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All Journal Jurnal Kedokteran MNJ (Malang Neurology Journal) Journal of Pain, Vertigo and Headache Journal of Psychiatry Psychology and Behavioral Research (JPPBR)
Zamroni Afif
Department Of Neurology School Of Medicine Brawijaya University
Humanities Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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LIGHT EXPOSURE’S EFFECTS ON INACTIVE STATE DURATION AND SLEEP LATENCY IN ZEBRAFISH (DANIO RERIO) LARVAE INSOMNIA MODEL Zamroni Afif; Mochammad Istiadjid Eddy Santoso; Husnul Khotimah; Irawan Satriotomo; Edi Widjajanto; Masruroh Rahayu; Shahdevi Nandar Kurniawan; Dheka Sapti Iskandar; Annisatul Hakimah; Syafiatul Azizah; Nurvia Andriani; Kartika Agustina
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.11

Abstract

Background: Insomnia is defined as difficulty falling or staying asleep or a sleep state that cannot restore the body's condition. The zebrafish (Danio rerio) is a vertebrate model that has been extensively studied to study sleep and neurological disorders. One of the most widely used methods to examine the effect of the light-dark cycle on the circadian system is by exposing animals and humans to pulse wave light. Objective: To see the effect of light exposure on zebrafish larvae by looking at inactive state duration and sleep latency in zebrafish (Danio rerio) larvae insomnia model. Methods: This study used four groups of zebrafish larvae i.e : (1) normal group (2) minutes of light exposure and 2 minutes off (2/2)), (3) Four minutes of light exposure and 1 minute off (4/1), and (4)  24 hours on (24/0). Observation of larval movement was carried out on 5, 6, and 7 dpf (day post fertilization). Observation time was 30 minutes before and after turned off of light exposure. Results: There were significant differences on days 5, 6, and 7 between the normal group and the three light treatment groups on inactive state duration and sleep latency in dark and light conditions with p-values (p<0.05) and (p< 0.031), but there was no significant difference among groups of light exposure 2 minutes on 2 minutes off, 4 minutes on 1 minute off, and 24 hours on. The 24-hour on treatment showed the most inactive state duration among the light treatments, while the sleep latency was found in the 24-hour treatment. Conclusion: Light treatment of 2 minutes on 2 minutes off, 4 minutes on 1 minute off, and 24 hours on can cause insomnia, but the most substantial insomnia effect is obtained from the 24-hour treatment.
THE RELATIONSHIP BETWEEN RISKS OF OBSTRUCTIVE SLEEP APNEA AND DRY EYE DISEASE Aldina, Rosy; Yanuar, Ferdian; Afif, Zamroni; Holipah; Prayitnaningsih, Seskoati
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.21

Abstract

Introduction: Dry Eye Disease (DED) may lead to decreased visual function, chronic tissue changes, eyelid, conjunctival, and corneal abnormality. The prevalence of DED in Asia ranges from 21.6%–37.6%. Several studies pointed out the relationship between DED and Obstructive Sleep Apnea (OSA). In patients with OSA, oxidative stress, hypoxia, and ocular surface inflammation increase, leading to a decrease in the functions of meibomian glands, goblet cells, corneal sensitivity, and tear production as a response to the stimulations from the lacrimal glands. The loss of conjunctival goblet cells and meibomian glands are implications of damage to the tear film quality, which results in DED. Method: This is a population-based cross-sectional study. Data were obtained from the database of Biomarker Smarthealth Research in Mendalanwangi, Sidorahayu, and Cepokomulyo Villages, which are located in Malang Regency, having risks of OSA (based on the STOP-BANG questionnaire), above ≥40 years old, and DED Examination with Tear Break-Up Time (TBUT), MGD (Meibominan Gland Dysfunction), Tear Meniscus (TM) involving a total of 518 respondents. The available data were then processed according to the variables and went through DED examinations. This study employed the purposive sampling method. Result: In this study, moderate risk of OSA suggests a significant influence on the occurrence of DED with an odds ratio (OR) 1.66 (p<0.05). In addition, moderate risk of OSA predisposes ADDE (Aqueous Deficiency Dry Eye)-type and Mix-type DED with OR 2.85 and 1.23 (p<0.05). High risk of OSA correlates with the occurrence of ADDE-type DED with OR 2.37 (p<0.05). The age group >60 years old shows a correlation with Mix-type DED with OR 2.09 (p<0.05). Women have a higher predisposition to ADDE-type with OR 2.58 (p<0.05). Conclusion: Moderate risk of OSA influences the occurrence of DED, both ADDE-type and Mix type; whereas high risk of OSA only correlates with ADDE-type. Older age plays a role in the occurrence of Mix-type DED and women have a higher tendency to present with ADDE- type.
THE ASSOCIATION BETWEEN STROKE DETERMINANT FACTORS AND SLEEP QUALITY IN POST-STROKE PATIENTS Afif, Zamroni; Arisetijono, Eko; Setijowati, Nanik; Sitompul, Boyke
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.09

Abstract

Background: Stroke is a serious condition can cause sudden loss of neurological function. Sleep disorders, such as insomnia, hypersomnia, sleep apnea, and restless leg syndrome, often occur in stroke patients and can worsen the post-stroke rehabilitation process, especially who have a history of diabetes mellitus (DM), hypertension, and heavy smoker. Effective management of post-stroke patients requires identifying and treating sleep quality disorders and associated risk factors to improve quality of life. Objective: This study aims to explore the association between DM, hypertension, and smoking in post-stroke patients and sleep quality. Methods: A cross-sectional study was conducted on post-stroke control patients at the Neurology Clinic at Dr. Saiful Anwar Hospital, East Java, from December 2023 to February 2024. Sleep quality disorder were measured using the Pittsburgh Sleep Quality Index (PSQI) within one month after outpatient treatment. Additional data were analyzed using the chi-square test and binary logistic regression. Results: Among the 74 participants, 25 patients (25.7%) had a history of DM, 68 (91.9%) with hypertension, and 20 (27%) were heavy smokers. There were 34 patients (45.9%) who experienced sleep quality disorders. There was a significant association between DM and sleep disorders (p=0.005), while hypertension and smoking did not show a significant correlation. History of DM was a significant predictor of sleep disorders (p=0.09 | OR 4.782, 95% CI 1.483–15.421). Conclusion: This study shows a significant association between history of DM in post-stroke patients and sleep quality based on PSQI.
Co-Authors Annisatul Hakimah Badrul Munir DAMAYANTI, ZUHRIA PUSPITA Dearisa Surya Yudhantara Dessika Rahmawati Dheka Sapti Iskandar Edi Widjajanto Eko Arisetijono Helena Era Millennie Herpan Syafii Harahap Holipah Husnul Khotimah Irawan Satriotomo Kartika Agustina Laksmi Muliawati Masruroh Rahayu Mochammad Istiadjid Eddy Santoso Muhammad Welly Dafif Nanik Setijowati Nurvia Andriani Reza Rachmantoko Rodhiyan Rakhmatiar Rosy Aldina Seskoati Prayitnaningsih Shahdevi Nandar Kurniawan, Shahdevi Nandar Sitompul, Boyke Syafiatul Azizah Widodo Mardi Santoso Yanuar, Ferdian