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All Journal Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi INDONESIAN JOURNAL OF PHARMACY JOPS (Journal Of Pharmacy and Science) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea

Auzal Halim

STIFARM Padang

Author-ID : 447126

Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Identification of physical interaction between trimethoprim and sulfamethoxazole by contact method koflerand crystallization reaction Erizal Zaini; Yeyet C. Sumirtapura; Sundani N. Soewandhi; Auzal Halim
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Identification of solid state interaction between TMP and SMZ by hot contact method Kofler and crystallization reaction had been carried out. The results of hot contact method Koflershown formation a new crystalline habit as long and thin needle shaped on contact zone (mixing zone) between Solid TMP and SMZ. It had a different melting point in compared to its single component. Crystallization reaction between two of supersaturated solution of component TMP and SMZ in methanol solvent also indicated the growth of crystal habit as similar as hot contact method Kofler. Solid state interaction between TMP and SMZ was confirmed by microscopic SEM, powder X-ray diffraction, and thermal DSC. Microscopic analysis by SEM showed significantly the change of habit and morphology of crystal as long and thin needle shaped. New powder X-ray diffraction (PXRD) interferences peaks were observed in addition to PXRD interference peaks of each component that proved formation of cocrystalline phase. Thermogram DSC indicated a new endothermic peak corresponding to melting point of a new cocrystalline phase at temperature 178,82 °C.Key words : trimethoprim, sulfamethoxazole, physical interaction, cocrystalline phase

Effect of Drug Information Service Quality Patient Satisfaction City Pharmacy X Padang DELLADARI MAYEFIS; AUZAL HALIM; RIDA HALIM
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.611 KB)

Penelitian ini ditujukan untuk menganalisis pengaruh kualitas pelayanan informasi obat berdasarkan dimensi kualitas jasa yang terdiri dari variabel-variabel reliability (kehandalan), responsiveness (cepat tanggap), assurance (jaminan), empathy (empati) dan tangible (nyata) serta kepuasan pasien. Variabel-variabel tersebut digunakan untuk menganalisis pengaruh kualitas pelayanan informasi obat terhadap kepuasan pasien di Apotek X Kota Padang. Sampel yang digunakan dalam penelitian ini adalah 100 responden, teknik pengambilan sampel ditentukan dengan purposive sampling. Metode analisis yang digunakan adalah metode regresi linier berganda dengan menggunakan uji-t, uji-F dengan taraf signifikansi α = 5%, serta uji- R2 dengan program SPSS versi 17,0. Hasil dari penelitian menunjukkan kualitas pelayanan informasi obat dimensi reliability, responsiveness, assurance , empathy dan tangible bersama-sama memberikan pengaruh signifikan terhadap kepuasan pasien Apotek X Kota Padang sebesar 16,7% (F-hitung = 3,771, p=0,004). Dimensi yang paling memuaskan pasien adalah dimensi yang mempunyai gap paling kecil, yaitu dimensi emphaty (-0.90).

Peningkatan Laju Disolusi Trimetoprim dengan Teknik Co-Grinding Menggunakan Polimer Polivinilpirolidon K-30 AUZAL HALIM; SYUKRAN HAMDENI; ERIZAL ZAINI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 1 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1085.687 KB)

Improvement of the dissolution rate of trimethoprim (TMP) as a model for a poorly water-soluble drug by solid state co-grinding technique with hydrophilic polymer polyvinylpyrrolidone K-30 (PVP K-30) using ball milling apparatus have been investigated. The ratios of drug to hydrophilic polymer were 1:1, 1:3 and 1:5. The solid state interaction of co-ground and physical mixture were characterized by powder X-ray diffraction, thermal DTA, SEM and FT-IR spectroscopy analysis. The dissolution studies were carried out in USP type I apparatus. The result of powder X-ray diffraction analysis showed that the co-grinding of TMP with PVP K-30 decreased the drug’s crystalinity. The endothermic peak of TMP of co-ground products shifted to lower temperature and peak intensity decreased significantly. Powder X-ray diffraction and DTA analysis indicated transformation of crystalline state of TMP to amorphous form by co-grinding with PVP K-30. FT-IR Spectra indicated that no chemical interaction between TMP and PVP K-30 in the co-grounds. Significant enhancement in dissolution rates were observed with the co-ground products of TMP and PVP K-30 as compared to the intact TMP and its physical mixture. In general, the dissolution rates of TMP in the co-grounds were enhanced as the polymer ratio increased.

