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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Penelitian dan Pengembangan Kesehatan Jurnal Tumbuhan Obat Indonesia Edu Masda Journal Jurnal Sylva Lestari Jurnal Farmasi Kryonaut Pharmaceutical Science Journal Jurnal Kefarmasian Indonesia Jurnal Farmasi Ikifa JIFTK (Jurnal Ilmu Farmasi Terapan dan Kesehatan)
Nanang Yunarto
STIKES Widya Dharma Husada, South Tangerang, Banten
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Optimasi Formula Mikroenkapsulasi Ekstrak Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dengan Penyalut Berbasis Air Nugraheni, Ade; Yunarto, Nanang; Sulistyaningrum, Novi
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3692

Abstract

Java turmeric (Curcuma xanthorrhiza Roxb.) is a native plant of Indonesia which has been proved as anti-inflamation, antioxidant, antimicrobial, antitumor, hepatoprotective and antihyperlipidemic agent. The bitter taste with pungent aroma of java turmeric, improper storage that decreasing essential oil and curcuminoid level can be prevented by coating java turmeric as microcapsule. Recently, many microcapsule formulation is made based on organic solvent which have high risk on toxicity and also flammable. The study aimed to produce microcapsule using water based coating material from mixture of tapioca starch and carboxymethylceIlulose (CMC). There are 3 formulas of coating material that were used in this study, with proportion (w/v) of tapioca starch and CMC in formula I (3% : 1 %), formula II (2% : 2 %), and formula III (1% : 3%). The results showed that microcapsule with coating material made from formula III was the best, regarding to the measurements of physical parameter (recovery, water content, absorption efficiency, flow rate and particle size) and chemical parameter (curcumin content) compared to formula I and II. The higher CMC concentration on coating material compotition, the better microcapsule will be produced.
Formulasi Sediaan Minuman Serbuk Fungsional Kombinasi Biji Jagung (Zea mays L. ) dan Madu Utami, Sheila Meitania; Ismaya, Nurwulan Adi; Ratnaningtyas, Tri Okta; Yunarto, Nanang
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5536

Abstract

Corn is a food ingredient that contains carotenoids that are very potential in preventing cancer, adding endurance, as antivirals, fungi, and parasites, carotenoids are also good for vision, growth and reproduction. The highest carotenoid compound in corn is lutein which has potential as an immunomodulator. Honey is also immunomodulatory by triggering macrophages to produce cytokines involved in killing bacteria and tissue repair. The combination of corn and honey in one drink will produce a health supplement preparation that contains antioxidants and immunomodulators that are good for health. The goal of this study was to get the best formula of instant granules physically. Instant granules are made from corn kernels that have been dried with a combination of honey which is processed by dry granulation with variations of corn kernels FI & FIV (15%), FII & FV (25%), FIII & FVI (35%), and FI & FIV honey (35%), FII & FV (25%), FIII & FVI (15%). Instant granules are conducted physical test evaluations including organoleptic tests, flow time, angle of repose, compressibility index, time of granules to dissolve, particle distribution, pH, viscosity of reconstituted and RDA test. The results showed that the granule flow time, angle of repose, compressibility index, time of granules to dissolve, granules particle distribution and viscosity of reconstituted overall physical testing showed no noticeable differences, except against the most preferred taste parameters FVI. So the best formulation has obtained is FVI and shows the result of the RDA test with total energy of 350 kcal/100 grams.
Determination of HPLC Chromatogram Profile of Katuk (Breynia androgyna (L.) Chakrab. & N.P.Balakr) Plants from Ristoja's Results using Chemometric Analysis Yunarto, Nanang; Alegantina, Sukmayati; Isnawati, Ani
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.6040

