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All Journal Jurnal Farmasi Klinik Indonesia Indonesian Journal of Medicine PROFESI (Profesional Islam): Media Publikasi Penelitian ABDI MOESTOPO: Jurnal Pengabdian pada Masyarakat Urecol Journal. Part C: Health Sciences Jurnal Pengabdian Masyarakat Sains dan Teknologi Jurnal Farmasi Klinik dan Sains Jurnal Kabar Masyarakat Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia Usadha Journal of Pharmacy Karya Nyata: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Global Health Research
Dwiki Fitri
Universitas Muhammadiyah Gombong
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Identification of Genomic Databases and Bioinformatics Analysis of Gene Variations in Behçet Syndrome Across Continental Populations Dwiki Fitri; Husnul Khuluq; Diah Kurniasih; Muhammad Ma'ruf
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.751

Abstract

Behçet's Syndrome is a rare multisystem inflammatory disorder with an etiology that is not yet fully understood. The disease is characterized by various clinical manifestations, including recurrent oral and genital ulcers, ocular lesions, skin abnormalities, arthritis, central nervous system involvement, and vascular complications. Understanding the genetic factors associated with Behçet's Syndrome across different populations may provide insights into its pathogenesis and potential therapeutic targets. This study aims to identify genetic variations associated with Behçet's Syndrome across populations from different continents using a bioinformatics approach. Data were analyzed from the GWAS Catalog, HaploReg v4.2, GTEx Portal, and Ensembl Genome. Single nucleotide polymorphisms (SNPs) associated with Behçet's Syndrome were identified, and their tissue-specific gene expression and allele frequency across populations were investigated. Two main SNPs, rs17482078 and rs2617170, were identified as missense mutations in the ERAP1 and KLRC4 genes, respectively, both of which have been linked to various autoimmune diseases. GTEx Portal analysis revealed that ERAP1 is expressed in 30 tissues, including skeletal muscle, blood, brain regions (putamen, caudate, hypothalamus), skin, pancreas, esophagus, and other organs. KLRC4 expression was observed in 18 tissues, including the cerebral cortex, lungs, heart, small intestine, thyroid, prostate, and additional tissues. Ensembl Genome data indicated population-specific allele frequency variation: rs17482078 in ERAP1 was highest in Africa (94.6%), followed by East Asia (94.2%), South Asia (93.5%), the Americas (88%), and Europe (78%). SNP rs2617170 showed the highest frequency in Africa (57%), followed by South Asia (46%), East Asia (45%), Europe (34%), and the Americas (33%). The findings highlight ERAP1 and KLRC4 as key genetic factors associated with Behçet's Syndrome and demonstrate population-specific allele frequency differences. These results provide valuable insights into the genetic architecture of the disease and may guide future studies on its pathogenesis and potential therapeutic strategies.
Sosialisasi dan Pemberian Puding Daun Kelor (Moringa Oleifera) Sebagai Upaya Pencegahan Stunting pada Balita di Posyandu Desa Ngombakan, Kecamatan Polokarto, Kabupaten Sukoharjo Dimas Aji Pratama; Dwiki Fitri; Aidatul Mufidah; Amalia Agamasi
Jurnal Pengabdian Masyarakat Sains dan Teknologi Vol. 5 No. 2 (2026): Juni: Jurnal Pengabdian Masyarakat Sains dan Teknologi
Publisher : Fakultas Teknik Universitas Cenderawasih

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58169/jpmsaintek.v5i2.1127

Abstract

Stunting is a chronic nutritional problem that remains a major public health challenge in Indonesia, including in Ngombakan Village, Polokarto District, Sukoharjo Regency. Moringa leaves (Moringa oleifera Lam.) are known as a superfood plant with nutritional content far exceeding conventional food ingredients, including protein, vitamin A, calcium, potassium, iron, and vitamin C, making them highly potential as a functional food for stunting prevention. This community service activity aims to improve the knowledge of mothers at the Posyandu of Ngombakan Village about stunting and the benefits of moringa leaves, while also introducing the innovation of moringa leaf pudding as a nutritious supplementary food for toddlers. The activity was carried out from August 13 to September 6, 2024 through 6 meetings at the posyandu using lecture methods, leaflet distribution, and pudding-making demonstrations. The results showed a significant increase in mothers' knowledge about stunting and the nutritional content of moringa leaves, as well as positive enthusiasm from participants in accepting moringa leaf pudding as an affordable and nutritious supplementary food alternative for toddlers.
Sosialisasi dan Pemberian Puding Daun Kelor (Moringa Oleifera) sebagai Upaya Pencegahan Stunting pada Balita di Posyandu Desa Ngombakan, Kecamatan Polokarto, Kabupaten Sukoharjo Dimas Aji Pratama; Dwiki Fitri; Aidatul Mufidah; Amalia Agamasi
Faedah: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia Vol. 4 No. 3 (2026): Agustus: Jurnal Hasil Kegiatan Pengabdian Masyarakat Indonesia
Publisher : FKIP, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59024/faedah.v4i3.1878

