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All Journal Jurnal Kartika Kimia Journal of Pharmaceutical and Sciences. Lansau: Jurnal Ilmu Kefarmasian Indonesian Journal of Community Empowerment Jurnal Pengabdian Masyarakat Borneo Journal of Pharmacy
RAHMAT MULIADI, RAHMAT
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Docking and Dynamics Studies: Identifying the Binding Ability of Quercetin Analogs to the ADP-Ribose Phosphatase of SARS CoV-2 Arfan, Arfan; Muliadi, Rahmat; Malina, Rachma; Trinovitasari, Nita; Asnawi, Aiyi
Jurnal Kartika Kimia Vol 5 No 2 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i2.143

Abstract

The SARS-CoV-2 coronavirus outbreak has resulted in severe pneumonia, even death (COVID-19). ADP-Ribose phosphatase (ADPR), a highly conserved macrodomain of this virus, was appropriate for viral RNA replication and transcription. According to studies, quercetin suppresses the main protease and 3-chymotrypsin and papain-like proteases, exhibiting antiviral efficacy against SARS CoV-2. However, quercetin analogs to ADPR have yet to be investigated. This study aims to obtain candidate compounds for ADPR based on binding energy, interaction mode, and binding stability using docking and molecular dynamics (MD) studies.The native ligand (AMP) has estimated binding energy based on docking results of -7.35 kcal/mol. Quercetin analogs, lig_C00013871 (Quercetin 3-(2''-galoylrutinoside), lig_C00006532 ([5',5']-Bisdihydroquercetin), and lig_C00013874 (Quercetin 3-(2G-(E)-p-coumaroylrutinoside) has more negative binding energy, with estimates of -9.43, -9.26, and -8.98 kcal/mol, respectively. These results align with binding energy estimates based on MM-GBSA of -14.76, -29.39, -34.90, and -42.79 kcal/mol for AMP, lig_C00006532, lig_C00013871, and lig_C00013874, respectively. According to the MD simulation, lig_C00006532 and lig_C00013874 will be more effective in stabilizing the ADPR complex. Finally, these two analogs are potential candidate compounds as ADPR inhibitors of SARS CoV-2.
Formulasi, Evaluasi dan Uji Iritasi Sediaan Toner Niacinamide Aspadiah, Vica; Sitti Zubaydah, Wa Ode; Muliadi, Rahmat; Anwar, Irvan; Jumilta
Lansau: Jurnal Ilmu Kefarmasian Vol. 2 No. 1 (2024): Lansau: Edisi April 2024
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/lansau.v2i1.20

Abstract

Toner merupakan sediaan kosmetika berbentuk cair yang umumnya digunakan sebagai pembersih wajah, dimana toner jenis ini mudah di aplikasikan dan mudah meresap ke dalam kulit, yang dalam penelitian ini diformulasikan selain untuk keseimbangan pH kulit tetapi juga dapat melembabkan kulit. Penelitian ini bertujuan untuk mengetahui formula terbaik dengan variasi konsentrasi etanol terhadap karakteristik dan stabilitas fisik dari sediaan toner. Metode penelitian yang digunakan adalah melakukan formulasi sediaan toner dengan menggunakan beberapa variasi konsentrasi etanol dan dievaluasi fisik yang terdiri dari organoleptik, homogenitas, pH, viskositas, dan stabilitas sediaan meliputi uji heating-cooling cycle, uji kesukaan/hedonik dan uji iritasi menggunakan kelinci. Hasil penelitian menunjukkan karakteristik sediaan berupa uji organoleptik dengan tidak berwarna, berbau khas dengan konsistensi yang cair, pH sediaan memenuhi persyaratan, homogen, nilai viskositas pada keseluruhan formula memenuhi syarat, stabilitas sediaan yang baik yang ditandai dengan tidak terjadinya pemisahan fase, pengujian iritasi tidak terjadi eritema dan edema. Berdasarkan hasil penelitian, keseluruhan formula memenuhi nilai uji karakteristik fisik, stabilitas fisik, uji hedonik serta uji iritasi sesuai dengan yang dipersyaratkan, sehingga penggunaan etanol dengan konsentrasi 5-25% dalam sediaan toner tidak mengiritasi kulit.
SOSIALISASI PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) SISWA-SISWI SD NEGERI 34 KENDARI Jabbar, Asriullah; Nasrudin, Nasrudin; Muliadi, Rahmat; Zahra, Nurul; Irmawati, Irmawati; Setiawan, Laode Wawan; Apriliani, Mumut; Rosmeydar, Rosmeydar; Mubarak, Mubarak; Y, Muhammad Ilyas; Juwita, Diana
MAJU : Indonesian Journal of Community Empowerment Vol. 2 No. 3 (2025): MAJU : Indonesian Journal of Community Empowerment, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/maju.v2i3.1254

