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All Journal Pharmascience Berkala Kedokteran Borneo Journal of Medical Laboratory Technology Jurnal Insan Farmasi Indonesia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Klinik dan Sains
Febrianti, Dwi Rizki
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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FORMULASI DAN EVALUASI GEL HAND SANITIZER DARI MINYAK ATSIRI BUNGA LILI (Lilium auratum) Febrianti, Dwi Rizki; Kumalasari, Eka; Niah, Rakhmadhan; Ariani, Novia; Supomo, Supomo; Sandi, Dita Ayulia Dwi
Jurnal Pharmascience Vol 11, No 1 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i1.13822

Abstract

Minyak atsiri bunga lili (lilium auratum) dapat berpotensi sebagai antibakteri dengan memformulasikan dalam bentuk sediaan gel hand sanitizer. Tujuan penelitian ini adalah untuk menentukan sediaan gel antiseptik (Hand sanitizer) minyak atsiri bunga lili dengan berbagai konsentrasi gelling agent carbopol 940 yang mempunyai sifat fisik yang baik dan memenuhi syarat. Carbopol 940 divariasikan dengan konsentrasi 0,667 % dan 1,334% dari total formula. Penelitian ini menggunakan metode eksperimental. Formula diuji sifat fisiknya, seperti uji organoleptis, pH, homogenitas, daya lekat dan daya sebar. Hasil penelitian menunjukkan dari kedua formula dengan variasi konsentrasi gelling agent carbopol 940 yaitu 0,667 % dan 1,334% memenuhi syarat uji sifat fisik. Didapatkan hasil formula yang mempunyai sifat fisik yang memenuhi standar uji sifat fisik adalah formula II dengan konsentrasi Carbopol 940 1,334%. Kata Kunci : Lilium Auratum, Hand Sanitizer, Carbopol 940, Uji Sifat Fisik, Antibakteri The essential oil of lili (Lilium auratum) can potentially be antibacterial by formulating in the form of hand sanitizer gel preparations. This study is to determine the preparation of antiseptic gel (Hand sanitizer) of lilies essential oil with various concentrations of gelling agent carbophol 940 which has good physical properties and qualifies. Carbophol 940 with a variation in concentration of 0.667% and 1.334% with experimental methods conducted trials on formulations so that a product of hand sanitizer gel preparations of lilies essential oil that has good physical properties and qualifies. The results of the research showed that from the two formulas with variations in the concentration of the gelling agent Carbopol 940, namely 0.667% and 1.334%, it met the requirements. The resulting formula which had good physical properties was formula II with the amount of Carbopol 1.334%.
Effectiveness of Ramania Leaves (Bouea macrophylla Griffith) from South Kalimantan as a Mosquito Larvae Biolarvicidal Aryzki, Saftia; Febrianti, Dwi Rizki
Berkala Kedokteran Vol 19, No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i2.17386

Abstract

Indonesia itself as a tropical country has many plants that can be used as biolarvicides, one of which is the ramania plant (Bouea macrophylla Griffith). Ramania fruit epidermis contains secondary metabolites such as flavonoids, saponins, phenolic tannins, alcohol, steroids and terpenoids where these compounds have a larvicidal effect. The purpose of this study was to determine the activity of the ethanol extract of the epidermis of the ramania fruit as a biolarvicidal Mosquito larvae from the LC50 value. This research is a laboratory experimental research. The treatment concentrations used in this study were 25 ppm, 50 ppm, and 100 ppm. Temephos 1% was used as a positive control. Concentrations were then tested on 20 larvae instar III. The results of SPSS analysis with a significance of <0.05 showed that there was an effect of treatment on the number of larvae deaths, where the results of Tuckey analysis showed that concentrations of 50 ppm and 100 ppm and Temephos 1% showed differences. which means the number of deaths of test larvae. The results showed that the ethanol extract of ramania rind of ramania fruit (Bouea macrophylla Griffith) was effective as a biolarvicidal mosquito larvae. The results of probit analysis showed that the LC50 of ethanol extract of ramania rind against larvae was 20,844 ppm which is a low toxic group in aquatic environments.
Aktivitas Baccaurea motleyana Mull.Arg. terhadap Salmonella thypi Febrianti, Dwi Rizki; Aryzki, Saftia; Khadijah, Maulida; Kumalasari, Eka; Niah, Rakhmadhan
Jurnal Pharmascience Vol 11, No 2 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.16498

