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Optimization of Propylene Glycol and Na CMC in Gel Serum Preparations of Chicken Bone Collagen Antioxidant (Gallus gallus domesticus) Saputri, Dian; Cahyani, Intan Martha; Kristantri, Rika Sebtiana; Pebriani, Tris Harni; Sari, Wulan Kartika
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.19932

One important component found in the dermis layer of the skin is collagen. A decrease in collagen levels can result in reduced skin thickness and strength, loss of elasticity, and decreased skin hydration. Chicken bones serve as a valuable alternative source for the commercial production of collagen, which can be used in easily applicable pharmaceutical preparations, such as gel serum. Antioxidant gel serum preparations are developed by optimizing chicken bone collagen gel serum combined with Na CMC (0-2%) and propylene glycol (8-10%) using the Simplex Lattice Design method, so it is obtained 8 consecutive runs, the comparison is R1 and R3 (1% : 9%), R2 and R8 (2% : 8%), R4 (0,5% : 9,5%), R5 (1,5% : 8,5%) R6 and R7 (0% : 10%). The results indicate that the optimal formula consists of 1.984% Na CMC and 8.016% propylene glycol, yielding a pH of 4.50, a viscosity of 1700 cps, adhesion of 1.72 seconds, spreadability of 6.15 cm, and an IC50 of 57,36 ppm. Validation tests using the T-test demonstrated no significant difference between the observation and prediction results, confirming that the obtained formula was valid.

Optimization of Propylene Glycol and Na CMC in Gel Serum Preparations of Chicken Bone Collagen Antioxidant (Gallus gallus domesticus) Saputri, Dian; Cahyani, Intan Martha; Kristantri, Rika Sebtiana; Pebriani, Tris Harni; Sari, Wulan Kartika
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.19932

One important component found in the dermis layer of the skin is collagen. A decrease in collagen levels can result in reduced skin thickness and strength, loss of elasticity, and decreased skin hydration. Chicken bones serve as a valuable alternative source for the commercial production of collagen, which can be used in easily applicable pharmaceutical preparations, such as gel serum. Antioxidant gel serum preparations are developed by optimizing chicken bone collagen gel serum combined with Na CMC (0-2%) and propylene glycol (8-10%) using the Simplex Lattice Design method, so it is obtained 8 consecutive runs, the comparison is R1 and R3 (1% : 9%), R2 and R8 (2% : 8%), R4 (0,5% : 9,5%), R5 (1,5% : 8,5%) R6 and R7 (0% : 10%). The results indicate that the optimal formula consists of 1.984% Na CMC and 8.016% propylene glycol, yielding a pH of 4.50, a viscosity of 1700 cps, adhesion of 1.72 seconds, spreadability of 6.15 cm, and an IC50 of 57,36 ppm. Validation tests using the T-test demonstrated no significant difference between the observation and prediction results, confirming that the obtained formula was valid.

Formulation of Theophylline Sustained-Release Tablets with a Combination of Eudragit RS 100 and Lactose Trisnaningtyas, Meysiska; Ikasari, Endang Diyah; Cahyani, Intan Martha
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26837

Sustained-release (SR) delivery of Theophylline is pharmaceutically essential due to its narrow therapeutic index and the need to maintain controlled plasma exposure. This study aims to investigate the release kinetics and matrix-modifying roles of Eudragit RS 100 and lactose in three SR tablet formulations of Theophylline. Tablets were produced with the wet granulation method and evaluated for physicochemical properties, dissolution behavior according to USP specifications, and kinetic model fitting. The physicochemical evaluation revealed clear differences among formulations. F-1 exhibited the highest hardness (10.48 ± 0.10 kg/cm²) but excessive friability (2.40 ± 0.01%), whereas F-2 and F-3 showed lower hardness values (8.25 ± 0.03 and 8.03 ± 0.02 kg/cm²) with acceptable friability (0.32 ± 0.03% and 0.34 ± 0.03%). Granule flow properties improved progressively from F-1 to F-3, as indicated by reduced Carr’s Index (16.17 ± 0.16 to 11.58 ± 0.32%) and Hausner Ratio (1.193 to 1.131), accompanied by increased flow rates (12.12 ± 0.03 to 14.48 ± 0.53 g/s) (p < 0.05). These physicochemical differences were reflected in dissolution behavior and drug-release kinetics, confirming the matrix-modifying effects of Eudragit RS 100 and lactose. Kinetic modeling demonstrated formulation-dependent release mechanisms: F-1 showed the highest correlation with the zero-order model (R² = 0.9858), suggesting a near constant drug-release rate, whereas F-2 exhibited the best fit to a second-order model (R² = 0.9635), indicating concentration-dependent release. In contrast, F-3 was optimally described by the Korsmeyer–Peppas model (R² = 0.9545), consistent with anomalous transport governed by combined diffusion and polymer relaxation.

