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All Journal Jurnal Kedokteran Syiah Kuala Indonesian Journal of Urology Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Majalah Kesehatan FKUB Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Respirologi Indonesia Majalah Patologi Indonesia Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Electrical Engineering and Computer Science Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Indonesian Applied Physics Letters Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana
Anny Setijo Rahaju, Anny Setijo
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Airlangga
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Pengenalan Kesehatan dan Keganasan Saluran Reproduksi Wanita pada Siswa SMAN 1 Gondang Nganjuk Mastutik, Gondo; Fauziah, Dyah; Rahniayu, Alphania; Rahaju, Anny Setijo; Sari, Aditya Sita
Jurnal Pengabdian Masyarakat Bhinneka Vol. 4 No. 1 (2025): Bulan September
Publisher : Bhinneka Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58266/jpmb.v4i1.488

Abstract

Latar Belakang. Pengetahuan komprehensif tentang anatomi, fisiologi, dan kondisi patologis yang memengaruhi sistem reproduksi wanita sangat penting untuk meningkatkan kesadaran akan kesehatan reproduksi. Siswa SMA, sebagai bagian dari generasi muda, diharapkan memiliki pemahaman yang memadai di bidang ini. Tujuan kegiatan ini adalah untuk meningkatkan pemahaman tentang kesehatan dan keganasan reproduksi wanita pada siswa di SMAN 1 Gondang-Nganjuk. Metode. Program pengabdian kepada masyarakat dilaksanakan dengan metode presentasi dan diskusi. Materi yang disampaikan meliputi anatomi, fisiologi, faktor risiko penyakit reproduksi, keganasan saluran reproduksi, serta pentingnya deteksi dini dan pemeriksaan kesehatan rutin. Media pembelajaran terdiri dari presentasi LCD, foto, video, dan leaflet. Peningkatan pengetahuan dinilai menggunakan kuesioner pretes dan postes. Hasil.  Kegiatan dilaksanakan pada 16 Juli 2025 yang diikuti oleh lebih dari 300 orang. Sebanyak 326 siswa mengikuti pretes, sementara 331 siswa mengikuti postes. Proporsi jawaban benar meningkat dari 59,23% pada pretes menjadi 67,88% pada pos tes. Kesimpulan. Terdapat peningkatan pemahaman tentang kesehatan dan keganasan reproduksi wanita pada siswa SMAN 1 Gondang Nganjuk sebesar 8,65%. Kegiatan ini direkomendasikan untuk dilaksanakan secara rutin di sekolah setahun sekali pada siswa baru sebagai upaya untuk mencegah penyakit menular seksual dan kanker.
Optimalisasi Deteksi Dini Kanker Serviks Melalui Peningkatan Kapasitas Tenaga Kesehatan dan Edukasi Komunitas di Puskesmas Ngariboyo, Kabupaten Magetan Sari, Aditya Sita; Rahniayu, Alphania; Kurniasari, Nila; Rahaju, Anny Setijo; Mastutik, Gondo; Fauziah, Dyah; Kusumastuti, Etty Hary; Susilo, Imam; Sandhika, Willy; Mustokoweni, Sjahjenny; Ilmiah, Khafidhotul
Jurnal Pengabdian Masyarakat Bhinneka Vol. 4 No. 1 (2025): Bulan September
Publisher : Bhinneka Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58266/jpmb.v4i1.549