KARAKTERISASI SIFAT FISIKOKIMIA SISTEM DISPERSI PADAT NIMODIPIN DENGAN POLOXAMER 188 MENGGUNAKAN METODE PENGGILINGAN BERSAMA Henni Rosaini; Yolla Erman Novita Sari; Indra Makmur; Auzal Halim; Wahyu Margi Sidoretno
JURNAL FARMASI DAN MAKANAN Vol 3 No 2 (2020): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v4i2.1351

Nimodipin merupakan salah satu senyawa yang tidak larut dalam air dan termasuk ke dalam Biopharmaceutical Classification System (BCS) kelas II. Sistem dispersi padat adalah campuran yang homogen dari satu atau lebih bahan aktif dalam matriks yang inert dengan tujuan meningkatkan bioavaibilitas dari bahan obat yang sukar larut. Penelitian ini bertujuan untuk melihat pengaruh penambahan poloxamer 188 terhadap sifat fisikokimia dan profil disolusi dari nimodipin yang dibuat dengan metode penggilingan bersama. Perbandingan nimodipin dengan poloxamer 188 untuk F1, F2, F3 berturut – turut adalah 1:9, 2:8, dan 3:7 (b/b). Karakterisasi campuran fisik dan dispersi padat meliputi distribusi ukuran partikel, XRD, FT-IR, DSC, penetapan kadar dan laju disolusi. Hasil penelitian menunjukan bahwa sifat fisikokimia dari setiap formula sudah berbentuk amorf dan nimodipin terdispersi ke dalam matriks polimer. Laju disolusi dari formula meningkat dibandingkan zat murni dan campuran fisik. Laju disolusi paling tinggi ditunjukkan pada F1, dimana pada waktu 60 menit persentase terdisolusinya sebesar 90,5920 %. Analisa statistik efisiensi disolusi menunjukkan perbedaan yang bermakna (sig<0,005) antara semua formula.

Mikroenkapsulasi Metronidazol Dengan Polimer Hpmc Menggunakan Metoda Penguapan Pelarut Auzal Halim; Reni Daniati; Rina Wahyuni
Jurnal Farmasi Higea Vol 5, No 1 (2013)
Publisher : STIFARM Padang

Microencapsulation of metronidazole using HPMC as a polymer by solvent evaporation method had been studied. Microcapsulhad been made into3formulation with 3 ratio variation between Metronidazole and HPMC, 1:1; 1:1.5; 1:2. Microcapsules were analyzed by SEM, DTA, FT-IR, particle sized distribution and dissolution profile. Microcapsules were white to slightly yellow and almost perfectly spherical.Disolution profiles of microcapsules showed that the greater amount of HPMC gave the slower release ofMetronidazole. Dissolution kinetics of microcapsule allowedHiguchi equation, where the realese of Metronidazole from microcapsules were controlled by diffution process.

Karakterisasi Kompleks Inklusi Simvastatin – Β-Siklodekstrin Metoda Co-Grinding dengan Variasi Waktu Penggilingan Maria Dona Octavia; Auzal Halim; Monica Afrinda
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

Characterization of simvastatin - b-cyclodextrin inclusion complexes by co-grinding method had been studied. Solid state simvastatin - b-cyclodextrin inclusion complex prepared by co-grinding method in 1:1 mol ratio. Simvastatin, b-cyclodextrin, simvastatin - b-cyclodextrin physical mixture and inclusion complexes were characterization by X-ray Diffraction (XRD), Fourier Transformation Infra red (FTIR), Differential Thermal Analysis (DTA), scanning electron microscope (SEM) and dissolution studies. X-Ray Diffraction results showed decreasing peak intensity diffractogram very sharp compared to pure simvastatin and differential thermal analysis (DTA) were showed the interaction between simvastatin and b-cyclodextrin. In vitro dissolution rate studies of simvastatin, simvastatin - b-cyclodextrin physical mixture and inclusion complexes. Simvastatin - b-cyclodextrin inclusion complex showed increasing dissolution rate significant compared to simvastatin - b-cyclodextrin physical mixture and pure simvatatin. The results showed the formation of inclusion complex between simvastatin and b-cyclodextrin by co-grinding method.

