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All Journal EKSAKTA: Journal of Sciences and Data Analysis Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Majalah Obat Tradisional Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Pharmaceutical and Medicinal Sciences JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Jurnal Pengabdian Masyarakat Bumi Raflesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Borneo Journal Of Pharmascientech Jurnal Ilmiah Pharmacy Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pengabdian Mandiri Borneo Journal of Pharmacy Bencoolen Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Agung Giri Samudra
Universitas Bengkulu
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PENGARUH VARIASI KONSENTRASI EXPLOTAB PADA SEDIAAN TABLET METODE GRANULASI BASAH EKSTRAK ALGA COKLAT Sargassum sp.: EFFECT OF VARIATIONS OF EXPLOTAB CONCENTRATION ON TABLETS PREPARATION WITH WET GRANULATION METHOD BROWN ALGAE EXTRACT Sargassum sp. Tiara Feni Lestari; Agung Giri Samudra; Dwi Dominica
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.425

Abstract

Alga coklat (Sargassum sp.) merupakan tanaman yang mengandung senyawa flavonoid, alkaloid, tanin, dan terpenoid. Salah satu pemanfaatan alga coklat dalam ilmu farmasi adalah sebagai zat aktif dalam obat. Pada penelitian ini obat dibuat dalam bentuk sediaan tablet yang memiliki komposisi sebagai zat aktif utama obat dan bahan penghancur yaitu explotab (sodium starch glycolat). Penelitian ini bertujuan untuk membuat tablet dari ekstrak alga coklat (Sargassum sp.) dengan cara sokhletasi menggunakkan pelarut etanol 96%. Tablet dibuat menjadi tiga formula dengan varian konsentrasi explotab yang berbeda agar dapat mengetahui konsentrasi terbaik explotab sebagai bahan penghancur. Ketiga varian konsentrasi tersebut adalah 3%, 5%, dan 7%. Keuntungan bahan explotab sebagai bahan penghancur yaitu kekuatan pada aksi kapiler yang akan menarik cairan ke dalam tablet, sehingga dalam formulasi tablet bahan ini akan mengembang dan menjadikan tablet pecah dan hancur kemudian melarut. Metode yang digunakan pada pembuatan tablet adalah granulasi basah. Hasil uji evaluasi granul meliputi sifat alir, sudut istirahat dan kompresibilitas telah memenuhi syarat. Hasil uji evaluasi fisik tablet yang terdiri dari waktu hancur, kerapuhan, kekerasan, keseragaman bobot dan keseragaman ukuran, namun pada uji kekerasan tablet tidak memenuhi syarat. Konsentrasi explotab yang semakin tinggi maka waktu hancur yang dihasilkan semakin cepat dan kekerasan tablet semakin menurun. Kekerasan tablet berhubungan dengan kerapuhan, dimana semakin keras tablet maka kerapuhannya juga akan semakin kecil.
FORMULASI TABLET EKSTRAK ALGA COKLAT (Sargassum sp.) DENGAN VARIASI POLIVINIL PIROLIDON SEBAGAI BAHAN PENGIKAT METODE GRANULASI BASAH: FORMULATION OF BROWN ALGAE EXTRACT TABLETS (Sargassum sp.) WITH VARIATIONS POLYVINYL PYROLIDONE AS BINDING MATERIAL WITH WET GRANULATION METHOD Dea Eka Rina; Agung Giri Samudra; Dwi Dominica
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.590