Abstract

Latar belakang: Kanker serviks merupakan masalah kesehatan global dengan angka morbiditas dan mortalitas yang tinggi, termasuk di Indonesia. Deteksi dini melalui pemeriksaan Pap smear masih menjadi metode yang sering dipakai, namun akurasi hasilnya sangat bergantung pada teknik pengambilan sampel yang adekuat. Tujuan: Pengabdian masyarakat ini bertujuan untuk Meningkatkan pengetahuan dan keterampilan tenaga kesehatan di Puskesmas Ngariboyo dalam teknik pengambilan sediaan Pap smear yang memadai, dan Meningkatkan kesadaran dan pengetahuan masyarakat tentang deteksi dini kanker serviks. Metode: Metode kegiatan terdiri dari dua bagian utama. Pertama, pelatihan bagi tenaga kesehatan yang meliputi webinar dan praktikum offline untuk mengukur adekuasi sediaan berdasarkan Sistem Bethesda. Kedua, penyuluhan dan skrining offline bagi 95 warga dan 101 peserta pemeriksaan Pap smear. Hasil Hasil pelatihan menunjukkan peningkatan signifikan pengetahuan tenaga kesehatan (nilai 80-100 meningkat dari 58,82% menjadi 82,35%). Penyuluhan juga berhasil meningkatkan pengetahuan masyarakat (nilai 80-100 meningkat dari 80% menjadi 94,74%). Hasil skrining menunjukkan 100% sediaan adekuat dan 100% hasil Negative for Intraepithelial Lesion or Malignancy (NILM). Kesimpulan: Disimpulkan bahwa program ini efektif dalam meningkatkan kapasitas tenaga kesehatan dan kesadaran masyarakat, sekaligus menghasilkan data dasar skrining kanker serviks yang berkualitas bagi wilayah Ngariboyo.
Distribution of Human Papilloma Virus (HPV) in Cervical Adenocarcinoma and Adenosquamous Carcinoma Mastutik, Gondo; Rahniayu, Alphania; Kurniasari, Nila; Rahaju, Anny Setijo; Harjanto, Budi
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Approximately 20-30% of all cervical cancer cases are adenocarcinoma and adenosquamous carcinoma. Around 70% of all of these types of cancer are related to infection of Human Papillomavirus (HPV). This study evaluated the distribution of HPV genotype in cervical adenocarcinoma and adenosquamous carcinoma. A cross-sectional study was conducted at the Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January to December 2015. The sample were 22 formalin-fixed paraffin-embedded (FFPE) of cervical adenocarcinoma tissues and adenosquamous carcinoma tissues. FFPE was used for DNA extraction and followed with HPV genotyping to detect 40 genotypes of HPV, including low risk (LR) and high risk (HR) HPV. The histopathological types of adenocarcinomas were adenocarcinoma NOS and mucinous adenocarcinoma, while the adenosquamous carcinoma types were adenosquamous carcinoma and adenosquamous carcinoma glassy. All of the specimens were infected by HPV. In cervical adenocarcinoma, the infection was by HPV 6, 11, 16, 18, 31, 45, 68B, and 72, and in adenosquamous carcinoma by HPV 6, 16, 18, 45, and 59. HPV 18 was predominant, which was found in 13/22 (59.1%) in adenocarcinoma and 19/22 (86.4%) in adenosquamous carcinoma. Single infection and multiple infections in adenocarcinoma were 13/22 (59.1%) and 9/22 (40.9%), while in adenosquamous carcinoma were 21/22 (95.5%) and 1/22 (4.5%) respectively. The most common HR HPVs found in this study were HPV 18, HPV 45, HPV 16 and LR HPV are HPV 11, HPV 6.
Short-term toxicity test of singalawang extract on male white rats kidney necrosis Naibaho, Ardy Hamonangan; Mustika, Arifa; Rahaju, Anny Setijo
Folia Medica Indonesiana Vol. 52, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Singawalang leaf is used as a traditional medicine by the communities suffering from pneumonia due to TB disease. However, experiments to explain it's toxicity are few. Therefore, this study was conducted to disclose it's toxicity. This was an experimental laboratory study using post–test only control group design. The sampling method was simple random sampling. The animals were randomly divided into 4 (four) groups, each group consisted of 8 (eight) mice, the control group (P0) received distilled water as a solvent material. Treatment group 1 (P1) obtained ethanol extract of singawalang (Petiveria alliaceae) in low doses of 90 mg/kgbw. Treatment group 2 (P2) obtained ethanol extract of singawalang (Petiveria alliaceae) in medium doses of 180 mg/kgbw. Treatment group 3 (P3) obtained ethanol extract of singawalang (Petiveria alliaceae) in high doses of 360 mg/kgbw. Th extracts were given with sonde once a day for 30 days. Results showed that the leaf ethanol extract singawalang (Petiveria alliaceae) does not induce sub-acute necrosis effects on kidney of male white mice (Mus musculus) in doses 90 mg/kgbw, 180 mg/kgbw, and 360 mg/kgbw.
Increased HIF-1alpha And VEGF Expression Found in Various T Stages of Clear Cell Renal Cell Carcinoma Octavianda, Yohana; Rahaju, Anny Setijo
Folia Medica Indonesiana Vol. 54, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