Pembuatan dan Karakterisasi Dispersi Padat Nifedipin dengan Poloxamer 188 Menggunakan Metode Peleburan Rina Wahyuni; Auzal Halim; Sri Oktavia; Rahmi Purwaningsih
Jurnal Farmasi Higea Vol 8, No 2 (2016)
Publisher : STIFARM Padang

Nifedipin is a poorly water soluble calcium channel blocking agent. Solid dispersion is one of several pharmaceutical technologies that enhance the bioavailability of poorly water-soluble drugs. The objective of this study was to prepare and characterize nifedipin-poloxamer 188 solid dispersion by fusion method. Combination of nifedipin and poloxamer 188 for F1, F2 and F3 were 1:9, 2:8 and 3:7 respectively. The physical mixture and solid dispersions were characterized for particles size distribution, drug-carrier interaction, drug content and dissolution rate. The physicochemical characterization showed a specific characterized of solid dispersion. As indicated from X Ray Diffractograms, DTA thermograms and SEM photographs, nifedipin was in the amorphous form and entrapped in polymer matrix. FTIR results proved no chemical interaction between nifedipin and poloxamer 188. SEM images showed a new morphology of solid dispersions compare with pure drug and physical mixture. The dissolution rate was increased with increasing polymer concentrations. F1 showed the highest dissolution rate among all formulas. Statistic analysis showed a significant differences (P<0.05) of dissolution efficiency among all formulas.

Uji Banding Kualitas Tablet Ketoprofen Generik Dengan Merek Dagang Maria Dona Octavia; Auzal Halim; Marlani Marlani
Jurnal Farmasi Higea Vol 8, No 1 (2016)
Publisher : STIFARM Padang

Ketoprofen is a non steroid Anti Inflamation Drug (NSAID) and most of ketoprofen tablets have been sold in the market are the ones which generic names and branded names. The aim of this research is to compare the quality of ketoprofen tablets 100 mg which are taken from the generic ones and the branded ones, the date were four types of ketoprofen tablets which consist of two types generic tablets and two types of branded tablets. The measurement of ketoprofen tablets quality is based on the quality standard of ketoprofen tablets which refers to The pharmacope Indonesian the fourth editions. The quality parameter of ketoprofen tablets involved similarity test of weight and size, solodity, friability analysis, disintegration time, composition standard test and disolution profile test. Disolution profil test of ketoprofen tablets was ronducted by using paddle method, measured by spectrofotometer UV, and tested by using phosphate buffer power Hidrogen 7.4 as its medium. Then the result was gotten in 60th minutes for each sample. Sample g1 = 94.89%, sample g2 = 97.52%, sample m1= 100.10% and sample m2= 101.08%. Composition standard test of ketoprofen tablets, was conducted by using spectrofotometer UV and tested by using methanol P 75% as its medium. The result of this shows that the quality of sample g1 = 98.92%, sample g2 = 97.02%, sample m1 = 97.97%, m2 = 100,71%. The result of quality parameter test shows that both of generic and branded ketoprofen tablet fullfiks the quality standard of pharmacope Indonesian the fourth editions.

