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All Journal Jurnal Veteriner Jurnal Kedokteran Syiah Kuala Indonesian Journal of Urology Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Majalah Kesehatan FKUB Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Respirologi Indonesia Majalah Patologi Indonesia Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Electrical Engineering and Computer Science Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Indonesian Applied Physics Letters Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana

Anny Setijo Rahaju, Anny Setijo

Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Airlangga

Author-ID : 496033

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Collecting Duct Carcinoma: A Rare Entity Ferdinant Martinus Djawa; Anny Setijo Rahaju
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 1 (2020)
Publisher : Universitas Muhammadiyah Surabaya

ABSTRACTCollecting duct carcinoma is a rare and highly aggressive subtype of renal cell carcinoma. The incidence rate is less than 1-2% of all renal tumors and usually, affect middle-aged adult, commonly in men. We reported a 76-year-old man complains of an intermittent painless gross hematuria, abdominal mass and left flank pain for approximately three months. The CT abdomen showed a slightly enhancing solid mass in the left kidney and para-aorta lymphadenopathy. Cut surfaces of the kidney showed a solid-cystic and ill-defined greyish-white tumor. Microscopically, tumor formed solid sheets and tubulopapillary structures lined by neoplastic cells, hobnailing nuclei, abnormal mitotic, and a desmoplastic stroma with lymphoplasmacytic infiltration, and the immunochemical profile were PAX8 (+) /p63 (-). Based on these findings, the diagnosis was a collecting duct carcinoma. This tumor arising from the collecting duct of Bellini in the renal medulla, accounts for less than 1-2% of all renal masses and important to be distinguished from other tumors due to differences in prognosis and therapeutic. Histopathological examination is needed to establish the diagnosis. A case of collecting duct carcinoma that occurred in a 76-year-old man has been reported. A definitive diagnosis can only be done with a detailed histopathological examination for patient management benefits.Keywords : renal cell carcinoma, collecting duct carcinoma, urothelial carcinoma, PAX8, p63

ORIGINAL ARTICLE: A COMPREHENSIVE STUDY OF PROSTATIC LESIONS AND ITS PROSTATE-SPECIFIC ANTIGEN LEVELS IN ANATOMICAL PATHOLOGY INSTALLATION OF RSUD DR. SOETOMO, SURABAYA FROM YEAR 2014 TO 2016 Izzan Khalidah Binti Muhamad; Anny Setijo Rahaju; Lukman Hakim
Jurnal Kedokteran Syiah Kuala Vol 19, No 1 (2019): Volume 19 Nomor 1 April 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v19i1.18049

Abstract. Background: Diseases primarily affects prostate gland are inflammation, hyperplasia, and malignant tumour. Gleason score (GS) is an essential facet and together with PSA are substantial in diagnosing, managing, and determining the prognosis of CaP. Purpose: The aims of this study is to investigate the prevalence of prostatic lesions and its PSA level among patients in anatomical pathology installation in RSUD Dr. Soetomo from year 2014 to 2016. Method: This research is a retrospective study of prostatic lesions that were conducted from year 2014 to 2016 (3 years) with emphasis on GS and PSA levels. Result: The distribution of histopathological lesion found are benign lesion, benign prostate hyperplasia, adenocarcinoma, prostatitis, benign prostate hyperplasia with prostatitis, prostatic intraepithelial neoplasia, non-Hodgkin lymphoma, sarcoma, transitional cell carcinoma, and squamous cell carcinoma. The most common findings in this cohort is benign lesion (34.6%) with age group of 61-70 years old (51.94%) and adenocarcinoma with high GS of 9 (60%). Meanwhile, patients with GS 8 (high risk patient) contributed for 84.8%. Most of the cases (69.2%) have elevated PSA level of 20 ng/ml. Conclusion: The prevalence of prostatic lesions were able to be determined in different age groups. High GS indicates a more aggressive type of adenocarcinoma suffered, high risk for CaP. The results show that the possibility to detect malignancy with rising PSA level are higher, although PSA is not considered as a specific marker.Keywords: prostate, histopathology, benign lesion, PSA.