Abstract

The importance of raising awareness of PHBS in school-age children because schools have a strategic role and position in health education and promotion efforts. PHBS indicators used include washing hands with clean water and consuming healthy snacks. The implementation of community service activities carried out at SD Negeri 34 Kendari,  in class IV was carried out in several stages: 1. Preparation 2. Implementation 3. Evaluation This socialization can increase the knowledge of students of SD Negeri 34 Kendari about how to live a clean and healthy life in the elementary school environment as evidenced by getting good and enthusiastic responses from students when answering questions and practicing the correct way to wash their hands.
SOSIALISASI DAN EDUKASI DAGUSIBU (DAPAT, GUNAKAN, SIMPAN, BUANG) OBAT YANG TEPAT DI SMP NEGERI 5 KENDARI Aspadiah, Vica; Hasnawati, Hasnawati; Nauli, Agnes; Ahmad, Murliyana; Hanija, Nur; Putri, Riski Melani; Tolohuly, Syahril Musafir Ratu; Akib, Nur Illiyin; Muliadi, Rahmat
BESIRU : Jurnal Pengabdian Masyarakat Vol. 2 No. 6 (2025): BESIRU : Jurnal Pengabdian Masyarakat, Juni 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v2i6.1294

Abstract

DAGUSIBU is a Family Movement Program focused on Drug Awareness, aimed at increasing public knowledge and awareness regarding the proper and responsible use of medications. This outreach effort is intended to educate the community on how to implement safe and appropriate drug usage based on the principles of the DAGUSIBU concept. The method applied involves interactive lectures combined with the distribution of questionnaires in the form of pre-tests and post-tests to assess participants’ understanding. The outcomes revealed that most participants showed improved knowledge and comprehension of drug use, as evidenced by the difference in their pre- and post-test results. They became more capable of distinguishing between prescription and non-prescription drugs, identifying legal sources for obtaining medications, and recognizing the importance of proper storage and disposal of pharmaceutical products. Therefore, DAGUSIBU serves as an effective and proactive strategy to promote family health and prevent the misuse of drugs within the community
PENINGKATKAN KESADARAN SISWA-SISWI SMKN 05 KENDARI MELALUI EDUKASI INTERAKTIF MENGENAI IDENTIFIKASI DAN PEMILIHAN KOSMETIK YANG AMAN DAN LEGAL Muliadi, Rahmat; Leorita, Mesi; Tias, Ayuning; Sarry, Elita Puspita; Rosmaria, Rosmaria; Hartawaty, Siska Septy; Septrilia, Shara; Aspadiah, Vica; Malik, Fadhliyah; Indalifiany, Astrid
BESIRU : Jurnal Pengabdian Masyarakat Vol. 2 No. 6 (2025): BESIRU : Jurnal Pengabdian Masyarakat, Juni 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v2i6.1338

Abstract

Educating young people about product safety is becoming increasingly important as the cosmetics industry evolves rapidly. A community outreach program was held at SMKN 05 Kendari in Southeast Sulawesi to enhance teenagers’ awareness of selecting safe and legally approved cosmetic products. The program utilized an engaging educational format, including presentations, group discussions, and interactive Q&A sessions, supported by PowerPoint slides. Key topics included identifying the differences between legal and illegal cosmetics, understanding the dangers of harmful substances in beauty products, and learning how to verify products using the BPOM KLIK platform. The outcome showed a noticeable improvement in participants' knowledge regarding the selection of safe cosmetics. This initiative is expected to encourage more informed consumer choices and help reduce the use of illegal cosmetics among teenagers
Natural Self-Foaming Clay Soap with Etlingera elatior Fruit Extract for Skincare Aspadiah, Vica; Zubaydah, Wa Ode Sitti; Indalifiany, Astrid; Sahidin, Sahidin; Fristiohady, Adryan; Malaka, Muhammad Hajrul; Muliadi, Rahmat; Parrung, Arsyani
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.5800