There is an increase in renal cell carcinoma in males aged over fifty years with smoking risk factors. Clear cell renal cell carcinoma is the most common malignant tumor found in the kidneys that have an aggressive nature. This carcinoma is classified according to TNM into T1, T2, T3 and T4 stages. The higher the T stage, the worse the prognosis of the patient, as it involves the role of the HIF-1a transcription factor accumulated under hypoxic condition due to inactivation of VHL, thus activating VEGF. So far, clear cell renal cell carcinoma frequently found in smoking males of fifth decade of age or older has not been explained.. An observational analytic study was conducted on the sample of paraffin blocks of patients with clear cell renal cell carcinoma in 2010-2016. T1, T2, T3, and T4 stages of 9 samples, 12 samples, 12 samples and 6 samples, respectively, were collected in Anatomic Pathology Laboratory, Dr. Soetomo Hospital, Surabaya. Detection of HIF-1a and VEGF expression was performed using immunohisto-chemical immunity with HIF-1a and VEGF antibodies. The results were analyzed statistically by Kruskal-Wallis and Mann-Whitney methods. The correlation between HIF-1a and VEGF in T stages was analyzed using Spearman method. There was a difference of HIF-1a expression between stage T1 with T2, T1 with T3, T1 with T4 (p=0.041, p=0.000, and p=0.002), stage T2 with T3 and stage T2 with T4 (p=0.001, and p=0.013). There was a difference in VEGF expression in stage T1 with T2, T1 with T3, T1 with T4 (p=0.007, p=0.000, and p=0.002), and stage T2 with T3 (p=0,001). There was a correlation between HIF-1a and VEGF expressions with all T stages (rs=0.624 with p 0.000). As a conclusion, the higher the stage of T, the higher the expression of HIF-1a and VEGF. The higher the levels of HIF-1a and VEGF, the worse the prognosis of clear cell renal carcinoma. HIF-1a and VEGF play a role in the pathogenesis of clear cell renal cell carcinoma. Thus, HIF-1a and VEGF can be developed as prognostic markers. Increased Hif-1aAnd Vegf Expression Found In Various T Stages Of Clear Cell Renal Cell Carcinoma
The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma Mastutik, Gondo; Rahniayu, Alphania; Kurniasari, Nila; Rahaju, Anny Setijo; Alia, Rahmi; Mustokoweni, Sjahjenny
Folia Medica Indonesiana Vol. 55, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Ethanol extract of leaves and petiole of pegagan (Centella asiatica) is potential as antimicrobial and antifertility. This study was to investigate whether ethanol extracts of leaf and petiole of Centella asiatica has potential as an antimicrobial and can decrease sperm quality and spermatogenic cells of mice. This was a randomized controlled study using Centella asiatica plant from which we made ethanol extract. The extract of the leaves and petiole of Centella asiatica was subjected to antimicrobial test using the bacteria S. aureus, S. epidermidis, and A. aerogenes. Then the observation was done after a 24-hour-old bacterial cultures by measuring the diameter of the clear zone in mm. Thereafter, the extract was given to randomly grouped mice that were divided into two groups receiving the leaf extract in one group and the petiole exract in another for 35 days. On day 36 the mice were sacrificed for spermatozoa quality and testicular histology examination. Statistical analyses used in this study were ANOVA and LSD tests. There was inhibition zone difference between leaf and petiole (p=0.000). Inhibition zone between bacteria S. epidermidis, S. aureus and A. aerogenes showed no difference (p=0.198). Inter-dose inhibition zone showed difference (p=0.000). Centella asiatica leaf extract showed inhibition zone better than that of Centella asiatica petiole extract. In spermatozoa quality test, there was effect of Centella asiatica leaf extract on sperm motility (p<0.05), viability (p<0.05), morphology (p<0.05) and concentration (p<0.05). No effect of pegagan petiole extract was found on sperm motility (p<0.05), viability (p<0.05), abnormal morphology (p<0.05) and concentration (p<0.05). Highest degradation of spermatozoa quality was obtained from Centella asiatica petiole extract at a concentration of 150 mg/kg bw. Spermatogenic cell test results showed no effect of Centella asiatica leaf extract in decreasing spermatogonia (p=0.000), spermatocytes (p=0.000), and spermatids (p=0.000) counts. No effect of pegagan petiole extract in decreasing the number of spermatogonia, spermatocytes and spermatids. The highest reduction spermatogenic cells of seminiferous tubules was obtained by Centella asiatica petiole extract in a concentration of 150 mg/kg bw. In conclusion: Centella asiatica leaf and petiole extract has antimicrobial potency as contra-ceptives
Analysis of the expression of fas/cd95 and hsp70 in low and high grade urothelial cell carcinoma of the bladder Heryanto, Heryanto; Kusumastuti, Etty Hary; Rahaju, Anny Setijo
Folia Medica Indonesiana Vol. 53, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Urothelial Cell Carcinoma (UCC), also called transitional cell carcinoma of the bladder, is the most common malignancy in urinary tract. The prognosis of this disease is highly dependent on the histological grading at diagnosis. Fas/CD95 has a role in apoptotic process, whereas HSP70 has an antiapoptotic role. This study aimed to analyze the expression of Fas/CD95 and HSP70 in low grade and high grade urothelial cell carcinoma in the bladder. This was an analytic observational study with cross sectional approach. Population and sample were paraffin blocks of urothelial cell carcinoma in the Laboratory of Anatomic Pathology, Dr. Soetomo Hospital, Surabaya in the period of January 2011-December 2016. Each grading of urothelial cell carcinoma was randomly sampled. Immunohistochemystry with Fas/CD95 and HSP70 were performed. Expression of Fas/CD95 and HSP70 were assessed semiquantitatively. Expression of Fas/CD95 and HSP70 were analyzed using Mann-Whitney test and Spearman test. The results showed there was significant different in expression of Fas/CD95 and HSP70 in low and high grades in urothelial cell carcinoma. There was no significant correlation between the expression of Fas/CD95 and HSP70 in urothelial cell carcinoma. As a conclusion, the role of CD95 and HSP70 expression can be useful as marker for the diagnosis, especially in the determination of the grade of differentiation.
The Potential of Ethanol Extract of Dutch Eggplant (Solanum betaceum) against caspase-3 Expression in the Kidneys of Mice (Mus musculus) Exposed to Lead Acetate Rifatus Solicha; Rahaju, Anny Setijo; Qorib, Mohammad Fathul; I’tishom, Reny; Arfian, Nur
Majalah Biomorfologi 2026: MAJALAH BIOMORFOLOGI (IN PRESS)
Publisher : Universitas Airlangga, Surabaya, Indonesia

