnamomum species native to Indonesia. Given the worldwide use of cinnamon, the famous spice derived from its bark, cinnamon is also considered to possess medicinal properties. Consequently, a comprehensive review of C. burmanni was conducted to explore its medicinal benefits. This paper reviews several studies on the traditional use of C. burmanni in Indonesia, its phytochemistry, and its pharmacological properties. Traditionally, C. burmanni is utilized not only as spices but also for medicinal purposes, food ingredients, and ritual purposes. The bark is the most commonly used part, while few other parts of the plant are used. Several phytochemical compounds of C. burmanni have been identified. C. burmanni also has been reported to exhibit a wide range of biological activities. From those studies, it can be concluded that the medicinal use of C. burmanni’s bark has been scientifically validated due to its rich content of active compounds. Furthermore, other parts of C. burmanni should be analyzed to determine their content of active compounds. Keywords: active compound, Cinnamomum burmanni, medicinal plant, spice, traditional medicine
The Pharmaceutical Availability of Gambier Leaves Bioactive Fraction Coated Tablet in Simulated Human Body Fluids Sulistyowati, Indah; Yunarto, Nanang; Aini, Nurul; Arifin, Kelik M
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i2.321

Abstract

The widespread usage of traditional medicine either in the developed or developing countries, makes traditional medicine requirements become a major concern in terms of assuring the safety and effectiveness of treatment. WHO suggested dissolution study to support traditional medicine clinical trials. The catechins from Gambier could reduce atherosclerotic lesions case caused by elevated levels of cholesterol, LDL, and triglycerides. Catechin is hygroscopic that becoming unstable. Raising the stability, Gambier is made to a coated tablet. This study aimed to determine the condition of gambier leaves bioactive fraction coated tablet in simulated human body fluids through an in vitro testing using dissolution tester. Three formulations coated tablet with different coating percentage had been tested using dissolution tester apparatus. The test was conducted in water, acid, and buffer as dissolution medium to generate the dissolution profile. Tablet evaluation showed that the three formulations dissolved 71.25% ± 6.26 to 91.05% ±3.05 in the water, acid, and buffer dissolution medium. The gambier leaves bioactive fraction coated tablet had more than 70% pharmaceutical availability in simulated human body fluids.
Aktivitas Antioksidan serta Penghambatan HMG CoA dan Lipase dari Kombinasi Ekstrak Daun Binahong-Rimpang Temu Lawak Yunarto, Nanang; Aini, Nurul; Oktoberia, Intan Sari; Sulistyowati, Indah; Kurniatri, Arifayu Addiena
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1930

