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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Amerta Nutrition Indonesian Journal of Community Services Journal of Advanced Multidisciplinary Research Journal of English Language and Education Jurnal Pengabdian Masyarakat Kedokteran Media Farmasi Indonesia Jurnal Akuntansi, Keuangan, Perpajakan dan Tata Kelola Perusahaan
Masfiyah Masfiyah, Masfiyah
Clinical Microbiology Department of Medical Faculty of Sultan Agung Islamic University Semarang
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Journal : Amerta Nutrition

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Pengaruh Kombinasi Probiotik, Ubi Jalar Ungu, dan Zinc terhadap Tebal Epitel Usus Mencit Jantan BALB/c Kolitis Ulseratif terinduksi Asam Asetat: Effect of Combination of Probiotics, Ipomoea Batatas, and Zinc on Thickness of Instestinal Epithelium in Mice Model of Acetic Acid-Induced Colitis Tsuraya, Ghefira; Yuniarifa, Conita; Hussaana, Atina; Riza, Mohamad; Masfiyah, Masfiyah
Amerta Nutrition Vol. 9 No. 2 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i2.2025.350-354

Abstract

Background: The use of probiotics to treat colitis is unsatisfactory, leading to a need for the combination with purple sweet potatoes (Ipomoea Batatas) and zinc. Objectives: This study aims to determine the effect of the combination of probiotics, purple sweet potatoes, and zinc on epithelial thickness.Methods: This was a post-test-only randomized controlled group experimental study using 30 mice divided into six groups, including KN, K-, K+, P1, P2, and P3. All groups except KN were induced with 4% acetic acid on day 1, then each received treatment for five days. KN, K+, P1, and P2 groups were given distilled water, sulfasalazine 1.3 mg/20 g BW, probiotics 0.078 mg/20 gBW + purple sweet potatoes 0.00169 g/20 gBW, and probiotics 0.078 mg/20 gBW + zinc 0.052 mg/20 gBW, respectively. Meanwhile, P3 received a combination of probiotics 0.078 mg/20 gBW + purple sweet potatoes 0.00169 g/20 gBW + zinc 0.0052 mg/20 gBW. Histological preparations were stained with Hematoxylin-Eosin and examined under 400× magnification across 10 fields of view. Results: The average epithelial thicknesses were KN (75.48±5.09), K− (28.02±5.60), K+ (69.1±13.82), P1 (47.05±9.41), P2 (48.6±9.73), and P3 (71.57±14.31). One-way analysis of variance (ANOVA) showed a significant difference among the groups with a p-value <0.001. Post Hoc LSD test identified significant differences (p-value<0.05) among all group pairs except between K+ and P3 (p-value=0.134) as well as P1 and P2 (p-value=0.349), but P3 had the highest average thickness value (71.57±14.31).Conclusions: The combination of probiotics, purple sweet potatoes, and zinc had an effect on intestinal epithelial thickness in male BALB/c mice with ulcerative colitis.
Co-Authors Aris Catur Bintoro Atina Hussaana Chodidjah Chodidjah Desvita Sari, Desvita Dian Ayu Listiarini Dina, Fatmawati Faiq, Achmad Hapsari Putri, Indri Hesti Wahyuningsih Karyadini, Hesti Wahyuningsih Hibatullah, M. Adam Ika Rosdiana Intisari, Dewi Iwang Yusuf Kusrina, Tity Lutfiyani, Ida Zulfa Maryani Maryani Merin Awu Sari, Merin Awu Moh Kholil Baitaputra Nasuha, Munthoha Nika Bellarinatasari Purnomo Hadi Putri, Indri Hapsari Rahayu Rahayu Rebriarina Hapsari Ridha Wahyutomo Riza, Mohamad Rochman Mujayanto Santosa, Wignyo Sardjana, Andriana Tjitria Widi Wardani Soraya, Yulice Stefani, Harumsari Subakir Subakir Suparmi Suparmi Tjahyadewi, Shelly Tri Nur Kristina Tsuraya, Ghefira V. Rizke Ciptaningtyas Yani Istadi Yunanda, Laurenz Diffa Yuniarifa, Conita