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All Journal Indonesian Journal of Tropical and Infectious Disease Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science MDJ (Makassar Dental Journal) Eduvest - Journal of Universal Studies
Chiquita Prahasanti
Department Of Periodontology, Faculty Of Dental Medicine, Universitas Airlangga
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Kelainan periodontal pra dan pasca perawatan ortodonti Chiquita Prahasanti
Makassar Dental Journal Vol. 1 No. 3 (2012): Vol 1 No 3, Juni 2012
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (72.347 KB) | DOI: 10.35856/mdj.v1i3.53

Abstract

Perawatan ortodontik merupaka perawatan yang sangat berkait erat dengan jaringan periodontal, karena pergerakan gigi yang dilakukan melibatkan semua unsur dari jaringan periodontal gigi. Menjaga kesehatan jaringan periodontal selama perawatan ortodontik mutlak untuk diperhatikan, karena keberhasilan perawatan akan tampak pada akhir masa perawatan ortodonsia. Perawatan ortodontik dapat merupakan bagian dari perawatan periodontal, karena banyak kasus periodontal membutuhkan perawatan ortodontik untuk mencapai hasil yang memuaskan. Penderita dengan kelainan periodontal bukan merupakan kontraindikasi untuk dilakukan perawatan ortodontik. Menjaga kebersihan rongga mulut sangatlah penting. Masalah periodontal pada anak-anak dan dewasa muda jarang dijumpai. Kemungkinan masalah periodontal akan sering ditemui pada penderita dewasa. Mengingat hal tersebut, maka sangatlah penting untuk mengidentifikasi penderita-penderita yang memiliki risiko terhadap kelainan periodontal sebelum melakukan perawatan ortodontik.
The expression of BMP4 and FGF2 in Wistar rats (Rattus norvegicus) post application of gourami fish (Osphronemus goramy) collagen Chiquita Prahasanti; Niken Luthfiyya Arini; Kurnia Dwi Wulan; Onge Victoria Hendro; I Komang Evan Wijaksana; Noer Ulfah; Banun Kusumawardani; Padmini Hari; Shahabe Saquib Abullais
Dental Journal Vol. 56 No. 2 (2023): June 2023
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i2.p115-121

Abstract

Background: Periodontitis is a chronic inflammatory disease of the periodontal tissue that is characterized by alveolar bone resorption. This occurs due to an imbalance of osteoblast and osteoclast during the bone formation and resorption processes. In order to obtain complete regeneration of periodontal tissue, bone grafting is frequently used in periodontal surgical therapy. Although each material has disadvantages, safe graft materials derived from animal sources can be employed as an alternative to bone graft materials. Osteoblast, osteoclast, calcified bone matrix, type I collagen, osteonectin, and hydroxyapatite can all be found in gourami scales, a form of food waste. BMP4 has osteoinduction functions, which are important in bone metabolism. Through angiogenic activity, FGF2 also contributes to periodontal regeneration. Purpose: The aim of the study was to assess the expression of BMP4 and FGF2 after the treatment group had been given gourami fish scale extract. Methods: Thirty-two experimental three-month-old male Wistar rats (150-200g) were randomly divided into four groups: a seven-day control group, a seven-day treatment group, a 14-day control group, and a 14-day treatment group. One mandibular incisor was extracted from each Wistar rat. The post-extraction socket was filled with blood for the control group and collagen extract for the treatment. Results: The one-way ANOVA test showed a significance level of 0.000 (p = <0.05). Conclusion: The expression of BMP4 and FGF2 increased after the application of collagen extract from gourami scales.
MMUNOHISTOCHEMICAL ANALYSIS OF NF-kB (P0/P) IN PATIENT WITH AGGRESSIVE AND CHRONIC PERIODONTITIS Prahasanti, Chiquita
Indonesian Journal of Tropical and Infectious Disease Vol. 4 No. 4 (2013)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (830.801 KB) | DOI: 10.20473/ijtid.v4i4.235

