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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kimia Riset Jurnal Penelitian Pendidikan IPA (JPPIPA) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kartika Kimia JURNAL FARMASI GALENIKA Indonesia Natural Research Pharmaceutical Journal (INRPJ) Science Midwifery Jurnal Abdimas Kartika Wijayakusuma Sciences of Pharmacy Borneo Journal of Pharmacy
Aiyi Asnawi
School of Pharmacy, ITB Bandung Jl. Ganesha No. 10 Bandung, Jawa Barat-Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Science Midwifery

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Review: RNA therapy for type 1 & 2 diabetes Bintang, Muhamad Ilham; Asnawi, Aiyi; Agita, Widhiya
Science Midwifery Vol 12 No 2 (2024): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i2.1594

Abstract

Diabetes is a group of metabolic disorders with high blood glucose levels. In type 1 diabetes, blood glucose increases due to damage to pancreatic beta cells. In type 2 diabetes, insulin production is ineffective in glucose uptake into target tissues, increasing glucose levels. Advances in RNA-based technologies indicate that RNA molecules have multiple roles in disease initiation and progression. This review discusses recent developments in RNA therapy for type 1 and type 2 diabetes. RNA therapies, such as mRNA, miRNA, siRNA, lncRNA, and circRNA, show great potential. mRNA and miRNA are important in pancreatic cell development, insulin resistance, insulin sensitivity, and insulin secretion. siRNA improves glucose regulation and improves beta cell dysfunction in T1D and T2D. lncRNAs regulate beta cell responses to inflammation and insulin resistance. circRNA plays a role in M1 macrophage activation associated with T1D pathogenesis and regulation of insulin transcription and secretion. RNA therapy offers revolutionary possibilities in the management and potential cure of type 1 and type 2 diabetes. It is believed to improve and change the clinical approach to diabetes, with research continuing to develop therapies that are safe, effective, and able to change the paradigm of diabetes treatment.
Evaluation of the interaction of diosgenin and its derivatives with cyclodextrin to form a water-soluble inclusion complex: A molecular docking study Rismawanti, Rusi; Asnawi, Aiyi; Muttaqin, Fauzan Zein
Science Midwifery Vol 12 No 3 (2024): August: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i3.1634

Abstract

Diosgenin as an herbal compound has been shown to have activity as an atherosclerosis agent, but the low solubility of the compound may hinder the research process of diosgenin as a medicinal substance. This study aimed to examine the interaction and affinity of diosgenin compounds and their derivatives with the macromolecule cyclodextrin to increase solubility by inclusion complex formation. Alpha and beta cyclodextrins and all ligands were optimized using the density functional theory (DFT) method and the 6-31G base set with hybrid functional B3LYP. Next, molecular docking was carried out using AutoDock. Of the 12 compounds that were tethered to each macromolecule, the compound 2-chloro-3-(((4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9- tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)naphthalene-1,4-dione (M18) and the α-cyclodextrins were found to have the lowest binding free energy (∆G) and inhibition constant (Ki) of -6.42 kcal/mol and 19.80 uM, respectively. The results of this study can be studied and continued as future research material to develop evidence of increasing solubility in compounds by forming inclusion complexes with macromolecules. In conclusion, diosgenin and cyclodextrin macromolecules interact to form a water-soluble inclusion complex.
Co-Authors A., Hamdayani L. Agita, Widhiya Aligita, Widhya Andriansyah, Ivan Arfan Arfan Bintang, Muhamad Ilham Budiana, Wempi Deden Indra Dinata, Deden Indra Dewi Kurnia Ellin Febrina Emma Emawati, Emma Farizan Nur Fazrina Funay, Riska Indradewa, Rhian Kasmawati, Henny La Ode Aman Malina, Rachma Muttaqin, Fauzan Zein Muttaqin, Fauzan Zein Nursamsiar Nursamsiar Pasongli, Kristina Pratama, Reza RAHMAT MULIADI, RAHMAT Rayani, Nur Rismawanti, Rusi Ruslin, Ruslin Sami, Fitriyanti J. Silviana, Lilis Syamsu Nur, Syamsu Trinovitasari, Nita Yuliantini, Anne Zaelani, Diki Ziska, Rahma