Abstract

Etlingera elatior (Wualae), a plant recognized for its flavonoid-derived antioxidant properties, presents a potential source for cosmeceutical applications. This study investigated the formulation and evaluation of a Self-Foaming Clay Soap (SFCS) incorporating an ethanol extract of E. elatior fruit. The SFCS base, comprising surfactant as a cleansing and foaming agent combined with bentonite clay for enhanced serviceability and oil adsorption, was formulated with varying concentrations of bentonite (0%, 5%, 10%, 15%, and 20% w/w), designated as FI to FV, respectively, alongside other necessary excipients. The resulting SFCS preparations underwent rigorous physical and chemical stability assessments following accelerated storage conditions (freeze-thaw cycles). Evaluated parameters included organoleptic properties, foam stability and height, viscosity, dispersibility, homogeneity, and pH. The evaluation revealed that Formulation II (FII), containing 5% w/w bentonite, exhibited the most favorable stability profile and met the established criteria for SFCS semisolid preparations. Specifically, FII demonstrated a foam stabilization rate of 84.61% and a foam height of 2.6 cm after freeze-thaw cycling, a viscosity of 10,000 cPs, a spreadability diameter of 4.1 cm, a homogeneous texture devoid of coarse particles, and a skin-compatible pH of 5. These findings suggest that an SFCS formulation incorporating a 5% w/w concentration of bentonite and E. elatior fruit extract holds promising potential as a stable and efficacious skincare preparation.
Sunscreen Innovation: Development of a Water-Resistant Compact Powder Formula Based on Titanium Dioxide for Optimal UV Protection Muliadi, Rahmat; Aspadiah, Vica; Sahumena, Muhammad Handoyo; Aftira, Nidya
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.961

Abstract

Background: Ultraviolet (UV) radiation contributes to skin aging and damage, necessitating effective protection. Sunscreens offer a solution by absorbing, scattering, and reflecting UV radiation, especially those containing titanium dioxide, which has strong UV-blocking properties. Innovation in the form of compact powder sunscreen presents a practical and efficient daily protection approach due to its easy-to-apply formulation. Objective: This study aimed to evaluate the physical characteristics of compact powder sunscreen formulations, including organoleptic properties, pH, homogeneity, adhesion, hardness, and the effect of titanium dioxide on the Sun Protection Factor (SPF) value. Methods: Formulations were prepared and evaluated through physical tests, including organoleptic assessment, pH, homogeneity, adhesion, and hardness, as well as SPF measurement using a UV-Vis spectrophotometer. Results: Titanium dioxide contributed to the light brown color, smooth texture, and vanilla scent of the formulations. It also enhanced the SPF value. The most optimal formulation was Formula 4, containing 25% titanium dioxide, which met the desired physical criteria and achieved an SPF value of 15.06, categorized as ultra protection. Conclusion: The addition of titanium dioxide positively affected the physical characteristics and SPF value of compact powder sunscreen. Formula 4, with 25% titanium dioxide, demonstrated the best results and the highest SPF, making it the most optimal formulation for UV protection
HIDUP SEHAT TANPA ROKOK BAGI SISWA SISWI SMP NEGERI 12 KONAWE SELATAN Jabbar, Asriullah; Muliadi, Rahmat; Nasrudin, Nasrudin; Malik, Fadhliyah; Ningsih, Aprilia Surya; Andriyani, Elfi; Rahayu, Faulia Fajar; Amaliah, Nur Syafitri; Hasanah, Nur Uswatun; Mubarak, Mubarak; Y, Muhammad Ilyas
BESIRU : Jurnal Pengabdian Masyarakat Vol. 1 No. 12 (2024): BESIRU : Jurnal Pengabdian Masyarakat, Desember 2024
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/wjm8qm77

Abstract

Smoking represents a significant public health concern, with the potential to cause a range of diseases. Among adolescents, this phenomenon is on the rise, challenging long-held taboos surrounding its use. The objective of this service was to provide information and education to students of SMPN 12 Konawe Selatan. This activity was conducted using the lecture method and leaflet distribution. The results obtained from the 45 students who attended the counselling session demonstrated an increase in understanding, as evidenced by the pre- and post-test results.
Co-Authors Aftira, Nidya Ahmad, Murliyana Aiyi Asnawi Amaliah, Nur Syafitri Andriyani, Elfi Anwar, Irvan Apriliani, Mumut Arfan Arfan Aspadiah, Vica Fadhliyah Malik Fahria Nadiryati Sadimantara Fristiohady, Adryan Hanija, Nur Hartawaty, Siska Septy Hasanah, Nur Uswatun Hasnawati Hasnawati Indalifiany, Astrid Irmawati Irmawati Jabbar, Asriullah Jumilta Juwita, Diana Malaka, Muhammad Hajrul Malina, Rachma Mesi Leorita, Mesi Mubarak Mubarak Nasrudin Nauli, Agnes Ningsih, Aprilia Surya Nur Illiyin Akib, Nur Illiyin Parrung, Arsyani Putri, Riski Melani Rahayu, Faulia Fajar Rosmaria, Rosmaria Rosmeydar, Rosmeydar SADIMANTARA, I GUSTI RAY Sahidin . Sahumena, Muhammad Handoyo Sarry, Elita Puspita Septrilia, Shara Setiawan, Laode Wawan Sitti Zubaydah, Wa Ode Tias, Ayuning Tolohuly, Syahril Musafir Ratu Trinovitasari, Nita wahyuni wahyuni Y, Muhammad Ilyas Zahra, Nurul Zubaydah, Wa Ode Sitti