Uji Pengaruh Surfaktan Tween 80 Dan Span 80 Terhadap Solubilisasi Dekstrometorfan Hidrobromida Rina Wahyuni; Auzal Halim; Rina Trifarmila
Jurnal Farmasi Higea Vol 6, No 1 (2014)
Publisher : STIFARM Padang

The solubilization of dextromethorphan hydrobromide using Tween 80 and Span 80 has been studied. CMC’s value of Tween 80 and Span 80 are determined by surface tension method using Du Nouy Tensiometer and refractive index method using ABBE refractometer. The solubility of dextromethorphan hydrobromide using Tween 80 and Span 80 was evaluated at concentrations below the CMC point, above the CMC point and at CMC point. CMC’s value of Tween 80 and Span 80 respectively are 5,9 µg/mL and 6,3µg/mL. The solubility of dextromethorphan hydrobromide using Tween 80 was greater than Span 80 at concentration above the CMC’s value.

Mikroenkapsulasi Isoniazid Menggunakan Natrium Carboxymethilcellulose (NaCMC) sebagai Polimer Dengan Metode Pengeringan Semprot Adik Ahmadi; Auzal Halim; Agel Sagreatra
Jurnal Farmasi Higea Vol 10, No 1 (2018)
Publisher : STIFARM Padang

Isoniazid merupakan obat antituberkulosis yang memiliki waktu paruh pendek. Penelitian ini bertujuan untuk memperpanjang pelepasan isoniazid dengan membentuk sediaan mikrokapsul menggunakan polimer NaCMC dengan metode pengeringan semprot. Mikrokapsul dibuat dalam 3 formula dengan perbandingan isoniazid dengan NaCMC yaitu 1:1; 1:2; 1:3. Karakterisasi mikrokapsul Isoniazid-NaCMC meliputi Penetapan kadar dan uji disolusi yang ditunjang dengan analisa distribusi ukuran partikel, SEM, XRD, DSC dan FT-IR. Penghambatan pelepasan obat paling baik ditunjukkan oleh formula 3 yaitu terdisolusi 95,33 % pada waktu 2 jam dibanding formula 1 sebesar 100,34% dan formula 2 sebesar 100,18 %. Hasil statistik efisiensi disolusi menggunakan uji ANOVA diperoleh nilai Sig. 0,000 (<0,05) dan menunjukkan bahwa terdapat pengaruh penambahan NaCMC terhadap laju disolusi isoniazid melalui uji Dunnet. Pemeriksaan yang dilakukan telah memenuhi syarat mikrokapsul dan mengkonfirmasi hasil disolusi. ukuran distribusi partikel telah memasuki rentang 5-5000 µm dan Morfologi SEM menunjukkan bentuk sferis. Perlambatan laju disolusi dikonfirmasi melalui pemeriksaan XRD yang menunjukkan penurunan intensitas dan derajat kristalin dari isoniazid dan penurunan nilai entalpi pada pemeriksaan DSC serta tidak adanya interaksi kimia antara isoniazid-NaCMC pada pemeriksaan FT-IR.

Co-Authors Adik Ahmadi Agel Sagreatra Amelia Sari, Amelia Aulia Shilvi DELLADARI MAYEFIS Dwi Setyawan Eka Syuryani Elva Yunengsih Elvi Rahma Yulisman Erizal Erizal Erizal Zaini Fathya Intan Lestari, Fathya Intan Helvia Angraeni Henny Lucida Iin Indah Sari Indra Makmur Khairil Armal Maizel Fitri Maria Dona Octavia Maria Dona Oktavia Marlani Marlani Mayariz, Afriza Monica Afrinda Muslim Suardi Nelvianti Nelvianti Oktavia Arianti Rahmadevi Rahmi Purwaningsih Reni Daniati RIDA HALIM Rieke Azhar Rika Indriyani Rina Trifarmila Rina Wahyuni Rini Agustin Rosaini, Henni Salman - Sari Kartika Sri Oktavia Sundani N. Soewandhi Sundani N. Soewandhi, Sundani N. SYUKRAN HAMDENI Tuty Taslim Wahyu Margi Sidoretno Wira Noviana, Wira Noviana Wira Noviana, Wira Noviana Yeni Novita Sari Yeyet C. Sumirtapura Yolla Erman Novita Sari Yustina Susi Irawati Zafrul, Addina Zilfia Zilfia

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