Penurunan Kerusakan Jaringan Paru Terinfeksi Tuberkulosis oleh Ekstrak Pegagan Melalui Peningkatan Ekspresi Tissue Inhibitor of Matrix Metalloproteinase-1 (SUPLEMENTATION OF EFFECT ANILYSIS OF CENTELLA ASIATICA EXTRACT IN REDUCE LUNG TUBERCULOSIS TISSUE D Arifa Mustika; Anny Setijo Rahaju; Roostantia Indrawati
Jurnal Veteriner Vol 15 No 4 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.428 KB)

Centella asiatica is a medicinal plant used for wound healing through increasing of collagen synthesis.This evidence generates a new expectation that it could be used for therapy of tuberculosis infection,especially for healing lung tissue damage. Until now, the effects and mechanisms onC. asiatica to cure thelung tissue damage due to M. tuberculosis infection remains unclear. The aim of this study was to prove theeffect and mechanism of ethanol extract of C. asiatica to repair the rats lung tissue damaged throughexpression of the enzimmatrix metalloproteinase-1(MMP-1)danenzimtissue inhibitor of matrixmetalloproteinase-1 (TIMP-1). The study was conducted in male rats. Twenty four rats were infected withM. tuberculosis through intratrachea and randomly divided into four groups. Group 1, 2 and 3 were thetreatment groups that they were given the ethanol extract of C. asiatica at dose 375mg/kgbw, 750 mg /kgbw, and 1500 mg / kgbw, orally and once a day for fourteen days. The fourth group was a control groupthat given distilled water. On day 15 rats were euthanized and lungs tissue have been taken. Evaluationof lungs tissue damage were assessed by the Dorman’s score in Hematoxylin Eosin and evaluation of the expression of MMP - 1 and TIMP 1 were performed by immunohistochemistry. Data of TIMP-1 wereanalyzed with ANOVA and data of lung tissue damage and MMP–1 were analyzed with Mann WhitneyU (á = 0.05). The results showed that there was a significant differences in the lungs tissue damagebetween the dose groups of 375 mg / kgbw and controls (p = 0.006), the dose groups at dose 750 mg / kgbwand controls (p = 0.004 ), the dose groups of 1500 mg / kgbw and controls (p = 0.043). There wasn’t asignificant difference between the treatment groups and control in the expression of MMP-1. In the expressionof TIMP – 1, there was a significant difference between the treatment group at dose of 750 mg / kg andcontrol. The conclusion of the study is the ethanol extract of C. asiatica has the ability to reduce lung tissuedamage of rats infected with M. tuberculosis, through increasesthe expression of TIMP-1

Skrining Kanker Serviks dengan Pemeriksaan Pap Smear di Puskesmas Tanah Kali Kedinding Surabaya dan Rumah Sakit Mawadah Mojokerto Gondo Mastutik; Rahmi Alia; Alphania Rahniayu; Nila Kurniasari; Anny Setijo Rahaju; Sjahjenny Mustokoweni
Majalah Obstetri dan Ginekologi Vol. 23 No. 2 (2015): Mei - Agustus 2015
Publisher : Universitas Airlangga

Tujuan: Penelitian ini bertujuan untuk mengetahui prevalensi lesi prekanker serviks dengan cara melakukan skrining kanker serviks menggunakan pemeriksaan Pap smear.Bahan dan Metode: Penelitian ini merupakan penelitian observasional deskriptif dengan metode pendekatan cross sectional yang dilakukan pada 140 wanita, terdiri dari 90 orang dari Puskes-mas Tanah Kali Kedinding Surabaya, dan 50 orang dari Rumah Sakit Mawadah Mojokerto, dengan usia 20-70 tahun. Pemeriksaan spesimen sitologi serviks dengan pengecatan Papaniculaou dan klasifikasi hasil pemeriksaaan sitologi berdasar-kan klasifikasi Papaniculaou dan sistim Bethesda. Pemeriksaan inspeksi visual asam asetat (IVA) adalah metode lain untuk skrining kanker serviks dilakukan dengan mengoleskan asam asetat 5% pada area serviks dan melakukan pengamatan satu menit kemudian.Hasil: Hasil pemeriksaaan Pap smear menunjukkan Papaniculaou kelas I (sama dengan normal pada klasifikasi sistim Bethesda) yaitu 12.1%, kelas II (sama dengan NILM pada klasifikasi sistim Bethesda) yaitu 86, 4%, dan kelas III (sama dengan LSIL pada klasifikasi sistim Bethesda) yaitu 1,4%. Hasil pemeriksaan IVA menunjukkan 6,43% positif dan 93,57% negatif. Hasil pemeriksa-an IVA positif terdapat pada 9/140 orang yang merupakan proses keradangan dan infeksi, bukan merupakan lesi prekanker.Simpulan: Prevalensi lesi prekanker yaitu 1,4%. Pemeriksaan IVA menunjukkan hasil positif semu yang disebabkan oleh proses radang atau infeksi pada serviks.