Abstract

Penyakit tifus adalah gangguan pada sistem pencernaan yang menyerang bagian usus halus dan terkadang dapat mempengaruhi aliran darah, kantong empedu, limfa, dan hati. Penyebab utama tifus adalah aktivitas bakteri Salmonella thypi, bakteri ini mampu mengontaminasi makanan ataupun minuman yang tidak terjaga sanitasinya. Baccaurea motleyana Mull.Arg memiliki kandungan senyawa antibakteri, diantaranya golongan flavonoid, saponin, dan tanin. Penelitian ini bertujuan untuk membuktikan aktivitas ekstrak daun rambai dalam menghambat S. thypi. Penelitian ini menggunakan metode ekstraksi maserasi dan uji antibakteri menggunakan metode difusi sumuran menggunakan nutrien agar (NA). Ekstraksi dengan maserasi dilakukan menggunakan pelarut etanol 70%. Kelompok perlakuan pada penelitian ini menggunakan seri  konsentrasi ekstrak 10%, 20%, 30%, dan kontrol negatif (water for injection) dengan tiga kali pengulangan. Ukuran diameter zona bening yang terbentuk diukur menggunakan jangka sorong digital. Hasil penelitian menunjukkan bahwa ekstrak daun rambai memiliki efek penghambatan terhadap pertumbuhan bakteri S. thypi. Rerata zona hambat dari ekstrak daun rambai dengan konsentrasi 10%, 20%, dan 30% masing-masing adalah 14,1 mm; 18,8 mm; dan 23,13 mm, sehingga dapat disimpulkan bahwa ekstrak daun B. motleyana memiliki aktivitas terhadap bakteri S. thypi. Kata Kunci: Antibakteri,  Zona Bening, Daun Rambai,  Difusi Padat, Salmonella thypi Typhoid disease is a disorder of the digestive system that attacks parts of the small intestine and can sometimes affect blood flow, gallbladder, lymph, and liver. The main cause of typhus is the activity of Salmonella thypi bacteria, this bacterium is able to contaminate food or drinks that are not maintained sanitation. Baccaurea motleyana Mull.Arg contains antibacterial compounds, including flavonoids, saponins, and tannins. This study aims to prove the activity of rambai leaf extract in inhibiting S. thypi. This study uses the maceration extraction method and antibacterial test using the well diffusion method using agar nutrients (NA). Extraction by maceration is carried out using a 70% ethanol solvent. The treatment group in this study used a series of 10%, 20%, 30% extract concentrations, and negative control (water for injection) with three repetitions. The size of the diameter of the formed clear zone is measured using a digital caliper. The results showed that rambai leaf extract had an inhibitory effect on the growth of S. thypi bacteria. The average inhibition zone of rambai leaf extract with concentrations of 10%, 20%, and 30% was 14.1 mm, respectively; 18.8 mm; and 23.13 mm, so it can be concluded that B. motleyana leaf extract has activity against S. thypi bacteria.
FORMULASI DAN KARAKTERISASI FITOSOM EKSTRAK TANAMAN BUNDUNG (Actinoscirpus grossus) SEBAGAI ANTIOKSIDAN Febrianti, Dwi Rizki; Noval; Dwi Rizki; Melviani; Mayna; Salwa Nisrina; Akhmad Fadhil Samara
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2410

Abstract

Free radicals are the cause of cell damage and death. Free radical molecules are highly unstable and reactive, and can cause cell damage and metabolic disorders. Antioxidants are compounds that can reduce the negative impact of oxidants, enzymes, and metal-binding proteins. Bundung plant (Actinoscirpus grossus) contains secondary metabolite compounds namely flavonoids, tannins, saponins, phenolics, steroids, and terpenoids. Bundung showed moderate antioxidant activity with an IC50 value of 128 ppm. Flavonoids have high polarity, but are difficult to absorb due to their large size and poor solubility in lipids. Phytosomes can overcome the absorption barriers of natural active ingredients, by converting hydrophilic phytoconstituents into hydrophobic or lipid soluble components thereby increasing bioavailability through increased ability to cross cellular membranes and enter into blood circulation. The purpose of this study was to obtain the formulation and characterization of phytosomes of bundung plant extract as an antioxidant. The method uses maceration until a thick extract is obtained. Then, phytosomes of bundung extract were made by thin layer hydration method using rotary vaccum evaporator. The results showed that phytosomes of bundung extract in formula 4 were the most optimal, having a particle size value of 282.63 nm, a polydispersity index of 0.278 nm, a zeta potential of -5.89 nm, an absorption efficiency of 100%, and the best vesicle morphology was evenly distributed, had relatively the same size between one vesicle and another, and there was no aggregation between vesicles.
EVALUASI ARAH KOMPETENSI LULUSAN PROGRAM STUDI PENDIDIKAN PROFESI APOTEKER PADA PENDIDIKAN TINGGI FARMASI DI KALIMANTAN SELATAN, INDONESIA Muhammad Reza Pahlevi; Noval; Febrianti, Dwi Rizki; Difa Intannia; Syahrizal Ramadhani; Melviani; Mustika Muthaharah
Jurnal Insan Farmasi Indonesia Vol 8 No 1 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v8i1.2431

