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All Journal E-Jurnal Medika Udayana Jurnal Kedokteran Brawijaya MEDISAINS Universa Medicina Paediatrica Indonesiana Window of Health : Jurnal Kesehatan Medical and Health Journal Linggamas: Jurnal Pengabdian Masyarakat Cermin Dunia Kedokteran
Qodri Santosa, Qodri
FK UNSOED
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Antimicrobial Resistance in Chronic Diarrhea: A Case Report of Cefazolin-Resistant Enteric Infection: Case Report Mahardhika, Gembong Satria; Izzati, Aulia Nurul; Laranti, Nimas Adiani Sekar; Hurulhanifa, Fatmanur; Shabrina, Hanifa Nur; Santosa, Qodri
Cermin Dunia Kedokteran Vol 53 No 10 (2026): Oktober 2026 - CDK 357
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i10.1944

Abstract

Introduction: Antimicrobial resistance is an emerging global health challenge that may lead to treatment failure and prolonged illness. Although cefazolin resistance is relatively uncommon, it can complicate infectious disease management, including chronic diarrhea. Case: A 7-month-old girl presented with fever and chronic mucoid diarrhea. Despite treatment with multiple antibiotics, including cefazolin, metronidazole, and vancomycin, her symptoms worsened, with diarrhea increasing to seven episodes daily, accompanied by severe anemia and malnutrition. Antibiotic susceptibility testing revealed isolated cefazolin resistance (MIC = 64 μg/mL). After susceptibility-guided treatment with intravenous ciprofloxacin and supportive care, the patient improved significantly and was discharged after 10 days. Discussion: This case highlights the importance of considering antimicrobial resistance in children with persistent diarrhea who fail to respond to empirical antibiotic therapy. Cefazolin resistance likely contributed to treatment failure and clinical deterioration. Early microbiological investigation and susceptibility-guided therapy were essential to achieve clinical recovery and prevent further complications. Conclusion: Clinicians should consider cefazolin-resistant enteric infection in cases of chronic diarrhea with poor response to empirical treatment. Prompt culture and antibiotic susceptibility testing are crucial to guide appropriate antimicrobial therapy and improve patient outcomes.
Co-Authors Ag Soemantri Agustina, Nenden Nursyamsi Alfi Muntafiah Andreanetta, Prisca Tiffany Ariadne Tiara Hapsari Arifah, Kurniawati Edy Priyanto Fadlilah, Synta Haqqul Hafiidhaturrahmah, Hafiidhaturrahmah Hurulhanifa, Fatmanur Izzati, Aulia Nurul Joko Setyono Lantip Rujito Laranti, Nimas Adiani Sekar Mahardhika, Gembong Satria Mujiburrahman, Husnan Nendyah Roestijawati Nor Sri Inayati, Nor Sri Oliviany, Windy Pratidina, Wening Gelar Sakina, Ghaida Salsabila, Sabrina Dhia Shabrina, Hanifa Nur Soeharyo Hadisaputro Soejoenoes, Ariawan Susilarto, Aris Dwi Syamsiedi, Naluri Widyaningsih Vitasari Indriani Widodo, Yundandhika Rizki Windiya, Fajar Wiwiek Fatchurohmah, Wiwiek