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Nanang Yunarto
Center For Biomedical And Basic Technology Of Health, Ministry Of Health
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Determination of HPLC Chromatogram Profile of Katuk (Breynia androgyna (L.) Chakrab. & N.P.Balakr) Plants from Ristoja's Results using Chemometric Analysis Yunarto, Nanang; Alegantina, Sukmayati; Isnawati, Ani
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.6040

Abstract

The katuk plant was known as Sauropus androgynous (L.) Merr, but the name is changed to Breynia androgyna (L.) Chakrab. & N.P. Balakr since the publication of Chakrab's & N.P. Balakr in the 2012 Journal of Plant Taxonomists. The content of chemical compounds and secondary metabolites of katuk leaf are strongly influenced by different habitat or location. Therefore, the Center for Research and Development of Medicinal Plants and Traditional Medicines, National Institute of Health Research and Development (NIHRD) has conducted Research on medicinal plants and herbs (RISTOJA) results on 58 samples of katuk plants originating from 7 provinces and used by 13 ethnic groups in Indonesia. This study aims to obtain plant quality based on the description of the High-Performance Liquid Chromatography (HPLC) chromatogram profile, in order to obtain the suitability of the efficacy of medicinal plants with their benefits for the community in an area. Test using HPLC with a gradient mobile phase, mixture of acetonitrile and methanol for 60 minutes. The results of the chromatogram were analyzed chemometrically by using Principal Component Analysis (PCA) data interpretation. PCA results showed that from HPLC chromatograms at 254 nm and 366 nm, each gave 3 different clusters, namely Clusters A, B and C where each cluster has the same chromatogram profile of katuk plants. Cluster A which was identified at a wavelength of 254 nm was the most used cluster by 7 ethnic groups with a total of 28 Katuk samples. Similarly, the chromatogram at a wavelength of 366 nm with the largest cluster is cluster A which is used by 11 ethnic groups with a total of 45 samples of katuk plants. where each cluster had the same chromatogram profile of katuk Plants.
Antioxidant and Inhibition Lipase Enzyme Activity of Centella asiatica Leaf Extract Yunarto, Nanang; Mawadatun, Ummi; Reswandaru, Uud Nourma; Sopian, Ahmad; Isnawati, Ani; Alegantina, Sukmayati
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6609

Abstract

Hyperlipidemia and many other metabolic diseases are related to oxidative stress. Centella asiatica is a herbal medicine with reported antioxidant effect in vitro. Centella asiatica contains secondary metabolites asiaticoside which are included in the terpenoid group. The study evaluated the respective antioxidant potential and lipase enzyme inhibition of Centella asiatica leaves extract (CAE). Centella asiatica were extracted in ethanol, and the extract was assayed for the measurement of asiaticoside. Ethanolic extracts of asiaticoside content were prepared for HPLC analysis The antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-diphenyl -1-picrylhydrazyl as well as reducing. The anti-hyperlipidemic effect was evaluated in vitro lipase inhibitory activity test carried out enzymatically using the ELISA method with simvastatin as a comparison. The results showed asiaticoside contain in CAE 1.26%; the IC50 value of the antioxidant test of CAE was 11.38 g/mL; the IC50 value of the lipase enzyme in the CAE was 26.14 g/mL. The antioxidant activity of CAE is categorized as very strong and has the potential to inhibit lipase enzymes. The study suggests that CAE has the potential to inhibit lipase activity, suppressing lipid digestion and thereby diminishing entry of lipids into the body.  
In vivo Study of Uric Acid Inhibitory of Catechin from Gambir [Uncaria gambir (Hunter) Roxb] in Male Rats Yunarto, Nanang; Ismaya, Nurwulan Adi; Reswandaru, Uud Nourma; Hermiyanti, Evika; Gumilang, Nabila Cahya; Salina, Fitri
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Hyperuricemia is a metabolic disease characterized by high levels of uric acid in the blood. In silico studies of catechin compounds using molecular docking were able to inhibit the activity of the xanthin oxidase enzyme so that it could reduce uric acid levels. One of the native Indonesian plants that contains catechin is gambier (Uncaria gambir (Hunter) Roxb). This research aims to obtain the efficacy and safety of gambier leaf catechins in reducing uric acid levels. In vivo efficacy testing at doses of 20, 40, and 40 mg/Kg BW with allopurinol as a comparison and the safety of gambier leaf catechin in hyperuricemic male mice through macroscopic and microscopic examination of the liver and kidney organs. The results of research on determining catechin levels using HPTLC obtained levels of 96.06%. Gambier leaf catechin at doses of 20, 40, and 40 mg/Kg BW was able to reduce uric acid levels in the blood serum of mice. The higher the dose of catechin, the better the anti-hyperuricemia effect. In the results of the safety parameters, gambier leaf catechins, there were no specific abnormalities in the liver and kidneys of mice both macroscopically and microscopically. Based on research, it can be concluded that gambier leaf catechin has great potential as an anti-hyperuricemia drug and has good safety if consumed for a long time.
EVALUASI FISIK FORMULASI SEDIAAN OBAT KUMUR YANG MENGANDUNG EKSTRAK BUAH STROBERI DAN DAUN PEPPERMINT Sopian, Ahmad Sopian; Yunarto, Nanang; Rahimah, Vina Nasriani
PHRASE (Pharmaceutical Science) Journal Vol 5, No 2 (2025): Pharmaceutical Science Journal Vol 5 No 2, 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v5i2.1176