Abstract

TThe prevalence of dyslipidemia in Indonesia continues to increase. Anredera cordifolia and Curcuma xanthorrhiza are empirically used in the community to overcome dyslipidemia disorders. Flavonoids as the main compounds in A. cordifolia and curcumin in C. xanthorrhiza have potential as antioxidant activity. This study aims to determine the in vitro mechanism of A. cordifolia and C. xanthorrhiza to reduce cholesterol associated with antioxidant activity. The testing was carried out on a combination of ethanol extracts of A. cordifolia leaves with C. xanthorrhiza rhizomes (1:1) and their single extract. The antioxidant activity test was conducted using DPPH method by making serial dilution of samples and ascorbic acid with adding DPPH. The inhibitory activity of HMG CoA and lipase enzymes was carried out enzymatically using ELISA as well as simvastatin as the comparison. The results showed that the highest antioxidant activity is in C. xanthorrhiza extract samples IC50 16.21 ± 1.74 µg/mL, but was less potential compared to ascorbic acid IC50 7,63±0,85 µg/mL. The most potential inhibition of HMG CoA and lipase is in C. xanthorrhiza samples IC50 8.35 ± 0.02 and 22.35 ± 1.26 µg/mL. The combination of A. cordifolia and C. xanthorrhiza (1: 1) is better than A. cordifolia extract but lower than C. xanthorrhiza extract in antioxidant activity as well as the inhibition of HMG CoA reductase and lipase. The result showed a correlation that the higher antioxidant activity, the higher inhibitory of HMG CoA reductase and lipase respectively.
Front Matter Volume 10 No 1 Tahun 2020 Yunarto, Nanang
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Back Matter Volume 10 No 1 Tahun 2020 Yunarto, Nanang
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Prospek Tanaman Obat sebagai Antihepatitis Yunarto, Nanang
Jurnal Kefarmasian Indonesia VOLUME 3, NOMOR 2, AGUSTUS 2013
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Hepatitis remains a serious global health problem because of the potential impact to morbidity and mortality. Prevalence of hepatitis patients in Indonesia either by viral infection or noninfection increases rapidly. The high cost of treatment hepatitis resulted in the switch in the use medicinal plants to cope with this disease. Several types of medicinal plants were proven to be antihepatitis such as meniran, temulawak, mengkudu and pegagan. The objective of this paper is to provide scientific information study of medicinal plants useful as antihepatitis and their development prospect. The method used in this study is to review the relevant scientific articles in international and national journals. Based on reference studies it has been reported that meniran, temulawak, mengkudu and pegagan have a great potential and prospective as antihepatitis drugs. The important challenge in development of medicinal plants is a constant quality as well as, continuous supply of raw materials and effect assured.
Optimasi Formula Tablet Salut Enterik Natrium Diklofenak dengan Bahan Penyalut Kollicoat 30 D Yunarto, Nanang
Jurnal Kefarmasian Indonesia VOLUME 4, NOMOR 2, AGUSTUS 2014
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Diclofenac sodium is an analgetic and antiinflammation drug and commonly used by oral administration. Because of it’s side effects that can cause stomach irritation, nausea and vomiting, it’s made in the form of enteric-coated. Enteric-coated formulations developed used organic solvent having toxicity and flammability risks. The aim of this study is to develop diclofenac sodium enteric-coated tablets with a water-based coating material. Coating material used is Kollicoat 30 D which is a derivative of acrylic polymer that can dispersed in water. Optimalization of the formula is done by the weight gain 4%, 6% and 8%. The result showed that enteric coated tablets used coating material with weight gain 8% gave the best result with all parameters meet the requirements of the test, there was no change in acid medium for 2 hours and stable released active ingredient in alkaline medium.
Formulation of Dihydroartemisinin-Piperaquine (DHP) Generic Tablet as Antimalarials Drug Yunarto, Nanang; Isnawati, Ani; Aini, Nurul; Kurniatri, Arifayu Addiena; Adelina, Rosa; Setyorini, Herni Asih
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 1, FEBRUARI 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i1.2911

Abstract

The incidence of malaria in Indonesia is about two million cases annually. Dihydroartemisinin-piperaquine (DHP) is the first line therapy recommended for uncomplicated malaria treatment, whereas DHP is still fully imported. The generic DHP tablet formulation has the potential to become the first of DHP drug which is locally produced. This study is aimed to formulate generic DHP film coated tablets for antimalaria drug. Tablets were compressed with the combination of wet granulation for piperaquine phosphate (PQP) and direct compression method for DHA and coated with a moisture barier coating material. The parameters to evaluate the quality of DHP tablets are physical properties, assay, and dissolution test. DHA and PQP assay were performed by HPLC method. The dissolution testing was conducted by in house method using HCl 0.1 N medium. The result shows physical properties of filmcoated tablets meet the requirement, i.e. uniform weight, 7.0-8.5 kp hardness, 0.02% friability and 3 minute 22 seconds disintegration. The assay to determine DHA in tablet was 95.17% and PQP was 97.05%. The result of dissolution testing shows the content of DHA and PQP in the tablet were 113.51% and 96.55%, respesctively. The formulation which is developed meets the general requirement of API in tablet 90–110% and dissolution requirement >75%.
Potensi Fraksi Etil Asetat Ekstrak Daun Gambir (Uncaria gambir Roxb.) sebagai Antihiperlipidemia Yunarto, Nanang; Elya, Berna; Konadi, Laurentia
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i1.2959