Abstract

South Kalimantan has four Pharmacy Higher Education Institutions (PTF) offering Pharmacist Professional Education Study Program (PSPPA), namely Lambung Mangkurat University (ULM), Borneo Lestari University (UNBL), Sari Mulia University (UNISM), and Muhammadiyah University of Banjarmasin (UMB). This research aims determine competency direction PSPPA graduates from PTF in South Kalimantan. Using descriptive research design qualitative case study method, the findings reveal that graduate profile PSPPA South Kalimantan does not fully reflect local and national characteristics  pharmacist, such as being religious, having national perspective, adhering professional ethics, and upholding the law. The graduate profile should encompass  institution's vision, academic excellence, moral values, specific characteristics higher education institution. PSPPA designed with min.36 credits over 2 semesters. ULM directs PSPPA competencies towards pharmaceutical practices in wetland environments, integrated into several courses. UNBL focus producing professional pharmacist with foundation Kalimantan's local wisdom, featuring integrated course pharmaceutical services. UNISM emphasizes excellence and collaboration  developing riverine potential, integrated Phytotherapy course, given South Kalimantan's, particularly Banjarmasin's, numerous river systems. Meanwhile, UMB develops PSPPA program characterized progressive Islamic value, with standout course Islamic Professionalism. The results align with graduate competency standards and pharmacist education curriculum standards  APTFI, Law No.17 of 2023, and Minister Education and Culture Regulation no.53 of 2023
KARAKTERISTIK PARAMETER SPESIFIK DAN NON SPESIFIK DAUN KRATOM (Mitragyna speciosa Korh.) ASAL KALIMANTAN SELATAN Febrianti, Dwi Rizki; Wahyuono, Subagus; Fakhrudin, Nanang; Riski, Akhmad; Kumalasari, Eka; Normilawati; Niah, Rakhmadhan; Mar'uf, Muhammad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2786

Abstract

Standardization is a process of fulfilling the requirements for raw materials of traditional medicine, aimed at ensuring and maintaining safety, consistent quality, and efficacy. Kratom leaves (Mitragyna speciosa) are a traditional medicinal plant found in the interior regions of Kalimantan. This plant functions as a source of energy due to its stimulant properties. This study aims to determine the standardization of kratom leaf extract simplicia, including both specific and non-specific parameters. The extraction method used in this study was maceration with ethanol. The results showed that the scientific name of kratom leaves is Mitragyna speciosa. The standardization of kratom leaf simplicia powder includes parameters such as loss on drying, total ash, water-insoluble ash, acid-insoluble ash, total microbial count (ALT), total yeast and mold count (AKK), and heavy metal contamination, with the following results: 9.5%; 5.51%; 3.58%; 0.39%; 6.9 × 10² cfu/g; >3.0 × 10³ cfu/g; <0.001 mg/kg. Meanwhile, the standardization of kratom leaf extract includes ash content and heavy metal contamination, with results of 6.06% and <0.001 mg/kg, respectively. The active compounds contained in the kratom leaf simplicia and extract are alkaloids, flavonoids, and tannins.
Potensi antibakteri Ekstrak Kulit Buah Pisang Kepok Mentah (Musa paradisiaca forma typica) Terhadap Staphylococcus aureus Secara in Vitro : Antibacterial Potential Of Raw Kepok Banana Peel Extract (Musa paradisiaca Forma Typica) Against Staphylococcus aureus In Vitro Ariani, Novia; Febrianti, Dwi Rizki; Puteri, Naimah
Borneo Journal of Medical Laboratory Technology Vol. 7 No. 1 (2024): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v7i1.7140