Abstract

Tanaman alga coklat (Sargassum sp.) dalam ilmu farmasi dapat dimanfaatkan sebagai salah satu zat aktif dalam obat. Obat yang dibuat dalam bentuk sediaan tablet ini memiliki komposisi alga coklat (Sargassum sp.) sebagai zat aktif utama obat dan bahan pengikat lainnya yang berupa polivinil pirolidon (PVP). Penelitian ini membahas lebih dalam mengenai keefektifan zat pengikat (PVP) dalam sediaan obat menggunakan metode granulasi basah. Ekstrak alga (Sargassum sp.)  yang pekat diperoleh dari ekstraksi dengan metode sokletasi menggunakan etanol 96%. Pembuatan tablet alga coklat (Sargassum sp.) diuji dengan zat pengikat (PVP) dalam 3 konsentrasi yang berbeda yaitu 3%, 5%, dan 9%. Sebelum memasuki tahapan pencetakan granul, sediaan obat harus melewati evaluasi sifat alir, sudut diam, dan kompresibilitas. Setelah itu dilakukan evaluasi sifat fisik tablet yang terdiri atas keseragaman bobot, keseragaman ukuran, kekerasan, waktu hancur, dan waktu paruh. Hasil yang didapatkan menunjukkan bahwa evaluasi uji sifat fisik granul dengan 3 variasi konsentrasi formula telah memenuhi syarat. Pada uji waktu hancur, kekerasan, keseragaman bobot, dan keseragaman ukuran tablet hanya konsentrasi PVP 5% saja yang memenuhi syarat dalam tablet obat alga coklat.
UJI PERBANDINGAN EFEKTIVITAS ANTIDIABETES EKSTRAK POLISAKARIDA DAN SENYAWA POLIFENOL ALGA COKLAT (Sargassum sp.) PADA MENCIT YANG DIINDUKSI ALOKSAN Agung Giri Samudra; Fathur Sani K; Moniq Chintama
Jurnal Ilmiah Manuntung Vol 4 No 1 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i1.157

Abstract

Diabetes is one of the most common diseases in the world. So there is an effort to prevent or treat the disease. As brown algae (Sargassum sp.) Contains polysaccharides that regulate sugar intake in the body, and polyphenols act as antioxidants that can stimulate insulin secretion in pancreatic β cells. This study aims to determine the effectiveness of Antidiabetes Polysaccharide Extract and Brown Algae Polifenol Compounds (Sargassum sp) On Alloxaninduced Mice. The test animals were grouped into 4 groups I (CMC 1%), Group II (Glibenclamide 0.52mg / 20grBB), Group III (5mg / 20grBB polyphenol extract), Group IV (5mg / 20grBB polysaccharide extract). Blood glucose was measured using Easy touch glucometer on days 0, 3, 7, 14, 21, and 28. Analyze data using one-way ANOVA, followed by LSD test. The percentage decrease in blood glucose level in positive control, polyphenol extract and polysaccharide were 42,86%, 58,12%, and 54,20%. Statistically, the polyphenolic extract and the brown algae polysaccharide lower the blood glucose level significantly compared with the negative control (p≤0,05). Decreased blood glucose in polyphenol extracts and polysaccharides showed statistically significant differences
PEMBUATAN VIRGIN COCONUT OIL (VCO) DENGAN METODE PENGASAMAN SEBAGAI KRIM TABIR SURYA BERBAHAN AKTIF TiO2 Agung Giri Samudra; Nurfijrin Ramadhani; Fathnur Sani K; Ulfa Febriyani
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i1.274

Abstract

Palm trees is one plantation commodities important in development sub the plantation sector, among others to meet the needs of domestic, and as a commodity export foreign exchange producing countries. Cream sunscreen is made with an emulsion phase (VCO, lanolin, stearic acid and cetyl alcohol) and aqueous phase (triethanolamine, glycerin, aquadest). TiO2 was added with various concentrations of F0 (0%), F1 (5%), F2 (10%), and F3 (15%). The research vco oil colorless and odorless typical fresh coconut. Produce the centrifugation does not happen the separation between the oil and the water pH value the range of 6.87-7.63; viscosity and range of cp 12400-21600; SPF value at F0 (0.189); F1 (2.857); F2 (4.252); F3 (6.154). Of the value of the two of them have met the standards according to the SPF concentration F2 and F3.
UJI AKTIVITAS EKSTRAK ETANOL DAUN EKOR NAGA (Rhaphidophora pinnata (L.f.) Schott.) SEBAGAI ANTIHIPERURISEMIA TERHADAP MENCIT PUTIH JANTAN Bella Pascila; Fathnur Sani K; Revis Asra; Agung Giri Samudra
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.389