Abstract

The katuk plant was known as Sauropus androgynous (L.) Merr, but the name is changed to Breynia androgyna (L.) Chakrab. & N.P. Balakr since the publication of Chakrab's & N.P. Balakr in the 2012 Journal of Plant Taxonomists. The content of chemical compounds and secondary metabolites of katuk leaf are strongly influenced by different habitat or location. Therefore, the Center for Research and Development of Medicinal Plants and Traditional Medicines, National Institute of Health Research and Development (NIHRD) has conducted Research on medicinal plants and herbs (RISTOJA) results on 58 samples of katuk plants originating from 7 provinces and used by 13 ethnic groups in Indonesia. This study aims to obtain plant quality based on the description of the High-Performance Liquid Chromatography (HPLC) chromatogram profile, in order to obtain the suitability of the efficacy of medicinal plants with their benefits for the community in an area. Test using HPLC with a gradient mobile phase, mixture of acetonitrile and methanol for 60 minutes. The results of the chromatogram were analyzed chemometrically by using Principal Component Analysis (PCA) data interpretation. PCA results showed that from HPLC chromatograms at 254 nm and 366 nm, each gave 3 different clusters, namely Clusters A, B and C where each cluster has the same chromatogram profile of katuk plants. Cluster A which was identified at a wavelength of 254 nm was the most used cluster by 7 ethnic groups with a total of 28 Katuk samples. Similarly, the chromatogram at a wavelength of 366 nm with the largest cluster is cluster A which is used by 11 ethnic groups with a total of 45 samples of katuk plants. where each cluster had the same chromatogram profile of katuk Plants.
Antioxidant and Inhibition Lipase Enzyme Activity of Centella asiatica Leaf Extract Yunarto, Nanang; Mawadatun, Ummi; Reswandaru, Uud Nourma; Sopian, Ahmad; Isnawati, Ani; Alegantina, Sukmayati
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6609

Abstract

Hyperlipidemia and many other metabolic diseases are related to oxidative stress. Centella asiatica is a herbal medicine with reported antioxidant effect in vitro. Centella asiatica contains secondary metabolites asiaticoside which are included in the terpenoid group. The study evaluated the respective antioxidant potential and lipase enzyme inhibition of Centella asiatica leaves extract (CAE). Centella asiatica were extracted in ethanol, and the extract was assayed for the measurement of asiaticoside. Ethanolic extracts of asiaticoside content were prepared for HPLC analysis The antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-diphenyl -1-picrylhydrazyl as well as reducing. The anti-hyperlipidemic effect was evaluated in vitro lipase inhibitory activity test carried out enzymatically using the ELISA method with simvastatin as a comparison. The results showed asiaticoside contain in CAE 1.26%; the IC50 value of the antioxidant test of CAE was 11.38 g/mL; the IC50 value of the lipase enzyme in the CAE was 26.14 g/mL. The antioxidant activity of CAE is categorized as very strong and has the potential to inhibit lipase enzymes. The study suggests that CAE has the potential to inhibit lipase activity, suppressing lipid digestion and thereby diminishing entry of lipids into the body.  
In vivo Study of Uric Acid Inhibitory of Catechin from Gambir [Uncaria gambir (Hunter) Roxb] in Male Rats Yunarto, Nanang; Ismaya, Nurwulan Adi; Reswandaru, Uud Nourma; Hermiyanti, Evika; Gumilang, Nabila Cahya; Salina, Fitri
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Hyperuricemia is a metabolic disease characterized by high levels of uric acid in the blood. In silico studies of catechin compounds using molecular docking were able to inhibit the activity of the xanthin oxidase enzyme so that it could reduce uric acid levels. One of the native Indonesian plants that contains catechin is gambier (Uncaria gambir (Hunter) Roxb). This research aims to obtain the efficacy and safety of gambier leaf catechins in reducing uric acid levels. In vivo efficacy testing at doses of 20, 40, and 40 mg/Kg BW with allopurinol as a comparison and the safety of gambier leaf catechin in hyperuricemic male mice through macroscopic and microscopic examination of the liver and kidney organs. The results of research on determining catechin levels using HPTLC obtained levels of 96.06%. Gambier leaf catechin at doses of 20, 40, and 40 mg/Kg BW was able to reduce uric acid levels in the blood serum of mice. The higher the dose of catechin, the better the anti-hyperuricemia effect. In the results of the safety parameters, gambier leaf catechins, there were no specific abnormalities in the liver and kidneys of mice both macroscopically and microscopically. Based on research, it can be concluded that gambier leaf catechin has great potential as an anti-hyperuricemia drug and has good safety if consumed for a long time.
KARAKTERISTIK DAN ANALISA KADAR ARTEMISININ DARI DAUN Artemisia annua L. DARI TIGA TEMPAT TUMBUH YANG BERBEDA Ahmad Sopian; Nanang Yunarto; Sulistyani
Jurnal Farmasi IKIFA Vol. 4 No. 1 (2025): JURNAL FARMASI IKIFA VOL.4 NO.1 APRIL TAHUN 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