Human pappilomavirus genotype in cervical tissue of patients with Cervical Intraepithelial Neoplasia (CIN) 1, CIN 2, and CIN 3 Gondo Mastutik; Rahmi Alia; Alphania Rahniayu; Anny Setijo Rahaju; Renny I’tishom; Suhartono Taat Putra
Majalah Obstetri dan Ginekologi Vol. 24 No. 3 (2016): September - December
Publisher : Universitas Airlangga

Objectives: to determine the genotype of HPV in patients with precancerous lesions of cervical tissue.Materials and Methods: An observational study with cross sectional study of patients paraffin block CIN1, CIN2, CIN3 was conducted in Dr Soetomo Hospital. HPV DNA was extracted from paraffin blocks, then performed PCR and genotyping of HPV. The sample consisted of 28 patients with cervical tissue paraffin blocks CIN1, CIN2 and CIN3. Patients aged between 26-74 years (standard deviation 10,12).Results: HPV genotypes that infect patients with CIN1 were HPV16 and 18, CIN2 were HPV16 and 52 and CIN3 were HPV16, 67, and combined infection HPV16/67 and HPV52/67. HPV genotypes in a single infection were 26/28 (HPV16, HPV18, HPV52 and HPV67), and multiple infections were 2/28 (HPV16/67 and HPV52/67).Conclusion: The most dominant HPV genotypes infect patients with precancerous lesions of the cervix were HPV16, HPV67, HPV52, and HPV18.

Problem diagnostic of Krukenberg tumor Reza Wangsanagara; Pungky Mulawardhana; Vicky Sumarki; Anny Setijo Rahaju; Tri Wulanhandarini
Majalah Obstetri dan Ginekologi Vol. 27 No. 1 (2019): April
Publisher : Universitas Airlangga

Objectives: to report the case of Krukenberg tumor in 57 years old woman, with complaints of abdominal enlargement since the last 10 months.Case Report: a 57 years old woman, multipara, post menopause, came to our hospital with complaints of enlarging abdomen. Abdominal physical examination showed enlarging abdomen, hard palpable mass, measured 17 cm in diameter, and limited mobility. Abdominal CT result showed solid mass of the right adnexal, expanding to upper right abdomen, omental cake, ascites, and left pleural effusion, right lobe hepatic cyst and multiple bilateral renal cysts. Patient was diagnosed as solid ovarian tumor, suspicious of malignancy. Colonoscopy revealed hemorrhoid interna. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was done. Histopathologic findings showed malignant ovarian tumor, signet ring cell carcinoma of the cervics, endometrium, myometrium, nodule in gastrocolica ligament, and prevesica urinaria nodule. IHC examination of the ovarian tumor showed possible source was of colorectal, supporting the diagnosis of Krukenberg tumor with CK20 (+) and CK7 (-)Conclusion: Krukenburg tumor is a rare ovarian malignancy. Clinical symptoms usually consist of abdominal distension, pain caused by large ovarian mass. Diagnosis of Krukenburg tumor is confirmed by characteristic histologic findings of malignant signet ring cells with cellular stroma. Management for ovarian tumor is surgery removal, with very poor prognosis.