Abstract

Hyperuricemia is a condition of abnormal health hence increasing urid acid level within blood that is up in normal value spesificaly for man is over 7,0 mg/dL and for woman is over 6,0 mg/dL. Ekor naga leaves (Rhaphidophora pinnata L.f.) have some second metabolic compound namely flavonoid and alkaloid that have a capability to hampering xhantine oxidase enzyme. The objective of this reseach is to know the effectiveness giving ethanol extract of ekor naga leaves for decreasing urid acid level and to know the effectiveness dose ethanol extract of ekor naga leaves for decreasing uric acid level. The sample of this reseach was ethanol extract of ekor naga leaves, allopurinol as positive control, chicken liver juice and potassium oxonate as inductioun of hyperuricemia. The design of this research is complete random design with 5 action where in one action consist of 5 mice. The group of action was K+ Allopurinol 0,26mg/kgBB, P1 extract 125mg/kgBB, P2 extract 250mg/kgBB, and P3 extract 375mg/kgBB. The best dose is dose II (250mg/kgBB) with percentage of decreasing uric acid is 45,22%. Than dose III (375 mg/kgBB) with perfentage of dereasing urid acid is 44,66%, and dose I (125 mg/kgBB) with percentage of the decreasing uric acid is 39,60%. Moreover, it can be concluded that all dose of ethanol extract ekor naga leaves have an activity as antyhiperuricemia.
Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male Rats Kasmadi, Fathnur Sani; Rahman, Ave Olivia; Rahman, Havizur; Yuliawati, Yuliawati; Samudra, Agung Giri
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.7525

Abstract

Rhaphidophora pinnata, a plant traditionally recognized for its wound-healing properties, contains active compounds such as megastigmane glycosides and damascenone, known for their anti-inflammatory effects. To enhance efficacy and user comfort, this study focused on developing an R. pinnata leaf extract nanoparticle gel. Previous research from our group highlighted the significant wound-healing potential of a conventional R. pinnata gel. This present study aimed to evaluate the wound-healing efficacy of a novel R. pinnata nanoparticle gel in male Wistar rats, specifically investigating the impact of nanotechnology application. Nanoparticles were successfully formulated via the ionic gelation method, utilizing 0.250 g of R. pinnata extract, 0.1% chitosan, 0.2% sodium tripolyphosphate, and 0.5% Tween 80. Characterization revealed an average nanoparticle size of 165.70±42.76 nm with a zeta potential of 22.0±1.83 mV. The wound-healing efficacy was assessed across five treatment groups: a positive control (Bioplasenton®), a plain gel base (Formula 0), and nanoparticle gels at 0.5% (Formula I), 1% (Formula II), and 1.5% (Formula III) extract concentrations. Statistical analysis using one-way ANOVA (p <0.05) demonstrated a significant difference in incision wound healing across the groups. Formula III, containing 1.5% R. pinnata nanoparticle extract, exhibited the most superior wound-healing effect, achieving 100% inhibition by day 14, elevated hydroxyproline levels (59 µg/mL), and histologically confirmed excellent skin tissue repair. Formulas II and I followed in efficacy. These compelling findings underscore the significant potential of utilizing nanotechnology in the development of topical preparations for accelerated and effective wound healing.
Efektivitas Khasiat Penyembuhan Luka Sayat Gel Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott) Berdasarkan Analisis Hidroksiprolin Sani K, Fathnur; Samudra, Agung Giri; Rahman, Havizur; Rahman, Ave Olivia
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 2 (2022): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i2.4084