Abstract

ABSTRAKWorld Health Organization (WHO) 2022 memperkirakan penyakit mulut mempengaruhi hampir 3,5 miliar orang diseluruh dunia. Berdasarkan Data RISKESDAS 2018 menunjukkan sebanyak 45% responden mengalami masalah gigi berlubang, 19% masalah gigi hilang atau tanggal sendiri, 10,4% kasus gigi goyah, dan 4,1% gigi ditambal. Data ini menunjukkan bahwa kesadaran masyarakat untuk memeriksa kesehatan gigi dan mulut masih kurang. Sehingga obat kumur dapat digunakan sebagai pencegahan atau pengobatan infeksi tenggorokan. Tujuan penelitian ini untuk mengetahui uji viskositas dan uji stabilitas fisik pada formulasi obat kumur ekstrak buah stroberi dan daun peppermint. Metode penelitian yang digunakan metode penelitian eksperimental. Hasil Penelitian yang diperoleh pada uji viskositas mendapatkan hasil rata-rata yaitu pada formulasi F0 (0%) 3,944 cp, F1 (5%) 4,016 cp, F2 (15%) 4,96 cp dan F3 (25%) 6,412 cp. Uji stabilitas fisik pada formulasi obat kumur ekstrak buah stroberi dan daun peppermint terdiri dari uji organoleptis, uji pH, uji kejernihan, dan uji homogenitas. Dari hasil yang didapatkan menunjukkan bahwa sediaan tidak stabil dan tidak memenuhi syarat standar obat kumur.
FORMULASI DAN EVALUASI SEDIAAN SABUN MANDI CAIR EKSTRA DAUN PUCUK MERAH (Syzygium myrtyfolium Walp.) DENGAN BASIS MINYAK ZAITUN Sopian, Ahmad; Yunarto, Nanang; Firdhausia, Iqrimah
Jurnal Farmasi Kryonaut Vol 3 No 2 (2024): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v3i2.109

Abstract

Debu, asap, polusi udara, bahkan paparan sinar matahari merupakan contoh masalah yang timbul pada kulit, tidak hanya itu perangkat elektronik seperti telepon pintar atau leptop yang bereaksi terhadap kradikal bebas. Matahari merupakan penyebab utama dalam masalah kulit sehingga kulit memerlukan nutrisi serta membersihkan dengan teratur dengan sabun. Paparan radikal bebas dan stress oksidatif menyebabkan permasalahan pada kulit sehingga menimbulkan penuaan dini. Daun pucuk merah memiliki aktitivitas antioksidan yang tinggi dalam menangkal radikal bebas. Minyak zaitun mengandung lemak nabati yang baik untuk melembabkan kulit. Meningkatnya minat masyarakat menggunakan sabun dari bahan alami saat ini, mendorong dilakukannya studi pemanfaatan daun pucuk merah untuk dikembangkan dalam sediaan sabun cair. Penelitian ini bertujuan untuk memperoleh formula optimal sabun cair ekstrak daun pucuk merah dengan basis minyak zaitun. Proses ekstraksi daun pucuk merah menggunakan metode maserasi. Formula sabun cair dibuat dengan empat formula yang terdiri F0 berisi bahan tambahan tanpa ekstrak daun pucuk merah; FI-III dengan variasi formula ekstrak daun pucuk merah 2,4, dan 8 gram. Pengujian aktivitas antioksidan menggunakan metode DPPH. Dari hasil penelitian seluruh formula sabun cair memenuhi persyaratan fisik yang mengacu SNI dan cukup stabil. Aktivitas antioksidan F0 memiliki IC50 167,95 µg/mL, FI 97,48 µg/mL, FII 75,87 µg/mL, dan FIII 49,63 µg/mL. Berdasarkan penelitian tersebut, ekstrak daun pucuk merah dapat diformulasikan dalam sediaan sabun cair dengan stabilitas fisik yang baik, serta aktivitas antioksidan terbaik pada formula III
Co-Authors Ade Nugraheni, Ade Ahmad Sopian, Ahmad Aini Nurul Aini, Nurul Ani Isnawati Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifin, Kelik M Berna Elya Dadang Suherman DIAH PERMATA SARI, DIAH PERMATA Firdhausia, Iqrimah Furqon, Ainun Gumilang, Nabila Cahya Handayani, Aisyah Hanief Mulia Ar Rossyid Hermiyanti, Evika Herni Asih Setyorini Indah Sulistyowati Indah Sulistyowati Indah Sulistyowati, Indah Indhira Oliffia Prameswari Intan Sari Oktoberia Intan Sari Oktoberia Kurniatri, Arifayu Addiena Lailaty, Intani Quarta Lisa Andriani Lienggonegoro Mawadatun, Ummi Mihardja, Laurentia K. Novi Sulistyaningrum Novi Sulistyaningrum Nurul Aini Nurwulan Adi Ismaya Qotrunnada Linggar Pinanditi Rahimah, Vina Nasriani Reswandaru, Uud Nourma Rosa Adelina Rosyidah, A'liyatur Salina, Fitri Sari, Dewi Ratih Tirto Sheila Meitania Utami Sopian, Ahmad Sopian Sukmayati Alegantina Sulistyowati, Indah Tri Madesa Patadungan Tri Okta Ratnaningtyas Uud Nourma Reswandaru