The Role of MMP-9 and VEGF in the Invasion State of Bladder Urothelial Carcinoma Novalia Chumaladewi Guntarno; Anny Setijo Rahaju; Nila Kurniasari
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1348

BACKGROUND: Bladder cancer is the tenth-most common cancer in worldwide and the majority are urothelial carcinomas. The depth of invasion plays important role in the prognostic and therapeutic factor in urothelial carcinomas. The expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) may associated with the progression of bladder carcinoma, such as depth of invasion. In this study, the correlation between these two markers in urothelial bladder carcinoma invasion will be analyzed.METHODS: An analytical observational research with cross-sectional were conducted on 54 formalin fixed paraffin-embedded tissue from radical cystectomy (RC) which were diagnosed as bladder urothelial carcinoma at the Anatomical Pathology Laboratory of Dr. Soetomo Academic Hospital, Surabaya and divided based on the T stage were immunostained using VEGF and MMP-9 monoclonal antibodies. The difference of VEGF and MMP-9 expression in T stage of bladder urothelial carcinoma were analyzed using Kruskal-Wallis and Anova test, the correlation between VEGF and MMP-9 expression in various T stage of bladder urothelial carcinoma were analyzed using Spearman test. RESULTS: This study showed no significant difference of VEGF expression among T stage of bladder urothelial carcinoma (p>0.05) but there was significant difference of MMP-9 expression in T stage of bladder urothelial carcinoma (p=0.043). There was a correlation between VEGF and MMP-9 in various T stage of bladder urothelial carcinoma (rs= 0.50, p=0.001).CONCLUSION: The significant correlation of VEGF and MMP-9 expression in bladder urothelial carcinoma may prove the synergistically role of both proteins in tumor invasion by MMP-9 degradation extracellular matrix.KEYWORDS: urothelial carcinoma, VEGF, MMP-9, T stage

THE MUTATION STATUS OF KRAS GENE CODON 12 AND 13 IN COLORECTAL ADENOCARCINOMA (Status Mutasi Gen Kras Kodon 12 dan 13 di Adenocarcinoma Kolorektal) Gondo Mastutik; Alphania Rahniayu; Anny Setijo Rahaju; Nila Kurniasari; Reny I’tishom
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1177

Kanker kolorektum merupakan salah satu kanker yang tersering di dunia. Target molekuler untuk pengobatan kanker kolorektumyaitu Epidermal Growth Factor Receptor (EGFR) dengan pemberian antibodi monoklonal anti-EGFR. Pemberian pengobatan ini tidakdapat memberikan efek dampak di pasien dengan status gen KRAS bentuk mutan, sehingga perlu dilakukan pemeriksaan status mutasigen KRAS. Telitian berupa deskriptif dengan pendekatan potong lintang yang bertujuan untuk mendapatkan data status mutasi genKRAS kodon 12 dan 13 di pasien adenocarcinoma colorectal. Deteksi mutasi KRAS dilakukan dengan teknik Polymerase Chain ReactionRestriction Fragment Length Polymorphism (PCR RFLP) yang dikonfirmasi dengan sekuensing. Sampel telitian adalah 30 blok parafinyang diperoleh dari Rumah Sakit Dr.Soetomo Surabaya masa waktu Januari-Desember 2013. Setelah dilakukan ekstraksi DNA terdapat21 sampel yang dapat digunakan untuk pemeriksaan lanjutan. Hasil PCR RFLP menunjukkan terdapat 7/21 mutasi pada kodon12 dan tidak terdapat mutasi gen KRAS pada kodon 13. Mutasi pada kodon 12 yaitu GGT>GCT, GGT>GGA dan GGT>GAT yangmenyebabkan perubahan asam amino Gly12Ala, Gly12Gly dan Gly12Asp. Simpulan telitian ini adalah mutasi gen KRAS kodon 12 padaadenocarcinoma colorectal di Rumah Sakit Dr. Soetomo Surabaya sebanyak 33%.

Correlation Between Pleural Fluid GenXpert® and Histopathology Finding of Pleural Biopsy in Tuberculous Pleural Effusion Sheilla Matheos; Isnin Anang Marhana; Anny Setijo Rahaju
Jurnal Respirologi Indonesia Vol 38, No 1 (2018)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v38i1.133