Abstract

Ekstrak daun ekor naga (Rhaphidophora pinnata (L.f) Schott) merupakan ekstrak yang telah teruji dari penelitian sebelumnya memiliki efek sebagai penyembuh luka sayat, luka bakar dan inflamasi. Efek ini didukung dengan adanya kandungan metabolit skeunder alkaloid, flavonoid, steroid, saponin dan tannin. Efek gel sebagai penyembuh luka sayat juga telah di publish. Tujuan penelitian ini adalah untuk mengetahui kadar hidroksiproline kulit yang mengalami luka sayat setelah pemberian gel ekstrak daun ekor naga selama 14 hari. Metode penelitian yang digunakan merupakan experimental design. Hewan uji yang digunakan masing-masing perlakuan sebanyak 5 ekor hewan uji. Kontrol Positif (Bioplacenton®), Formula 0 (Basis Gel), Formula 1 (Konsentrasi ekstrak daun ekor naga 10%), Formula 2 (Konsentrasi ekstrak daun ekor naga 15%), dan Formula 3 (Konsentrasi ekstrak daun ekor naga 20%). Pengamatan yang dilakukan adalah skrining fitokimia, dan kadar hidroksiproline. Hasil penelitian menunjukkan bahwa formula 2 merupakan formula yang memiliki efektivitas terbaik dalam pembentukan kolagen yaitu sebesar 35,251±4,16 µg/mL. Dimana secara statistik memiliki perbedaan yang bermakna (p<0,05) antar kelompok perlakuan. Kesimpulan bahwa gel ekstrak daun ekor naga memiliki pengaruh terhadap kadar hidroksiprolin pada kasus luka sayat hewan uji.
Gastroprotective Effect of Chitosan- Based Formulation with Chromolaena odorata L. and Peperomia pellucida L. Extracts in Ethanol-Induced Gastric Injury in Rats Pertiwi, Reza; Prima Yudha, Sal; Notriawan, Doni; Giri Samudra, Agung; Hanuun, Aanisah; Prameswari, Florencaya Prameswari; Bekti Widiansyah, Alif; Saputra, Hendri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 22 No. 2 (2025): September 2025
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v22i2.29054

Abstract

Gastroprotection refers to the effect of compounds that protect the gastric mucosa. Peperomia pellucida L. and Chromolaena odorata L. have demonstrated gastroprotective activities. Chromolaena odorata L., in particular, shows inhibition of gastric mucosal damage due to the presence of secondary metabolites such as flavonoids, phenolics, and tannins. Chitosan is a drug carrier that enhances drug bioavailability and allows pharmacological effects to be achieved at lower doses. This study aims to evaluate the gastroprotective activity of chitosan-based formulations containing Peperomia pellucida L. and Chromolaena odorata L. leaf extracts in rats. The contribution of this research lies in demonstrating the synergistic potential of medicinal plant extracts with chitosan as a delivery system, thereby providing a safer, more effective, and innovative therapeutic strategy for gastric ulcer management. Chitosan formulations containing Peperomia pellucida L. and Chromolaena odorata L. extracts were prepared and tested on male rats. The rats were divided into seven groups: Group I (normal control), Group II (negative control), Group III (positive control, treated with sucralfate), Groups IV and V (treated with chitosan-Chromolaena odorata formulations at doses of 100 and 200 mg/kg BW), and Groups VI and VII (treated with chitosan-Peperomia pellucida formulations at doses of 100 and 200 mg/kg BW). Treatments were administered orally for 14 days. On day 14, one hour after the final treatment, all groups except the normal group received oral absolute ethanol at a dose of 5 mL/kg BW to induce gastric injury. Gastric ulcer index, protection ratio, and histopathological changes were evaluated. The ulcer index values for the negative control, positive control, and treatment groups with doses of 100, 200, and 400 mg/kg BW were 4.89, 0.89, 0.33, 0.11, 1.00, and 0.78, respectively. The chitosan-based formulations containing Chromolaena odorata L. and Peperomia pellucida L. extracts demonstrated significant gastroprotective effects in ethanol-induced gastric injury in rats.
Aktivitas Inhibisi A-Amilase Ekstrak Karagenan dan Senyawa Polifenol dari Eucheuma denticulatum Samudra, Agung Giri; Nugroho, Agung Endro; Husni, Amir
Media Farmasi: Jurnal Ilmu Farmasi Vol. 12 No. 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v12i1.3023

Abstract

Penelitian ini untuk mengetahui kemampuan karagenan dan polifenol dariEucheuma denticulatum terhadap karbohidrat enzim α-amilase secara in vitro. Ekstrasi karagenan menggunakan larutan kalium hidroksida 0,5%. Polifenol diekstraksi dengan 50% (v/v) metanol. Identifikasi karagenan ditentukan dengan Fourier Transform Infrared (FTIR). Kandungan total fenol ekstrak ditentukan menurut metode Folin-Ciocalteu. Kemudian hasil ekstraksi diuji daya hambat aktivitas α-amilase. Ekstrak karagenan dan polifenol mempunyai kemampuan menghambat aktivitas IC50  α-amilase yaitu 12,16 dan  11,64 mg/mL. Ekstrak Polifenol   memiliki daya hambat α-amilase lebih tinggi dari pada ekstrak karagenan.Kata Kunci: Eucheuma denticulatum, karagenan, polifenol, α-amilase.
FORMULASI NANOPARTIKEL KITOSAN EKSTRAK METANOL ALGA LAUT COKLAT (Sargassum hystrix) DENGAN METODE GELASI IONIK Agung Giri Samudra; Nurfijrin Ramadhani; Fathnur Sani K; Gina Lestari; Bambang Hernawan Nugroho
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.428

