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All Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi JSFK (Jurnal Sains Farmasi & Klinis) Buletin Ilmiah Nagari Membangun Jurnal Farmasi Higea JURNAL MEDIA KESEHATAN Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Sains dan Teknologi Farmasi Indonesia Journal of Pharmaceutical and Sciences. Journal of Health Economic and Policy Research (JHEPR)
Najmiatul Fitria
Departmen Of Pharmacology And Clinical Pharmacy. Faculty Of Pharmacy. Universitas Andalas. Padang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Narra J

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Aspirin-clopidogrel combination therapy for ischemic stroke patients: Clinical efficacy and cost-effectiveness analyses in low-resource setting Fitria, Najmiatul; Febiana, Dian; Akram, Muhammad; Yosmar, Rahmi
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.758

Abstract

Understanding the cost-effectiveness of aspirin-clopidogrel combination therapy is crucial in determining its influence on coagulation parameters, specifically prothrombin time (PT) and activated partial thromboplastin time (APTT). The aim of this study was to assess the cost-effectiveness and clinical impact of using the aspirin-clopidogrel combination compared to aspirin alone in managing ischemic stroke. Employing an observational research design, inpatient ischemic stroke cases receiving the aspirin-clopidogrel combination were compared to those treated with aspirin alone. Focusing on the hospital's perspective on costs, the research specifically analyzed medical expenses without discounting costs or effects. The analysis involved comparing the direct medical costs and coagulation parameters between the two treatment groups. Our data revealed that the aspirin-clopidogrel combination demonstrated superior cost-effectiveness over aspirin alone, indicated by the incremental cost-effectiveness ratio (ICER) values for PT (IDR -246,930/second) and APTT (IDR -119,270/second). This indicated that the combination therapy was associated with lower costs while yielding better clinical parameter values. The ICER analysis placed the aspirin-clopidogrel combination in the southeast quadrant, marking its dominance over aspirin monotherapy by demonstrating higher effectiveness at lower costs. These results suggest that combination therapy might be a favorable alternative for managing ischemic stroke, presenting a viable option for consideration in clinical practice. The findings underscore the potential economic and clinical advantages of employing the aspirin-clopidogrel combination in routine stroke management protocols.
Probiotic-rich fermented milk from Lactiplantibacillus plantarum IIA-1A5: Effects on pregnancy health in the animal model Sukma, Ade; Suharto, El LS.; Melia, Sri; Juliyarsi, Indri; Vebriyanti, Ely; Fitria, Najmiatul; Rahmadian, Yudi; Hajrawati, Hajrawati; Arief, Irma I.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1052

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Previous studies of Lactiplantibacillus plantarum IIA-1A5 have shown its potential as a probiotic in modulating gut microbiota and providing health benefits; however, its effects during pregnancy remain underexplored. The aim of this study was to assess the safety of fermented milk enriched with L. plantarum IIA-IA5 in pregnant mice. An experimental study was conducted at Universitas Andalas, Padang, Indonesia. Two groups of pregnant mice (Mus musculus L.) were used, each with six mice. The control group received sterilized milk (10 mL/kg body weight (BW)), while the intervention group was given fermented milk containing L. plantarum IIA-1A5 (107 colony forming unit (CFU)/mL). The evaluated outcomes included maternal weight changes, fetal counts and measurements, and assessments of fetal morphology and skeletal development. Results indicated that the morphology of fetuses showed no significant differences between the control and intervention groups; both groups demonstrated normal development with no detected resorption sites, growth retardation, or hemorrhage. For skeletal development, both groups had the same bone counts, including frontal, parietal, intraparietal, exoccipital, supraoccipital, nasal, pre-maxilla, mandibular, thoracal, lumbar, sternum, and extremities. This study highlights that L. plantarum IIA-1A5-enriched fermented milk was safe, as no significant morphological or bone developmental abnormalities were observed, indicating its potential as a dietary supplement to support pregnancy health. However, further studies involving larger sample sizes may be needed to provide a more comprehensive assessment of its outcomes and safety.
Co-Authors Abdul Muthalib Abdul Muthalib Ade Sukma Ade Sukma Ade Sukma Al Rizka, Nabila Almahdy - A Almahdy A Amni , Hudiyah Anata, Fahira Tri Andela, Mila Arief, Irma I. Asra, Ridho Aulia Zahara Rizki, Nadiatul Chytra Bertdiana Ersa D. Novia Deni Novia Dian Ayu Juwita Dian Suhery Dita Permatasari Dita Permatasari Fahira Tri Anata Febiana, Dian Fitri Handayani Fivi Melva Diana, Fivi Melva Hajrawati, Hajrawati Hansen Nasif Husnia, Khairatul Indri Juliyarsi Khairatul Husnia Lailaturrahmi Lailaturrahmi Lailaturrahmi Lailaturrahmi Lailaturrahmi, Lailaturrahmi Lailiani, Resa Leliani Fitri Anggraini Leliani Fitri Anggraini Machlaurin, Afifah Mardatillah Mardatillah Mariza, Wilnando Melia, Sri Melia, Sri Mila Andela Muhammad Akram Nauratul Ikramah Nguyen, Thang Nur Rahmadani, Intan Nurul Afifah Almunawwarah Rahmadian, Yudi Rahmi Yosmar Rahmi Yosmar Ramadani, Mery Resa Lailiani Rusdi Djamal Sarah Puti Amalia Sari Yulanda Sari, Yelly Oktavia Sri Melia Sri Nani Jelmila Suharto, El LS. Syaputri, Yolanda Zazna Syed Wasif Gillani Tuty Anggraini Vebriyanti, Ely Wilnando Mariza Yelly Oktavia Sari Yolanda Zazna Syaputri Zazna Syaputri, Yolanda