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Abstract

Background: Lead (Pb) exposure remains an environmental health concern due to its toxicity, particularly to the kidneys, where it can cause nephrotoxicity. The accumulation of lead acetate induces oxidative stress through elevated reactive oxygen species (ROS) levels, which subsequently activate the apoptosis pathway characterized by increased caspase-3 expression. Caspase-3 serves as the primary executor enzyme in apoptosis and functions as a key indicator of kidney cell injury. Natural antioxidants, such as the ethanol extract of Dutch eggplant (Solanum betaceum), are rich in flavonoids and can protect kidney tissue by neutralizing free radicals and inhibiting apoptosis. Given these properties, Solanum betaceum has emerged as a candidate for protecting the kidneys against damage caused by heavy metals. Objective: This study investigated whether ethanol-extracted Dutch eggplant could protect the kidneys of mice (Mus musculus) exposed to lead acetate by looking at its effect on caspase-3 expression. The research also examined whether the extract’s protective effect depended on the dose given. Materials and Methods: This experimental research employed a post-test control group design. The authors classified the mice into five groups (K0, K1, P1, P2, and P3). The treatment groups received Dutch eggplant extract at varying doses administered concurrently with lead acetate exposure. Caspase-3 expression was evaluated using immunohistochemistry (IHC) and assessed using an H-score, followed by statistical analysis with SPSS. Results: Lead acetate increased caspase-3 expression compared to the negative control group (K1: 122.00 vs. K0: 71.00). Administration of Dutch eggplant extract reduced caspase-3 expression in a dose-dependent manner. Conclusion: The ethanol extract of Dutch eggplant has demonstrated potential nephroprotective effects against lead acetate-induced kidney damage by reducing caspase-3 expression.
Accuracy of Fine Needle Biopsy (FNAB) in Lymph Nodes Tuberculosis Sari, Aditya Sita; Kurniasari, Nila; Rahaju, Anny Setijo; Kusumastuti, Etty Hary; Rahniayu, Alphania
Health and Medical Journal Vol. 8 No. 1 (2026): HEME January 2026
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v8i1.1875