Abstract

Stunting is a chronic nutritional problem that remains a major public health challenge in Indonesia, including in Ngombakan Village, Polokarto District, Sukoharjo Regency. Moringa leaves (Moringa oleifera Lam.) are known as a superfood plant with nutritional content far exceeding conventional food ingredients, including protein, vitamin A, calcium, potassium, iron, and vitamin C, making them highly potential as a functional food for stunting prevention. This community service activity aims to improve the knowledge of mothers at the Posyandu of Ngombakan Village about stunting and the benefits of moringa leaves, while also introducing the innovation of moringa leaf pudding as a nutritious supplementary food for toddlers. The activity was carried out from August 13 to September 6, 2024 through 6 meetings at the posyandu using lecture methods, leaflet distribution, and pudding-making demonstrations. The results showed a significant increase in mothers' knowledge about stunting and the nutritional content of moringa leaves, as well as positive enthusiasm from participants in accepting moringa leaf pudding as an affordable and nutritious supplementary food alternative for toddlers.
Pengolahan Sampah Organik menjadi Pupuk Organik Cair (POC) sebagai Upaya Pemanfatan Limbah Organik di Desa Peniron Shafitri Nire Pangestika; Siti Mutoharoh; Dwiki Fitri; Fauzan Yoga Pratama; Dian Nur Pratiwi; Rahyuni Meylani Asmarayani; Zalfa Uniqha Salsabilla; Riska Tri Marlina Bisaroh; Angga Gilang Pambudi; Juanka Bagus Fathurrahman; Bimantaka Cahyo Yonanda; Khaleda Handy Widiastuti
Jurnal Kabar Masyarakat Vol. 4 No. 3 (2026): Agustus: JURNAL KABAR MASYARAKAT
Publisher : Institut Teknologi dan Bisnis Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54066/jkb.v4i3.4899

Abstract

Household waste, particularly organic waste, remains an environmental problem that requires appropriate management and utilization. Organic waste generated from household activities has the potential to be reused as a useful product, one of which is through the production of liquid organic fertilizer (LOF). This community service activity aimed to introduce the utilization of household organic waste as a raw material for producing LOF to the community of Peniron Village. The activity began with observations and interviews to identify the existing conditions of household waste management in Peniron Village. This was followed by education on organic waste management and a demonstration of LOF production, followed by post-activity monitoring to determine the utilization of the LOF produced. The educational and demonstration activities introduced an alternative method of utilizing household organic waste to produce LOF, as well as the use of organic materials available in the surrounding environment. The monitoring results showed that the LOF produced was still being utilized by the community after the activity. The findings indicated that some community members continued producing LOF independently after the activity by utilizing household organic waste. The resulting LOF was then used for watering plants. These findings indicate that the utilization of organic waste continued to be practiced by the community after the community service activity. This activity can serve as an alternative approach to introducing simple household organic waste management by utilizing materials readily available in the surrounding environment.
Co-Authors Agamasi, Amalia Aidatul Mufidah Ainni, Ayu Nissa Alifah, Dika Amalia Agamasi Amalia, Senya Puteri Angga Gilang Pambudi Ayu Nissa Ainni Bimantaka Cahyo Yonanda Cantika, Citra Dhea Diah Kurniasih Diah Kurniasih Dian Nur Pratiwi Dimas Aji Pratama Endang Yuniarti Endang Yuniarti Fauzan Yoga Pratama Febrianti, Dwi Rizki Fitriyati, Laeli Husnul Khuluq Husnul Khuluq Intiyani, Rafila Iwan Santoso, Iwan Juanka Bagus Fathurrahman Khaleda Handy Widiastuti Khuluq, Husnul Khuluq, Muh Husnul Lalu Muhammad Irham Maruf, Muhammad Miyarso, Condrosuro Muhammad Ma'ruf Muhammad Ma'ruf Nabila Luthfia Zahra Nanik Sulistyani Pangestika, Shafitri Nire Puspitaningrum, Anisa Nova Rahyuni Meylani Asmarayani Riska Tri Marlina Bisaroh Rudi, Nyoman Salamah, Siti Hajar Sianu, Rahman S Sinta Wahyu Septiani Siti Mutoharoh Sulistiyani, Nanik Tri Cahyani Widiastuti Wahyu Rahmatulloh Wibowo, Anisa Devi Karisma Winarno, Tunjung Wirawan Adikusuma Zahra, Nabila Luthfia Zalfa Uniqha Salsabilla