The Optimization of Polyvinyl Alcohol and Stearic Acid in Citronella EssentialOil (Cymbopogon nardus L. Rendle) Paper Soap Formula as An Antibacterial for Staphylococcus aureus Sumule, Arsiaty; Endang Diyah Ikasari; Cahyani, Intan Martha; Vitara, Dea
Pharmaceutical Journal of Indonesia Vol. 11 No. 2 (2026)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Introduction: Hands that look clean can be a medium for transmitting germs. Therefore, one of the prevention efforts that can be done is diligently washing hands using soap and running water, so that practical soap preparations such as paper soap are needed. The high content of terpenoid compounds and strong antibacterial activity in citronella essential oil (Cymbopogon nardus L. Rendle) has the potential to be developed in paper soap preparations. The paper soap formulation of citronella essential oil was prepared using a combination of PVA and stearic acid. Objective: This study aims to determine the effect of the using PVA and stearic acid on physical characteristics in the citronella essential oil paper soap and determine the ratio of the concentrations of PVA and stearic acid in the optimum formula using the Simplex Lattice Design method. Methods: Paper soap formula optimization analyzed by Simplex Lattice Design method using Design Expert 10.0.1. Optimized parameters were pH, foam stability, free alkali, tensile strength, and percentage elongation. The optimum formula was tested for antibacterial activity of Staphylococcus aureus. Results: The results of Design Expert 10.0.1 showed that the optimum formula with a concentration ratio of PVA was 5.113% and stearic acid was 2.387%. The experimental results obtained an average of pH 10.95; foam stability 90.66%; free alkali 0.08%; tensile strength 0.7185 N/m2; and percentage elongation 15.12%. The results of the one sample T-test showed that these observations are differed not significantly to the result of the predictions indicating that the equation of each optimization parameter was valid except for the percentage elongation. The optimum formula has antibacterial activity of Staphylococcus aureus with a diameter of 8.52 mm. Conclusion: PVA and stearic acid have a significant effect on optimization response.

The Optimization of Polyvinyl Alcohol and Stearic Acid in Citronella EssentialOil (Cymbopogon nardus L. Rendle) Paper Soap Formula as An Antibacterial for Staphylococcus aureus Sumule, Arsiaty; Endang Diyah Ikasari; Cahyani, Intan Martha; Vitara, Dea
Pharmaceutical Journal of Indonesia Vol. 11 No. 2 (2026)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Introduction: Hands that look clean can be a medium for transmitting germs. Therefore, one of the prevention efforts that can be done is diligently washing hands using soap and running water, so that practical soap preparations such as paper soap are needed. The high content of terpenoid compounds and strong antibacterial activity in citronella essential oil (Cymbopogon nardus L. Rendle) has the potential to be developed in paper soap preparations. The paper soap formulation of citronella essential oil was prepared using a combination of PVA and stearic acid. Objective: This study aims to determine the effect of the using PVA and stearic acid on physical characteristics in the citronella essential oil paper soap and determine the ratio of the concentrations of PVA and stearic acid in the optimum formula using the Simplex Lattice Design method. Methods: Paper soap formula optimization analyzed by Simplex Lattice Design method using Design Expert 10.0.1. Optimized parameters were pH, foam stability, free alkali, tensile strength, and percentage elongation. The optimum formula was tested for antibacterial activity of Staphylococcus aureus. Results: The results of Design Expert 10.0.1 showed that the optimum formula with a concentration ratio of PVA was 5.113% and stearic acid was 2.387%. The experimental results obtained an average of pH 10.95; foam stability 90.66%; free alkali 0.08%; tensile strength 0.7185 N/m2; and percentage elongation 15.12%. The results of the one sample T-test showed that these observations are differed not significantly to the result of the predictions indicating that the equation of each optimization parameter was valid except for the percentage elongation. The optimum formula has antibacterial activity of Staphylococcus aureus with a diameter of 8.52 mm. Conclusion: PVA and stearic acid have a significant effect on optimization response.

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