Abstract

The content of marine algae Sargassum hystrix includes polysaccharides (alginates), polyphenols, proteins, peptides, amino acids, lipids, minerals, and several vitamins. However, the use of natural ingredients has limitations, namely that it often fails in the clinical phase due to low bioavailability. One effort that can be done to overcome this problem is to formulate nanoparticles using chitosan polymer and sodium tri-polyphosphate. This study aims to formulate nanoparticles from the methanol extract of Sargassum hystrix with various chitosan concentration ratios. The methanol extract of Sargassum hystrix was obtained by extraction using the maceration method with 50% methanol as a solvent. The results of the extract were made colloidal nanoparticles using ionic gelation techniques using a variation of the methanol extract of Sargassum hystrix: chitosan: NaTPP: Tween 80, Formulation 1 (0.75 gram: 0.1% 18 mL: 0.1% 9 mL: 0.5% 3 mL); Formulation 2 (0.75 gram: 0.2% 18 mL: 0.2% 9 mL: 0.5% 3 mL); Formulation 3 (0.75 gram: 0.1% 18 mL: 0.2% 9 mL: 0.5% 3 mL); Formulation 4 (0.75 gram: 0.2% 18 mL: 0.1% 9 mL: 0.5% 3 mL). The nanoparticle colloids formed were characterized by particle size (nm), and the zeta potential (mV), Formula 1 (212.65 ± 45.32; -11.4 ± 5.65), Formula 2 (514.55 ± 56.35; -8.85 ± 1.34), Formula 3 (219.35 ± 43.76; -14.5 ± 1.83), Formula 4 (326.5 ± 3.39; -1.25 ± 17.88). All formulas show that they can form nanoparticle formulas between 1-1000 nm., But the preparation that will be more stable is formula 3 because it has a zeta potential that is close to +/- 30 mV.
Co-Authors Abd. Halim Umar Abd. Rasyid Syamsuri Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Amalinda Setya Kartika Amir Husni Annisa Muslimah Apriza Hongko Putra Armando, Jimmy Asril Burhan Ave Olivia Rahman Bambang Hernawan Nugroho Bekti Widiansyah, Alif Bella Friska Bella Pascila Chintama, Moniq Cyntia Dwi Utami Cyntia Dwi Utami Dara Permata Sari Dea Eka Rina Dian Handayani Dimas Adhi Pradana Dominica, Dwi Dwi Ani Wijayanti Enda Oktri Mayora Fathur Sani K Febriyani, Ulfa Gatot Prasetya Gina Lestari Hanuun, Aanisah Hayati, Farida Hendri Saputra Ichwan Ridwan Rais Jimmy Armando K, Fathur Sani Khaeruddin Marwati Marwati Mayora, Enda Oktri Mita Kurnia Moniq Chintama Muh Azwar AR Nori Wirahmi Notriawan, Doni Nurfijrin Nurfijrin Ramadhani Nurfijrin Ramadhani Nurfijrin Ramadhani, Nurfijrin nurwani purnama aji Oktarina, Widiawati Prameswari, Florencaya Prameswari Prima Yudha, Sal Rahman, Havizur Reny Syahruni Revis Asra Reza Pertiwi Reza Pertiwi Sani K, Fathnur Sari Yanti Sari, Dara Permata Sitarina Widyarini Sitarina Widyarini Suci Rahmawati Tiara Feni Lestari Tiara Feni Lestari Tya Chalifatul Maulina Ulfa Febriyani Ulvi Ditasari Wafa Syahidah Wahyu Alamsyah Widiawati Oktarina Yuliawati Yuska Novianti