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Abstract

Artemisia annua L merupakan satu-satunya spesies dalam genus Artemisia yang menghasilkan artemisinin. Rendahnya kandungan artemisinin ini masih menjadi permasalahan dalam industri farmasi. Kandungan artemisinin terbanyak terdapat pada bagian daun. Penelitian ini bertujuan untuk menganalisa karakteristik dan kadar artemisinin dari simplisia daun Artemisia annua L. dari tiga tempat tumbuh yang berbeda. Pemeriksaan karakteristik menggunakan parameter spesufik dan non spesifik dan Metode yang digunakan untuk penetapan kadar adalah High performance Liquid Chromatography (HPLC) yang efektif untuk campuran senyawa yang konsentrasinya kecil. Hasil pemeriksaan organoleptis serbuk simplisia daun Artemisia annua L. dari tiga tempat yang berbeda memiliki karakteristik yang sama, ketiga sampel berbentuk serbuk daun, berwarna hijau dengan bau khas yang wangi dan memiliki rasa yang pahit. Pada pemeriksaan kadar air, ketiga sampel memiliki kadar yang berbeda, kadar air sampel Cibodas 9,17%, sampel Lembang 8,79% dan sampel Tawangmangu 8,28%. Hasil pemeriksaan kadar abu juga menunjukkan hasil yang berbeda, sampel Lembang 0,46%,  sample Cibodas 0,42% dan sampel Tawangmangau dengan kadar abu 0,36%. Hasil penetapan kadar artemisinin dari ketiga sampel juga menunjukkan perbedaan hasil, sample Tawangmangu dengan kadar artemisinin 0,71%, sampel Cibodas 0,26% dan sample Lembang 0,09%. Berdasarkan hasil penelitian ini hasil kadar abu dan kadar air ketiga sampel telah memenuhi syarat mutu simplisia dan kadar artemisinin tertinggi dari ketiga tempat berasal dari sampel Tawangmangu dengan kadar 0,71%.
Uji Antihipertensi Ekstrak Etanol 96% Daun Kubis (Brassica oleracea L.) Pada Tikus Putih Jantan (Rattus norvegicus) Galur Wistar Ahmad Sopian; Nanang Yunarto; Dina Aulia Firdaus
Jurnal Ilmu Farmasi Terapan dan Kesehatan Vol. 2 No. 2 (2024): Jurnal Ilmu Farmasi Terapan dan Kesehatan Vol.2 No.2 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

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Abstract

ABSTRAK Hipertensi termasuk ke dalam salah satu masalah kesehatan penyumbang kematian terbesar di seluruh dunia. Berdasarkan data Riskesdas pada tahun 2018 presentase tekanan darah tinggi di Indonesia mengalami kenaikan hingga 34,1%. Hipertensi disebabkan karena peningkatan produksi hormon yang mempertahankan natrium, peningkatan aktivitas sistem saraf simpatis, hingga kurangnya asupan kalsium dan kalium dalam tubuh. Daun kubis mengandung senyawa bioaktif yang bermanfaat bagi kesehatan khususnya flavonoid yang memiliki sifat sebagai antihipertensi. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak etanol 96% daun kubis terhadap penurunan tekanan darah pada tikus jantan. Penelitian dilakukan secara in vivo dengan metode postest only control group desain. Prosedur kerja dilakukan melalui determinasi tanaman, ekstraksi, pemberian ekstrak terhadap tikus jantan yang telah di induksi dengan prednison + NaCl 2,5% dan pengukuran tekanan darah menggunakan alat pengukur tekanan darah NIBP (Non-Invasive Blood Pressure). Hewan uji terdiri dari 5 kelompok yaitu kontrol negatif, kontrol positif (captopril), ekstrak kubis dengan variasi dosis (100 mg/KgBB, 200 mg/KgBB dan 400 mg/KgBB).Penelitian dilakukan selama 14 hari. Analisis data menggunakan one way ANOVA. Diperoleh data bahwa ekstrak etanol 96% daun kubis yang mengandung senyawa flavonoid sebesar 8,622 mgQE/g, pada dosis 400 mg/KgBB mampu secara signifikan menurunkan tekanan darah sistol dan diastol pada hewan coba jika dibandingkan dengan kontrol negatif pada p<0,05.
EVALUASI FISIK FORMULASI SEDIAAN OBAT KUMUR YANG MENGANDUNG EKSTRAK BUAH STROBERI DAN DAUN PEPPERMINT Sopian, Ahmad Sopian; Yunarto, Nanang; Rahimah, Vina Nasriani
PHRASE (Pharmaceutical Science) Journal Vol 5, No 2 (2025): Pharmaceutical Science Journal Vol 5 No 2, 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v5i2.1176