Backgrounds: Tuberculosis pleural effusion is the most common extrapulmonary TB after lymphadenitis TB, but a definite diagnosis is still a challenge. Pleural biopsy has historically been the gold standard procedure for the diagnosis of pleural tuberculosis. GenXpert® is a computerize test based in nucleic acid amplification tahat automatically detect MTB and rifampicin resistance. This study aimed to prove the correlation between pleural fluid GenXpert® and histopathological findings of pleural biopsy in patients with pleural tuberculosis. Methods: This study used an observational analytic design with a cross-sectional design conducted in Dr. Soetomo Hospital, Surabaya in March-June 2017. Statistic analysis was using chi square test and contingensi coofisient. The pleural GenXpert® was tested in 23 patients with pleural effusion and their biopsy speciments underwent histopathological analysis. Results: Histopathological findings of pleural biopsy was positive in 4 subjects and pleural fluid GenXpert® resulted positive in 6 subjects. There was significant correlation between pleural fluid GenXpert® and histopathological findings of specimen pleural biopsy in patients with pleural tuberculosis (P=0.040) with moderate strenght (P=0.014). Sensitivity and specificity of pleural fluid GenXpert® were 75.0% dan 84.2% respectively. Conclusions: There was significant correlation between pleural fluid GenXpert® and histopathological findings of pleural biopsy in patients with pleural tuberculosis. (J Respir Indo 2018; 38(1): 1-6)

Tubule Formation Segmentation Of Histopathological Image Of Breast Cancer By Using Clustering Method Hadiyyatan Waasilah; Riries Rulaningtyas; Winarno Winarno; Anny Setijo Rahaju
Indonesian Applied Physics Letters Vol. 1 No. 1 (2020): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/iapl.v1i1.21338

Histopathological assessment is one of the examinations that allows the classification of breast cancer based on its level. Histopathological assessment factors are based on tubule formation, nuclear pleomorphism, and the mitotic count. This study only focused on tubule formation. The tubule formation was represented by a lumen surrounded a nucleus. The segmentation of tubule histopathology of breast cancer method was using a combination of k-means clustering and graph cut. The image data used in this study were 15 images of breast cancer histopathology preparations using 5 variations in the number of clusters (k) in the k-means clustering method. The best results of tubule formation segmentation using k = 4, with an average value of balanced accuracy was 81.08% and the most optimal balanced accuracy results was 94.34%.

Co-Authors Abdurrahman Hasyim Asy’ari Alphania Rahniayu Aniek Meidi, Aniek Aniek Meidy Utami Ari Wanda, Dewi Sartika Ariadna Anggi Pasang Ariani, Grace Arifa Mustika Arifa Mustika Aulia Nur Fadila Budi Harjanto Budi Harjanto Dewi Sartika A. W. Dewi, Rosa Amalia DWI SURYANTO DYAH FAUZIAH, DYAH Eddie Saputra Ferdinant Martinus Djawa Fira Soraya Gondo Mastutik Hadiyyatan Waasilah HERAWATI, LILIK Heriyawati, Heriyawati Heryanto Heryanto Heryanto Heryanto I'tishom, Reny Ilmiah, Khafidhotul Imam Susilo Isnin Anang Marhana Izzan Khalidah Binti Muhamad I’tishom, Reny Katherine Kho Khafidhotul Ilmiah Khafidhotul Ilmiah Krismaningrum, Veronika Intan Kusumastuti , Etty Hary Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Leonita Agustin Hambalie Linda Dewanti Mas`udi, Achmad Fayyad Naibaho, Ardy Hamonangan Nila Kurniasari Nila Kurniasari Novalia Chumaladewi Guntarno Nur Arfian, Nur Octavianda, Yohana Osmalina Nur Rahma PUNGKY MULAWARDHANA, PUNGKY Qonitatillah, Ana Qorib, Mohammad Fathul Rahmi Alia Rahmi Alia Rahmi Alia, Rahmi Renny I’tishom Reza Wangsanagara Ridholia Ridholia Ridholia Ridholia, Ridholia Rifatus Solicha Riries Rulaningtyas Roostantia Indrawati S.Pd. M Kes I Ketut Sudiana . Salman Aziz, Muhamad Abi Sari, Aditya Sita Sheilla Matheos Sita Sari, Aditya Sjahjenny Mustokoweni, Sjahjenny Soetojo Soetojo Solly Aryza Suhartono Taat Putra Tarmono Djojodimedjo Tri Wulanhandarini Trianto, Heru Fajar Tuti Andayani Ummi Hanifah Vicky Sumarki Willy Sandhika Winarno, Winarno Wira Santoso Ongko Wiratama, Priangga Adi Yohana Octavianda

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