Abstract

Hyperlipidemia is the main risk factor for atherosclerosis and coronary heart disease. Ethyl acetate fraction of gambier leaves extract (Uncaria gambir Roxb.) contains catechin secondary metabolites which have potency to be used as antihyperlipidemic. This study aimed to examine the antihyperlipidemic effect of ethyl acetate fraction of gambier leaves extract in vivo. Thirty six males of Sprague Dawley strain, 2,5 months old, were randomly divided into six groups: normal group, negative group (distilled water), positive group (simvastatin 2 mg/200 g bw), dose I (5 mg/200 g bw fraction), II (10 mg/200 g bw fraction) and III (20 mg/200 g bw fraction) groups. Rats were induced with high cholesterol and saturated fat feeds for 28 days, except in the normal group. Furthermore, rats were given the treatment for 28 days. The results showed when compared than negative control, dose III reduced of total cholesterol, triglycerides, LDL levels and increased HDL level (p
Quantitative Analysis of Bioactive Compounds in Extract and Fraction of Star Fruit (Averrhoa carambola L.) Leaves using High Performance Liquid Chromatography Yunarto, Nanang; Sulistyaningrum, Novi
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 1, FEBRUARI 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i1.3481

Abstract

Star fruit (Averrhoa carambola L.) is potential as raw material for medicine, native in tropic areas, including Indonesia. According to other study report, star fruit leaves containing flavonoids apigenin and quercetin as potential anti-inflammatory and anticancer agents. The raw material for the drug in Indonesia mostly obtained through imports from other countries. In order to support the independence of traditional medicine raw materials, it is important to standardize the quality of traditional medicine raw materials, in this case is star fruit leaves by High Performance Liquid Chromatography (HPLC) method. The sample used is star fruit leaves extract obtained from maceration process using ethanol 70%; water fraction, ethyl acetate and hexane fractions obtained from fractionation process of the ethanolic extract. Physical parameters analyzed in sample include appearance, color, odor, taste, extract yield, water content, loss of drying, total ash content, residual solvent. Chemical parameters analyzed include apigenin and quercetin contents. The results shows that star fruit leaves used in this study meet the standards of Indonesian Herbal Pharmacopoeia with highest apigenin (6.37%) and quercetin (4.49%) content are in ethyl acetate fraction.
Co-Authors Ade Nugraheni, Ade Ahmad Sopian Ahmad Sopian Ahmad Sopian, Ahmad Aini Nurul Aini, Nurul Ani Isnawati Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifin, Kelik M Berna Elya Dadang Suherman DIAH PERMATA SARI, DIAH PERMATA Dian Septiyani Dina Aulia Firdaus Esde Dianusana Etieka Firdha Senja Maelaningsih Firdhausia, Iqrimah Furqon, Ainun Gumilang, Nabila Cahya Handayani, Aisyah Hanief Mulia Ar Rossyid Hermiyanti, Evika Herni Asih Setyorini Herni Asih Setyorini Humaira Fadhilah Ida Diana Sari Indah Sulistyowati Indah Sulistyowati Indah Sulistyowati, Indah Indhira Oliffia Prameswari Intan Sari Oktoberia Intan Sari Oktoberia Kurniatri, Arifayu Addiena Lailaty, Intani Quarta Lidya Pratiwi Afri Tjaja Lisa Andriani Lienggonegoro Mawadatun, Ummi Mihardja, Laurentia K. Nenden Nurhasanah Novi Sulistyaningrum Novi Sulistyaningrum Novi Sulistyaningrum Nurul Aini Nurwulan Adi Ismaya Nyoman Fitri Qotrunnada Linggar Pinanditi Rahimah, Vina Nasriani Reswandaru, Uud Nourma Rini Purnamasari Rosa Adelina Rosyidah, A'liyatur Salina, Fitri Sari, Dewi Ratih Tirto Sayyidah Sayyidah Sheila Meitania Utami Siti Arda Mauliti Sopian, Ahmad Sopian Sukmayati Alegantina Sulistyani Sulistyowati, Indah Tri Madesa Patadungan Tri Okta Ratnaningtyas Uud Nourma Reswandaru Uud Nourma Reswandaru Yunita Yunita