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All Journal Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi INDONESIAN JOURNAL OF PHARMACY JOPS (Journal Of Pharmacy and Science) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea
Auzal Halim
STIFARM Padang
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Dimetil Sulfoksida Terhadap Penetrasi Ketokonazol Melalui Membran Sel Difusi Franz Auzal Halim; Maizel Fitri; Maria Dona Octavia
Jurnal Farmasi Higea Vol 5, No 1 (2013)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (755.646 KB) | DOI: 10.52689/higea.v5i1.73

Abstract

Evaluation about the effect of dimethyl sulfoxide in ketoconazole gel formulation and its penetration using Franz diffusion cell membrane has been done. This gel formulation was using base are dimethyl sulfoxide and tragacant. The vertical type cell of Franz diffusion cell, was used for the penetration test and its quantity determination was done by using spectrophotometry method. The ketoconazole penetration quantity and its capacity of penetrating from dimethyl sulfoxide and tragacanth base are F1: 8.34µg/mL and 21.275%, F2: 10.36µg/mL and 13.705%  F3: 6.56 µg/mL and 16.318% then F4: 10.36µg/mL and 26.030%.
Pengaruh Besar Ukuran Partikel Terhadap Sifat – Sifat Tablet Metronidazol Maria Dona Octavia; Auzal Halim; Rika Indriyani
Jurnal Farmasi Higea Vol 4, No 2 (2012)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1100.748 KB) | DOI: 10.52689/higea.v4i2.64

Abstract

The influence of particle size toward the characteristics of Metronidazole tablets has been studied. Metronidazole that is used for first formua is not crushed, for the second formula is used Metronidazole powder cruhed for 30 minutes, and for the third formula is used Metronidazole powder that is crushed for 3 hours. The crushing process of the powder is done by using Ball mill. The result is analysed by SEM, DTA, FT IR, and particle distribution. DTA data (mettler Toledo) shows the changing of thermodynamic characteristics that occurs when the sample is given heat energy in form of melting shown by endoterm. From the three formula are made Metronidazole tablets by using wet granulation. The formulations of Metronidazole use mucilago gelatin as a binder, lactose as excipients, amylum as desintegrant and aerosil as a lubricant. Tablet evaluation involves the same size, same weight, the strength determining of level and dissolution. Dissolution test is done by using basket method and the level determined by the method of UV Spectrophotometer  at the maximum absorption wavelength of 276.5 nm in HCl 0,1 N. The result of the assay formula 1 is 82,6248%, the formula 2 is 87.3086% and the formula 3 is 95.7037%. Result of dissolution measurement at 60 minutes showed that the average dissolution is 47.902%, 68,584% and 69.320%. The dissolution profile test uses HCl 0,1 N. The analysis of dissolution profile is done by the equality orde 0, orde 1, Higuchi and Korsmeyer peppas. Dissolution profile of Metronidazole tablets approach to Korsmeyer peppas.
Perbandingan Kemampuan Polimer HPMC dengan Gom Arab dalam Meningkatkan Kecepatan Disolusi Tablet Karbamazepin Rina Wahyuni; Auzal Halim; Eka Syuryani
Jurnal Farmasi Higea Vol 7, No 1 (2015)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (777.262 KB) | DOI: 10.52689/higea.v7i1.113

Abstract

The effect of HPMC and gom arabic to do dissolution ability of carbamazepine tablets made by wet granulation has been. There are 5 formulas of carbamazepine granules, mind each formula was containing 40% w/w of carbamazepine. Carbamazepine wese coated by HPMC polymers and gom arabic by spray drying process. formula 0 countain carbamazepine with coanted HPMC and  gom arabic witle formula 1 and 2 is countain carbamazepine coated by HPMC polymers with  concentration 5% w/w and 10% w/w respectively. Formula 3 and 4 is countain  carbamazepine which counted by gom arabic with  concentration 5% and 10% respectively. The result shows that formula 2 show the highest dissolution rate 134.7133%.
KOMPLEKS INKLUSI AMLODIPIN BESILAT-β-SIKLODEKSTRIN DENGAN METODA CO-GRINDING Zafrul, Addina; Halim, Auzal; Mayariz, Afriza; Octavia, Maria Dona
Jurnal Farmasi Higea Vol 16, No 1 (2024)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v16i1.617

Abstract

Kompleks inklusi amlodipin besilat- β-siklodekstrin dibuat dengan metode co-grinding dengan perbandingan mol 1:1. Karakterisasi menggunakan Fourier Transformation Infra-red (FTIR), Scanning Electron Microskop (SEM), X-ray Diffraction (XRD), dan uji disolusi. Hasil FTIR menunjukan bilangan gelombang yang sama karena interaksi fisika dari kedua komponen penyusun yang menunjukkan bahwa tidak terdapat interaksi kimia antara amlodipin besilat dan β-siklodekstrin. Pada analisa SEM, habit amlodipin besilate tunggal sudah berbeda dengan habit amlodipin besilat pada kompleks inklusi amlodipin besilat-β-siklodekstrin yang menunjukan adanya interaksi dengan metoda co-grinding. Difraksi Sinar-X menunjukkan penurunan intensitas puncak difraktogram yang sangat tajam dibandingkan dengan amlodipin besilat murni. Uji disolusi in vitro kompleks inklusi amlodipin besilat-β-siklodekstrin menunjukkan peningkatan laju disolusi yang signifikan dibandingkan amlodipin besilat-β-siklodekstrin campuran fisik dan amlodipin besilat murni. Hasil penelitian menunjukkan terbentuknya kompleks inklusi antara amlodipin besilat dan β-siklodekstrin dengan metode co-grinding.
Co-Authors Adik Ahmadi Agel Sagreatra Amelia Sari, Amelia Aulia Shilvi DELLADARI MAYEFIS Dwi Setyawan Eka Syuryani Elva Yunengsih Elvi Rahma Yulisman Erizal Erizal Erizal Zaini Fathya Intan Lestari, Fathya Intan Helvia Angraeni Henny Lucida Iin Indah Sari Indra Makmur Khairil Armal Maizel Fitri Maria Dona Octavia Maria Dona Oktavia Marlani Marlani Mayariz, Afriza Monica Afrinda Muslim Suardi Nelvianti Nelvianti Oktavia Arianti Rahmadevi Rahmi Purwaningsih Reni Daniati RIDA HALIM Rieke Azhar Rika Indriyani Rina Trifarmila Rina Wahyuni Rini Agustin Rosaini, Henni Salman - Sari Kartika Sri Oktavia Sundani N. Soewandhi Sundani N. Soewandhi, Sundani N. SYUKRAN HAMDENI Tuty Taslim Wahyu Margi Sidoretno Wira Noviana, Wira Noviana Wira Noviana, Wira Noviana Yeni Novita Sari Yeyet C. Sumirtapura Yolla Erman Novita Sari Yustina Susi Irawati Zafrul, Addina Zilfia Zilfia