Abstract

Background: Nuclear factor-kappaB (NF-κB) is a protein complex that plays a role in transcription factors and in response to inflammation. Periodontitis is a periodontal disorder caused by various bacteria such as A. actinomycetemcomitan and P.gingivalis whose LPS is closely related to NFκB (p50/p65). Aim: This study observed whether NF-κB (p50/p65) played a role in aggressive and chronic periodontitis. Methods: Data were obtained from periodontal tissue 40 patients with aggressive periodontitis and 40 patients with chronic periodontitis. Samples were derived from periodontal tissue with abnormalities and NFκB (p50/p65) protein expression test was performed by immunohistochemistry. The statistical test used was the t-test. Results: In NF-κB (p50) the t value was -12 041 and significance 0.000, with α = 5%, showing significant difference in protein expression of NF-κB (p50) between patients with aggressive periodontitis and chronic periodontitis. OR estimation for the value of protein expression of NFκB (p50) was 0.64 (sign. = 0.000). It shows that if the protein expression of NFκB (p50) of the respondents is incremented by 1 (one) unit, the risk of chronic periodontitis increases 1.64 times. Box plot diagram shows that the distribution of the protein expression of NFκB (p50) between patients with aggressive periodontitis and chronic periodontitis patients is significantly different. In NF-κB (p65) the Z value was -7.137 and significance of 0000, with α= 5%, showed significant differences in protein expression of NF-κB (p65) between patients with aggressive periodontitis and chronic periodontitis. OR estimates for protein expression of NFκB (p65) was 0.66 (sign. = 0.000). This indicates that if the protein expression of NFκB (p65) respondents is incremented by 1 (one) unit, the risk of chronic periodontitis increases 1.5 times. Box plot diagram shows that the distribution of the protein expression of NFκB (p65) between patients with aggressive and chronic periodontitis patients is significantly different. Conclusion: The protein expression of NF-κB (p50/p65) has more influence on the incidence of chronic periodontitis patients, so it can be used as a marker for chronic periodontitis.
Viabilitas Fibroblast Freeze – Dried Amniotic And Fresh Amniotic In BHK21 Cell indrawati, Dwi wahyu; Prahasanti, Chiquita; Setyawatie, Ernie Maduratna
Eduvest - Journal of Universal Studies Vol. 4 No. 6 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i6.1455

Abstract

Amniotic membrane is the inner most lining of the human placenta that is normally discanded after parturition. The membrane has numerous growth factors, proteins and stem cell reserves that help in accelerating wound healing with regeneration of the lost tissues. The preserved human amniotic membrane is a novel tissue engineerrined biomaterial that is recently trial in field of medicine dentistry to regenerate the lost tissues and accelerate repair. This review paper unfolds the inherent structure, properties, mechanisms and the application of this neglected tissue that makes it a potential for regeneration especially in the field of oral and periodontal surgeries. This research has been conducted to measure the difference of viabilitas fibroblast concentration between fresh amniotic and freeze – died amniotic membranes. Experimental three group test design was exployed with amniotic membrane. Amniotic membrane was divided into two parts. The first parts was without preservation amniotic, the test with BHK21 cell for control group, the second part was with reservation freeze –dried amniotic and the last experiment was with preservation fresh amniotic membrane. The result experiment are viabilitas fibroblast freeze – dried amniotic more than fresh amniotic membrane.
Induced pluripotent stem cells in periodontal reconstructive therapy: A narrative review of pre-clinical studies Hendrawan, Reza Dony; Prahasanti, Chiquita; Savitri, Irma Josefina; Hari, Padmini
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 4 (2023): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i4.p280-286