Abstract

ABSTRAKWorld Health Organization (WHO) 2022 memperkirakan penyakit mulut mempengaruhi hampir 3,5 miliar orang diseluruh dunia. Berdasarkan Data RISKESDAS 2018 menunjukkan sebanyak 45% responden mengalami masalah gigi berlubang, 19% masalah gigi hilang atau tanggal sendiri, 10,4% kasus gigi goyah, dan 4,1% gigi ditambal. Data ini menunjukkan bahwa kesadaran masyarakat untuk memeriksa kesehatan gigi dan mulut masih kurang. Sehingga obat kumur dapat digunakan sebagai pencegahan atau pengobatan infeksi tenggorokan. Tujuan penelitian ini untuk mengetahui uji viskositas dan uji stabilitas fisik pada formulasi obat kumur ekstrak buah stroberi dan daun peppermint. Metode penelitian yang digunakan metode penelitian eksperimental. Hasil Penelitian yang diperoleh pada uji viskositas mendapatkan hasil rata-rata yaitu pada formulasi F0 (0%) 3,944 cp, F1 (5%) 4,016 cp, F2 (15%) 4,96 cp dan F3 (25%) 6,412 cp. Uji stabilitas fisik pada formulasi obat kumur ekstrak buah stroberi dan daun peppermint terdiri dari uji organoleptis, uji pH, uji kejernihan, dan uji homogenitas. Dari hasil yang didapatkan menunjukkan bahwa sediaan tidak stabil dan tidak memenuhi syarat standar obat kumur.
Strategy for Strengthening Pharmacy Services in Primary Health Centers in Indonesia Nanang Yunarto; Ida Diana Sari; Novi Sulistyaningrum; Siti Arda Mauliti; Herni Asih Setyorini; Nyoman Fitri; Arifayu Addiena Kurniatri; Esde Dianusana Etieka
Jurnal Kefarmasian Indonesia VOLUME 16, NUMBER 1, JUNE 2026
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Implementation of pharmaceutical service standards in Indonesian primary health centers remains suboptimal despite recent regulatory mandates Government Regulation No. 28/2024 and Ministry of Health Regulation No. 26/2020, with persistent gaps in workforce distribution, clinical competency, facility infrastructure, supervision, and drug management systems. This study aimed to identify root causes of low implementation and to develop prioritized, operational strategies for strengthening pharmacy services in primary health centers across Indonesia. We conducted focus group discussions and direct field observations using the Minister of Health technical guidelines as the assessment framework; participants included provincial and district health office representatives, heads of community health centers, pharmacists, and pharmaceutical technicians across 20 primary health centers in ten provinces representing Indonesia. Findings reveal five interrelated barriers: chronic shortage and maldistribution of pharmacists and vocational pharmacy staff, with >50% of district-level centers lacking pharmacists; inadequate clinical pharmacy competencies and limited continuing professional development, restricting delivery of PIO, counseling, MESO, home pharmacy care, and visit services; insufficient pharmacy infrastructure and equipment (small, combined warehouse-workspaces, lack of dedicated counseling rooms, refrigeration, and monitoring devices); weak, irregular guidance and supervision at district/city level compounded by absent sanction mechanisms; and fragmented, time-consuming e-purchasing and multiple reporting systems that divert pharmacist time from clinical care. The study recommends a prioritized, integrated policy package clear implementing regulations with routine standardized supervision and sanctions, affirmative HR recruitment and incentive schemes, staged infrastructure upgrades, blended certified competency training with clinical mentoring, and integration/simplification of drug management/reporting system to enhance service quality, ensure medicine availability, and safeguard patient safety in primary care.