Abstract

Introduction: Tuberculosis (TB) is an infection caused by Mycobacterium Tuberculosis (Mtb) that can attack various organs such as peripheral lymph nodes. Fine needle aspiration biopsy (FNAB) is often used as one of the modalities of diagnosis of lymph node tuberculosis to determine the management of patients. Objective: The objective of this study is to evaluate the accuracy, efficiency, and effectiveness of FNAB in diagnosing lymph node tuberculosis. The findings will assess whether FNAB can be adopted as a standard diagnostic and management tool for patients with this condition. Methods: This is an observational analytic cross-sectional study in the population of patients with suspicion of lymph node tuberculosis at the Anatomical Pathology Unit of Dr. Soetomo General Academic Hospital Surabaya in one year period. FNAB examination was performed with Modified Grunwald Giemsa (MGG) and Ziehl Nielsen (ZN) staining to detect AFB (Acid Fast Bacilli) organisms, as well as PCR (Polymerase Chain Reaction) of peripheral blood. The results were analysed using Chi square statistic test. Results: The sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of FNAB examinations were 100%, 33%, 59% and 100%, respectively, meanwhile the sensitivity and specificity of PCR peripheral blood examination were 8% and 70% compared to the ZN examination of the FNA aspiration material. Conclusion: FNAB had a higher sensitivity than PCR of peripheral blood to detect Mycobacterium Tuberculosis infection; on the other hand PCR of peripheral blood had a higher specificity than FNAB to detect Mycobacterium Tuberculosis infection.
Tubule Formation Segmentation Of Histopathological Image Of Breast Cancer By Using Clustering Method Waasilah, Hadiyyatan; Rulaningtyas, Riries; Winarno, Winarno; Rahaju, Anny Setijo
Indonesian Applied Physics Letters Vol. 1 No. 1 (2020): Indonesian Applied Physics Letters - June 2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iapl.v1i1.21338

Abstract

Histopathological assessment is one of the examinations that allows the classification of breast cancer based on its level. Histopathological assessment factors are based on tubule formation, nuclear pleomorphism, and the mitotic count. This study only focused on tubule formation. The tubule formation was represented by a lumen surrounded a  nucleus. The segmentation of tubule histopathology of breast cancer method was using a combination of k-means clustering and graph cut. The image data used in this study were 15 images of breast cancer histopathology preparations using 5 variations in the number of clusters (k) in the k-means clustering method. The best results of tubule formation segmentation using k = 4, with an average value of balanced accuracy was 81.08% and the most optimal balanced accuracy results was 94.34%.
Co-Authors Abdurrahman Hasyim Asy’ari Alphania Rahniayu Aniek Meidi, Aniek Aniek Meidy Utami Ari Wanda, Dewi Sartika Ariadna Anggi Pasang Ariani, Grace Arifa Mustika Arifa Mustika Aulia Nur Fadila Budi Harjanto Budi Harjanto Dewi Sartika A. W. Dewi, Rosa Amalia DWI SURYANTO DYAH FAUZIAH, DYAH Eddie Saputra Ferdinant Martinus Djawa Fira Soraya Gondo Mastutik HERAWATI, LILIK Heriyawati, Heriyawati Heryanto Heryanto Heryanto Heryanto I'tishom, Reny Ilmiah, Khafidhotul Imam Susilo Isnin Anang Marhana Izzan Khalidah Binti Muhamad I’tishom, Reny Katherine Kho Khafidhotul Ilmiah Khafidhotul Ilmiah Krismaningrum, Veronika Intan Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Leonita Agustin Hambalie Linda Dewanti Mas`udi, Achmad Fayyad Mohammad Fathul Qorib Naibaho, Ardy Hamonangan Nila Kurniasari Novalia Chumaladewi Guntarno Nur Arfian, Nur Octavianda, Yohana Osmalina Nur Rahma PUNGKY MULAWARDHANA, PUNGKY Qonitatillah, Ana Rahmi Alia Rahmi Alia Rahmi Alia, Rahmi Renny I’tishom Reza Wangsanagara Ridholia Ridholia Ridholia Ridholia, Ridholia Rifatus Solicha Riries Rulaningtyas Roostantia Indrawati S.Pd. M Kes I Ketut Sudiana . Salman Aziz, Muhamad Abi Sari, Aditya Sita Sheilla Matheos Sjahjenny Mustokoweni, Sjahjenny Soetojo Soetojo Solly Aryza Suhartono Taat Putra Tarmono Djojodimedjo Tri Wulanhandarini Trianto, Heru Fajar Tuti Andayani Ummi Hanifah Vicky Sumarki Waasilah, Hadiyyatan Willy Sandhika Winarno Winarno Wira Santoso Ongko Wiratama, Priangga Adi Yohana Octavianda