Abstract

Background: Regenerative periodontal surgical therapy faces significant challenges due to the limited ability of the body to regenerate damaged periodontal tissue. One of the primary goals in regenerative periodontal therapy is regaining periodontal tissue attachment after destruction by periodontal disease. Currently, stem cells, harnessing three pivotal components”cells, biomaterials, and growth factors”are widely used in periodontal regeneration. Stem cells can be obtained from various sources, either by isolating cells from bone marrow, teeth, and muscles or through the somatic cell programming method (reprogramming) known as induced pluripotent stem cells (iPSCs). Purpose: This review aims to describe the potential use of iPSCs in the treatment of periodontal defects. Review: Search strategies were developed using the PubMed, LILACS, Scielo, and Wiley online databases during the period of 2012–2022. Ten articles met the inclusion criteria. iPSCs were obtained by inducing somatic cells from both dental and non-dental sources with factors Oct3/4, Sox2, Klf4, and c-Myc. Periodontal tissue regeneration procedures can be augmented with iPSCs. Unlike tooth-based stem cells, iPSCs offer several advantages, such as unlimited cell sources and the capability to differentiate into any cell type, including periodontal tissue. The potential of iPSCs extends to correcting periodontal bone defects and forming new periodontal tissues, such as alveolar bone, cementum, and periodontal ligament. However, iPSCs do have limitations, including the need for clinical trials, cell programming production facilities, and optimization of differentiated-cell functionality. Conclusion: The combined use of iPSCs in cell-based tissue engineering holds vast potential for future periodontal treatment strategies.
The number of osteoblasts and osteoclasts in bone remodeling of bone defects caused by peri-implantitis using Anadara granosa bone graft: an experimental study Ariestania, Vivin; Hendrijantini, Nike; Prahasanti, Chiquita; Kurniawan, Hansen; Ashrin, Meinar Nur; Nanik, Chaterina Diyah; Apsari, Anindita; Megantara, Rizko Wira Artha; Sari, Rima Parwati; Hermanto, eddy; Fauzia, Bunga; Matsuyama, Miwa
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.64295

Abstract

Introduction: Peri-implantitis treatment aims to replace the damaged bone with new and healthy tissue during bone remodeling process. Bone grafts are materials used to stimulate the formation of new bone. Bone graft material derived from Anadara granosa (AG) can be synthesized into hydroxyapatite–tricalcium phosphate (HA-TCP) at a 70:30 ratio, which supports bone regeneration, as indicated by an increase in osteoblast numbers and decrease in osteoclast numbers. This study aims to analyze the effectiveness of Anadara granosa bone graft in the number of osteoblasts and osteoclasts during bone remodeling process. Methods: This study employed an experimental design with a post-test only control group. A total of 84 mice were divided into 12 groups (7 mice per group): negative control (K−), positive control (K+), and treatment group (P), each observed on days 14 and 28. Histological analysis was performed to count osteoblasts and osteoclasts. Data were analyzed using one-way ANOVA. Results: The number of osteoclasts was significantly reduced in the treatment groups (P14: 7.00 ± 1.528; P28: 6.57 ± 1.512) compared to the positive controls (K+14: 13.86 ± 2.410; K+28: 14.29 ± 1.496). On the contrary, the number of osteoblasts increased in the treatment groups (P14: 7.14 ± 1.676; P28: 8.57 ± 1.272) compared to the positive controls (K+14: 2.57 ± 1.512; K+28: 3.86 ± 1.574). Statistical analysis indicated that osteoblasts showed significant differences after AG treatment (p<0.05), and the ANOVA test showed significant differences in osteoclast number after AG treatment (p<0.05).      Conclusion: The number of osteoblasts increases while the number of osteoclast reduces in bone remodelling of bone defect caused by peri-implantitis using AG bone graft.
Co-Authors Agus Sobar Mulyana Apsari, Anindita Ariestania, Vivin Banun Kusumawardani Eddy Hermanto Fauzia, Bunga Hari, Padmini Harianto Notopuro Haryono Utomo Hendrawan, Reza Dony I Komang Evan Wijaksana Indrawati, Dwi Wahyu Irma Josefina Savitri Iwan Ruhadi Iwan Ruhadi Kurnia Dwi Wulan Kurniawan, Hansen Matsuyama, Miwa Megantara, Rizko Wira Artha Meinar Nur Ashrin Nanik, Chaterina Diyah Nike Hendrijantini Niken Luthfiyya Arini Nita Margaretha Noer Ulfah Onge Victoria Hendro Padmini Hari Rima Parwati Sari, Rima Parwati Setyawatie, Ernie Maduratna Shahabe Saquib Abullais Vincent Laksono Yuli Nugraeni, Yuli