In-Silico Study and Antioxidant Capacity from Jamaican Cherry, Red Ginger, Thyme Combination as Multi-target Nutraceutical for Chronic Obstructive Pulmonary Disease Sayyidah Sayyidah; Nenden Nurhasanah; Lidya Pratiwi Afri Tjaja; Nanang Yunarto
Jurnal Kefarmasian Indonesia VOLUME 16, NUMBER 1, JUNE 2026
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Chronic obstructive pulmonary disease (COPD) is one of the health concerns in Indonesia with 4.8 million people suffer from COPD. Global Adult Tobacco Survey Indonesia reported 70.2 million active smokers in 2021. This trend raises concerns about the future trajectory of COPD cases in the country. COPD is a chronic condition that impairs the lower respiratory system due to progressive stimuli that initiate oxidant-antioxidant imbalance contributes to dysregulated inflammation cascade response. Some natural ancient plants that had been used to relieve respiratory discomfort are Ginger (Zingiber officinale var.Rubrum) and Thyme (Thymus vulgaris). In order to give synergetic mechanism to imboost antioxidant capacity also mitigate COPD symptoms, this research combine both plants with Jamaican Cherry (Muntingia calabura) leave as a powder drink formulation. This study is conducted to analysis the potential of these combination through in-silico along with antioxidant capacity evaluation from each formulation.  Total 75 compounds that meet Lipinski rules from the plants had been screened to identify the overlapping genes. Based on Network Pharmacology and validated with molecular docking analysis the potential targets based on the best degree value were IL-8(-11.2 kcal/mol), TNF-α (-8.9 kcal/mol), MMP-9(-7.7 kcal/mol) and IL-6(-7 kcal/mol). The highest binding affinity compound was 3’-hydroxydaidzein from Jamaican Cherry. The powder drink formulation made through wet granulation and antioxidant evaluated using DPPH(1,1-diphenyl-2-picrylhydrazyl) method. The antioxidant capacity was IC50 39.99 ppm; 36.10 ppm ; and 28.30 ppm for F1, F2 and F3 respectively compared to ascorbic acid 13.03 ppm. To conclude, this natural combination nutraceutical has potential as supportive natural remedy for COPD.
Co-Authors Ade Nugraheni, Ade Ahmad Sopian Ahmad Sopian Ahmad Sopian, Ahmad Aini Nurul Aini, Nurul Ani Isnawati Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifayu Addiena Kurniatri Arifin, Kelik M Berna Elya Dadang Suherman DIAH PERMATA SARI, DIAH PERMATA Dian Septiyani Dina Aulia Firdaus Esde Dianusana Etieka Firdha Senja Maelaningsih Firdhausia, Iqrimah Furqon, Ainun Gumilang, Nabila Cahya Handayani, Aisyah Hanief Mulia Ar Rossyid Hermiyanti, Evika Herni Asih Setyorini Herni Asih Setyorini Humaira Fadhilah Ida Diana Sari Indah Sulistyowati Indah Sulistyowati Indah Sulistyowati, Indah Indhira Oliffia Prameswari Intan Sari Oktoberia Intan Sari Oktoberia Kurniatri, Arifayu Addiena Lailaty, Intani Quarta Lidya Pratiwi Afri Tjaja Lisa Andriani Lienggonegoro Mawadatun, Ummi Mihardja, Laurentia K. Nenden Nurhasanah Novi Sulistyaningrum Novi Sulistyaningrum Novi Sulistyaningrum Nurul Aini Nurwulan Adi Ismaya Nyoman Fitri Qotrunnada Linggar Pinanditi Rahimah, Vina Nasriani Reswandaru, Uud Nourma Rini Purnamasari Rosa Adelina Rosyidah, A'liyatur Salina, Fitri Sari, Dewi Ratih Tirto Sayyidah Sayyidah Sheila Meitania Utami Siti Arda Mauliti Sopian, Ahmad Sopian Sukmayati Alegantina Sulistyani Sulistyowati, Indah Tri Madesa Patadungan Tri Okta Ratnaningtyas Uud Nourma Reswandaru Uud Nourma Reswandaru Yunita Yunita