Abstract

Staphylococcus aureus (S. aureus) merupakan bakteri gram positif yang secara alami berfungsi sebagai flora normal pada kulit. Pada konsentrasi yang besar S. aureus dapat menjadi bakteri patogen penyebab penyakit kulit pada anak maupun orang dewasa. Salah satu alternatif terapi yang dapat digunakan adalah bahan alami dari kulit buah pisang kepok (Musa paradisiaca forma typica). Kulit buah pisang kepok (Musa paradisiaca forma typica) mengandung senyawa flavonoid, alkaloid, tanin, dan saponin yang memiliki aktivitas sebagai antibakteri yang dapat menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk mengetahui daya hambat ekstrak kulit buah pisang kepok (Musa paradisiaca forma typica), dengan berbagai konsentrasi. Penelitian ini merupakan penelitian eksperimental dengan menggunakan metode Difusi Sumuran yang terbagi menjadi 8 kelompok uji yaitu 6 kelompok konsentrasi perlakuan, 1 kelompok kontrol negatif dan 1 kelompok kontrol positif dengan 4 kali pengulangan. Hasil penelitian menunjukkan bahwa ekstrak kulit buah pisang kepok (Musa paradisiaca forma typica) dapat menghambat pertumbuhan bakteri S. aureus. Daya hambat esktrak pada kosentrasi 70%, 80%, 90%, 100%, 110%, 120% dengan rata-rata diameter zona hambat masing-masing 3,06 mm; 3,59 mm; 3,72 mm; 4,77 mm; 6,49 mm; 5,87 mm. Dapat disimpulkan bahwa ekstrak pisang kepok mentah memiliki potensi sebagai antibakteri terhadap S. Aureus.
Identifikasi Mutu Simplisia dan Ekstrak Serta Uji Aktivitas Antioksidan Ekstrak Daun Sungkai (Peronema canescens Jack) Ma'ruf, Muhammad; Febrianti, Dwi Rizki; Kumalasari, Eka; Amukti, Danang Prasetyaning; Santoso, Blegoh Iwan
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1862

Abstract

Sungkai (Peronema canescens Jack.) merupakan salah satu tanaman yang telah lama dimanfaatkan oleh masyarakat sebagai obat tradisional untuk berbagai jenis penyakit. Tanaman ini khususnya pada bagian daun diketahui mengandung flavonoid alkaloid saponin tanin dan terpenoid atau steroid yang berperan sebagai antioksidan. Namun data terkait variasi mutu simplisia dan ekstrak daun sungkai masih terbatas sehingga berpotensi memengaruhi konsistensi aktivitas dan kualitas produk herbal. Penelitian ini bertujuan untuk mengetahui kandungan kimia dalam simplisia dan ekstrak daun sungkai, serta menguji kemampuan antioksidannya dengan metode DPPH. Penelitian ini diawali dengan pengambilan daun sungkai segar yang kemudian diolah menjadi simplisia dan diekstraksi menggunakan etanol 96% melalui metode maserasi. Karakterisasi simplisia dan ekstrak dilakukan melalui uji organoleptik, penetapan parameter spesifik dan nonspesifik, serta skrining fitokimia. Uji aktivitas antioksidan dilakukan dengan metode DPPH menggunakan vitamin C sebagai pembanding serta mengacu pada kriteria klasifikasi nilai IC₅₀ untuk menentukan tingkat kekuatan aktivitas antioksidan. Hasil penelitian ini menunjukkan bahwa simplisia dan ekstrak daun sungkai mengandung alkaloid, flavonoid, saponin, tanin, serta terpenoid/steroid. Parameter mutu simplisia memenuhi standar Farmakope Herbal Indonesia. Uji DPPH menghasilkan nilai IC₅₀ vitamin C sebesar 7,80 ppm dan ekstrak daun sungkai sebesar 14,55 ppm. Keduanya termasuk kategori aktivitas antioksidan sangat kuat, meskipun ekstrak daun sungkai sedikit lebih rendah dibanding vitamin C. Temuan ini menunjukkan bahwa daun sungkai berpotensi dikembangkan sebagai sumber antioksidan alami serta menjadi dasar dalam upaya standardisasi bahan baku dan pengembangan sediaan herbal.
Co-Authors Akhmad Fadhil Samara Amalia, Senya Puteri Ariani, Novia Aryzki, Saftia Cantika, Citra Dhea Danang Prasetyaning Amukti Difa Intannia Dwi Rizki Eka Kumalasari Fitri, Dwiki Khadijah, Maulida Ma'ruf, Muhammad Mar'uf, Muhammad Maruf, Muhammad Mayna Melviani Muhammad Reza Pahlevi Mustika Muthaharah Nanang Fakhrudin, Nanang Niah, Rakhmadhan Normilawati Noval Puspitaningrum, Anisa Nova Puteri, Naimah Riski, Akhmad Saftia Aryzki Salwa Nisrina Sandi, Dita Ayulia Dwi Santoso, Blegoh Iwan Subagus Wahyuono Supomo Supomo Syahrizal Ramadhani