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All Journal e-Journal Pustaka Kesehatan Indonesian Journal of Human Nutrition Journal of Agromedicine and Medical Sciences Universa Medicina International Journal of Health and Information System (IJHIS)
Rena Normasari
Fakultas Kedokteran Universitas Jember
Computer Science & IT Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health

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The Protection Effect Of Methanol Extract From Asam Jawa Seed On Testicular Tissue Damage Induced By Aluminium Chloride (AlCL3) Rena Normasari; Muhammad Iqbal Fauzi; Ayu Munawaroh Aziz
Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i1.19645

Abstract

Aluminum is known has neurotoxin effect that can lead to alzheimer's disease, dementia, and parkinson's. Metal ions such as aluminum can distract homeostasis and increase oxidative stress level, formation of reactive oxygen species (ROS) that can overwhelm antioxidant defenses and cause DNA damage, lipid peroxidase, leading to the destruction of testicular cells. Tamarindus indica’s seeds are one of the traditional plant and useful as antioxidants. Tamarindus indica’s seeds are able to protect testicular cells from damage caused by ROS. The purpose of this study to determine the effect of methanol extract from Tamarindus indica’s seeds to prevent aluminum chloride induced testicular damage to be measured from the histopathological features. This study is a quasi experimental design with a posttest design only with non-equivalent groups using thirty male Wistar rats divided into five groups, one control group and four treatment groups. The control group was given 1 mL of aquabides solution orally. Group P1 was given a dose of aluminum solution 300 mg/kgBW orally. Groups P2, P3, and P4 were each given an aluminum solution at dose of 300 mg/kgBW orally and an extract solution at a dose of 25, 50, 100 mg/kgBW orally for 10 weeks. The results of the observations showed that the scores varied between groups. Data analysis using Kruskal-Wallis test obtained p value = 0.006 (p <0.05). Post Hoc test using Mann Whitney obtained varied p values. Post Hoc analysis between K and P1 groups, P1 and P3 groups, P1 and P4 groups showed a significant difference with p value <0.05. Based on the results of this study, methanol extract from tamarind seeds (Tamarindus indica) that was given to male wistar rats had prevented histopathological damage to the testes of rats induced by aluminum chloride (AlCl3). Keywords: aluminium, testicular cell, Tamarindus indica
Beras Analog dapat Mencegah Kerusakan Ginjal pada Tikus Induksi Kombinasi HFD dan STZ Hairrudin Hairrudin; Prajesiaji Praba Kumara; Rena Normasari
Indonesian Journal of Human Nutrition Vol. 8 No. 1 (2021)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2021.008.01.2

Abstract

Pengaturan diet pada diabetes mellitus (DM) dibutuhkan untuk mengendalikan kadar glukosa darah dan mencegah terjadinya komplikasi pada ginjal. Beras analog merupakan beras tiruan yang dibuat dari bahan pangan nonberas atau campuran dengan beras melalui teknik tertentu sehingga menyerupai beras. Beras analog diperkirakan dapat memperbaiki pengendalian kadar glukosa dan mencegah kerusakan ginjal karena memiliki kandungan serat dan resistant starch (RS) yang tinggi. Penelitian ini bertujuan untuk mengetahui efek beras analog dalam mencegah kerusakan ginjal pada tikus DM. Penelitian eksperimental ini menggunakan sampel ginjal tikus Wistar. Tikus dikelompokkan menjadi 4 kelompok (n=24), yaitu: kelompok kontrol (K0) dan tiga kelompok perlakuan (P). Kelompok K0 diberi pelet standar selama penelitian. Kelompok perlakuan diberi diet tinggi lemak selama 40 hari dan diiduksi streptozotocin (STZ) dosis 35 mg/kgBB pada hari ke-33. Hari ke-40 kelompok perlakuan dibagi menjadi 3 kelompok masing-masing diberi diet beras (PB), diet beras analog 1 (PBA1), dan diet beras analog 2 (PBA2) selama 3 minggu. Kerusakan ginjal diamati melalui gambaran histopatologi ginjal dan dinilai menggunakan sistem skoring berdasarkan tingkat glomerulosklerosis dan kerusakan tubulus. Hasil penelitian menunjukkan median skor glomerulosklerosis dan kerusakan tubulus pada K0=0,5 dan 1,0; PB=3,0 dan 4,0; PBA1=1,0 dan 2,5; PBA2=2,0 dan 3,0. Terdapat perbedaan signifikan (p<0,05) antara kelompok PB dengan PBA1 dan PBA2. Kesimpulannya adalah beras analog dapat mencegah kerusakan ginjal pada tikus DM
The Correlation Between Low Birth Weight And Stunting Incidence In Balet Baru Village, Sukowono District, Jember Regency Rachmawati, Dwita Aryadina; Normasari, Rena; Nurmaida, Eny; Hakiim, Arsyzilma; Sudarmanto, Yohanes; Parti, Dita Diana; Sofiana, Kristianningrum Dian; Astuti, Ida Srisurani Wiji; Putri, Elvia Rahmi Marga; Sulihah, Nurfaizah Titisari
International Journal of Health and Information System Vol. 3 No. 1 (2025): May
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/ijhis.v3i1.69

Abstract

Stunting is an indicator of chronic nutritional disorders and is still a complex public health problem. One of the direct risk factors for stunting is Low Birth Weight (LBW). This study is an analytical observational study that aims to determine the correlation between the history of Low Birth Weight (LBW) and the incidence of stunting in toddlers. The research was carried out in Balet Baru Village, Sukowono District, Jember Regency. The population in this study were all children aged 6 months to 5 years who are recorded in the Maternal and Child Health (KIA) register in Balet Baru Village. The total number of research subjects was 168 toddlers in a case-control design. Bivariate analysis is used to determine the relationship between LBW history and stunting incidence using the Chi-Square test. The results of the analysis showed a p-value of 0.002 (p < 0.05), which means that there is a statistically significant correlation between the history of LBW and the incidence of stunting in children aged 6 months to 5 years. An odds ratio (OR) value of 4.640 shows that children with a history of LBW have a 4.64 times greater risk of stunting than children without a history of LBW.
Co-Authors Ardhina Mahadica Nugroho Arsyzilma Hakiim Asyirah Mujahidah Fillah Azham Purwandhono Aziz, Ayu Munawaroh Bagus Hermansyah Cholis Abrori, Cholis Desie Dwi Wisudanti Dita Diana Parti Dwita Aryadina Rachmawati Fairuztya Naila Maris Galuh Dharanindya Ica Manohara Hairrudin Hairrudin Herdiyana, Firman Ida Srisurani Wiji Astuti Indah Pratiwi Kesy Sasta Handani Kiki Andari Kristianningrum Dian Sofiana Laksmi Indreswari Luh Putu Ratna Sundari Made Masagung Kawiartha Muhammad Hasan Muhammad Hasan Muhammad Iqbal Fauzi Nely Masruroh Nurmaida, Eny Prajesiaji Praba Kumara Putri, Elvia Rahmi Marga Putu Ratih Pradnyani Dewi Rini Riyanti Rony Prasetyo Rosita Dewi Sheilla Rachmania, Sheilla Sheillavi Fauziah Alex Saddamiah Sudarmanto, Yohanes sulihah, nurfaizah titisari Ulfa Elfiah Wiwien Sugih Utami Yonas Hadisubroto Yosalfa Adhista Kurniawan Yunita Dewi Anggraeni Zahrah Febianti